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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-methyl-N-[(2-methylsulfanylpyrimidin-5-yl)methyl]-2-pyridin-4-ylethanamine —— C14H18N4S
    N-methyl-N-[(2-methylsulfanylpyrimidin-5-yl)methyl]-2-pyridin-4-ylethanamine
    —— (3R,7R,8aS)-3-methyl-2-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-ol —— C17H22N4O2S
    (3R,7R,8aS)-3-methyl-2-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-ol
    —— (3R,8aR)-3-methyl-2-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine —— C17H22N4OS
    (3R,8aR)-3-methyl-2-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine
    —— (2S)-2-methyl-1-[(2S)-2-(4-methyl-5-methylsulfanyl-1,2,4-triazol-3-yl)pyrrolidin-1-yl]-3-(3,4,5-trimethylpyrazol-1-yl)propan-1-one —— C18H28N6OS
    (2S)-2-methyl-1-[(2S)-2-(4-methyl-5-methylsulfanyl-1,2,4-triazol-3-yl)pyrrolidin-1-yl]-3-(3,4,5-trimethylpyrazol-1-yl)propan-1-one
    —— N-methyl-1-(4-methylsulfanylphenyl)methanimine oxide —— C9H11NOS
    N-methyl-1-(4-methylsulfanylphenyl)methanimine oxide
    —— 4-[(3R)-1-[(2-ethylsulfanylpyrimidin-5-yl)methyl]piperidin-3-yl]-2-thiophen-2-yl-1H-pyrimidin-6-one —— C20H23N5OS2
    4-[(3R)-1-[(2-ethylsulfanylpyrimidin-5-yl)methyl]piperidin-3-yl]-2-thiophen-2-yl-1H-pyrimidin-6-one
    —— (2S)-3-(4-chloropyrazol-1-yl)-2-methyl-1-[(2R)-2-(4-methyl-5-methylsulfanyl-1,2,4-triazol-3-yl)pyrrolidin-1-yl]propan-1-one —— C15H21ClN6OS
    (2S)-3-(4-chloropyrazol-1-yl)-2-methyl-1-[(2R)-2-(4-methyl-5-methylsulfanyl-1,2,4-triazol-3-yl)pyrrolidin-1-yl]propan-1-one
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]acetamide —— C23H20FN3O2S2
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]acetamide
    —— (2R)-1-[(2-chloro-4-fluorophenyl)methyl]-3-[(2-methylphenyl)methyl]-2-(4-methylsulfanylphenyl)-1,3-diazinane —— C26H28ClFN2S
    (2R)-1-[(2-chloro-4-fluorophenyl)methyl]-3-[(2-methylphenyl)methyl]-2-(4-methylsulfanylphenyl)-1,3-diazinane
    —— (2S)-1-[(4-fluorophenyl)methyl]-3-[(3-methylphenyl)methyl]-2-(4-methylsulfanylphenyl)-1,3-diazinane —— C26H29FN2S
    (2S)-1-[(4-fluorophenyl)methyl]-3-[(3-methylphenyl)methyl]-2-(4-methylsulfanylphenyl)-1,3-diazinane
    —— 2-[[4-methyl-5-[(2R)-1-[(2-morpholin-4-ylpyrimidin-4-yl)methyl]pyrrolidin-2-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol —— C18H27N7O2S
    2-[[4-methyl-5-[(2R)-1-[(2-morpholin-4-ylpyrimidin-4-yl)methyl]pyrrolidin-2-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol
    —— N-[(Z)-1-(4-hydroxyphenyl)ethylideneamino]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H20N4O2S3
    N-[(Z)-1-(4-hydroxyphenyl)ethylideneamino]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (5E)-2-(5-chloro-2-methylphenyl)imino-5-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-1,3-thiazolidin-4-one —— C21H14Cl2N2O2S2
    (5E)-2-(5-chloro-2-methylphenyl)imino-5-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-1,3-thiazolidin-4-one
    —— (2E)-3-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}-2-cyano-N-(4-methylphenyl)prop-2-enamide —— C21H14BrClN2O2S
    (2E)-3-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}-2-cyano-N-(4-methylphenyl)prop-2-enamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-1-(3-hydroxyphenyl)ethylideneamino]-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]triazole-4-carboxamide —— C17H17N11O3S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-1-(3-hydroxyphenyl)ethylideneamino]-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]triazole-4-carboxamide
    —— 1-(2,3-dimethylphenyl)-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]thiourea —— C17H19N3S2
    1-(2,3-dimethylphenyl)-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]thiourea
    —— (E)-3-amino-2-[2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetyl]but-2-enenitrile —— C11H11N3O2S
    (E)-3-amino-2-[2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetyl]but-2-enenitrile
    —— 2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[1-[[1-(4-methylphenyl)cyclopropyl]methyl]piperidin-4-yl]acetamide —— C21H28N4O2S
    2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[1-[[1-(4-methylphenyl)cyclopropyl]methyl]piperidin-4-yl]acetamide
    —— N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-ethylacetamide —— C21H28N6O3S
    N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-ethylacetamide
    —— N-[(Z)-(2-bromophenyl)methylideneamino]-2-phenylsulfanylacetamide —— C15H13BrN2OS
    N-[(Z)-(2-bromophenyl)methylideneamino]-2-phenylsulfanylacetamide
    —— N-[(Z)-benzylideneamino]-2-(4-methyl-6-morpholin-4-ylpyrimidin-2-yl)sulfanylacetamide —— C18H21N5O2S
    N-[(Z)-benzylideneamino]-2-(4-methyl-6-morpholin-4-ylpyrimidin-2-yl)sulfanylacetamide
    —— [(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]thiourea —— C14H11ClN4O2S2
    [(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]thiourea
    —— 2-[(Z)-(4-bromophenyl)methylideneamino]oxy-N'-[(E)-(3-oxo-1-benzothiophen-2-ylidene)methyl]propanehydrazide —— C19H16BrN3O3S
    2-[(Z)-(4-bromophenyl)methylideneamino]oxy-N'-[(E)-(3-oxo-1-benzothiophen-2-ylidene)methyl]propanehydrazide
    —— N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H14FN3OS4
    N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 3-[2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-4-methyl-1,3-thiazol-2-one —— C16H17N3O2S2
    3-[2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-4-methyl-1,3-thiazol-2-one
    —— N-[(2R)-heptan-2-yl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H25N3O2S
    N-[(2R)-heptan-2-yl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-heptan-2-yl]acetamide —— C21H32N4O2S
    2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-heptan-2-yl]acetamide
    —— 2-(2-Bromophenyl)-5-[(5-phenyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-oxadiazole —— C18H12BrN3O2S
    2-(2-Bromophenyl)-5-[(5-phenyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[[4-amino-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]acetamide —— C20H18FN5O2S2
    2-[[4-amino-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]acetamide
    —— 5-(2-Anilinovinyl)-3-[(2-chloro-6-fluorobenzyl)sulfanyl]-4-isothiazolecarbonitrile —— C19H13ClFN3S2
    5-(2-Anilinovinyl)-3-[(2-chloro-6-fluorobenzyl)sulfanyl]-4-isothiazolecarbonitrile
    —— (2R)-N-(2-phenylsulfanylphenyl)-2-[(2-pyrrol-2-ylidene-3H-1,3,4-oxadiazol-5-yl)sulfanyl]propanamide —— C21H18N4O2S2
    (2R)-N-(2-phenylsulfanylphenyl)-2-[(2-pyrrol-2-ylidene-3H-1,3,4-oxadiazol-5-yl)sulfanyl]propanamide
    —— (2R)-N-ethyl-2-[(2-pyrrol-2-ylidene-3H-1,3,4-oxadiazol-5-yl)sulfanyl]propanamide —— C11H14N4O2S
    (2R)-N-ethyl-2-[(2-pyrrol-2-ylidene-3H-1,3,4-oxadiazol-5-yl)sulfanyl]propanamide
    —— (2S)-2-[[5-(2,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-phenylsulfanylphenyl)propanamide —— C25H23N3O4S2
    (2S)-2-[[5-(2,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-phenylsulfanylphenyl)propanamide
    —— 2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-heptan-2-yl]acetamide —— C22H28N4OS2
    2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-heptan-2-yl]acetamide
    —— 2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexyl-N-propan-2-ylacetamide —— C14H22F3N5OS
    2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexyl-N-propan-2-ylacetamide
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(Z)-[(3Z)-3-[[2-(4-bromo-2,5-dimethylphenyl)sulfanylacetyl]hydrazinylidene]cyclohexylidene]amino]acetamide —— C26H30Br2N4O2S2
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(Z)-[(3Z)-3-[[2-(4-bromo-2,5-dimethylphenyl)sulfanylacetyl]hydrazinylidene]cyclohexylidene]amino]acetamide
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[2-(2-methylphenyl)ethyl]propanamide —— C18H20ClNOS
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[2-(2-methylphenyl)ethyl]propanamide
    —— 3-(Tert-butyl)-4-((5-nitro-2-(2-pyridylthio)phenyl)methylene)-1-phenyl-2-pyrazolin-5-one —— C25H22N4O3S
    3-(Tert-butyl)-4-((5-nitro-2-(2-pyridylthio)phenyl)methylene)-1-phenyl-2-pyrazolin-5-one
    —— 5-[(2Z)-2-benzylidenehydrazinyl]-3-methylsulfanyl-1,2-thiazole-4-carbonitrile —— C12H10N4S2
    5-[(2Z)-2-benzylidenehydrazinyl]-3-methylsulfanyl-1,2-thiazole-4-carbonitrile
    —— (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[5-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propan-1-one —— C25H33N5O3S
    (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[5-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propan-1-one
    —— N-[(Z)-benzylideneamino]-2-methylsulfanylpyrimidin-5-amine —— C12H12N4S
    N-[(Z)-benzylideneamino]-2-methylsulfanylpyrimidin-5-amine
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]propanamide —— C15H16ClNOS2
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]propanamide
    —— (7E)-2-methylsulfanyl-4-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-5,6-dihydrocyclopenta[b]pyridine-3-carbonitrile —— C19H14N2S3
    (7E)-2-methylsulfanyl-4-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-5,6-dihydrocyclopenta[b]pyridine-3-carbonitrile
    —— N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H22N4O3S3
    N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— [(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl] 2-(2-cyanophenyl)sulfanylbenzoate —— C22H15N3O3S2
    [(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl] 2-(2-cyanophenyl)sulfanylbenzoate
    —— [(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl] 2-(2-cyanophenyl)sulfanylbenzoate —— C22H15N3O3S2
    [(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl] 2-(2-cyanophenyl)sulfanylbenzoate
    —— (5Z)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(2-oxo-2-piperidin-1-ylethyl)-1,3-thiazolidine-2,4-dione —— C23H20ClN3O5S2
    (5Z)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(2-oxo-2-piperidin-1-ylethyl)-1,3-thiazolidine-2,4-dione
    —— 3,4,4-trimethyl-5-[(Z)-[4-(methylsulfanyl)benzylidene](oxido)-lambda~5~-azanyl]-1,3-thiazolidine-2-thione —— C14H18N2OS3
    3,4,4-trimethyl-5-[(Z)-[4-(methylsulfanyl)benzylidene](oxido)-lambda~5~-azanyl]-1,3-thiazolidine-2-thione
    —— N-[(Z)-[4-bromo-5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]pyridine-2-carboxamide —— C17H11BrClN3O2S
    N-[(Z)-[4-bromo-5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]pyridine-2-carboxamide
    —— (2S)-2-[4-[(2R)-4-oxo-3,1-benzoxathiin-2-yl]phenyl]-3,1-benzoxathiin-4-one —— C22H14O4S2
    (2S)-2-[4-[(2R)-4-oxo-3,1-benzoxathiin-2-yl]phenyl]-3,1-benzoxathiin-4-one