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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (Z)-1-(3-prop-2-ynylsulfanyl-1,2,4-triazol-4-yl)-3-thiophen-2-ylprop-2-en-1-one —— C12H9N3OS2
    (Z)-1-(3-prop-2-ynylsulfanyl-1,2,4-triazol-4-yl)-3-thiophen-2-ylprop-2-en-1-one
    —— (2E,5Z)-5-{[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene}-2-[(3-chlorophenyl)imino]-1,3-thiazolidin-4-one —— C21H13ClN4O2S2
    (2E,5Z)-5-{[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene}-2-[(3-chlorophenyl)imino]-1,3-thiazolidin-4-one
    —— (E)-N-(3-benzylsulfanyl-5-methyl-1,2,4-triazol-4-yl)-3-[5-(3-chloro-4-methylphenyl)furan-2-yl]prop-2-enamide —— C24H21ClN4O2S
    (E)-N-(3-benzylsulfanyl-5-methyl-1,2,4-triazol-4-yl)-3-[5-(3-chloro-4-methylphenyl)furan-2-yl]prop-2-enamide
    —— (E)-3-(1,3-benzothiazol-2-yl)-4-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]but-3-enoic acid —— C21H16N4O4S2
    (E)-3-(1,3-benzothiazol-2-yl)-4-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]but-3-enoic acid
    —— (2R)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one —— C19H19N3OS2
    (2R)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one
    —— N-(3-methylbutyl)-2-[(5S)-2-[(2E)-2-[(4-methylsulfanylphenyl)methylidene]hydrazinyl]-4-oxo-1,3-thiazol-5-yl]acetamide —— C18H24N4O2S2
    N-(3-methylbutyl)-2-[(5S)-2-[(2E)-2-[(4-methylsulfanylphenyl)methylidene]hydrazinyl]-4-oxo-1,3-thiazol-5-yl]acetamide
    —— (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(3-nitrophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one —— C22H12ClN3O5S3
    (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-(3-nitrophenyl)-2-sulfanylidene-1,3-thiazolidin-4-one
    —— 3-chloro-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-5-(trifluoromethyl)pyridin-2-amine —— C14H11ClF3N3S
    3-chloro-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-5-(trifluoromethyl)pyridin-2-amine
    —— 4-amino-3-methylsulfanyl-6-[(Z)-2-thiophen-2-ylethenyl]-1,2,4-triazin-5-one —— C10H10N4OS2
    4-amino-3-methylsulfanyl-6-[(Z)-2-thiophen-2-ylethenyl]-1,2,4-triazin-5-one
    —— N-[(4S)-4-chlorocyclohexa-1,5-dien-1-yl]-2-(4,6-diaminopyrimidin-2-yl)sulfanylacetamide —— C12H14ClN5OS
    N-[(4S)-4-chlorocyclohexa-1,5-dien-1-yl]-2-(4,6-diaminopyrimidin-2-yl)sulfanylacetamide
    —— N-[(4R)-4-chlorocyclohexa-1,5-dien-1-yl]-2-(4,6-diaminopyrimidin-2-yl)sulfanylacetamide —— C12H14ClN5OS
    N-[(4R)-4-chlorocyclohexa-1,5-dien-1-yl]-2-(4,6-diaminopyrimidin-2-yl)sulfanylacetamide
    —— 5-acetyl-2-[(Z)-but-2-enyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C13H14N2OS
    5-acetyl-2-[(Z)-but-2-enyl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— (Z)-4-(6-benzylsulfanylimidazo[2,1-b][1,3]thiazol-5-yl)but-3-en-2-one —— C16H14N2OS2
    (Z)-4-(6-benzylsulfanylimidazo[2,1-b][1,3]thiazol-5-yl)but-3-en-2-one
    —— (5E)-2-(hydroxyamino)-5-[(4-methylsulfanylphenyl)methylidene]-1,3-thiazol-4-one —— C11H10N2O2S2
    (5E)-2-(hydroxyamino)-5-[(4-methylsulfanylphenyl)methylidene]-1,3-thiazol-4-one
    —— N-[(Z)-[2-(4-chlorophenyl)sulfanylphenyl]methylideneamino]-1,3-benzothiazol-2-amine —— C20H14ClN3S2
    N-[(Z)-[2-(4-chlorophenyl)sulfanylphenyl]methylideneamino]-1,3-benzothiazol-2-amine
    —— N-[2-(3,4-dimethoxyphenyl)ethyl]-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-2-(4-fluorophenyl)sulfanylbenzamide —— C30H35FN2O5S2
    N-[2-(3,4-dimethoxyphenyl)ethyl]-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-2-(4-fluorophenyl)sulfanylbenzamide
    —— 2-(4-bromophenyl)sulfanyl-N-(2,2-dimethoxyethyl)-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonylbenzamide —— C24H31BrN2O5S2
    2-(4-bromophenyl)sulfanyl-N-(2,2-dimethoxyethyl)-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonylbenzamide
    —— N-benzyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-2-(4-fluorophenyl)sulfanyl-N-(2-phenylethyl)benzamide —— C35H37FN2O3S2
    N-benzyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-2-(4-fluorophenyl)sulfanyl-N-(2-phenylethyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-N-(2,2-dimethoxyethyl)-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonylbenzamide —— C24H31BrN2O5S2
    2-(4-bromophenyl)sulfanyl-N-(2,2-dimethoxyethyl)-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonylbenzamide
    —— (E)-3-amino-2-[2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]but-2-enenitrile —— C10H11N5O2S
    (E)-3-amino-2-[2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]but-2-enenitrile
    —— 2-(3-chlorophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-[(2R)-1-phenylbutan-2-yl]benzamide —— C30H35ClN2O3S2
    2-(3-chlorophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-[(2R)-1-phenylbutan-2-yl]benzamide
    —— 3-nitro-N-[(Z)-(5-quinolin-8-ylsulfanylfuran-2-yl)methylideneamino]benzamide —— C21H14N4O4S
    3-nitro-N-[(Z)-(5-quinolin-8-ylsulfanylfuran-2-yl)methylideneamino]benzamide
    —— 1-(2-methylphenyl)-3-(2-methylsulfanylphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]azepine —— C21H23N3S
    1-(2-methylphenyl)-3-(2-methylsulfanylphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]azepine
    —— 2-(4-bromophenyl)sulfanyl-5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-morpholin-4-ylpropyl)benzamide —— C27H36BrN3O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-morpholin-4-ylpropyl)benzamide
    —— N-benzyl-2-(3-chlorophenyl)sulfanyl-5-[(3S,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-phenylethyl)benzamide —— C35H37ClN2O3S2
    N-benzyl-2-(3-chlorophenyl)sulfanyl-5-[(3S,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-phenylethyl)benzamide
    —— (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione —— C22H13ClN2O4S2
    (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
    —— (5Z)-3-(4-bromophenyl)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one —— C23H15BrN2O3S3
    (5Z)-3-(4-bromophenyl)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
    —— N-[(Z)-(4-methylphenyl)methylideneamino]-N-[4-[(1-methyltetrazol-5-yl)sulfanylmethyl]-1,3-thiazol-2-yl]acetamide —— C16H17N7OS2
    N-[(Z)-(4-methylphenyl)methylideneamino]-N-[4-[(1-methyltetrazol-5-yl)sulfanylmethyl]-1,3-thiazol-2-yl]acetamide
    —— (2S)-2-[4-[4-[(2S)-1-oxo-1-(2,4,6-trimethylanilino)propan-2-yl]sulfanylphenyl]sulfanylphenyl]sulfanyl-N-(2,4,6-trimethylphenyl)propanamide —— C36H40N2O2S3
    (2S)-2-[4-[4-[(2S)-1-oxo-1-(2,4,6-trimethylanilino)propan-2-yl]sulfanylphenyl]sulfanylphenyl]sulfanyl-N-(2,4,6-trimethylphenyl)propanamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(E)-nonan-2-ylideneamino]acetamide —— C17H25ClN2OS
    2-(4-chlorophenyl)sulfanyl-N-[(E)-nonan-2-ylideneamino]acetamide
    —— (2R,6S)-4-[4-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]sulfonylphenyl]sulfanylphenyl]sulfonyl-2,6-dimethylmorpholine —— C24H32N2O6S3
    (2R,6S)-4-[4-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]sulfonylphenyl]sulfanylphenyl]sulfonyl-2,6-dimethylmorpholine
    —— methyl (E)-2-cyano-3-(2-ethylsulfanyl-5-methylfuran-3-yl)prop-2-enoate —— C12H13NO3S
    methyl (E)-2-cyano-3-(2-ethylsulfanyl-5-methylfuran-3-yl)prop-2-enoate
    —— (2R)-2-[[5-(anilinomethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-(3-hydroxyphenyl)methylideneamino]propanamide —— C22H24N6O2S
    (2R)-2-[[5-(anilinomethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-(3-hydroxyphenyl)methylideneamino]propanamide
    —— (Z)-2-tert-butylsulfonyl-3-(dimethylamino)prop-2-enenitrile —— C9H16N2O2S
    (Z)-2-tert-butylsulfonyl-3-(dimethylamino)prop-2-enenitrile
    —— 6-[(Z)-3-(dimethylamino)prop-2-enoyl]-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C11H13N3O2S
    6-[(Z)-3-(dimethylamino)prop-2-enoyl]-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 5-[(2E)-2-hydroxyimino-2-phenylethyl]sulfanyl-4-[(2Z)-2-hydroxyimino-2-phenylethyl]sulfanyl-1,3-dithiole-2-thione —— C19H16N2O2S5
    5-[(2E)-2-hydroxyimino-2-phenylethyl]sulfanyl-4-[(2Z)-2-hydroxyimino-2-phenylethyl]sulfanyl-1,3-dithiole-2-thione
    —— N-[(Z)-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylideneamino]-3-nitrobenzamide —— C19H13N5O4S
    N-[(Z)-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylideneamino]-3-nitrobenzamide
    —— 2-[6-[(4-chlorophenyl)methylamino]pyrimidin-4-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C18H21ClN4O2S
    2-[6-[(4-chlorophenyl)methylamino]pyrimidin-4-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— N-[(2R)-butan-2-yl]-2-[(7-oxo-3-phenyl-6-propyl-[1,2]thiazolo[4,5-d]pyrimidin-5-yl)sulfanyl]acetamide —— C20H24N4O2S2
    N-[(2R)-butan-2-yl]-2-[(7-oxo-3-phenyl-6-propyl-[1,2]thiazolo[4,5-d]pyrimidin-5-yl)sulfanyl]acetamide
    —— (3S)-N-[(3,4-diethoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C27H32N4O3S
    (3S)-N-[(3,4-diethoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-[(3,5-dimethoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C25H28N4O3S
    (3S)-N-[(3,5-dimethoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(2-methylphenyl)methyl]-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4OS
    (3R)-N-[(2-methylphenyl)methyl]-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— 2-[3-(2-methylphenyl)sulfanylpyrazin-2-yl]sulfanyl-N-[(1S)-1-phenylethyl]acetamide —— C21H21N3OS2
    2-[3-(2-methylphenyl)sulfanylpyrazin-2-yl]sulfanyl-N-[(1S)-1-phenylethyl]acetamide
    —— (Z)-3-pyridin-2-ylsulfanyl-1-thiophen-2-ylprop-2-en-1-one —— C12H9NOS2
    (Z)-3-pyridin-2-ylsulfanyl-1-thiophen-2-ylprop-2-en-1-one
    —— (3S)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C26H30N4O2S
    (3S)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(2-methoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H26N4O2S
    (3S)-N-(2-methoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(4-bromophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H23BrN4OS
    (3S)-N-(4-bromophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-[(3-bromophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23BrN4OS
    (3R)-N-[(3-bromophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C26H30N4O2S
    (3R)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]-N-(2-methylpropyl)piperidine-3-carboxamide —— C21H28N4OS
    (3S)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]-N-(2-methylpropyl)piperidine-3-carboxamide