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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C21H22ClN5O2S
    (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— N-[(1R)-1-cyano-1-cyclopropylethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide —— C16H20N2OS
    N-[(1R)-1-cyano-1-cyclopropylethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]acetamide —— C16H15ClN2OS2
    2-(4-chlorophenyl)sulfanyl-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]acetamide
    —— (2S)-2-(1-benzylimidazol-2-yl)sulfanyl-N-(cyclohexylmethyl)propanamide —— C20H27N3OS
    (2S)-2-(1-benzylimidazol-2-yl)sulfanyl-N-(cyclohexylmethyl)propanamide
    —— (2R)-2-(1-benzylimidazol-2-yl)sulfanyl-N-(cyclohexylmethyl)propanamide —— C20H27N3OS
    (2R)-2-(1-benzylimidazol-2-yl)sulfanyl-N-(cyclohexylmethyl)propanamide
    —— ethyl 5-[(2R)-2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C22H26N4O4S
    ethyl 5-[(2R)-2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— (2R)-2-(1-benzylimidazol-2-yl)sulfanyl-N-[(2S)-2-phenylpropyl]propanamide —— C22H25N3OS
    (2R)-2-(1-benzylimidazol-2-yl)sulfanyl-N-[(2S)-2-phenylpropyl]propanamide
    —— 3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-4-amine —— C15H15ClN4OS
    3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-4-amine
    —— (2R)-2-(1-benzylimidazol-2-yl)sulfanyl-N-[2-(cyclohexen-1-yl)ethyl]propanamide —— C21H27N3OS
    (2R)-2-(1-benzylimidazol-2-yl)sulfanyl-N-[2-(cyclohexen-1-yl)ethyl]propanamide
    —— 2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]ethanone —— C27H30N4O3S
    2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]ethanone
    —— (2S)-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexyl-N-methylpropanamide —— C24H30N4O2S
    (2S)-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclohexyl-N-methylpropanamide
    —— (2S)-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(cyclohexylmethyl)propanamide —— C24H30N4O2S
    (2S)-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(cyclohexylmethyl)propanamide
    —— (2R)-N-benzyl-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide —— C25H26N4O2S
    (2R)-N-benzyl-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide
    —— (2R)-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(cyclohexen-1-yl)ethyl]propanamide —— C25H30N4O2S
    (2R)-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(cyclohexen-1-yl)ethyl]propanamide
    —— 2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide —— C24H23ClN4O2S
    2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide
    —— (2S)-N-benzyl-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C24H24N4O2S
    (2S)-N-benzyl-2-[[4-benzyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— 2-[[5-[2-[[(1R)-1-cyano-1-cyclopropylethyl]amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H15N5O2S3
    2-[[5-[2-[[(1R)-1-cyano-1-cyclopropylethyl]amino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(2-methylphenyl)ethyl]acetamide —— C19H18ClN3OS3
    2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(2-methylphenyl)ethyl]acetamide
    —— (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylmethyl)propanamide —— C19H25N3O2S
    (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylmethyl)propanamide
    —— (2R)-N-cyclohexyl-N-methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H23N3OS3
    (2R)-N-cyclohexyl-N-methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— ethyl 2,4-dimethyl-5-[(2S)-2-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C22H26N4O4S
    ethyl 2,4-dimethyl-5-[(2S)-2-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylmethyl)propanamide —— C19H25N3O2S
    (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylmethyl)propanamide
    —— (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one —— C23H12ClF3N2O3S3
    (5E)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one
    —— (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[2-(cyclohexen-1-yl)ethyl]propanamide —— C20H25N3O2S
    (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[2-(cyclohexen-1-yl)ethyl]propanamide
    —— (2E)-2-[(4-ethylphenyl)methylidene]-1-benzothiophen-3-one —— C17H14OS
    (2E)-2-[(4-ethylphenyl)methylidene]-1-benzothiophen-3-one
    —— 2-[(2Z)-2-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]hydrazinyl]-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile —— C22H18ClN5O3S
    2-[(2Z)-2-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]hydrazinyl]-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile
    —— 2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-methylphenyl)ethyl]acetamide —— C24H30N4OS2
    2-[[4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-methylphenyl)ethyl]acetamide
    —— 4-chloro-N-[(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]benzamide —— C20H13Cl2N3O3S
    4-chloro-N-[(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]benzamide
    —— methyl (E)-4-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]but-2-enoate —— C9H11N3O3S
    methyl (E)-4-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]but-2-enoate
    —— (2R)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]propanamide —— C22H25N3O2S
    (2R)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]propanamide
    —— N-[(Z)-(4-bromophenyl)methylideneamino]-2-(5-ethyl-4-methyl-2-methylsulfanyl-6-oxopyrimidin-1-yl)acetamide —— C17H19BrN4O2S
    N-[(Z)-(4-bromophenyl)methylideneamino]-2-(5-ethyl-4-methyl-2-methylsulfanyl-6-oxopyrimidin-1-yl)acetamide
    —— ethyl 2,4-dimethyl-5-[2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl]-1H-pyrrole-3-carboxylate —— C22H26N4O4S2
    ethyl 2,4-dimethyl-5-[2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl]-1H-pyrrole-3-carboxylate
    —— (2R)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]cyclohexan-1-one —— C21H19N3OS
    (2R)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]cyclohexan-1-one
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C18H27NO3S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— (2S)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one —— C21H22ClN5O2S2
    (2S)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)acetamide —— C17H20N2O3S
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)acetamide
    —— 6-amino-1,3-dimethyl-5-[(2S)-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]propanoyl]pyrimidine-2,4-dione —— C19H20N4O3S2
    6-amino-1,3-dimethyl-5-[(2S)-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]propanoyl]pyrimidine-2,4-dione
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(1E)-1-(thiophen-2-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C18H15ClN8O2S2
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(1E)-1-(thiophen-2-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-(2,3,5,6-tetramethylphenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C18H23NOS2
    2-(2,3,5,6-tetramethylphenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C18H27NO3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— N-[(1R)-1-cyano-1-cyclopropylethyl]-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)acetamide —— C17H20N2O3S
    N-[(1R)-1-cyano-1-cyclopropylethyl]-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)acetamide
    —— 2-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-cyano-1-cyclopropylethyl]acetamide —— C23H31N5OS2
    2-[[5-[(5R)-5-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-cyano-1-cyclopropylethyl]acetamide
    —— (2S)-N-(cyclohexylmethyl)-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)propanamide —— C19H27NO3S
    (2S)-N-(cyclohexylmethyl)-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)propanamide
    —— 2-[[4-benzyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide —— C24H30ClN5OS
    2-[[4-benzyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide
    —— N-[(2R)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C20H31NO3S2
    N-[(2R)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— 6-amino-1,3-dimethyl-5-[(2R)-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]propanoyl]pyrimidine-2,4-dione —— C19H20N4O3S2
    6-amino-1,3-dimethyl-5-[(2R)-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]propanoyl]pyrimidine-2,4-dione
    —— 2-(2,3,5,6-tetramethylphenyl)sulfanyl-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C18H23NOS2
    2-(2,3,5,6-tetramethylphenyl)sulfanyl-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C18H19ClN4OS2
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C16H22N4O2S2
    1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 3-benzyl-5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-4-methyl-1,2,4-triazole —— C18H18ClN3S
    3-benzyl-5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-4-methyl-1,2,4-triazole