内酯类
内酯类化合物是一类含有环状结构的化合物，通常通过一个碳氧双键将两个羟基连接在一个四元、五元或六元的内环中形成。这类化合物广泛存在于自然界中，并且在有机化学、化学化工以及生物医药领域有着重要的应用价值。
内酯的分类- 按环大小划分：根据内酯环的大小，可以将其分为四元、五元和六元内酯。
- 按碳原子数划分：依据组成内酯的碳原子数量不同，可进一步划分为二、三、四等碳链长度不同的内酯。
- 内酯结构中通常包含一个或多个环状氧基团。其独特的环状结构使得它们在水溶液中能够以开环形式存在。
- 在生物体内，某些内酯通过酶的催化作用可实现快速转化，在药物设计和研究领域具有重要应用价值。
- 医药领域：许多抗生素、抗真菌药及抗癌药物都含有内酯结构。例如，四环素类抗生素就含有五元或六元内酯。
- 工业化学：内酯作为重要的化工原料，在合成树脂、塑料和涂料等领域有着广泛应用。
- 分析化学与生物传感器：利用内酯的可逆开环性质进行分析检测；通过构建特定识别分子对提高生物传感系统的特异性。
- 内酯化合物通常具有一定的药理活性，如抗炎、抗菌等作用。这与其独特的空间构象和极性有关。
- 在细胞信号传导过程中，内酯的环开裂或闭合可以影响特定蛋白质之间的相互作用。
总之，内酯作为一种重要的化学结构单元，在多个领域发挥着不可替代的作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | 4-Benzyl-3-[bis(methylsulfanyl)methylidene]oxolan-2-one | 136495-13-1 | C14H16O2S2 |
| —— | (3aR,3bS,6aR,7aR)-5-Hydroxy-3b,4,4,6a-tetramethyl-3-oxo-1,3,3a,3b,4,6a,7,7a-octahydro-pentaleno[1,2-c]furan-6-carboxylic acid methyl ester | 102358-53-2 | C16H22O5 |
| —— | 117624-93-8 | C20H40O4Si2 | |
| —— | Dihydro-3-(phenylseleno)-3-methyl-5-phenyl-2-furanone | 73262-47-2 | C17H16O2Se |
| —— | (2SR,4RS,5S)-5-[N-(tert-butoxycarbonyl)amino]-2-cyano-7-methyl-1,4-octanolactone | 628318-85-4 | C15H24N2O4 |
| —— | (6aR,10aS)-8-Chloromethyl-7-(2-furan-3-yl-ethyl)-7-methyl-octahydro-2-oxa-cyclopenta[d]naphthalen-3-one | 18411-68-2 | C20H27ClO3 |
| —— | 4-propyl-3-trimethylsilanyl-oxetan-2-one | 343787-26-8 | C9H18O2Si |
| —— | 41502-67-4 | C16H18O6 | |
| —— | 1040834-07-8 | C26H32O4Si | |
| —— | 1431563-45-9 | C78H21O16P | |
| —— | 3β-bromo-4α-hydroxy-5,7α,6β(H)-guaia-1(10),11(13)-dien-12,6-olide | 1228392-80-0 | C15H19BrO3 |
| —— | 4-<2-(t-butyldimethylsiloxy)ethyl>-3-(bis(methylthio)methylene) dihydro-2(3H)-furanone | 136495-17-5 | C15H28O3S2Si |
| —— | (4-acetonyl-5-oxo-2-phenyl-tetrahydro-[2]furyl)-acetic acid | 106593-06-0 | C15H16O5 |
| —— | (1R,4S,5R,7R)-7-tert-butoxy-5-methyl-4-pivaloyloxymethyl-3-oxabicyclo[3.2.0]heptan-2-one | 1044593-51-2 | C17H28O5 |
| —— | 65563-72-6 | C20H22O6 | |
| —— | 111513-90-7 | C11H17O5 | |
| —— | 3α-hydroxy-4β-formyl-5,7α,6β(H)-guai-1(10),11(13)-dien-12,6-olide | 1426068-09-8 | C16H20O5 |
| —— | (4S,5S)-3,3-dichloro-4-(chloromethyl)-5-ethyloxolan-2-one | 87224-00-8 | C7H9Cl3O2 |
| —— | (2ξ,5α)-2,6',7',8',9',11'-hexahydro-4'H-17a-oxa-3',4',11',12'-tetraaza-cyclotrideca[2,3]-17a-homo-androstane-17,5',10'-trione | 16987-69-2 | C26H38N4O4 |
| —— | (2R,4S)-2-ethyl-4-(hydroxymethyl)-2-methyl-4-butanolide | 80348-82-9 | C8H14O3 |
| —— | endo-4-Methyl-3-oxabicyclo<3.2.0>hepta-6-en-2-on | 59664-88-9 | C7H8O2 |
| —— | 7,7-Dimethoxy-4-methyl-3-oxabicycl<4.2.0>octan-2-on | 59664-92-5 | C10H16O4 |
| —— | tert-butyl (2S,3R,4R)-4-hydroxy-2,4-dimethyl-6-oxotetrahydro-2H-pyran-3-ylcarbamate | 1301684-86-5 | C12H21NO5 |
| —— | (2S,4S)-2-allyl-4-(hydroxymethyl)-2-methyl-4-butanolide | 80348-87-4 | C9H14O3 |
| —— | (3aS,4aS,7aS,8aS)-5,5-Dimethyl-7a-vinyl-octahydro-benzo[1,2-b;4,5-c']difuran-2-one | 121401-24-9 | C14H20O3 |
| —— | (4S,6S)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-methyl-tetrahydro-pyran-2-one | 158661-88-2 | C23H30O3Si |
| —— | (1'RS,2'E,3RS)-3-<3'-(methylsulfonyl)-1'-pentylprop-2'-enyl>butan-4-olide | 119011-09-5 | C13H22O4S |
| —— | 4-oxo-5-oxa-spiro[2.4]heptane-1,2-dicarboxylic acid diethyl ester | 40587-46-0 | C12H16O6 |
| —— | Nepetaefolinol-acetat | 55784-82-2 | C22H30O7 |
| —— | ethyl (E)-4-methyl-5-oxotetrahydrofuran-2-ylideneacetate | 84374-94-7 | C9H12O4 |
| —— | methyl (1R,4S,7S,8R,9R)-7-hydroxy-9-methyl-11-oxo-9-[(E)-3-oxoprop-1-enyl]-10-oxatricyclo[6.3.2.01,7]tridecane-4-carboxylate | 457622-30-9 | C18H24O6 |
| —— | (1R,4R,7R,8R)-7,8-Dihydroxy-2,5-dioxa-bicyclo[2.2.2]octane-3,6-dione | 120907-22-4 | C6H6O6 |
| —— | t-6-Hydroxy-r-1-oxaspiro<4.6>undecan-2-on | 80922-74-3 | C10H16O3 |
| —— | 5-ethoxy-4,5-dihydro-3-methyl-3-phenylfuran-2(3H)-one | 97024-25-4 | C13H16O3 |
| —— | ((S)-5-Oxo-tetrahydro-furan-3-yl)-acetic acid tert-butyl ester | 108330-08-1 | C10H16O4 |
| —— | 5-Oxa-tricyclo[5.3.2.0<sup>4,8</sup>]dodeca-2,9,11-trien-6-one | 23813-01-6 | C11H10O2 |
| —— | 2-Methyl-2-(1-methyl-allyl)-5-oxo-4-phenyl-tetrahydro-furan-3-carboxylic acid ethyl ester | 104413-21-0 | C18H22O4 |
| —— | S-(3-methyl-2-oxooxolan-3-yl) 2-bromoethanethioate | 118534-94-4 | C7H9BrO3S |
| —— | 3,3-dichloro-4-hydroxy-5,5-dimethyltetrahydro-2H-pyran-2-one | 1333332-45-8 | C7H10Cl2O3 |
| —— | (3aS,6aR)-6a-Acetyl-tetrahydro-cyclopenta[b]furan-2,3-dione 3-oxime | 52482-05-0 | C9H11NO4 |
| —— | (S)-6,7-Bis-chloromethyl-3-oxa-bicyclo[3.2.0]heptane-2,4-dione | 38665-90-6 | C8H8Cl2O3 |
| —— | (Z)-1,8,8-trimethyl-4-(pyridin-4-ylimino)-3-oxabicyclo-[3.2.1]octan-2-one | 1256484-23-7 | C15H18N2O2 |
| —— | 4-methyl-5-oxo-tetrahydro-furan-2,3-dicarboxylic acid | 68836-31-7 | C7H8O6 |
| —— | (3aS,5S,6S,7aR)-5,6-dihydroxy-perhydro-isobenzofuranone | 145680-93-9 | C8H12O4 |
| —— | 5-(bromo(cyclohexyl)methyl)dihydrofuran-2(3H)-one | 1384163-69-2 | C11H17BrO2 |
| —— | (2aR,5aR,8aS,8bR)-2a,5a-Dimethyl-decahydro-naphtho[1,8-bc]furan-2-one | 90734-42-2 | C13H20O2 |
| —— | 2,6-dibromo-2,6-dideoxy-L-glucono-1,4-lactone | 152786-43-1 | C6H8Br2O4 |
| —— | (3S,5S)-5-(hydroxymethyl)-3-methyl-3-propyloxolan-2-one | 80348-84-1 | C9H16O3 |
| —— | 3-oxo-1,4a,7,7a-tetrahydro-1,4-etheno-cyclopenta[<i>c</i>]pyran-4-carboxylic acid methyl ester | 54857-51-1 | C12H12O4 |
| —— | 3-[1-(Dimethyl-phenyl-silanyl)-meth-(Z)-ylidene]-dihydro-furan-2-one | 128549-51-9 | C13H16O2Si |
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 182
- 183
- 184
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 193
- 194
- 195
- 196
- 197
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 205
- 206
- 207
- 208
- 209
- 210
- 211
- 212
- 213
- 214
- 215
- 216
- 217
- 218
- 219
- 220
- 221
- 222
- 223
- 224
- 225
- 226
- 227
- 228
- 229
- 230
- 231
- 232
- 233
- 234
- 235
- 236
- 237
- 238
- 239
- 240
- 241
- 242
- 243
- 244
- 245
- 246
- 247
- 248
- 249
- 250
- 251
- 252
- 253
- 254
- 255
- 256
- 257
- 258
- 259
- 260
- 261
- 262
- 263
- 264
- 265
- 266
- 267
- 268
- 269
- 270
- 271
- 272
- 273
- 274
- 275
- 276
- 277
- 278
- 279
- 280
- 281
- 282
- 283
- 284
- 285
- 286
- 287
- 288
- 289
- 290
- 291
- 292
- 293
- 294
- 295
- 296
- 297
- 298
- 299
- 300
联系我们
关注我们
公众号
