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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (1R,2R,5R)-2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-6,8-dioxabicyclo[3.2.1]octan-4-one —— C15H11F3N2O4S
    (1R,2R,5R)-2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-6,8-dioxabicyclo[3.2.1]octan-4-one
    —— (1R,2R,5R)-2-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-6,8-dioxabicyclo[3.2.1]octan-4-one —— C15H11F3N2O3S2
    (1R,2R,5R)-2-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-6,8-dioxabicyclo[3.2.1]octan-4-one
    —— [(2S)-3-chloro-2-hydroxypropyl] carbamimidothioate —— C4H9ClN2OS
    [(2S)-3-chloro-2-hydroxypropyl] carbamimidothioate
    —— (8'aS)-8'a-methylspiro[1,3-dithiane-2,6'-3,4,7,8-tetrahydro-2H-naphthalene]-1'-one —— C14H20OS2
    (8'aS)-8'a-methylspiro[1,3-dithiane-2,6'-3,4,7,8-tetrahydro-2H-naphthalene]-1'-one
    —— ethyl (7R)-7-(3-chlorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C22H18ClN7O2S2
    ethyl (7R)-7-(3-chlorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— ethyl (7S)-7-(3-chlorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C22H18ClN7O2S2
    ethyl (7S)-7-(3-chlorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7R)-7-(2-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C21H16FN7O2S2
    methyl (7R)-7-(2-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7S)-7-(3-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C21H16FN7O2S2
    methyl (7S)-7-(3-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7S)-7-[4-(dimethylamino)phenyl]-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C23H22N8O2S2
    methyl (7S)-7-[4-(dimethylamino)phenyl]-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7S)-7-(2-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C21H16FN7O2S2
    methyl (7S)-7-(2-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7S)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-thiophen-2-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C19H15N7O2S3
    methyl (7S)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-thiophen-2-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7R)-7-(4-chlorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C21H16ClN7O2S2
    methyl (7R)-7-(4-chlorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— ethyl (7R)-7-(3-hydroxyphenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C22H19N7O3S2
    ethyl (7R)-7-(3-hydroxyphenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— ethyl (7S)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-pyridin-3-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C21H18N8O2S2
    ethyl (7S)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-pyridin-3-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7S)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-pyridin-4-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C20H16N8O2S2
    methyl (7S)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-pyridin-4-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— methyl (7S)-7-(4-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate —— C21H16FN7O2S2
    methyl (7S)-7-(4-fluorophenyl)-5-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate
    —— 2-[(R)-propan-2-ylsulfinyl]ethanamine —— C5H13NOS
    2-[(R)-propan-2-ylsulfinyl]ethanamine
    —— 2-methylpropyl (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C15H18N2O3S
    2-methylpropyl (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— (4R,8E)-2-amino-6-ethyl-4-(4-methylsulfanylphenyl)-8-[(4-methylsulfanylphenyl)methylidene]-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile —— C26H27N3OS2
    (4R,8E)-2-amino-6-ethyl-4-(4-methylsulfanylphenyl)-8-[(4-methylsulfanylphenyl)methylidene]-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
    —— 2-[(S)-cyclohexylsulfinyl]ethanamine —— C8H17NOS
    2-[(S)-cyclohexylsulfinyl]ethanamine
    —— (2R)-3-[(S)-tert-butylsulfinyl]-2-methylpropanoic acid —— C8H16O3S
    (2R)-3-[(S)-tert-butylsulfinyl]-2-methylpropanoic acid
    —— N-[(Z)-(3-chlorophenyl)methylideneamino]-2-(4-methylphenyl)sulfanylacetamide —— C16H15ClN2OS
    N-[(Z)-(3-chlorophenyl)methylideneamino]-2-(4-methylphenyl)sulfanylacetamide
    —— 3-[(S)-ethylsulfinyl]propan-1-amine —— C5H13NOS
    3-[(S)-ethylsulfinyl]propan-1-amine
    —— N-[(Z)-(3-bromophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H13BrN4OS2
    N-[(Z)-(3-bromophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(E)-(3-fluorophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H13FN4OS2
    N-[(E)-(3-fluorophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 3-[(R)-tert-butylsulfinyl]propan-1-amine —— C7H17NOS
    3-[(R)-tert-butylsulfinyl]propan-1-amine
    —— butyl (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C15H18N2O3S
    butyl (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— N-[(Z)-(2-fluorophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H13FN4OS2
    N-[(Z)-(2-fluorophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(E)-(2-fluorophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H13FN4OS2
    N-[(E)-(2-fluorophenyl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— [(2R)-2-methylbutyl] (2R)-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate —— C16H20N2O2S2
    [(2R)-2-methylbutyl] (2R)-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate
    —— ethyl (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C13H14N2O3S
    ethyl (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— 2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(E)-pyridin-2-ylmethylideneamino]acetamide —— C16H13N5OS2
    2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(E)-pyridin-2-ylmethylideneamino]acetamide
    —— N-[(Z)-(3-methylthiophen-2-yl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H14N4OS3
    N-[(Z)-(3-methylthiophen-2-yl)methylideneamino]-2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— cyclohexyl (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C17H20N2O3S
    cyclohexyl (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(Z)-(4-ethylphenyl)methylideneamino]acetamide —— C13H15N5OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(Z)-(4-ethylphenyl)methylideneamino]acetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(Z)-(2-chloro-6-fluorophenyl)methylideneamino]acetamide —— C11H9ClFN5OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(Z)-(2-chloro-6-fluorophenyl)methylideneamino]acetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]acetamide —— C13H16N6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(E)-[4-(dimethylamino)phenyl]methylideneamino]acetamide
    —— 2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide —— C16H13N5OS2
    2-[(5-phenyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide
    —— butyl (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate —— C9H15N3O2S2
    butyl (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate
    —— [(2R)-butan-2-yl] (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate —— C9H15N3O2S2
    [(2R)-butan-2-yl] (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate
    —— propyl (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate —— C8H13N3O2S2
    propyl (2R)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate
    —— 2-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide —— C17H13ClN4OS2
    2-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide
    —— N-[(Z)-(2-fluorophenyl)methylideneamino]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C18H14FN3OS2
    N-[(Z)-(2-fluorophenyl)methylideneamino]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— 2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide —— C17H14N4OS2
    2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide
    —— [(2R)-butan-2-yl] 2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetate —— C15H17NO2S2
    [(2R)-butan-2-yl] 2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetate
    —— N-benzyl-2-[[5-[(3-chloro-4-methylanilino)methyl]-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C24H28ClN5O2S
    N-benzyl-2-[[5-[(3-chloro-4-methylanilino)methyl]-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 5-amino-1-[(1S)-1-cyclopropylethyl]-3-methylsulfanylpyrazole-4-carbonitrile —— C10H14N4S
    5-amino-1-[(1S)-1-cyclopropylethyl]-3-methylsulfanylpyrazole-4-carbonitrile
    —— 2,4-dimethyl-N-[[4-[[(2S)-oxolan-2-yl]methyl]-5-(2-piperidin-1-ylethylsulfanyl)-1,2,4-triazol-3-yl]methyl]aniline —— C23H35N5OS
    2,4-dimethyl-N-[[4-[[(2S)-oxolan-2-yl]methyl]-5-(2-piperidin-1-ylethylsulfanyl)-1,2,4-triazol-3-yl]methyl]aniline
    —— N-[[(2R)-butan-2-yl]carbamothioyl]cyclohexanecarboxamide —— C12H22N2OS
    N-[[(2R)-butan-2-yl]carbamothioyl]cyclohexanecarboxamide
    —— N-[[(2R)-2-ethylhexyl]carbamothioyl]cyclohexanecarboxamide —— C16H30N2OS
    N-[[(2R)-2-ethylhexyl]carbamothioyl]cyclohexanecarboxamide