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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(4-nitrophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one —— C22H12ClN3O5S3
    (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(4-nitrophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
    —— (4E)-5-methyl-4-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2-phenylpyrazol-3-one —— C24H19N3O3S
    (4E)-5-methyl-4-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2-phenylpyrazol-3-one
    —— (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(3-methylphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one —— C23H15ClN2O3S3
    (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(3-methylphenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
    —— N-[(E)-(4-methylsulfanylphenyl)methylideneamino]decanamide —— C18H28N2OS
    N-[(E)-(4-methylsulfanylphenyl)methylideneamino]decanamide
    —— (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one —— C19H15ClN2O3S3
    (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one
    —— 2-naphthalen-1-yl-N-[(Z)-[5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl]methylideneamino]acetamide —— C24H16N4O4S2
    2-naphthalen-1-yl-N-[(Z)-[5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl]methylideneamino]acetamide
    —— 2-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile —— C17H23N3O2S
    2-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile
    —— (21S)-19-chloro-17-methylsulfanyl-5,8-dioxa-14-thia-1,12,16,18-tetrazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-2,4(9),10,12,15(20),16,18-heptaen-21-ol —— C15H11ClN4O3S2
    (21S)-19-chloro-17-methylsulfanyl-5,8-dioxa-14-thia-1,12,16,18-tetrazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-2,4(9),10,12,15(20),16,18-heptaen-21-ol
    —— 2-[(7R)-3-[(2-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C19H15FN4O2S
    2-[(7R)-3-[(2-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-3-cyclopropyl-6-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C15H13FN4O2S
    2-[(7S)-3-cyclopropyl-6-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(E)-[(1R)-cyclohex-3-en-1-yl]methylideneamino]-5-(phenylsulfanylmethyl)triazole-4-carboxamide —— C19H20N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(E)-[(1R)-cyclohex-3-en-1-yl]methylideneamino]-5-(phenylsulfanylmethyl)triazole-4-carboxamide
    —— 2-[(7R)-3-(2-methylfuran-3-yl)-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C15H12N4O3S2
    2-[(7R)-3-(2-methylfuran-3-yl)-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— (20S)-18-chloro-16-methylsulfanyl-5,7-dioxa-13-thia-1,11,15,17-tetrazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-2,4(8),9,11,14(19),15,17-heptaen-20-ol —— C14H9ClN4O3S2
    (20S)-18-chloro-16-methylsulfanyl-5,7-dioxa-13-thia-1,11,15,17-tetrazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-2,4(8),9,11,14(19),15,17-heptaen-20-ol
    —— (20R)-18-chloro-16-methylsulfanyl-5,7-dioxa-13-thia-1,11,15,17-tetrazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-2,4(8),9,11,14(19),15,17-heptaen-20-ol —— C14H9ClN4O3S2
    (20R)-18-chloro-16-methylsulfanyl-5,7-dioxa-13-thia-1,11,15,17-tetrazapentacyclo[10.8.0.02,10.04,8.014,19]icosa-2,4(8),9,11,14(19),15,17-heptaen-20-ol
    —— 2-[(7S)-6-(4-fluorophenyl)-3-(2-methylfuran-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C17H13FN4O3S
    2-[(7S)-6-(4-fluorophenyl)-3-(2-methylfuran-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— [2-[[(1R,2S,3R)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl] 2-(2-methylphenyl)sulfanylacetate —— C19H27NO3S
    [2-[[(1R,2S,3R)-2,3-dimethylcyclohexyl]amino]-2-oxoethyl] 2-(2-methylphenyl)sulfanylacetate
    —— (E)-3-(butan-2-ylamino)-2-[2-(butan-2-ylamino)-1-[(E)-2-(butan-2-ylamino)-1-cyanoethenyl]sulfonylethenyl]sulfonylprop-2-enenitrile —— C20H33N5O4S2
    (E)-3-(butan-2-ylamino)-2-[2-(butan-2-ylamino)-1-[(E)-2-(butan-2-ylamino)-1-cyanoethenyl]sulfonylethenyl]sulfonylprop-2-enenitrile
    —— 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C18H23N3O5S2
    2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(E)-[(1R)-cyclohex-3-en-1-yl]methylideneamino]-5-[(4-methylphenyl)sulfanylmethyl]triazole-4-carboxamide —— C20H22N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(E)-[(1R)-cyclohex-3-en-1-yl]methylideneamino]-5-[(4-methylphenyl)sulfanylmethyl]triazole-4-carboxamide
    —— 7-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C22H25N5OS3
    7-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— (2R)-2-(4-methylphenyl)sulfanyl-N-[[2-(methylsulfamoylmethyl)phenyl]methyl]propanamide —— C19H24N2O3S2
    (2R)-2-(4-methylphenyl)sulfanyl-N-[[2-(methylsulfamoylmethyl)phenyl]methyl]propanamide
    —— 2-[(7S)-3-(3,5-dimethylpyrazol-1-yl)-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C18H18N6O2S
    2-[(7S)-3-(3,5-dimethylpyrazol-1-yl)-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 7-[[5-[(5S)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C22H25N5OS3
    7-[[5-[(5S)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 2-[(7R)-3-(3,5-dimethylpyrazol-1-yl)-6-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C17H15FN6O2S
    2-[(7R)-3-(3,5-dimethylpyrazol-1-yl)-6-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-3-(3,5-dimethylpyrazol-1-yl)-6-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C17H15FN6O2S
    2-[(7S)-3-(3,5-dimethylpyrazol-1-yl)-6-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[[5-[(E)-2-(5-methylfuran-2-yl)ethenyl]-1H-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-3-methyl-1-phenylbutyl]acetamide —— C22H26N4O2S
    2-[[5-[(E)-2-(5-methylfuran-2-yl)ethenyl]-1H-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-3-methyl-1-phenylbutyl]acetamide
    —— (2R)-N-benzyl-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]butanamide —— C19H18ClN3OS3
    (2R)-N-benzyl-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]butanamide
    —— 3-Methyl-5-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)sulfanyl-1,2,4-triazol-4-amine —— C9H10N8S
    3-Methyl-5-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)sulfanyl-1,2,4-triazol-4-amine
    —— (E)-1-[2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-5-nitrophenyl]-N-(1,2,4-triazol-4-yl)methanimine —— C19H16N8O2S
    (E)-1-[2-[(4-ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-5-nitrophenyl]-N-(1,2,4-triazol-4-yl)methanimine
    —— 3-((3-Chloro-5-(trifluoromethyl)-2-pyridinyl)sulfanyl)-5-(2-(4-methoxyphenylamino)vinyl)-4-isothiazolecarbonitrile —— C19H12ClF3N4OS2
    3-((3-Chloro-5-(trifluoromethyl)-2-pyridinyl)sulfanyl)-5-(2-(4-methoxyphenylamino)vinyl)-4-isothiazolecarbonitrile
    —— 3-{(Z)-[3-(butan-2-yl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-7-methyl-2-(phenylsulfanyl)-4H-pyrido[1,2-a]pyrimidin-4-one —— C23H21N3O2S3
    3-{(Z)-[3-(butan-2-yl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-7-methyl-2-(phenylsulfanyl)-4H-pyrido[1,2-a]pyrimidin-4-one
    —— 2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[1-[(1-phenylcyclopropyl)methyl]piperidin-4-yl]acetamide —— C20H26N4O2S
    2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[1-[(1-phenylcyclopropyl)methyl]piperidin-4-yl]acetamide
    —— methyl 2-[5-chloro-2-[[(E)-2-cyano-3-(ethoxycarbonylamino)-3-oxoprop-1-enyl]amino]-3-fluorophenyl]sulfanylacetate —— C16H15ClFN3O5S
    methyl 2-[5-chloro-2-[[(E)-2-cyano-3-(ethoxycarbonylamino)-3-oxoprop-1-enyl]amino]-3-fluorophenyl]sulfanylacetate
    —— ethyl (5aS,8aR)-1-[(2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanoyl]-2,5,6,7,8,8a-hexahydrocyclopenta[b]azepine-5a-carboxylate —— C21H29N3O3S
    ethyl (5aS,8aR)-1-[(2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanoyl]-2,5,6,7,8,8a-hexahydrocyclopenta[b]azepine-5a-carboxylate
    —— (14E)-14-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-11-(3,4-dimethoxyphenyl)-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-13-one —— C34H26N4O4S2
    (14E)-14-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-11-(3,4-dimethoxyphenyl)-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-13-one
    —— methyl (2S)-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C10H10N2O3S2
    methyl (2S)-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— (2Z,5E)-5-({4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-2-[(4-ethoxyphenyl)imino]-1,3-thiazolidin-4-one —— C22H16BrClN2O3S2
    (2Z,5E)-5-({4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-2-[(4-ethoxyphenyl)imino]-1,3-thiazolidin-4-one
    —— 3-{(2Z)-2-[4-(methylsulfanyl)benzylidene]hydrazinyl}-4H-1,2,4-triazol-4-amine —— C10H12N6S
    3-{(2Z)-2-[4-(methylsulfanyl)benzylidene]hydrazinyl}-4H-1,2,4-triazol-4-amine
    —— 3-nitro-N-[(Z)-[5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl]methylideneamino]benzamide —— C19H11N5O6S2
    3-nitro-N-[(Z)-[5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl]methylideneamino]benzamide
    —— N-[(Z)-[4-bromo-5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-5-nitropyridin-2-amine —— C16H10BrClN4O3S
    N-[(Z)-[4-bromo-5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-5-nitropyridin-2-amine
    —— ethyl (2Z)-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-2-[(5-piperidin-1-ylfuran-2-yl)methylidene]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C27H29N3O4S2
    ethyl (2Z)-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-2-[(5-piperidin-1-ylfuran-2-yl)methylidene]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— (5E)-3-phenyl-5-{[5-(phenylsulfanyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione —— C20H13NO3S2
    (5E)-3-phenyl-5-{[5-(phenylsulfanyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
    —— (4S)-4-(4-fluorophenyl)-1-[(2-propylsulfanylpyrimidin-5-yl)methyl]azepan-4-ol —— C20H26FN3OS
    (4S)-4-(4-fluorophenyl)-1-[(2-propylsulfanylpyrimidin-5-yl)methyl]azepan-4-ol
    —— N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-2-morpholin-4-ylacetamide —— C20H22N4O4S
    N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-2-morpholin-4-ylacetamide
    —— N-[(E)-(4-methylsulfanylphenyl)methylideneamino]undecanamide —— C19H30N2OS
    N-[(E)-(4-methylsulfanylphenyl)methylideneamino]undecanamide
    —— 2-[[4-(furan-2-ylmethyl)-5-[(3R)-3-methylpiperidin-1-yl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-3-methylbutan-2-yl]acetamide —— C20H31N5O2S
    2-[[4-(furan-2-ylmethyl)-5-[(3R)-3-methylpiperidin-1-yl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-3-methylbutan-2-yl]acetamide
    —— 3-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]quinazolin-4-one —— C22H16N4O3S
    3-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]quinazolin-4-one
    —— ethyl (2Z)-2-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-5-(2-methoxynaphthalen-1-yl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C33H26N4O5S2
    ethyl (2Z)-2-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-5-(2-methoxynaphthalen-1-yl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— (5Z)-3-[(3,4-dichlorophenyl)methyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione —— C24H16Cl2N2O4S2
    (5Z)-3-[(3,4-dichlorophenyl)methyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione
    —— 3-[(2-fluorophenyl)methylsulfanyl]-6-[2-[[(Z)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]amino]phenyl]-2H-1,2,4-triazin-5-one —— C27H21FN6O2S
    3-[(2-fluorophenyl)methylsulfanyl]-6-[2-[[(Z)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]amino]phenyl]-2H-1,2,4-triazin-5-one