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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-((1-methyl-1H-tetrazol-5-yl)thio)-1-(7-(o-tolyl)-1,4-thiazepan-4-yl)ethanone —— C16H21N5OS2
    2-((1-methyl-1H-tetrazol-5-yl)thio)-1-(7-(o-tolyl)-1,4-thiazepan-4-yl)ethanone
    —— N-(1-cyano-1,2-dimethylpropyl)-2-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanyl]acetamide —— C16H20N4OS
    N-(1-cyano-1,2-dimethylpropyl)-2-[(3-cyano-4,6-dimethylpyridin-2-yl)sulfanyl]acetamide
    —— 1-((1R,5S)-8-azabicyclo[3.2.1]oct-2-en-8-yl)-2-((4-fluorophenyl)thio)ethanone —— C15H16FNOS
    1-((1R,5S)-8-azabicyclo[3.2.1]oct-2-en-8-yl)-2-((4-fluorophenyl)thio)ethanone
    —— N-[(2R)-butan-2-yl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C12H15N3O2S2
    N-[(2R)-butan-2-yl]-2-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— ethyl N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]carbamate —— C11H14N2O2S
    ethyl N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]carbamate
    —— [(Z)-(4-methylsulfanylphenyl)methylideneamino]urea —— C9H11N3OS
    [(Z)-(4-methylsulfanylphenyl)methylideneamino]urea
    —— 2-((4-fluorophenyl)thio)-N-(((1R,3S,5r,7r)-2-methoxyadamantan-2-yl)methyl)acetamide —— C20H26FNO2S
    2-((4-fluorophenyl)thio)-N-(((1R,3S,5r,7r)-2-methoxyadamantan-2-yl)methyl)acetamide
    —— N-[(2S)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C19H24N2O3S3
    N-[(2S)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (2R)-3-amino-2-[2-[[5-[4-(difluoromethylsulfanyl)anilino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-3-enenitrile —— C15H13F2N5OS3
    (2R)-3-amino-2-[2-[[5-[4-(difluoromethylsulfanyl)anilino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-3-enenitrile
    —— 2-(pyrimidin-2-ylthio)-N-((1-(thiazol-2-yl)pyrrolidin-2-yl)methyl)acetamide —— C14H17N5OS2
    2-(pyrimidin-2-ylthio)-N-((1-(thiazol-2-yl)pyrrolidin-2-yl)methyl)acetamide
    —— N-[(1S)-1-[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]ethyl]-2-phenylsulfanylpyridine-3-carboxamide —— C21H24N2OS
    N-[(1S)-1-[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]ethyl]-2-phenylsulfanylpyridine-3-carboxamide
    —— (2R)-2-[[5-[(5R)-5-ethyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylethyl]propanamide —— C26H32N4OS2
    (2R)-2-[[5-[(5R)-5-ethyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylethyl]propanamide
    —— (5S)-5-methyl-N-[(Z)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide —— C20H20N6O3S2
    (5S)-5-methyl-N-[(Z)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
    —— (2R)-3-amino-2-[2-(2-chlorophenyl)sulfanylacetyl]but-3-enenitrile —— C12H11ClN2OS
    (2R)-3-amino-2-[2-(2-chlorophenyl)sulfanylacetyl]but-3-enenitrile
    —— 3-(phenylthio)-N-(2-(3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl)ethyl)propanamide —— C18H20F3N3O2S
    3-(phenylthio)-N-(2-(3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl)ethyl)propanamide
    —— (5R)-5-methyl-N-[(Z)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide —— C20H20N6O3S2
    (5R)-5-methyl-N-[(Z)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide
    —— N-(2-(6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl)ethyl)-3-(phenylthio)propanamide —— C17H21N3O2S
    N-(2-(6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl)ethyl)-3-(phenylthio)propanamide
    —— 3-phenylsulfanyl-N-[2-(3-pyridin-2-yl-4,5,6,7-tetrahydroindazol-1-yl)ethyl]propanamide —— C23H26N4OS
    3-phenylsulfanyl-N-[2-(3-pyridin-2-yl-4,5,6,7-tetrahydroindazol-1-yl)ethyl]propanamide
    —— (Z)-4-(4-bromophenyl)-N-(2-methoxyethyl)-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1,3-thiazol-2-imine —— C20H20BrN3OS2
    (Z)-4-(4-bromophenyl)-N-(2-methoxyethyl)-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1,3-thiazol-2-imine
    —— 2-(4-fluorophenyl)sulfanyl-N-(oxan-4-yl)-N-(thiophen-2-ylmethyl)acetamide —— C18H20FNO2S2
    2-(4-fluorophenyl)sulfanyl-N-(oxan-4-yl)-N-(thiophen-2-ylmethyl)acetamide
    —— 2,5-dimethyl-N-[(Z)-(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylideneamino]benzenesulfonamide —— C19H17N5O4S2
    2,5-dimethyl-N-[(Z)-(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylideneamino]benzenesulfonamide
    —— 2-(1-methyltetrazol-5-yl)sulfanyl-N-(2-morpholin-4-ylethyl)-N-(oxan-4-yl)acetamide —— C15H26N6O3S
    2-(1-methyltetrazol-5-yl)sulfanyl-N-(2-morpholin-4-ylethyl)-N-(oxan-4-yl)acetamide
    —— 2-(4-fluorophenyl)sulfanyl-N-(2-morpholin-4-ylethyl)-N-(oxan-4-yl)acetamide —— C19H27FN2O3S
    2-(4-fluorophenyl)sulfanyl-N-(2-morpholin-4-ylethyl)-N-(oxan-4-yl)acetamide
    —— 1-benzyl-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea —— C20H24N2O2S
    1-benzyl-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea
    —— (Z)-4-(3-bromophenyl)-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-N-prop-2-enyl-1,3-thiazol-2-imine —— C20H18BrN3S2
    (Z)-4-(3-bromophenyl)-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-N-prop-2-enyl-1,3-thiazol-2-imine
    —— 1-cyclohexyl-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea —— C19H28N2O2S
    1-cyclohexyl-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea
    —— 1-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)-3-propylurea —— C16H24N2O2S
    1-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)-3-propylurea
    —— 1-(3-fluorophenyl)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)methanesulfonamide —— C19H22FNO3S2
    1-(3-fluorophenyl)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)methanesulfonamide
    —— (NZ)-N-[(4-methylsulfanylphenyl)methylidene]hydroxylamine —— C8H9NOS
    (NZ)-N-[(4-methylsulfanylphenyl)methylidene]hydroxylamine
    —— 2-(cyclopentylthio)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)acetamide —— C19H27NO2S2
    2-(cyclopentylthio)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)acetamide
    —— 4,4,4-trifluoro-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butanamide —— C16H20F3NO2S
    4,4,4-trifluoro-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butanamide
    —— 5-ethyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)thiophene-2-sulfonamide —— C18H23NO3S3
    5-ethyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)thiophene-2-sulfonamide
    —— N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)cyclohexanesulfonamide —— C18H27NO3S2
    N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)cyclohexanesulfonamide
    —— 1-((1R,3s)-adamantan-1-yl)-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea —— C23H32N2O2S
    1-((1R,3s)-adamantan-1-yl)-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea
    —— N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)cyclobutanecarboxamide —— C17H23NO2S
    N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)cyclobutanecarboxamide
    —— 3-methyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butanamide —— C17H25NO2S
    3-methyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butanamide
    —— 3,3-dimethyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butanamide —— C18H27NO2S
    3,3-dimethyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butanamide
    —— N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)cyclopropanecarboxamide —— C16H21NO2S
    N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)cyclopropanecarboxamide
    —— N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butane-1-sulfonamide —— C16H25NO3S2
    N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)butane-1-sulfonamide
    —— N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)methanesulfonamide —— C13H19NO3S2
    N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)methanesulfonamide
    —— 3-methoxy-1-methyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole-4-carboxamide —— C18H23N3O3S
    3-methoxy-1-methyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole-4-carboxamide
    —— 2-ethoxy-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)acetamide —— C16H23NO3S
    2-ethoxy-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)acetamide
    —— N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]pyridine-3-carboxamide —— C17H14N6O3S
    N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]pyridine-3-carboxamide
    —— (E)-N-[(4-phenylsulfanyloxan-4-yl)methyl]-3-thiophen-2-ylprop-2-enamide —— C19H21NO2S2
    (E)-N-[(4-phenylsulfanyloxan-4-yl)methyl]-3-thiophen-2-ylprop-2-enamide
    —— N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)isobutyramide —— C16H23NO2S
    N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)isobutyramide
    —— 2-((4-fluorophenyl)thio)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)acetamide —— C20H22FNO2S2
    2-((4-fluorophenyl)thio)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)acetamide
    —— 5-((2-((4-Chlorobenzyl)thio)thiazol-4-yl)methyl)-3-(thiophen-2-yl)-1,2,4-oxadiazole —— C17H12ClN3OS3
    5-((2-((4-Chlorobenzyl)thio)thiazol-4-yl)methyl)-3-(thiophen-2-yl)-1,2,4-oxadiazole
    —— 5-((2-((2,5-Dimethylbenzyl)thio)thiazol-4-yl)methyl)-3-methyl-1,2,4-oxadiazole —— C16H17N3OS2
    5-((2-((2,5-Dimethylbenzyl)thio)thiazol-4-yl)methyl)-3-methyl-1,2,4-oxadiazole
    —— 5-((2-((4-Chlorobenzyl)thio)thiazol-4-yl)methyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole —— C18H13ClN4OS2
    5-((2-((4-Chlorobenzyl)thio)thiazol-4-yl)methyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole
    —— 1-(4-(2-hydroxy-2-(thiophen-2-yl)ethyl)piperazin-1-yl)-2-((1-methyl-1H-tetrazol-5-yl)thio)ethanone —— C14H20N6O2S2
    1-(4-(2-hydroxy-2-(thiophen-2-yl)ethyl)piperazin-1-yl)-2-((1-methyl-1H-tetrazol-5-yl)thio)ethanone