内酯类
内酯类化合物是一类含有环状结构的化合物，通常通过一个碳氧双键将两个羟基连接在一个四元、五元或六元的内环中形成。这类化合物广泛存在于自然界中，并且在有机化学、化学化工以及生物医药领域有着重要的应用价值。
内酯的分类- 按环大小划分：根据内酯环的大小，可以将其分为四元、五元和六元内酯。
- 按碳原子数划分：依据组成内酯的碳原子数量不同，可进一步划分为二、三、四等碳链长度不同的内酯。
- 内酯结构中通常包含一个或多个环状氧基团。其独特的环状结构使得它们在水溶液中能够以开环形式存在。
- 在生物体内，某些内酯通过酶的催化作用可实现快速转化，在药物设计和研究领域具有重要应用价值。
- 医药领域：许多抗生素、抗真菌药及抗癌药物都含有内酯结构。例如，四环素类抗生素就含有五元或六元内酯。
- 工业化学：内酯作为重要的化工原料，在合成树脂、塑料和涂料等领域有着广泛应用。
- 分析化学与生物传感器：利用内酯的可逆开环性质进行分析检测；通过构建特定识别分子对提高生物传感系统的特异性。
- 内酯化合物通常具有一定的药理活性，如抗炎、抗菌等作用。这与其独特的空间构象和极性有关。
- 在细胞信号传导过程中，内酯的环开裂或闭合可以影响特定蛋白质之间的相互作用。
总之，内酯作为一种重要的化学结构单元，在多个领域发挥着不可替代的作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | methyl 2-(2-oxooxan-3-yl)acetate | 73746-83-5 | C8H12O4 |
| —— | (3R,5R)-5-((5S,6R)-6-(methoxymethoxy)-10,10-dimethyl-9,9-diphenyl-2,4,8-trioxa-9-silaundecan-5-yl)-3-methyldihydrofuran-2(3H)-one | 1426145-91-6 | C28H40O7Si |
| —— | 2-((3R,3aS,5aR,6S)-3-Ethyl-2-oxo-5-phenyl-hexahydro-cyclopenta[c]furo[3,2-b]furan-6-yl)-malonic acid monomethyl ester | 100457-69-0 | C21H24O7 |
| —— | 1,11-Bis-(5-oxo-tetrahydrofuran-2-yl)-4,8-dithia-undecane | 412934-68-0 | C17H28O4S2 |
| —— | lactucin-8-O-acetate | 83117-61-7 | C17H18O6 |
| —— | 2,5-dideoxy-D-threo-pentono-γ-lactone methoxymethyl ether | 108671-99-4 | C7H12O4 |
| —— | (3S,5R)-3-Methyl-5-[(R)-2-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-propyl]-3-trimethylsilanyloxy-dihydro-furan-2-one | 87680-16-8 | C21H36O4Si |
| —— | 3-[(E)-1-hydroxybut-2-enylidene]-3,4,5,6-tetrahydropyran-2(2H)-one | 1346518-45-3 | C9H12O3 |
| —— | Dihydro-erlilesin A | 113393-98-9 | C17H22O5 |
| —— | 4-(2-(triethylsilylperoxy)propan-2-yl)tetrahydro-2H-pyran-2-one | 1422656-06-1 | C14H28O4Si |
| —— | (-)-(3R,4R,5S)-3-butyl-5-dimethylphenylsilylmethyl-4-hydroxy-2-furanone | 333724-43-9 | C17H26O3Si |
| —— | methyl 8-exo-8-iodo-3-oxo-2-oxabicyclo<3.3.1>nonane-5-carboxylate | 114584-51-9 | C10H13IO4 |
| —— | 3-Ethyl-3-hydroxy-4-methyl-tetrahydro-pyran-2-one | 114199-61-0 | C8H14O3 |
| —— | (+/-)-3-bromo-5-hydroxy-4-oxo-bicyclo[3.2.2]nona-2,8-diene-6<i>exo</i>,7<i>exo</i>-dicarboxylic acid-anhydride | 20379-78-6 | C11H7BrO5 |
| —— | 3-acetyl-11β-N,N-dimethylacetaminohexahydrosantonin | 74493-44-0 | C19H31NO4 |
| —— | 6-allyl-3,3-dimethyltetrahydro-2H-pyran-2-one | 1267665-11-1 | C10H16O2 |
| —— | trans-5-Isopropyl-cis-cyclohexandicarbonsaeure-1,3-anhydrid | 91352-17-9 | C11H16O3 |
| —— | 6-tert-butyl-1-deuterio-5-methyl-3-oxabicyclo[3.2.0]hept-6-ene-2,4-dione | 78920-86-2 | C11H14O3 |
| —— | [(S)-1-((2S,4S)-4-Benzyl-5-oxo-tetrahydro-furan-2-yl)-pentyl]-carbamic acid tert-butyl ester | 129785-63-3 | C21H31NO4 |
| —— | 3-(3-(adamantan-2-yl)-2-methyl-2-(triethylsilylperoxy)propyl)-3-methyldihydrofuran-2(3H)-one | 1321200-04-7 | C25H44O4Si |
| —— | 1-(trimethylsilyl)-5-oxaspiro[2.4]hept-1-en-4-one | 1106930-25-9 | C9H14O2Si |
| —— | 4(R)-methyl-3(S)-(1(S),4-dimethyl-2(E)-pentenyl)dihydro-2(3H)-furanone | 110455-55-5 | C12H20O2 |
| —— | (2aS,2a1S,5aS,5bS,7aR)-4,4,5a-trimethyloctahydrocyclobuta[1,4]cyclobuta[1,2,3-cd]benzofuran-1(2aH)-one | 62054-04-0 | C14H20O2 |
| —— | dichloro-6,6 hexene-5 olide-4 | 98325-69-0 | C6H6Cl2O2 |
| —— | methyl 1,3,3a,4,5,6,7,7a-octahydro-4-hydroxy-1,1-dimethyl-4-phenylisobenzofuran-7-carboxylate | 151091-56-4 | C18H20O6 |
| —— | 2-Hydroperoxy-2,3-dimethyl-1,6-dioxa-4-aza-spiro[4.5]dec-3-en-7-one | 343949-50-8 | C9H13NO5 |
| —— | (4R,6R)-6-[(1R,2E,4E,6R,8E)-9-bromo-6-methoxy-3-methyl-1-tri(propan-2-yl)silyloxynona-2,4,8-trienyl]-4-methoxyoxan-2-one | 1010440-93-3 | C26H45BrO5Si |
| —— | (1S,6S)-6-Isopropyl-3-oxa-bicyclo[4.1.0]heptane-2,4-dione | 80114-55-2 | C9H12O3 |
| —— | 4-oxa-9-methyl-5-(N-ethylcarbamoyloxy)-tricyclo[5,2,1,02,6 ]dec-8-en-3-one | 56232-40-7 | C13H17NO4 |
| —— | tert-butyl (1SR,2SR,9RS)-2-cyano-11,11-dimethyl-4-oxo-5-oxatricyclo<7.3.0.0<sup>3,7</sup>>dodec-3-ene-2-carboxylate | 79898-58-1 | C19H25NO4 |
| —— | 8,16,24-Trimethyl-1,9,17-trioxa-cyclotetracosane-2,10,18-trione | 120982-18-5 | C24H42O6 |
| —— | 1360818-23-0 | C27H52O6Si2 | |
| —— | 2-butyl-4-ethyl-4-butanolide | 54491-11-1 | C10H18O2 |
| —— | (S)-5-Oxo-tetrahydro-furan-2-carboxylic acid (6-hydroxy-hexyl)-amide | 192050-83-2 | C11H19NO4 |
| —— | (3aS,4S,6aR)-4-[(E)-3-oxooct-1-enyl]-3a,4,6,6a-tetrahydro-3H-thieno[3,4-b]furan-2-one | 127309-17-5 | C14H20O3S |
| —— | (R,Z)-3-(2-hydroxyethylidene)-5-(2-methylprop-1-en-1-yl)dihydrofuran-2(3H)-one | 1158094-17-7 | C10H14O3 |
| —— | (3aS,4S,6aR)-2-oxo-3a,4,6,6a-tetrahydro-3H-thieno[3,4-b]furan-4-carbaldehyde | 127269-07-2 | C7H8O3S |
| —— | 3,3-Dimethyl-2,4-dioxa-dispiro<5.0.6.1>tetradecandion-(1,5) | 727-04-8 | C14H20O4 |
| —— | (2R,4R,5S)-2-(2-propyl)-4-hydroxy-5-<(tert-butyloxycarbonyl)amino>-7-methyloctanoic acid δ-lactone | 115860-03-2 | C17H31NO4 |
| —— | (3aR,7S,8aS)-tert-butyl 7-methyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-carboxylate | 1622093-86-0 | C15H22O4 |
| —— | (3R,3aR,4S,6aR)-4-hydroxy-3-(tert-butyldimethylsilanyloxymethyl)hexahydro-1H-cyclopenta[c]furan-1-one | 909911-45-1 | C14H26O4Si |
| —— | (-)-8-Hydroxy-3-methyl-6-trimethylsilyl-3,4,4a,5,6,7-hexahydroisocoumarin | 126680-93-1 | C13H22O3Si |
| —— | 1226979-54-9 | C15H18O2 | |
| —— | 3α,20(R)-dihydroxy-5β-pregnan-18-oic acid γ-lactone | 93781-07-8 | C21H32O3 |
| —— | 2,5-dideoxy-5-iodo-3-O-(tert-butyldimethylsilyl)-D-ribonic acid-γ-lactone | 159685-39-9 | C11H21IO3Si |
| —— | 1228283-47-3 | C15H30O3Si | |
| —— | (-)-(S)-N-[3-(2-trimethylsilyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide | 1273550-91-6 | C15H27NO3S2Si |
| —— | (1'R*,2'R*,4'aR*,8'aR*)-2',3',4',4'a,6',7',8',8'a-Octahydro-2'-methyl-6'-(butylthiomethylene)spiro<furan-3(2H),1'(5'H)-naphthalene>-5(4H),5'-dione | 69748-81-8 | C19H28O3S |
| —— | (2S,4S,5R)-6-cyclohexyl-5-iodo-2-(1-methylethyl)-4-hexanolide | 118832-51-2 | C15H25IO2 |
| —— | 5(S)-<<(tert-Butyldiphenylsilyl)oxy>methyl>-4(R)-ethyl-3(R)-methyldihydro-2(3H)-furanone | 137870-89-4 | C24H32O3Si |
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 182
- 183
- 184
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 193
- 194
- 195
- 196
- 197
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 205
- 206
- 207
- 208
- 209
- 210
- 211
- 212
- 213
- 214
- 215
- 216
- 217
- 218
- 219
- 220
- 221
- 222
- 223
- 224
- 225
- 226
- 227
- 228
- 229
- 230
- 231
- 232
- 233
- 234
- 235
- 236
- 237
- 238
- 239
- 240
- 241
- 242
- 243
- 244
- 245
- 246
- 247
- 248
- 249
- 250
- 251
- 252
- 253
- 254
- 255
- 256
- 257
- 258
- 259
- 260
- 261
- 262
- 263
- 264
- 265
- 266
- 267
- 268
- 269
- 270
- 271
- 272
- 273
- 274
- 275
- 276
- 277
- 278
- 279
- 280
- 281
- 282
- 283
- 284
- 285
- 286
- 287
- 288
- 289
- 290
- 291
- 292
- 293
- 294
- 295
- 296
- 297
- 298
- 299
- 300
- 301
- 302
- 303
- 304
- 305
- 306
- 307
- 308
- 309
- 310
- 311
- 312
- 313
- 314
- 315
- 316
- 317
- 318
- 319
- 320
- 321
- 322
- 323
联系我们
关注我们
公众号
