内酯类
内酯类化合物是一类含有环状结构的化合物，通常通过一个碳氧双键将两个羟基连接在一个四元、五元或六元的内环中形成。这类化合物广泛存在于自然界中，并且在有机化学、化学化工以及生物医药领域有着重要的应用价值。
内酯的分类- 按环大小划分：根据内酯环的大小，可以将其分为四元、五元和六元内酯。
- 按碳原子数划分：依据组成内酯的碳原子数量不同，可进一步划分为二、三、四等碳链长度不同的内酯。
- 内酯结构中通常包含一个或多个环状氧基团。其独特的环状结构使得它们在水溶液中能够以开环形式存在。
- 在生物体内，某些内酯通过酶的催化作用可实现快速转化，在药物设计和研究领域具有重要应用价值。
- 医药领域：许多抗生素、抗真菌药及抗癌药物都含有内酯结构。例如，四环素类抗生素就含有五元或六元内酯。
- 工业化学：内酯作为重要的化工原料，在合成树脂、塑料和涂料等领域有着广泛应用。
- 分析化学与生物传感器：利用内酯的可逆开环性质进行分析检测；通过构建特定识别分子对提高生物传感系统的特异性。
- 内酯化合物通常具有一定的药理活性，如抗炎、抗菌等作用。这与其独特的空间构象和极性有关。
- 在细胞信号传导过程中，内酯的环开裂或闭合可以影响特定蛋白质之间的相互作用。
总之，内酯作为一种重要的化学结构单元，在多个领域发挥着不可替代的作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | helicascolide C | 1393544-23-4 | C12H18O3 |
|
| —— | Artenolide | 113807-34-4 | C30H40O8 |
|
| —— | tetrahydro-3-(3-methylbut-2-enyl)pyran-2-one | 412026-41-6 | C10H16O2 |
|
| —— | 7-(2-Phenylethyl)-3-phenylselanyloxepan-2-one | 199797-20-1 | C20H22O2Se |
|
| —— | (3RS,5S)-3-phenylseleno-5-methyldihydro-2(3H)-furanone | 112775-67-4 | C11H12O2Se |
|
| —— | (R)-6-<<(tert-butyldiphenylsilyl)oxy>methyl>-3,4,5,6-tetrahydro-2H-pyran-2-one | 175398-33-1 | C22H28O3Si |
|
| —— | 7-(2-phenethyl)-2-oxepanone | 199797-18-7 | C14H18O2 |
|
| —— | (5S)-5-(3-Iodo-2-methylprop-2-en-1-yl)oxolan-2-one | 404356-75-8 | C8H11IO2 |
|
| —— | (+/-)-4-(tert-butyldiphenylsilyloxymethyl)-4H,5H-dihydrofuran-2-one | 328386-16-9 | C21H26O3Si |
|
| —— | 6-[2'-(tert-butyldimethylsilanyloxy)-1,1'-dimethyl-ethyl]-4-triisopropylsilanyloxy-tetrahydropyran-2-one | 611236-91-0 | C24H50O4Si2 |
|
| —— | (1S,2R,6R,7R,8S)-2-but-3-enyl-7-[tert-butyl(dimethyl)silyl]oxy-1,8-dimethyl-3,10-dioxatricyclo[6.3.0.02,6]undecane-4,9-dione | 902768-23-4 | C21H34O5Si |
|
| —— | 6-oxaspiro[3.4]octan-5-one | 84565-26-4 | C7H10O2 |
|
| —— | α-Methylen-β-pentyl-γ-butyrolacton | 137669-66-0 | C10H16O2 |
|
| —— | 2-ethyl-4-hydroxy-4-methyl-5-oxo-tetrahydro-furan-2-carbonitrile | 122693-57-6 | C8H11NO3 |
|
| —— | (1R,3S,5R,8S,11S)-3,5-dimethyl-7-oxo-2,6-dioxatricyclo[9.2.2.01,8]pentadeca-9,14-diene-12,12,13,13-tetracarbonitrile | 201848-53-5 | C19H16N4O3 |
|
| —— | 5-propoxymethyl-dihydro-furan-2-one | 105273-65-2 | C8H14O3 |
|
| —— | γ-Isopentenyl-butyrolacton | 22908-68-5 | C10H18O2 |
|
| —— | 5-isopentyl-dihydro-furan-2-one | 2429-94-9 | C9H16O2 |
|
| —— | Ethyl 5-chloromethyl-2-oxo-tetrahydrofuran-3-carboxylate | 5406-65-5 | C8H11ClO4 |
|
| —— | cis,trans-3-carboxy-4-phenyl-tetrahydrofuran-2-on | 1016-01-9 | C11H10O4 |
|
| —— | 7-cyclohexyl-oxepan-2-one | 34680-84-7 | C12H20O2 |
|
| —— | 2-Carboxy-4-phenylbutyrolacton | 6005-95-4 | C11H10O4 |
|
| —— | (3Z)-8a-hydroxy-8,8-dimethyl-3-[(4-methyl-5-oxo-2H-furan-2-yl)oxymethylidene]-5,6,7,8b-tetrahydro-3aH-indeno[1,2-b]furan-2-one | 143572-84-3 | C19H22O6 |
|
| —— | α-(Diisopropoxyphosphinyl)-δ-valerolactone | 151746-93-9 | C11H21O5P |
|
| —— | 6-but-3-ynyl-3-chloro-6-cyclopentyl-dihydro-pyran-2,4-dione | 612062-76-7 | C14H17ClO3 |
|
| —— | α-phenylmethylene-δ-lactone | 40541-35-3 | C12H12O2 |
|
| —— | (S)-4-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester | 1056676-01-7 | C17H29NO5 |
|
| —— | (4S,2'S)-2,2-dimethyl-4-(5-oxotetrahydrofuran-2-yl)oxazolidine-3-carboxylic acid tert-butyl ester | 906662-77-9 | C14H23NO5 |
|
| —— | 5-benzyl-4-phenyl-dihydro-furan-2,3-dione | 6362-70-5 | C17H14O3 |
|
| —— | (3R,5S)-dihydro-5-(methoxymethyl)-3-(octadec-17-en-9-ynyl)furan-2(3H)-one | 1333896-66-4 | C24H40O3 |
|
| —— | (3R,5S)-dihydro-5-(hydroxymethyl)-3-(octadec-17-en-9-ynyl)furan-2(3H)-one | 1333896-65-3 | C23H38O3 |
|
| —— | (3R,5S)-dihydro-5-(methoxymethyl)-3-(octadeca-9,11-diynyl)furan-2(3H)-one | 1333896-63-1 | C24H38O3 |
|
| —— | (3S,5S,1'S,3'S)-5-(1'-amino-3'-hydroxymethyl-4'-methylpentyl)-3-isopropyl-dihydrofuran-2-one | 179993-29-4 | C14H27NO3 |
|
| —— | Coriamyrtin | 2571-86-0 | C15H18O5 |
|
| —— | propoxy-6 octanolide-4 | 93676-80-3 | C11H20O3 |
|
| —— | 5-(2-chloroethyl)dihydrofuran-2(3H)-one | 5864-77-7 | C6H9ClO2 |
|
| —— | 5-(2 (benzylthio)ethyl)dihydrofuran-2(3H)-one | 6725-60-6 | C13H16O2S |
|
| —— | (3aR,6R)-6-methyl-8-[tri(isopropyl)-silanyloxy]-3,3a,6,7-tetrahydrocyclohepta[c]furan-1-one | 860480-94-0 | C19H32O3Si |
|
| —— | 4,4-dimethyl-tetrahydro-pyran-2-one | 22791-80-6 | C7H12O2 |
|
| —— | 3,3-Dichloro-4-(chloro-phenylmethyl)oxolan-2-one | 87223-95-8 | C11H9Cl3O2 |
|
| —— | (4,4-dichloro-5-oxo-2-phenyltetrahydrofuran-3-yl)methyl acetate | 957470-75-6 | C13H12Cl2O4 |
|
| —— | 3-methylene-tetrahydro-pyran-2-one | 42023-19-8 | C6H8O2 |
|
| —— | 4-(Dimethoxyphosphinothioylmethyl)oxetan-2-one | 80986-68-1 | C6H11O4PS |
|
| —— | Ethyl 2-butyl-4,5-dioxooxolane-3-carboxylate | 921894-22-6 | C11H16O5 |
|
| —— | 8,8-dimethyl-3-oxabicyclo<3.2.1>octane-2,4-dione | 5763-51-9 | C9H12O3 |
|
| —— | (5S)-5-methyl-5-phenyldihydrofuran-2(3H)-one | 7210-42-6 | C11H12O2 |
|
| —— | (R)-5-methyl-5-phenyl-3,4-dihydro(5H)-furan-2-one | 88314-79-8 | C11H12O2 |
|
| —— | 5-butoxymethyl-3-chlorooxolan-2-one | 78508-82-4 | C9H15ClO3 |
|
| —— | (R)-5-(iodomethyl)-5-phenyldihydrofuran-2(3H)-one | 398142-09-1 | C11H11IO2 |
|
| —— | ε-(2-chloroethyl)-ε-caprolactone | 120476-62-2 | C8H13ClO2 |
|
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 182
- 183
- 184
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 193
- 194
- 195
- 196
- 197
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 205
- 206
- 207
- 208
- 209
- 210
- 211
- 212
- 213
- 214
- 215
- 216
- 217
- 218
- 219
- 220
- 221
- 222
- 223
- 224
- 225
- 226
- 227
- 228
- 229
- 230
- 231
- 232
- 233
- 234
- 235
- 236
- 237
- 238
- 239
- 240
- 241
- 242
- 243
- 244
- 245
- 246
- 247
- 248
- 249
- 250
- 251
- 252
- 253
- 254
- 255
- 256
- 257
- 258
- 259
- 260
- 261
- 262
- 263
- 264
- 265
- 266
- 267
- 268
- 269
- 270
- 271
- 272
- 273
- 274
- 275
- 276
- 277
- 278
- 279
- 280
- 281
- 282
- 283
- 284
- 285
- 286
- 287
- 288
- 289
- 290
- 291
- 292
- 293
- 294
- 295
- 296
- 297
- 298
- 299
- 300
- 301
- 302
联系我们
关注我们
公众号
