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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(3S)-3-(2-hydroxyethylsulfanyl)butyl]sulfanylethanol —— C8H18O2S2
    2-[(3S)-3-(2-hydroxyethylsulfanyl)butyl]sulfanylethanol
    —— (2R)-2-phenylsulfanyloxolane —— C10H12OS
    (2R)-2-phenylsulfanyloxolane
    —— 2-nitro-2-[(1S)-1-phenylsulfanylethyl]propane-1,3-diol —— C11H15NO4S
    2-nitro-2-[(1S)-1-phenylsulfanylethyl]propane-1,3-diol
    —— 1-methyl-3-[(1R,2R)-2-(methylcarbamothioylamino)cyclohexyl]thiourea —— C10H20N4S2
    1-methyl-3-[(1R,2R)-2-(methylcarbamothioylamino)cyclohexyl]thiourea
    —— (E)-3-(1,3-benzothiazol-2-yl)-4-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]but-3-enoic acid —— C20H15N5O4S2
    (E)-3-(1,3-benzothiazol-2-yl)-4-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]but-3-enoic acid
    —— [(1R)-1-bromo-2-[(2R)-2-bromo-2-phenylethyl]sulfonylethyl]benzene —— C16H16Br2O2S
    [(1R)-1-bromo-2-[(2R)-2-bromo-2-phenylethyl]sulfonylethyl]benzene
    —— (E)-2-cyano-3-methoxybut-2-enethioamide —— C6H8N2OS
    (E)-2-cyano-3-methoxybut-2-enethioamide
    —— (3R)-3-ethoxy-5-phenyl-2,3-dihydro-1,4-benzothiazepine —— C17H17NOS
    (3R)-3-ethoxy-5-phenyl-2,3-dihydro-1,4-benzothiazepine
    —— [(2R)-2-chlorobutyl]sulfanyl-[(1S)-1,2,2-trichloroethyl]sulfanylmethanone —— C7H10Cl4OS2
    [(2R)-2-chlorobutyl]sulfanyl-[(1S)-1,2,2-trichloroethyl]sulfanylmethanone
    —— 5-[ethoxy(ethyl)phosphinothioyl]oxy-4-ethylsulfanyl-2-methylpyridazin-3-one —— C11H19N2O3PS2
    5-[ethoxy(ethyl)phosphinothioyl]oxy-4-ethylsulfanyl-2-methylpyridazin-3-one
    —— methyl (2S)-2-(2-aminophenyl)sulfanyl-2-[(5S)-3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-yl]acetate —— C19H18N2O3S3
    methyl (2S)-2-(2-aminophenyl)sulfanyl-2-[(5S)-3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-yl]acetate
    —— methylsulfanyl-[(S)-methylsulfanyl(methylsulfonyl)methyl]sulfanylmethanethione —— C5H10O2S5
    methylsulfanyl-[(S)-methylsulfanyl(methylsulfonyl)methyl]sulfanylmethanethione
    —— (4Z)-2-(3,4-dimethylphenyl)-4-[(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylidene]-1,3-oxazol-5-one —— C22H16N4O4S
    (4Z)-2-(3,4-dimethylphenyl)-4-[(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylidene]-1,3-oxazol-5-one
    —— 3-[(Z)-C-methyl-N-[[2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-4-ium-2-yl]sulfanyl]acetyl]amino]carbonimidoyl]phenolate —— C20H20N4O2S3
    3-[(Z)-C-methyl-N-[[2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-4-ium-2-yl]sulfanyl]acetyl]amino]carbonimidoyl]phenolate
    —— (2S)-3-(3-fluorophenyl)-2-(4-methylsulfanylphenyl)-1,3-thiazolidin-4-one —— C16H14FNOS2
    (2S)-3-(3-fluorophenyl)-2-(4-methylsulfanylphenyl)-1,3-thiazolidin-4-one
    —— [(8R)-7-methyl-1,4-dithiaspiro[4.5]dec-6-en-8-yl]methanol —— C10H16OS2
    [(8R)-7-methyl-1,4-dithiaspiro[4.5]dec-6-en-8-yl]methanol
    —— ethyl (6R)-2-fluoro-6H-benzo[b][4,1]benzoxathiepine-6-carboxylate —— C16H13FO3S
    ethyl (6R)-2-fluoro-6H-benzo[b][4,1]benzoxathiepine-6-carboxylate
    —— 1-[[(1R)-2,2-dichlorocyclopropyl]methylsulfanyl]-4-methylbenzene —— C11H12Cl2S
    1-[[(1R)-2,2-dichlorocyclopropyl]methylsulfanyl]-4-methylbenzene
    —— 1-[[(1S)-2,2-dichlorocyclopropyl]methylsulfanyl]-4-methylbenzene —— C11H12Cl2S
    1-[[(1S)-2,2-dichlorocyclopropyl]methylsulfanyl]-4-methylbenzene
    —— (2Z)-2-[3,3-dichloro-2-(4-methylphenyl)sulfanyl-1-nitroprop-2-enylidene]-1,3-oxazolidine —— C13H12Cl2N2O3S
    (2Z)-2-[3,3-dichloro-2-(4-methylphenyl)sulfanyl-1-nitroprop-2-enylidene]-1,3-oxazolidine
    —— (4Z)-5-tert-butyl-4-[[2-(4-chlorophenyl)sulfanyl-5-nitrophenyl]methylidene]-2-phenylpyrazol-3-one —— C26H22ClN3O3S
    (4Z)-5-tert-butyl-4-[[2-(4-chlorophenyl)sulfanyl-5-nitrophenyl]methylidene]-2-phenylpyrazol-3-one
    —— 3-(5-Methoxy-pyrimidin-2-ylsulfanyl)-prop-2-EN-1-OL —— C8H10N2O2S
    3-(5-Methoxy-pyrimidin-2-ylsulfanyl)-prop-2-EN-1-OL
    —— 3-(2-Methylsulfanyl-pyrimidin-5-yloxy)-prop-2-EN-1-OL —— C8H10N2O2S
    3-(2-Methylsulfanyl-pyrimidin-5-yloxy)-prop-2-EN-1-OL
    —— 2-((4-fluorophenyl)thio)-N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidin-4-yl)acetamide —— C18H21FN4O2S
    2-((4-fluorophenyl)thio)-N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidin-4-yl)acetamide
    —— N-(2-methyl-3-oxo-5,6,7,8-tetrahydrocinnolin-6-yl)-2-pyridin-4-ylsulfanylacetamide —— C16H18N4O2S
    N-(2-methyl-3-oxo-5,6,7,8-tetrahydrocinnolin-6-yl)-2-pyridin-4-ylsulfanylacetamide
    —— 2-((4-Fluorophenyl)thio)-1-(3-(5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)ethanone —— C18H16FN3O2S2
    2-((4-Fluorophenyl)thio)-1-(3-(5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)ethanone
    —— N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidin-4-yl)-3-(phenylthio)propanamide —— C19H24N4O2S
    N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperidin-4-yl)-3-(phenylthio)propanamide
    —— 2-(4-fluorophenyl)sulfanyl-N-(3-oxo-5,6,7,8-tetrahydro-2H-cinnolin-6-yl)acetamide —— C16H16FN3O2S
    2-(4-fluorophenyl)sulfanyl-N-(3-oxo-5,6,7,8-tetrahydro-2H-cinnolin-6-yl)acetamide
    —— 2-(4-fluorophenyl)sulfanyl-N-[[3-(2-oxopyridin-3-ylidene)-1,2,4-oxadiazol-5-yl]methyl]acetamide —— C16H13FN4O3S
    2-(4-fluorophenyl)sulfanyl-N-[[3-(2-oxopyridin-3-ylidene)-1,2,4-oxadiazol-5-yl]methyl]acetamide
    —— N-[1-(5-methyl-1H-pyrazol-3-yl)piperidin-4-yl]-2-pyridin-4-ylsulfanylacetamide —— C16H21N5OS
    N-[1-(5-methyl-1H-pyrazol-3-yl)piperidin-4-yl]-2-pyridin-4-ylsulfanylacetamide
    —— 2-(1-methyltetrazol-5-yl)sulfanyl-N-[1-(5-thiophen-2-yl-1H-pyrazol-3-yl)piperidin-4-yl]acetamide —— C16H20N8OS2
    2-(1-methyltetrazol-5-yl)sulfanyl-N-[1-(5-thiophen-2-yl-1H-pyrazol-3-yl)piperidin-4-yl]acetamide
    —— 1-(2-amino-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-3-(4-(methylthio)phenyl)propan-1-one —— C16H18N4OS
    1-(2-amino-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-3-(4-(methylthio)phenyl)propan-1-one
    —— 1-(2-amino-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-((4-fluorophenyl)thio)ethanone —— C14H13FN4OS
    1-(2-amino-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-((4-fluorophenyl)thio)ethanone
    —— N-(2-(2,4-dioxooxazolidin-3-yl)-1-phenylethyl)-2-((4-fluorophenyl)thio)acetamide —— C19H17FN2O4S
    N-(2-(2,4-dioxooxazolidin-3-yl)-1-phenylethyl)-2-((4-fluorophenyl)thio)acetamide
    —— 2-((4-fluorophenyl)thio)-N-((2-(thiophen-2-yl)pyridin-4-yl)methyl)acetamide —— C18H15FN2OS2
    2-((4-fluorophenyl)thio)-N-((2-(thiophen-2-yl)pyridin-4-yl)methyl)acetamide
    —— 1-((1-(1-(3-(phenylthio)propanoyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)pyrrolidin-2-one —— C19H23N5O2S
    1-((1-(1-(3-(phenylthio)propanoyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)pyrrolidin-2-one
    —— 3-(phenylthio)-N-(pyridin-3-yl(tetrahydro-2H-pyran-4-yl)methyl)propanamide —— C20H24N2O2S
    3-(phenylthio)-N-(pyridin-3-yl(tetrahydro-2H-pyran-4-yl)methyl)propanamide
    —— 3-[2-(2-Chlorophenyl)vinyl]-2-quinoxalinyl phenyl sulfide —— C22H15ClN2S
    3-[2-(2-Chlorophenyl)vinyl]-2-quinoxalinyl phenyl sulfide
    —— 3-(phenylthio)-1-(4-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)-1,4-diazepan-1-yl)propan-1-one —— C20H28N4O3S2
    3-(phenylthio)-1-(4-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)-1,4-diazepan-1-yl)propan-1-one
    —— (NZ)-N-[2-(4-chlorophenyl)sulfanylcyclooctylidene]hydroxylamine —— C14H18ClNOS
    (NZ)-N-[2-(4-chlorophenyl)sulfanylcyclooctylidene]hydroxylamine
    —— (2E)-2-[(2-methylsulfanylanilino)methylidene]-1-benzothiophen-3-one —— C16H13NOS2
    (2E)-2-[(2-methylsulfanylanilino)methylidene]-1-benzothiophen-3-one
    —— (5Z)-3-(2-methoxyethyl)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione —— C20H18N2O5S2
    (5Z)-3-(2-methoxyethyl)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione
    —— 2-(4-Fluorophenyl)sulfanyl-1-[4-(1-methylimidazol-4-yl)sulfonyl-1,4-diazepan-1-yl]ethanone —— C17H21FN4O3S2
    2-(4-Fluorophenyl)sulfanyl-1-[4-(1-methylimidazol-4-yl)sulfonyl-1,4-diazepan-1-yl]ethanone
    —— N-[(Z)-1-(4-bromophenyl)ethylideneamino]-2-[[5-[(4-chloroanilino)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C22H22BrClN6OS
    N-[(Z)-1-(4-bromophenyl)ethylideneamino]-2-[[5-[(4-chloroanilino)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-(2-hydroxy-2-(thiophen-2-yl)-2-(thiophen-3-yl)ethyl)-3-(phenylthio)propanamide —— C19H19NO2S3
    N-(2-hydroxy-2-(thiophen-2-yl)-2-(thiophen-3-yl)ethyl)-3-(phenylthio)propanamide
    —— 1-(Phenylthio)-2-(P-tolylthio)ethylene —— C15H14S2
    1-(Phenylthio)-2-(P-tolylthio)ethylene
    —— (6Z)-5-imino-3-(isobutylthio)-6-(1H-pyrrol-2-ylmethylene)-5,6-dihydro-7H-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one —— C14H15N5OS2
    (6Z)-5-imino-3-(isobutylthio)-6-(1H-pyrrol-2-ylmethylene)-5,6-dihydro-7H-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-one
    —— (4E)-4-[[2-(4-bromo-2,5-dimethylphenyl)sulfanylacetyl]hydrazinylidene]-4-thiophen-2-ylbutanoic acid —— C18H19BrN2O3S2
    (4E)-4-[[2-(4-bromo-2,5-dimethylphenyl)sulfanylacetyl]hydrazinylidene]-4-thiophen-2-ylbutanoic acid
    —— disodium;hexane-1,6-dithiol —— C6H14Na2S2+2
    disodium;hexane-1,6-dithiol
    —— O-(3-aminooxypropyl) N-aminocarbamothioate —— C4H11N3O2S
    O-(3-aminooxypropyl) N-aminocarbamothioate