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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-2-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methylpropanamide —— C17H21ClN4O3S3
    (2S)-2-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methylpropanamide
    —— (5Z)-3-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione —— C28H23N3O5S2
    (5Z)-3-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione
    —— 1-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H26N4O3S2
    1-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 3-[2-[[5-(2-ethyl-6-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-4-methyl-1,3-thiazol-2-one —— C17H20N4OS3
    3-[2-[[5-(2-ethyl-6-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-4-methyl-1,3-thiazol-2-one
    —— (2E)-N-methyl-2-({5-[(4-methylphenyl)sulfanyl]furan-2-yl}methylidene)hydrazinecarbothioamide —— C14H15N3OS2
    (2E)-N-methyl-2-({5-[(4-methylphenyl)sulfanyl]furan-2-yl}methylidene)hydrazinecarbothioamide
    —— (2R)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-N,N-di(propan-2-yl)propanamide —— C24H28N4OS
    (2R)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-N,N-di(propan-2-yl)propanamide
    —— (2R)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide —— C25H21FN4OS
    (2R)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide
    —— (Z)-1-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]-N-(1,2,4-triazol-4-yl)methanimine —— C16H10N6O2S2
    (Z)-1-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]-N-(1,2,4-triazol-4-yl)methanimine
    —— (1R)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethanamine —— C11H12ClN3OS
    (1R)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethanamine
    —— tert-butyl N-[(1R)-1-[5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]carbamate —— C19H25ClFN3O3S
    tert-butyl N-[(1R)-1-[5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]carbamate
    —— tert-butyl N-[(1R,2R)-1-[5-[(2,5-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate —— C21H31N3O3S
    tert-butyl N-[(1R,2R)-1-[5-[(2,5-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate
    —— 2-(4-chlorophenyl)sulfanyl-N-[(2S)-2-(furan-2-yl)-2-piperidin-1-ylethyl]acetamide —— C19H23ClN2O2S
    2-(4-chlorophenyl)sulfanyl-N-[(2S)-2-(furan-2-yl)-2-piperidin-1-ylethyl]acetamide
    —— tert-butyl N-[(1R,2R)-2-methyl-1-[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate —— C20H29N3O3S
    tert-butyl N-[(1R,2R)-2-methyl-1-[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate
    —— tert-butyl N-[(1R)-1-[5-[(3-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate —— C16H20FN3O3S
    tert-butyl N-[(1R)-1-[5-[(3-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamate
    —— tert-butyl N-[(1R,2S)-2-methyl-1-(5-propan-2-ylsulfanyl-1,3,4-oxadiazol-2-yl)butyl]carbamate —— C15H27N3O3S
    tert-butyl N-[(1R,2S)-2-methyl-1-(5-propan-2-ylsulfanyl-1,3,4-oxadiazol-2-yl)butyl]carbamate
    —— tert-butyl N-[(1R)-1-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-2-methylpropyl]carbamate —— C13H23N3O3S
    tert-butyl N-[(1R)-1-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-2-methylpropyl]carbamate
    —— (4Z)-2-(1,3-benzothiazol-2-yl)-5-[(4-chlorophenyl)sulfanylmethyl]-4-[1-(2-phenylsulfanylanilino)ethylidene]pyrazol-3-one —— C31H23ClN4OS3
    (4Z)-2-(1,3-benzothiazol-2-yl)-5-[(4-chlorophenyl)sulfanylmethyl]-4-[1-(2-phenylsulfanylanilino)ethylidene]pyrazol-3-one
    —— 2-(5-aminotetrazol-1-yl)-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]acetamide —— C11H13N7OS
    2-(5-aminotetrazol-1-yl)-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]acetamide
    —— (2S)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-amine —— C6H11N3S2
    (2S)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-amine
    —— 2-(4-fluorophenyl)sulfanyl-N-[2-[(5Z)-5-[(4-methylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]acetamide —— C21H19FN2O3S2
    2-(4-fluorophenyl)sulfanyl-N-[2-[(5Z)-5-[(4-methylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]acetamide
    —— 4-(3,4-dimethoxyphenyl)-2-[(E)-2-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]ethenyl]-1,3-thiazole —— C23H20N4O4S2
    4-(3,4-dimethoxyphenyl)-2-[(E)-2-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]ethenyl]-1,3-thiazole
    —— (Z)-N-(3-benzylsulfanyl-[1,2,4]triazolo[4,3-b][1,2,4]triazol-7-yl)-1-phenylmethanimine —— C17H14N6S
    (Z)-N-(3-benzylsulfanyl-[1,2,4]triazolo[4,3-b][1,2,4]triazol-7-yl)-1-phenylmethanimine
    —— (5R,7S)-5-(4-ethylphenyl)-7-(4-methylsulfanylphenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine —— C19H21N5S
    (5R,7S)-5-(4-ethylphenyl)-7-(4-methylsulfanylphenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
    —— 6-[(2R)-1-(azepan-1-yl)-1-oxobutan-2-yl]-2-ethylsulfanylpyrimido[4,5-d]pyrimidin-5-one —— C18H25N5O2S
    6-[(2R)-1-(azepan-1-yl)-1-oxobutan-2-yl]-2-ethylsulfanylpyrimido[4,5-d]pyrimidin-5-one
    —— (2S)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)propanamide —— C19H19FN4OS2
    (2S)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)propanamide
    —— [(2R)-1-(2,6-difluoroanilino)-1-oxopropan-2-yl] 2-(2-cyanophenyl)sulfanylbenzoate —— C23H16F2N2O3S
    [(2R)-1-(2,6-difluoroanilino)-1-oxopropan-2-yl] 2-(2-cyanophenyl)sulfanylbenzoate
    —— (2R)-2-(4-bromophenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide —— C15H20BrNO3S2
    (2R)-2-(4-bromophenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide
    —— (2R)-2-(4-bromophenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide —— C15H20BrNO3S2
    (2R)-2-(4-bromophenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide
    —— N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-3-nitrobenzamide —— C21H16N4O5S
    N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-3-nitrobenzamide
    —— (2S)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-[2-(4-methylsulfanylphenyl)ethyl]propanamide —— C17H23N3OS
    (2S)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-[2-(4-methylsulfanylphenyl)ethyl]propanamide
    —— methyl 2-[4-[(Z)-methoxyiminomethyl]-2-nitrophenyl]sulfanylbenzoate —— C16H14N2O5S
    methyl 2-[4-[(Z)-methoxyiminomethyl]-2-nitrophenyl]sulfanylbenzoate
    —— (4S)-3-methyl-1-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]-4-(4-methylsulfanylphenyl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C24H22N6OS
    (4S)-3-methyl-1-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]-4-(4-methylsulfanylphenyl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— (4S)-3-methyl-4-(4-methylsulfanylphenyl)-1-(5-phenyl-1,2,4-triazin-3-yl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C23H20N6OS
    (4S)-3-methyl-4-(4-methylsulfanylphenyl)-1-(5-phenyl-1,2,4-triazin-3-yl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-(4-fluorophenyl)sulfanylacetamide —— C16H15ClFNOS
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-(4-fluorophenyl)sulfanylacetamide
    —— N-[(1R)-1-(4-bromophenyl)ethyl]-2-phenylsulfanylacetamide —— C16H16BrNOS
    N-[(1R)-1-(4-bromophenyl)ethyl]-2-phenylsulfanylacetamide
    —— [2-[[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-(4-bromo-2,5-dimethylphenyl)sulfanylacetate —— C16H20BrNO5S2
    [2-[[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-(4-bromo-2,5-dimethylphenyl)sulfanylacetate
    —— [2-[[(3R)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-(4-bromo-2,5-dimethylphenyl)sulfanylacetate —— C16H20BrNO5S2
    [2-[[(3R)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-(4-bromo-2,5-dimethylphenyl)sulfanylacetate
    —— (2R)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]propanamide —— C16H21N3OS2
    (2R)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]propanamide
    —— [2-oxo-2-[[(1S)-1-thiophen-2-ylethyl]amino]ethyl] 2-(2-cyanophenyl)sulfanylbenzoate —— C22H18N2O3S2
    [2-oxo-2-[[(1S)-1-thiophen-2-ylethyl]amino]ethyl] 2-(2-cyanophenyl)sulfanylbenzoate
    —— N-[(2R)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]acetamide —— C25H28N4O3S2
    N-[(2R)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]acetamide
    —— 5-[5-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C20H19N5O2S3
    5-[5-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— [2-[[(2S)-butan-2-yl]-[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-(2-cyanophenyl)sulfanylbenzoate —— C24H26N2O5S2
    [2-[[(2S)-butan-2-yl]-[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-(2-cyanophenyl)sulfanylbenzoate
    —— 5-(2,4-dinitrophenyl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C13H13N5O5S2
    5-(2,4-dinitrophenyl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— 4-chloro-5-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-[5-(trifluoromethyl)pyridin-2-yl]pyridazin-3-one —— C17H14ClF3N6O2S2
    4-chloro-5-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-[5-(trifluoromethyl)pyridin-2-yl]pyridazin-3-one
    —— N-[[(2S)-oxolan-2-yl]methyl]-5-(2-phenylquinazolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-amine —— C21H19N5OS2
    N-[[(2S)-oxolan-2-yl]methyl]-5-(2-phenylquinazolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-amine
    —— 5-[5-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C20H19N5O2S3
    5-[5-(4-methoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— (3S)-1-[4-(1-benzyltetrazol-5-yl)sulfanyl-3-nitrophenyl]sulfonyl-3-methylpiperidine —— C20H22N6O4S2
    (3S)-1-[4-(1-benzyltetrazol-5-yl)sulfanyl-3-nitrophenyl]sulfonyl-3-methylpiperidine
    —— 3-(2,4-dinitrophenyl)sulfanyl-5-(4-methoxyphenyl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazole —— C20H19N5O6S
    3-(2,4-dinitrophenyl)sulfanyl-5-(4-methoxyphenyl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazole
    —— (2R)-N-(thiophen-2-ylmethyl)-2-(2,4,6-trimethylphenyl)sulfanylpropanamide —— C17H21NOS2
    (2R)-N-(thiophen-2-ylmethyl)-2-(2,4,6-trimethylphenyl)sulfanylpropanamide
    —— (2S)-N-(thiophen-2-ylmethyl)-2-(2,4,6-trimethylphenyl)sulfanylpropanamide —— C17H21NOS2
    (2S)-N-(thiophen-2-ylmethyl)-2-(2,4,6-trimethylphenyl)sulfanylpropanamide