内酯类
内酯类化合物是一类含有环状结构的化合物，通常通过一个碳氧双键将两个羟基连接在一个四元、五元或六元的内环中形成。这类化合物广泛存在于自然界中，并且在有机化学、化学化工以及生物医药领域有着重要的应用价值。
内酯的分类- 按环大小划分：根据内酯环的大小，可以将其分为四元、五元和六元内酯。
- 按碳原子数划分：依据组成内酯的碳原子数量不同，可进一步划分为二、三、四等碳链长度不同的内酯。
- 内酯结构中通常包含一个或多个环状氧基团。其独特的环状结构使得它们在水溶液中能够以开环形式存在。
- 在生物体内，某些内酯通过酶的催化作用可实现快速转化，在药物设计和研究领域具有重要应用价值。
- 医药领域：许多抗生素、抗真菌药及抗癌药物都含有内酯结构。例如，四环素类抗生素就含有五元或六元内酯。
- 工业化学：内酯作为重要的化工原料，在合成树脂、塑料和涂料等领域有着广泛应用。
- 分析化学与生物传感器：利用内酯的可逆开环性质进行分析检测；通过构建特定识别分子对提高生物传感系统的特异性。
- 内酯化合物通常具有一定的药理活性，如抗炎、抗菌等作用。这与其独特的空间构象和极性有关。
- 在细胞信号传导过程中，内酯的环开裂或闭合可以影响特定蛋白质之间的相互作用。
总之，内酯作为一种重要的化学结构单元，在多个领域发挥着不可替代的作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | (3R,4S,5R)-3-(azidomethyl)-4-hydroxy-5-(hydroxymethyl)oxolan-2-one | 1093104-51-8 | C6H9N3O4 |
| —— | (R)-2-hydroxy-1-((S)-5-oxotetrahydrofuran-2-yl)ethyl-methanesulfonate | 1125824-31-8 | C7H12O6S |
| —— | (3E)-3-[1-(ethylamino)ethylidene]oxolane-2,4-dione | 1248589-92-5 | C8H11NO3 |
| —— | α,α-diphenyl-γ-methyl-γ,δ-pentenoic acid | 109394-96-9 | C18H18O2 |
| —— | (5S)-5-hydroxyoxepan-2-one | 331475-11-7 | C6H10O3 |
| —— | (4S,7S)-4-Acetyl-7-methyl-oxepan-2-one | 87086-67-7 | C9H14O3 |
| —— | 2-oxo-octahydrobenzofuran-3-carbonitrile | 88503-02-0 | C9H11NO2 |
| —— | (E)-5-Butoxy-3-ethylidene-2-oxo-4,5-dihydrofuran | 142038-44-6 | C10H16O3 |
| —— | 15-(4-fluorophenyl)-16-oxadispiro[5.1.6.3]heptadecane-7,17-dione | 1220995-72-1 | C22H27FO3 |
| —— | (1R,5S)-1-[(1R)-2-(tert-butyldiphenylsilyloxy)-1-hydroxyethyl]-7,7-dimethyl-2-oxabicyclo[3.2.0]heptan-3-one | 1040833-50-8 | C26H34O4Si |
| —— | 4,5-Dihydro-3,5-dimethyl-5-propyl-2(3H)-furanon | 143635-49-8 | C9H16O2 |
| —— | (1R)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid | 67111-66-4 | C10H14O4 |
| —— | (5,5-dimethyl-2-oxo-tetrahydro-[3]furyl)-glyoxylic acid ethyl ester | 91101-02-9 | C10H14O5 |
| —— | 131323-96-1 | C22H22O3 | |
| —— | 6-exo-diethylamino-2-oxabicyclo<3.3.0>oct-7-en-3-one | 75758-51-9 | C11H17NO2 |
| —— | (3aS,4S,4aR,7aS,8R,9aS)-4-Hydroxy-4a,8-dimethyl-decahydro-azuleno[6,5-b]furan-2,5-dione | 73590-08-6 | C14H20O4 |
| —— | (3aR,4aS,5S,5aR,6aR)-5-(3-keto-carbamoylhydrazone-butyl)-5a-methyl-3-methylene-3a,4,4a,5,6,6a-hexahydrocyclopropa[f]benzofuran-2-one | 1245771-02-1 | C16H23N3O3 |
| —— | 6,6-dipropyl-dihydro-pyran-2,4-dione | 119523-87-4 | C11H18O3 |
| —— | 3-(2-hydroxyethyl)-2-oxaspiro[4.4]nonan-1-one | 1193397-51-1 | C10H16O3 |
| —— | 3,4-dibromo-5-allenyl-5H-furan-2-one | 669771-34-0 | C7H4Br2O2 |
| —— | (S)-3,4-Dichloro-5-chloromethyl-dihydro-furan-2-one | 53558-92-2 | C5H5Cl3O2 |
| —— | (4aS,5S,6R)-6-Hydroxy-5-vinyl-4,4a,5,6-tetrahydro-3H-pyrano[3,4-c]pyran-1-one | 92619-54-0 | C10H12O4 |
| —— | 1286278-20-3 | C9H14O4 | |
| —— | 4-Hydroxy-2-carboxy-pentansaeurelacton | 25277-91-2 | C6H8O4 |
| —— | (4R,5S)-5-methyl-5-nitro-4-phenyltetrahydro-2H-pyran-2-one | 1261267-49-5 | C12H13NO4 |
| —— | Oxim d. γ,γ-(2-Oxo-pentamethylen)-γ-butyrolacton | 90643-58-6 | C9H13NO3 |
| —— | 5-tert-Butyl-4,5-dihydro-3,5-dimethyl-2(3H)-furanon | 143635-06-7 | C10H18O2 |
| —— | (4aR,7S)-7-isopropenyl-4a-methyl-4a,5,6,7-tetrahydrochroman-2-one | 140198-52-3 | C13H18O2 |
| —— | 12-(4-chlorophenyl)-13-oxadispiro[3.1.5.3]tetradecane-5,14-dione | 1057479-02-3 | C19H21ClO3 |
| —— | 5-hydroxy-3-methyl-5,9b-bis(trifluoromethyl)-3H-[1,3]oxazolo[2,3-a]isoindol-2-one | 100330-25-4 | C13H9F6NO3 |
| —— | (3aR,5R,6aR,1'S)-(+)-5-(1-Hydroxyethyl)hexahydro-2H-cyclopenta-<b>-furan-2-on | 151867-51-5 | C9H14O3 |
| —— | [3aR,4R(3S),5R,6aS]-4-(3-fluorooctyl)-5-hydroxy-hexahydro-2H-cyclopenta[b]furan-2-one | 733037-19-9 | C15H25FO3 |
| —— | 6-azido-3,6-dideoxy-D-ribo-hexono-1,4-lactone | 457073-41-5 | C6H9N3O4 |
| —— | (2S,3R,4S)-4-Ethyl-5-oxo-2-phenyl-tetrahydro-furan-3-carbaldehyde O-benzyl-oxime | 870716-68-0 | C20H21NO3 |
| —— | (+/-)-6<i>t</i>-acetoxy-(5a<i>r</i>,8a<i>c</i>8b<i>c</i>)-4,5,5a,6,8a,8b-hexahydro-naphtho[1,8-<i>bc</i>]furan-2-one | 107623-89-2 | C13H14O4 |
| —— | (3S,4R)-4-Methyl-3-vinyl-tetrahydro-pyran-2-one | 107365-06-0 | C8H12O2 |
| —— | syn-3-ethyl-4-phenyldihydrofuran-2(3H)-one | 1613041-15-8 | C12H14O2 |
| —— | (+/-)-4,5-trans Z-5-iodomethyl-4-methoxy-3-pentylidenetetrahydrofuran-2-one | 78257-78-0 | C11H17IO3 |
| —— | (3aR,5aS,10aS,10bS)-1,2,3,3a,5a,6,7,8,10a,10b-Decahydro-9-oxa-cyclohepta[e]inden-10-one | 123731-39-5 | C13H18O2 |
| —— | (1S,2R,4S,5R)-2-bromo-4-[tert-butyl(dimethyl)silyl]oxy-1-hydroxy-6-oxabicyclo[3.2.1]octane-3,7-dione | 189366-38-9 | C13H21BrO5Si |
| —— | (3R,4S)-3,4-bis(1-adamantyl)oxetan-2-one | 77984-33-9 | C23H32O2 |
| —— | α-Isoproypl-α-methyl-β-propiolacton | 23588-74-1 | C7H12O2 |
| —— | 2,2-bisethoxycarbonyl-5-phenylseleno-3,4-tetrahydrothiopyrancarbolactone | 116012-80-7 | C19H22O6SSe |
| —— | (Z)-4,4-Dimethyl-2-oxo-6-hydroximino-2H,4H,5H,6H,7H-furo-<3,4-b>pyran | 72900-50-6 | C9H11NO4 |
| —— | (3S,3aS,5aS,9S,9aR,9bS)-7-hydroxy-3,5a,9-trimethyl-9-vinyl-3a,4,5,5a,6,7,8,9,9a,9b-decahydronaphtho<1,2-b>furan-2(3H)-one | 128039-77-0 | C17H26O3 |
| —— | 6-bromo-5-tert-butyldiphenylsilyloxy-2,3,6-trideoxy-L-threo-hexono-1,4-lactone | 261722-24-1 | C22H27BrO3Si |
| —— | (3S,3aR,3bR,6R,6aS,6bS)-3,6-Bis-(2,2-dimethyl-6-oxo-tetrahydro-pyran-4-yl)-3a,6a-dimethyl-tetrahydro-1,4-dioxa-cyclobutadicyclopentene-2,5-dione | 71473-24-0 | C24H32O8 |
| —— | (Z)-10-(tert-butyl)-8-methyl-3,4,5,6,9,10-hexahydro-2H-oxecin-2-one | 1392283-84-9 | C14H24O2 |
| —— | Oxabicyclo<3.3.2>undecan-dion | 70260-39-8 | C10H14O3 |
| —— | (R)-3-Chloro-3-isopropyl-1-oxa-spiro[3.11]pentadecan-2-one | 138589-73-8 | C17H29ClO2 |
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 182
- 183
- 184
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 193
- 194
- 195
- 196
- 197
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 205
- 206
- 207
- 208
- 209
- 210
- 211
- 212
- 213
- 214
- 215
- 216
- 217
- 218
- 219
- 220
- 221
- 222
- 223
- 224
- 225
- 226
- 227
- 228
- 229
- 230
- 231
- 232
- 233
- 234
- 235
- 236
- 237
- 238
- 239
- 240
- 241
- 242
- 243
- 244
- 245
- 246
- 247
- 248
- 249
- 250
- 251
- 252
- 253
- 254
- 255
- 256
- 257
- 258
- 259
- 260
- 261
- 262
- 263
- 264
- 265
- 266
- 267
- 268
- 269
- 270
- 271
- 272
- 273
- 274
- 275
- 276
- 277
- 278
- 279
- 280
- 281
- 282
- 283
- 284
- 285
- 286
- 287
- 288
- 289
- 290
- 291
- 292
- 293
- 294
- 295
- 296
- 297
- 298
- 299
- 300
联系我们
关注我们
公众号
