内酯类
内酯类化合物是一类含有环状结构的化合物，通常通过一个碳氧双键将两个羟基连接在一个四元、五元或六元的内环中形成。这类化合物广泛存在于自然界中，并且在有机化学、化学化工以及生物医药领域有着重要的应用价值。
内酯的分类- 按环大小划分：根据内酯环的大小，可以将其分为四元、五元和六元内酯。
- 按碳原子数划分：依据组成内酯的碳原子数量不同，可进一步划分为二、三、四等碳链长度不同的内酯。
- 内酯结构中通常包含一个或多个环状氧基团。其独特的环状结构使得它们在水溶液中能够以开环形式存在。
- 在生物体内，某些内酯通过酶的催化作用可实现快速转化，在药物设计和研究领域具有重要应用价值。
- 医药领域：许多抗生素、抗真菌药及抗癌药物都含有内酯结构。例如，四环素类抗生素就含有五元或六元内酯。
- 工业化学：内酯作为重要的化工原料，在合成树脂、塑料和涂料等领域有着广泛应用。
- 分析化学与生物传感器：利用内酯的可逆开环性质进行分析检测；通过构建特定识别分子对提高生物传感系统的特异性。
- 内酯化合物通常具有一定的药理活性，如抗炎、抗菌等作用。这与其独特的空间构象和极性有关。
- 在细胞信号传导过程中，内酯的环开裂或闭合可以影响特定蛋白质之间的相互作用。
总之，内酯作为一种重要的化学结构单元，在多个领域发挥着不可替代的作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | (6E,6'E)-6,6'-(ethane-1,2-diylidene)bis(tetrahydro-2H-pyran-2-one) | 1138337-61-7 | C12H14O4 |
| —— | (6R)-4-(2-hydroxy-2R-phenylethyl)-4-iodomethyl-6-phenyl-1,3-dioxan-2-one | 259682-18-3 | C19H19IO4 |
| —— | 2-chloro-5-methylene-1,3-dioxolan-4-one | 106915-33-7 | C4H3ClO3 |
| —— | 2-Methylene-3-(2'-hydroxycycloheptyl)propanoic Acid, δ-Lactone (Cis-Isomer) | 128243-16-3 | C11H16O2 |
| —— | (3aR,5R,5aR,6R,8aR,8bR)-2,2,6-Trimethyl-7-oxo-octahydro-furo[2',3':3,4]benzo[1,2-d][1,3]dioxole-5-carboxylic acid methyl ester | 127306-27-8 | C14H20O6 |
| —— | 3-(1-ethoxyaminoethylidene)-5,6-dimethyltetrahydropyrane-2,4-dione | 58433-50-4 | C11H17NO4 |
| —— | (S)-7-Pentyl-oxepan-2-one | 115510-49-1 | C11H20O2 |
| —— | (1S,5R,8S)-8-Methoxy-6-oxa-bicyclo[3.2.1]octan-7-one | 158195-45-0 | C8H12O3 |
| —— | 1-chloro-3-methylene-cyclobutane-1r,2c-dicarboxylic acid-anhydride | 86741-80-2 | C7H5ClO3 |
| —— | cis-1.2.3.4.4a.5.6.7.8.8a-Decahydro-4-hydroxy-8-methyl-naphthoesaeure-δ-lacton-(1.5) | 66278-37-3 | C12H18O3 |
| —— | 59556-23-9 | C12H16O2 | |
| —— | 2-(trimethylsilylmethyl)-4-phenyl-γ-butyrolactone | 75142-67-5 | C14H20O2Si |
| —— | (3aR,4S,5S,6R,6aR)-6-Bromo-5-hydroxy-4-methoxymethyl-hexahydro-cyclopenta[b]furan-2-one | 56460-55-0 | C9H13BrO4 |
| —— | (1R,2R,6S,7R)-3-Oxa-tricyclo[5.3.2.0<sup>2,6</sup>]dodec-11-en-4-one | 54566-24-4 | C11H14O2 |
| —— | 1203867-62-2 | C12H14N4O2 | |
| —— | (3R,4S)-3-Isopropenyl-4-methyl-tetrahydro-pyran-2-one | 107365-08-2 | C9H14O2 |
| —— | 2,3,6-tri-O-tert-butyldimethylsilyl-5-O-pivaloyl-D-galactono-1,4-lactone | 659721-23-0 | C29H60O7Si3 |
| —— | (R)-6-Furan-3-yl-4-hydroxy-3-methyl-tetrahydro-pyran-2-one | 255870-31-6 | C10H12O4 |
| —— | (3S,4S)-4-<(1R)-1-hydroxy-2-propen-1-yl>-3-trifluoroacetylamino-4-butanolide | 174582-92-4 | C9H10F3NO4 |
| —— | [(1R,2R,5S,8R,9S,10S)-5-ethyl-2,9-dihydroxy-5,11,11-trimethyl-15-oxo-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-yl] acetate | 1351231-67-8 | C22H32O6 |
| —— | (R)-3-Methylene-5-propyl-dihydro-furan-2-one | 100907-30-0 | C8H12O2 |
| —— | (1R,2S,7R,10S,E)-7-hydroxy-2-methyl-3,11-dioxabicyclo-[8.1.0]undec-8-en-4-one | 1360619-06-2 | C10H14O4 |
| —— | methyl (2S)-2-[(1R,2S)-2-(iodomethyl)cyclohexyl]-2-[(3S)-5-oxooxolan-3-yl]acetate | 1310492-05-7 | C14H21IO4 |
| —— | 5-Oxatricyclo[5.3.1.03,9]undecan-4-one | 96929-67-8 | C10H14O2 |
| —— | (3aR,8aS)-3-Methylene-3,3a,6,7,8,8a-hexahydro-cyclohepta[b]furan-2-one | 60916-78-1 | C10H12O2 |
| —— | trans-3-arachidonyl-4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one | 125757-30-4 | C25H38O4 |
| —— | (E)-(1aR,5aS,10aS)-2,9-Dihydroxy-4-hydroxymethyl-8-methoxymethyl-10a-methyl-1a,3,5a,8,8a,9,10,10a-octahydro-2H-1,6-dioxa-cyclopenta[a]cyclopropa[e]cyclodecen-7-one | 57498-92-7 | C16H24O7 |
| —— | Syneilesinolide-A-monomethylester | 62334-62-7 | C11H18O5 |
| —— | furan-2,3,4-trione 3,4-dioxime | 943598-35-4 | C4H4N2O4 |
| —— | N-Isopropyl-picrotoxininamid-6-acetat | 58281-93-9 | C20H27NO7 |
| —— | (3S,4R,5S)-4-bromo-3,5-dimethyl-5-phenyldihydrofuran-2(3H)-one | 950489-16-4 | C12H13BrO2 |
| —— | (5E)-5-[(3R)-4,4,4-trichloro-3-triethylsilyloxybutylidene]pyran-2-one | 1093435-85-8 | C15H23Cl3O3Si |
| —— | Acetic acid 1-[(4S,5R)-5-methyl-4-(4-methyl-pent-3-enyl)-2-oxo-dihydro-furan-(3Z)-ylidene]-ethyl ester | 170964-90-6 | C15H22O4 |
| —— | (4aS,8aR)-8a-(2-Iodo-ethyl)-octahydro-isochromen-3-one | 58240-87-2 | C11H17IO2 |
| —— | (+/-)-2-(4'-Chlor-2'-methyl-1'-oxobutyl)-2-ethyl-4-butanolid | 127915-18-8 | C11H17ClO3 |
| —— | (4S,5S)-4-ethenyl-5-hydroxyoxan-2-one | 81661-47-4 | C7H10O3 |
| —— | 1415213-34-1 | C10H16O4 | |
| —— | (3S,4R,5R)-5-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-3,4-dihydroxy-dihydro-furan-2-one | 211365-03-6 | C12H24O6Si |
| —— | (1R,2R,6S,7S)-5-cyclopentyl-4-oxatricyclo[5.2.1.02,6]dec-8-en-3-one | 84566-11-0 | C14H18O2 |
| —— | (6S)-6-[(2R,3R)-3-[tert-butyl(dimethyl)silyl]oxypentan-2-yl]-3-methyloxane-2,4-dione | 950479-04-6 | C17H32O4Si |
| —— | (1S,2R,5R)-1-Methyl-2-vinyl-6-oxa-bicyclo[3.2.1]octane-4,7-dione | 73240-78-5 | C10H12O3 |
| —— | S-ethyl 2-((2S,3S)-3-(tert-butyldimethylsilyloxy)-5-oxotetrahydrofuran-2-yl)ethanethioate | 1268695-23-3 | C14H26O4SSi |
| —— | (2R,5S,7S,5'S)-spiro[1-oxa-8-oxo-2-phenyl-3-oxabicyclo[3.3.0]octane]-7,3'-[5'-phenyldihydrofuran-2'-one] | 1340543-07-8 | C21H19NO4 |
| —— | (8β,9α,14α)-11β-carboxy-11α,13α-(γ-lactone)-2-methoxy-17α-vinylgona-1,3,5(10)-triene (5,6-O-isopropylidene-α-D-glucofuranos-3-yl) ester | 1107647-65-3 | C31H38O10 |
| —— | 3,3-bis(3-iodopropyl)oxepan-2-one | 163012-24-6 | C12H20I2O2 |
| —— | 2-(2-Hydroxy-2-phenylethyl)-4-phenyl-γ-butyrolacton | 30333-24-5 | C18H18O3 |
| —— | exo-2-hydroxynorbornane-1-acetic acid lactone | 87494-97-1 | C9H12O2 |
| —— | (+/-)-(1R*,2S*,5S*,6R*,7S*)-5-(2-hydroxyprop-2-yl)-6-methyl-4-oxatricyclo<5.3.0.0<sup>2,6</sup>>decan-3-one | 124867-83-0 | C13H20O3 |
| —— | (+)-5-epi-garvensintriol | 1231752-35-4 | C13H16O5 |
| —— | 2,6-dideoxy-3-O-methyl-4-triethylsiloxy-L-arabino-hexono-1,5-lactone | 1186076-52-7 | C13H26O4Si |
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 182
- 183
- 184
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 193
- 194
- 195
- 196
- 197
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 205
- 206
- 207
- 208
- 209
- 210
- 211
- 212
- 213
- 214
- 215
- 216
- 217
- 218
- 219
- 220
- 221
- 222
- 223
- 224
- 225
- 226
- 227
- 228
- 229
- 230
- 231
- 232
- 233
- 234
- 235
- 236
- 237
- 238
- 239
- 240
- 241
- 242
- 243
- 244
- 245
- 246
- 247
- 248
- 249
- 250
- 251
- 252
- 253
- 254
- 255
- 256
- 257
- 258
- 259
- 260
- 261
- 262
- 263
- 264
- 265
- 266
- 267
- 268
- 269
- 270
- 271
- 272
- 273
- 274
- 275
- 276
- 277
- 278
- 279
- 280
- 281
- 282
- 283
- 284
- 285
- 286
- 287
- 288
- 289
- 290
- 291
- 292
- 293
- 294
- 295
- 296
- 297
- 298
- 299
- 300
联系我们
关注我们
公众号
