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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[2-[(5Z)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H15FN4O5S2
    N-[2-[(5Z)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C24H20N4O5S
    1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 6-(2-nitrophenyl)sulfanyl-5-phenyl-N-[(Z)-thiophen-2-ylmethylideneamino]thieno[2,3-d]pyrimidin-4-amine —— C23H15N5O2S3
    6-(2-nitrophenyl)sulfanyl-5-phenyl-N-[(Z)-thiophen-2-ylmethylideneamino]thieno[2,3-d]pyrimidin-4-amine
    —— N-[2-[(5Z)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(4-methylphenyl)sulfanylacetamide —— C21H20N2O3S2
    N-[2-[(5Z)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(4-methylphenyl)sulfanylacetamide
    —— (E)-3-amino-2-[2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile —— C12H10N4O3S
    (E)-3-amino-2-[2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile
    —— N-[2-[(5Z)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(2-fluorophenyl)sulfanylacetamide —— C20H17FN2O3S2
    N-[2-[(5Z)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(2-fluorophenyl)sulfanylacetamide
    —— N-[2-[(5Z)-5-[(4-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(4-methylphenyl)sulfanylacetamide —— C21H19FN2O3S2
    N-[2-[(5Z)-5-[(4-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(4-methylphenyl)sulfanylacetamide
    —— N-[2-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(2-methylphenyl)sulfanylacetamide —— C21H20N2O3S2
    N-[2-[(5E)-5-benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(2-methylphenyl)sulfanylacetamide
    —— 2-[N-(dimethylsulfamoyl)-2,5-dimethylanilino]-N-(2-phenylsulfanylphenyl)acetamide —— C24H27N3O3S2
    2-[N-(dimethylsulfamoyl)-2,5-dimethylanilino]-N-(2-phenylsulfanylphenyl)acetamide
    —— (2S)-N-[(2S)-1-methoxypropan-2-yl]-2-phenylsulfanylpropanamide —— C13H19NO2S
    (2S)-N-[(2S)-1-methoxypropan-2-yl]-2-phenylsulfanylpropanamide
    —— 1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C22H20F3N5O3S
    1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(5-methyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C24H25N5O3S
    1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(5-methyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (8S)-3-methyl-8-(4-methylsulfanylphenyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile —— C16H17N3OS2
    (8S)-3-methyl-8-(4-methylsulfanylphenyl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile
    —— ethyl (2Z)-2-[(5Z)-3-[(4-fluorophenyl)methyl]-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]acetate —— C22H20FNO3S2
    ethyl (2Z)-2-[(5Z)-3-[(4-fluorophenyl)methyl]-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]acetate
    —— N-[2-[(5Z)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide —— C21H22FN5O3S2
    N-[2-[(5Z)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide
    —— 1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C21H21N5O3S
    1-[(7E)-3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2R)-2-cyclohexylsulfonylpropanoic acid —— C9H16O4S
    (2R)-2-cyclohexylsulfonylpropanoic acid
    —— N-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-2-(4-methylphenyl)sulfanylacetamide —— C13H16N4OS2
    N-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-2-(4-methylphenyl)sulfanylacetamide
    —— N-[3-(5-amino-1,3,4-thiadiazol-2-yl)propyl]-3-(4-chlorophenyl)sulfanylpropanamide —— C14H17ClN4OS2
    N-[3-(5-amino-1,3,4-thiadiazol-2-yl)propyl]-3-(4-chlorophenyl)sulfanylpropanamide
    —— N-cyclohexyl-2-[[5-[(4-ethylphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H25N3O2S
    N-cyclohexyl-2-[[5-[(4-ethylphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-3-phenylsulfanylpropanamide —— C13H16N4OS2
    N-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-3-phenylsulfanylpropanamide
    —— N-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-3-(4-methylphenyl)sulfanylpropanamide —— C14H18N4OS2
    N-[2-(5-amino-1,3,4-thiadiazol-2-yl)ethyl]-3-(4-methylphenyl)sulfanylpropanamide
    —— 2-[(3-Chlorophenyl)methylsulfanyl]-5-[(4-ethylphenyl)methyl]-1,3,4-oxadiazole —— C18H17ClN2OS
    2-[(3-Chlorophenyl)methylsulfanyl]-5-[(4-ethylphenyl)methyl]-1,3,4-oxadiazole
    —— 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-N-[2-[(5Z)-5-[(4-methylsulfanylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]acetamide —— C21H23N3O4S3
    2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-N-[2-[(5Z)-5-[(4-methylsulfanylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]acetamide
    —— N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-3-(4-chlorophenyl)sulfanylpropanamide —— C12H13ClN4OS2
    N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-3-(4-chlorophenyl)sulfanylpropanamide
    —— 2-[(4-Ethylphenyl)methyl]-5-[(2-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C19H20N2OS
    2-[(4-Ethylphenyl)methyl]-5-[(2-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[[5-[(4-Ethylphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-propylpiperazin-1-yl)ethanone —— C20H28N4O2S
    2-[[5-[(4-Ethylphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-propylpiperazin-1-yl)ethanone
    —— 2-[(4-Bromophenyl)methylsulfanyl]-5-[(3,4-dimethylphenyl)methyl]-1,3,4-oxadiazole —— C18H17BrN2OS
    2-[(4-Bromophenyl)methylsulfanyl]-5-[(3,4-dimethylphenyl)methyl]-1,3,4-oxadiazole
    —— 2-[(3,4-Dimethylphenyl)methyl]-5-[(4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazole —— C18H17FN2OS
    2-[(3,4-Dimethylphenyl)methyl]-5-[(4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(1-ethyl-3-methylpyrazol-4-yl)methanimine —— C11H14F2N6S
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(1-ethyl-3-methylpyrazol-4-yl)methanimine
    —— 2-[(4-Ethylphenyl)methyl]-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-oxadiazole —— C20H18N4O2S
    2-[(4-Ethylphenyl)methyl]-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(1-ethylpyrazol-4-yl)methanimine —— C10H12F2N6S
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(1-ethylpyrazol-4-yl)methanimine
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(4-fluorophenyl)methanimine —— C11H9F3N4S
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(4-fluorophenyl)methanimine
    —— 3-[(Z)-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]iminomethyl]phenol —— C11H10F2N4OS
    3-[(Z)-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]iminomethyl]phenol
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-pyridin-3-ylmethanimine —— C10H9F2N5S
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-pyridin-3-ylmethanimine
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(1-ethyl-5-methylpyrazol-4-yl)methanimine —— C11H14F2N6S
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(1-ethyl-5-methylpyrazol-4-yl)methanimine
    —— N-[(E)-[3-(4-bromophenyl)pyrazol-4-ylidene]methyl]-3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-amine —— C14H11BrF2N6S
    N-[(E)-[3-(4-bromophenyl)pyrazol-4-ylidene]methyl]-3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-amine
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(3-fluorophenyl)methanimine —— C11H9F3N4S
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(3-fluorophenyl)methanimine
    —— (Z)-1-(4,5-dibromothiophen-2-yl)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]methanimine —— C9H6Br2F2N4S2
    (Z)-1-(4,5-dibromothiophen-2-yl)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]methanimine
    —— 4-bromo-3-[(Z)-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]iminomethyl]phenol —— C11H9BrF2N4OS
    4-bromo-3-[(Z)-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]iminomethyl]phenol
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(3-methylthiophen-2-yl)methanimine —— C10H10F2N4S2
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(3-methylthiophen-2-yl)methanimine
    —— (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(5-methylthiophen-2-yl)methanimine —— C10H10F2N4S2
    (Z)-N-[3-(difluoromethyl)-5-methylsulfanyl-1,2,4-triazol-4-yl]-1-(5-methylthiophen-2-yl)methanimine
    —— methyl 2-[[5-[(2Z)-2-[(2-fluorophenyl)methylidene]hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetate —— C12H12FN5O2S
    methyl 2-[[5-[(2Z)-2-[(2-fluorophenyl)methylidene]hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 2-[(5-{(2Z)-2-[1-(pyridin-2-yl)ethylidene]hydrazinyl}-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(tricyclo[3.3.1.1~3,7~]dec-2-yl)acetamide —— C21H27N7OS
    2-[(5-{(2Z)-2-[1-(pyridin-2-yl)ethylidene]hydrazinyl}-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(tricyclo[3.3.1.1~3,7~]dec-2-yl)acetamide
    —— (7Z)-3-[chloro(difluoro)methyl]-6-(2,4-difluorophenyl)-7-[(5-methylthiophen-2-yl)methylidene]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C17H9ClF4N4S2
    (7Z)-3-[chloro(difluoro)methyl]-6-(2,4-difluorophenyl)-7-[(5-methylthiophen-2-yl)methylidene]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— 3-[(3-bromophenyl)methylsulfanyl]-N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-1H-1,2,4-triazol-5-amine —— C20H23BrN6S
    3-[(3-bromophenyl)methylsulfanyl]-N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-1H-1,2,4-triazol-5-amine
    —— (7Z)-7-[(4-bromo-1-ethyl-1H-pyrazol-5-yl)methylidene]-3-(difluoromethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C17H13BrF2N6S
    (7Z)-7-[(4-bromo-1-ethyl-1H-pyrazol-5-yl)methylidene]-3-(difluoromethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— Smssf-0625219 —— C23H18BrN3O2S2
    Smssf-0625219
    —— N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-3-(pyridin-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-amine —— C19H23N7S
    N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-3-(pyridin-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-amine
    —— 2-(4-methylphenoxy)-N-[(Z)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]acetamide —— C19H17N3O3S
    2-(4-methylphenoxy)-N-[(Z)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]acetamide