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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-N-methyl-2-phenylsulfanyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]propanamide —— C16H18F3N3OS
    (2R)-N-methyl-2-phenylsulfanyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]propanamide
    —— 2-(4,6-Diaminopyrimidin-2-yl)sulfanylethyl-dimethylazanium —— C8H16N5S+
    2-(4,6-Diaminopyrimidin-2-yl)sulfanylethyl-dimethylazanium
    —— 2-(2-chlorophenyl)sulfanyl-N-methyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]acetamide —— C15H15ClF3N3OS
    2-(2-chlorophenyl)sulfanyl-N-methyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]acetamide
    —— (2S)-N-methyl-2-phenylsulfanyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]propanamide —— C16H18F3N3OS
    (2S)-N-methyl-2-phenylsulfanyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]propanamide
    —— 2-(2-Tert-butylsulfanylphenyl)acetate —— C12H15O2S-
    2-(2-Tert-butylsulfanylphenyl)acetate
    —— (2S)-3-methyl-2-pyridin-2-ylsulfanylbutanoate —— C10H12NO2S-
    (2S)-3-methyl-2-pyridin-2-ylsulfanylbutanoate
    —— 5-(1-methoxyiminoethyl)-3-methylthio-1,2,4-triazine —— C7H10N4OS
    5-(1-methoxyiminoethyl)-3-methylthio-1,2,4-triazine
    —— (2R)-3-methyl-2-pyridin-2-ylsulfanylbutanoate —— C10H12NO2S-
    (2R)-3-methyl-2-pyridin-2-ylsulfanylbutanoate
    —— 2-Thiophen-3-ylsulfanylacetate —— C6H5O2S2-
    2-Thiophen-3-ylsulfanylacetate
    —— (2S)-2-thiophen-2-ylsulfanylpropanoate —— C7H7O2S2-
    (2S)-2-thiophen-2-ylsulfanylpropanoate
    —— 2-(2-Formylthiophen-3-yl)sulfanylacetate —— C7H5O3S2-
    2-(2-Formylthiophen-3-yl)sulfanylacetate
    —— (2R)-2-thiophen-2-ylsulfanylpropanoate —— C7H7O2S2-
    (2R)-2-thiophen-2-ylsulfanylpropanoate
    —— [2-(4-Fluoro-3-hydroxyphenyl)sulfanylphenyl]methyl-dimethylazanium —— C15H17FNOS+
    [2-(4-Fluoro-3-hydroxyphenyl)sulfanylphenyl]methyl-dimethylazanium
    —— 2-[4-Chloro-6-(diethylamino)pyrimidin-2-yl]sulfanylacetate —— C10H13ClN3O2S-
    2-[4-Chloro-6-(diethylamino)pyrimidin-2-yl]sulfanylacetate
    —— (6S)-6-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C16H19N5O2S2
    (6S)-6-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (6R)-6-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C16H19N5O2S2
    (6R)-6-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (6S)-3-phenyl-6-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5,6-dihydro-2H-1,2,4-oxadiazine —— C18H19N5OS2
    (6S)-3-phenyl-6-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (6R)-6-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C16H20N4O2S
    (6R)-6-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (6R)-6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C13H14N4OS2
    (6R)-6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (6R)-3-phenyl-6-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5,6-dihydro-2H-1,2,4-oxadiazine —— C18H19N5OS2
    (6R)-3-phenyl-6-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (2R)-2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C8H10N3O3S-
    (2R)-2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— (2S)-2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C8H10N3O3S-
    (2S)-2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— (2R)-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate —— C8H9N2O3S-
    (2R)-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate
    —— (6R)-6-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C14H17N5OS
    (6R)-6-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (6S)-6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C13H14N4OS2
    (6S)-6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— 4-cyclopropyl-3-thiophen-2-yl-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,2,4-triazole —— C15H14F3N5S2
    4-cyclopropyl-3-thiophen-2-yl-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,2,4-triazole
    —— N,N-dimethyl-3-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylpropane-1-sulfonamide —— C11H21N5O3S2
    N,N-dimethyl-3-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylpropane-1-sulfonamide
    —— 3-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C16H20ClN3O2S2
    3-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— (2S)-2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C20H28N4OS2
    (2S)-2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— (6R)-6-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C18H19N5O2S
    (6R)-6-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— N,N-dimethyl-3-[1-[[(2S)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylpropane-1-sulfonamide —— C11H21N5O3S2
    N,N-dimethyl-3-[1-[[(2S)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylpropane-1-sulfonamide
    —— (6S)-6-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C18H19N5O2S
    (6S)-6-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— 4-benzyl-3-cyclopropyl-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,2,4-triazole —— C18H18F3N5S
    4-benzyl-3-cyclopropyl-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,2,4-triazole
    —— (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylbutanoate —— C10H13N2O2S-
    (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylbutanoate
    —— 3-benzyl-4-ethyl-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,2,4-triazole —— C17H18F3N5S
    3-benzyl-4-ethyl-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,2,4-triazole
    —— (6R)-6-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine —— C20H21N5O2S
    (6R)-6-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine
    —— (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanoate —— C9H11N2O2S-
    (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanoate
    —— (5R,7R)-3-(aminomethyl)adamantane-1-thiol —— C11H19NS
    (5R,7R)-3-(aminomethyl)adamantane-1-thiol
    —— 3-(furan-2-yl)-5-[[(6R)-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazin-6-yl]methylsulfanyl]-1,2,4-triazol-4-amine —— C16H16N6O2S
    3-(furan-2-yl)-5-[[(6R)-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazin-6-yl]methylsulfanyl]-1,2,4-triazol-4-amine
    —— (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanoate —— C9H11N2O2S-
    (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanoate
    —— 3-(furan-2-yl)-5-[[(6S)-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazin-6-yl]methylsulfanyl]-1,2,4-triazol-4-amine —— C16H16N6O2S
    3-(furan-2-yl)-5-[[(6S)-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazin-6-yl]methylsulfanyl]-1,2,4-triazol-4-amine
    —— N-(2-methoxyethyl)-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C11H14F3N5OS2
    N-(2-methoxyethyl)-5-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 6-Ethylsulfanyl-3,3-dimethyl-8-morpholin-4-yl-1,4-dihydrothiopyrano[3,4-c]pyridin-7-ium-5-carbonitrile —— C17H24N3OS2+
    6-Ethylsulfanyl-3,3-dimethyl-8-morpholin-4-yl-1,4-dihydrothiopyrano[3,4-c]pyridin-7-ium-5-carbonitrile
    —— 4-[(2R)-5-piperidin-1-ium-1-ylpentan-2-yl]sulfanylphenol —— C16H26NOS+
    4-[(2R)-5-piperidin-1-ium-1-ylpentan-2-yl]sulfanylphenol
    —— 4-[(2S)-5-piperidin-1-ium-1-ylpentan-2-yl]sulfanylphenol —— C16H26NOS+
    4-[(2S)-5-piperidin-1-ium-1-ylpentan-2-yl]sulfanylphenol
    —— Methyl 3-oxobutanimidothioate —— C5H9NOS
    Methyl 3-oxobutanimidothioate
    —— (2S)-2-(2-bromophenyl)sulfanyl-N-(2-methylpropyl)propanamide —— C13H18BrNOS
    (2S)-2-(2-bromophenyl)sulfanyl-N-(2-methylpropyl)propanamide
    —— (2S)-1-(azepan-1-yl)-2-(2-bromophenyl)sulfanylpropan-1-one —— C15H20BrNOS
    (2S)-1-(azepan-1-yl)-2-(2-bromophenyl)sulfanylpropan-1-one
    —— (2S)-N-benzyl-2-(2-bromophenyl)sulfanyl-N-methylpropanamide —— C17H18BrNOS
    (2S)-N-benzyl-2-(2-bromophenyl)sulfanyl-N-methylpropanamide
    —— (2R)-2-(2-bromophenyl)sulfanyl-N,N-di(propan-2-yl)propanamide —— C15H22BrNOS
    (2R)-2-(2-bromophenyl)sulfanyl-N,N-di(propan-2-yl)propanamide