内酯类
内酯类化合物是一类含有环状结构的化合物，通常通过一个碳氧双键将两个羟基连接在一个四元、五元或六元的内环中形成。这类化合物广泛存在于自然界中，并且在有机化学、化学化工以及生物医药领域有着重要的应用价值。
内酯的分类- 按环大小划分：根据内酯环的大小，可以将其分为四元、五元和六元内酯。
- 按碳原子数划分：依据组成内酯的碳原子数量不同，可进一步划分为二、三、四等碳链长度不同的内酯。
- 内酯结构中通常包含一个或多个环状氧基团。其独特的环状结构使得它们在水溶液中能够以开环形式存在。
- 在生物体内，某些内酯通过酶的催化作用可实现快速转化，在药物设计和研究领域具有重要应用价值。
- 医药领域：许多抗生素、抗真菌药及抗癌药物都含有内酯结构。例如，四环素类抗生素就含有五元或六元内酯。
- 工业化学：内酯作为重要的化工原料，在合成树脂、塑料和涂料等领域有着广泛应用。
- 分析化学与生物传感器：利用内酯的可逆开环性质进行分析检测；通过构建特定识别分子对提高生物传感系统的特异性。
- 内酯化合物通常具有一定的药理活性，如抗炎、抗菌等作用。这与其独特的空间构象和极性有关。
- 在细胞信号传导过程中，内酯的环开裂或闭合可以影响特定蛋白质之间的相互作用。
总之，内酯作为一种重要的化学结构单元，在多个领域发挥着不可替代的作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | 2-Hexyl-5-methyl-1,3-dioxa-spiro[5.5]undecan-4-one | 74942-39-5 | C16H28O3 |
| —— | 5-benzyl-6-phenyloxane-2,4-dione | 1020850-95-6 | C18H16O3 |
| —— | (3aS,6aS,9S,10aR)-4-[tert-butyl(dimethyl)silyl]oxy-9-ethenyl-3,3a,4,6a,7,8,9,10-octahydrobenzo[h][2]benzofuran-1-one | 1384477-69-3 | C20H32O3Si |
| —— | (3S,5R)-3-Chloro-5-chloromethyl-dihydro-furan-2-one | 53558-89-7 | C5H6Cl2O2 |
| —— | (4R<sup>*</sup>,5S<sup>*</sup>)-4-hydroxy-5-methyl-4-isopropenyl-1-oxacyclohexan-2-one | 135973-93-2 | C9H14O3 |
| —— | 12α,13α-epoxypicrasa-3,14-dien-16-one | 141317-48-8 | C20H26O3 |
| —— | (-)-(4R,6S,8R,9S,9aS)-6-(acetoxymethyl)-8,9-dihydroxy-4-phenyl-9a-(trifluoromethyl)hexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one | 1379671-76-7 | C18H20F3NO6 |
| —— | (1S,5S)-6-exo,7-endo-dihydroxy-3-oxo-2-oxabicyclo<3.3.0>octane | 80734-99-2 | C7H10O4 |
| —— | 1,2-diaminocyclohexane isocitratomonoethyl ester platinum(II) complex | 96322-34-8 | C14H24N2O7Pt |
| —— | 2-[(1S,3'R,4S,5R)-5'-oxospiro[bicyclo[2.2.2]oct-2-ene-5,4'-oxolane]-3'-yl]acetaldehyde | 1399897-38-1 | C13H16O3 |
| —— | endo,endo-8,9-diacetoxy-exo-2-methyl-3-oxa-cis-bicyclo<4.3.0>nonan-4-one | 78309-86-1 | C13H18O6 |
| —— | (3R)-3-ethyl-3-methyl-4-butanolide | 40710-01-8 | C7H12O2 |
| —— | tannunolide C | 131740-75-5 | C15H18O2 |
| —— | 3a-Methyl-1,2,3a,5a,8,9,9a,9b-octahydro-6-oxa-cyclopenta[a]naphthalene-3,7-dione | 81303-09-5 | C13H16O3 |
| —— | 9-deoxygelsemide | 159974-16-0 | C10H12O4 |
| —— | 5,5-dibutyl-3-methylene-dihydro-furan-2-one | 66986-19-4 | C13H22O2 |
| —— | 3-(4-fluorophenyl)-4-oxo-3a,4,6,6a-tetrahydrofuro<3,4-d>isoxazole | 107166-75-6 | C11H8FNO3 |
| —— | (3α,3aβ,9aα)-octahydro-3-(chloromethyl)cycloocta(b)furan-2(3H)-one | 97191-08-7 | C11H17ClO2 |
| —— | (1S,4S,5R,7S)-4-(tert-Butyldimethylsilyloxy)-7-hydroxy-4-(prop-2-enyl)-2-oxabicyclo<3.3.0>octan-3-one | 137956-37-7 | C16H28O4Si |
| —— | 3,3,4,4-Tetramethyl-α-methylen-δ-valerolacton | 66797-97-5 | C10H16O2 |
| —— | (4R,6R)-6-But-3-enyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-one | 121772-51-8 | C15H28O3Si |
| —— | (R)-2-((3R,4S)-4-Methyl-2-oxo-tetrahydro-furan-3-yl)-propionaldehyde | 115047-64-8 | C8H12O3 |
| —— | cardionidine | 142609-18-5 | C21H25NO5 |
| —— | 4-ethyl-4-hydroxy-5-methyl-1-oxacyclohexan-2-one | 135973-94-3 | C8H14O3 |
| —— | 3β-acetoxy-20-oxo-7-nor-5β,6α-pregnane-6,5-carbolactone | 15385-00-9 | C23H32O5 |
| —— | (2S,3S,4S)-2,3-dihydro-4-isopropyl-2-methyltetronic acid | 112923-83-8 | C8H14O3 |
| —— | (+)-2(R)-allo-Protolichesterinsaeuremethylesterpyrazolin | 144408-15-1 | C21H36N2O4 |
| —— | (3S,5R,9S)-3-(1-iodo-1-methylethyl)-9-hydroxy-1-oxo-2-oxaspiro[4.4]non-6-ene-7-carboxaldehyde | 1071199-03-5 | C12H15IO4 |
| —— | 2-O-benzyl-2-C-methyl-D-erythrono-1,4-lactone | 81347-85-5 | C12H14O4 |
| —— | 4,4-dicyclopropyl-5-hydroxydihydro-2-furanone | 112641-95-9 | C10H14O3 |
| —— | Trifluoro-acetic acid (4aR,7S,8aR)-3-oxo-8a-vinyl-3,4,4a,7,8,8a-hexahydro-1H-isochromen-7-yl ester | 467220-04-8 | C13H13F3O4 |
| —— | (3aR,6S,7R,8S,8aS)-6-[tert-butyl(dimethyl)silyl]oxy-8-iodo-7-methyl-3,3a,4,5,6,7,8,8a-octahydrocyclohepta[b]furan-2-one | 1026413-28-4 | C16H29IO3Si |
| —— | 8a-Methyl-3-methylene-octahydro-cyclohepta[b]furan-2-one | 67498-59-3 | C11H16O2 |
| —— | (4R,6R)-4-Methoxy-6-((R)-1-triisopropylsilanyloxy-but-2-ynyl)-tetrahydro-pyran-2-one | 348084-50-4 | C19H34O4Si |
| —— | 3-acetyl-4,5-dihydro-3-(hydroxymethyl)furan-2(3H)-one | 1046768-91-5 | C7H10O5 |
| —— | (1S,5S,6S,9S)-9-isopropyl-6-methyl-11-oxo-10,12-dioxatricyclo[7.3.0.01,6]dodec-5-yl acetate | 874120-18-0 | C16H24O5 |
| —— | 18-hydroxy-5α-androstane-3-one-17β-carboxylic acid lactone | 86698-75-1 | C20H28O3 |
| —— | (3aR,5aR,6R,9S,9aS,9bR)-3,3a,5a,6,7,8,9,9a-octahydro-4,9-dimethyl-6-triisopropylsilyloxynaphtho[2,1-c]furan-1(9bH)-one | 1115372-06-9 | C23H40O3Si |
| —— | cis-2-methyl-3-phenyl-2-vinyl-5-pentanolide | 114199-50-7 | C14H16O2 |
| —— | 3,3-Dichloro-1-oxa-spiro[3.6]decan-2-one | 133611-53-7 | C9H12Cl2O2 |
| —— | (S)-5-(iodomethyl)-5-methyldihydrofuran-2(3H)-one | 1196873-11-6 | C6H9IO2 |
| —— | 1α,2β,3β,4β,5β,6α-tricyclo[4.2.1.0<sup>2,5</sup>]nona-7-en-3,4-dicarboxylic anhydride | 137411-67-7 | C11H10O3 |
| —— | (3S,3aS,6aR)-3-Methyl-1-((S)-1-phenyl-ethyl)-tetrahydro-furo[3,2-c]isoxazol-5-one | 103302-57-4 | C14H17NO3 |
| —— | (3R,4R,5R,6S)-4-hydroxy-6-((S)-1-hydroxypropan-2-yl)-3,5-dimethyltetrahydro-2H-pyran-2-one | 1096707-36-6 | C10H18O4 |
| —— | 4-Allyl-2-oxa-bicyclo[3.2.1]octan-3-one | 80797-70-2 | C10H14O2 |
| —— | 12-chloro-1,3-dimethyl-6-oxatricyclo<8.3.0.03,7>tridecane-2,5,13-trione | 139712-99-5 | C14H17ClO4 |
| —— | 6-endo-hydroxy-5-exo-iodo-3-endo-phenylnorborn-2-endo-2-ylacetic acid δ-lactone | 86960-72-7 | C15H15IO2 |
| —— | (7S,9R)-7,9-Dimethyl-2-oxa-spiro[4.5]decan-3-one | 344571-30-8 | C11H18O2 |
| —— | 1420965-16-7 | C11H12O4 | |
| —— | 5-Methyl-3-oxo-4-oxa-tricyclo[6.2.1.0<sup>2,7</sup>]undeca-2(7),9-diene-9,10-dicarboxylic acid dimethyl ester | 61259-68-5 | C15H16O6 |
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 34
- 35
- 36
- 37
- 38
- 39
- 40
- 41
- 42
- 43
- 44
- 45
- 46
- 47
- 48
- 49
- 50
- 51
- 52
- 53
- 54
- 55
- 56
- 57
- 58
- 59
- 60
- 61
- 62
- 63
- 64
- 65
- 66
- 67
- 68
- 69
- 70
- 71
- 72
- 73
- 74
- 75
- 76
- 77
- 78
- 79
- 80
- 81
- 82
- 83
- 84
- 85
- 86
- 87
- 88
- 89
- 90
- 91
- 92
- 93
- 94
- 95
- 96
- 97
- 98
- 99
- 100
- 101
- 102
- 103
- 104
- 105
- 106
- 107
- 108
- 109
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 117
- 118
- 119
- 120
- 121
- 122
- 123
- 124
- 125
- 126
- 127
- 128
- 129
- 130
- 131
- 132
- 133
- 134
- 135
- 136
- 137
- 138
- 139
- 140
- 141
- 142
- 143
- 144
- 145
- 146
- 147
- 148
- 149
- 150
- 151
- 152
- 153
- 154
- 155
- 156
- 157
- 158
- 159
- 160
- 161
- 162
- 163
- 164
- 165
- 166
- 167
- 168
- 169
- 170
- 171
- 172
- 173
- 174
- 175
- 176
- 177
- 178
- 179
- 180
- 181
- 182
- 183
- 184
- 185
- 186
- 187
- 188
- 189
- 190
- 191
- 192
- 193
- 194
- 195
- 196
- 197
- 198
- 199
- 200
- 201
- 202
- 203
- 204
- 205
- 206
- 207
- 208
- 209
- 210
- 211
- 212
- 213
- 214
- 215
- 216
- 217
- 218
- 219
- 220
- 221
- 222
- 223
- 224
- 225
- 226
- 227
- 228
- 229
- 230
- 231
- 232
- 233
- 234
- 235
- 236
- 237
- 238
- 239
- 240
- 241
- 242
- 243
- 244
- 245
- 246
- 247
- 248
- 249
- 250
- 251
- 252
- 253
- 254
- 255
- 256
- 257
- 258
- 259
- 260
- 261
- 262
- 263
- 264
- 265
- 266
- 267
- 268
- 269
- 270
- 271
- 272
- 273
- 274
- 275
- 276
- 277
- 278
- 279
- 280
- 281
- 282
- 283
- 284
- 285
- 286
- 287
- 288
- 289
- 290
- 291
- 292
- 293
- 294
- 295
- 296
- 297
- 298
- 299
- 300
联系我们
关注我们
公众号
