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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N'-[(E)-{3-nitro-4-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]phenyl}methylidene]pyridine-4-carbohydrazide —— C20H12N6O5S2
    N'-[(E)-{3-nitro-4-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]phenyl}methylidene]pyridine-4-carbohydrazide
    —— [(E)-[2-(4-methoxyphenyl)sulfanylphenyl]methylideneamino]urea —— C15H15N3O2S
    [(E)-[2-(4-methoxyphenyl)sulfanylphenyl]methylideneamino]urea
    —— 2,4-dichloro-N-[(E)-[5-[(4,5-diphenyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methylideneamino]benzamide —— C26H17Cl2N5O2S
    2,4-dichloro-N-[(E)-[5-[(4,5-diphenyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methylideneamino]benzamide
    —— 3-Hydroxy-N'-[(E)-[3-nitro-4-(quinolin-5-ylsulfanyl)phenyl]methylidene]benzohydrazide —— C23H16N4O4S
    3-Hydroxy-N'-[(E)-[3-nitro-4-(quinolin-5-ylsulfanyl)phenyl]methylidene]benzohydrazide
    —— N'-[(E)-(4-Chlorophenyl)methylidene]-2-[(2-methylphenyl)sulfanyl]acetohydrazide —— C16H15ClN2OS
    N'-[(E)-(4-Chlorophenyl)methylidene]-2-[(2-methylphenyl)sulfanyl]acetohydrazide
    —— N'-[(E)-(4-Fluorophenyl)methylidene]-2-[(2-methylphenyl)sulfanyl]acetohydrazide —— C16H15FN2OS
    N'-[(E)-(4-Fluorophenyl)methylidene]-2-[(2-methylphenyl)sulfanyl]acetohydrazide
    —— N-[(E)-[5-[(4,5-diphenyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methylideneamino]-2-nitrobenzamide —— C26H18N6O4S
    N-[(E)-[5-[(4,5-diphenyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methylideneamino]-2-nitrobenzamide
    —— N'-[3-nitro-4-(5-quinolinylsulfanyl)benzylidene]pentanohydrazide —— C21H20N4O3S
    N'-[3-nitro-4-(5-quinolinylsulfanyl)benzylidene]pentanohydrazide
    —— N'-{(E)-[5-(quinolin-8-ylsulfanyl)furan-2-yl]methylidene}octanehydrazide —— C22H25N3O2S
    N'-{(E)-[5-(quinolin-8-ylsulfanyl)furan-2-yl]methylidene}octanehydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]triazole-4-carboxamide —— C14H14N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]triazole-4-carboxamide
    —— N'-{4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrobenzylidene}pentanohydrazide —— C19H18N4O3S2
    N'-{4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrobenzylidene}pentanohydrazide
    —— N'-[(E)-[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene]-4-fluorobenzohydrazide —— C21H13FN4O3S2
    N'-[(E)-[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene]-4-fluorobenzohydrazide
    —— 2-nitro-N'-{[5-(8-quinolinylsulfanyl)-2-furyl]methylene}benzohydrazide —— C21H14N4O4S
    2-nitro-N'-{[5-(8-quinolinylsulfanyl)-2-furyl]methylene}benzohydrazide
    —— 3-(ethylsulfanyl)-N-[(E)-thiophen-2-ylmethylidene]-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-7-amine —— C10H10N6S2
    3-(ethylsulfanyl)-N-[(E)-thiophen-2-ylmethylidene]-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-7-amine
    —— N'-[(E)-[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene]-2-methoxyacetohydrazide —— C17H14N4O4S2
    N'-[(E)-[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene]-2-methoxyacetohydrazide
    —— (2R)-2-benzylsulfanyl-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]propanamide —— C21H30N4OS2
    (2R)-2-benzylsulfanyl-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]propanamide
    —— (2S)-2-benzylsulfanyl-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]propanamide —— C21H30N4OS2
    (2S)-2-benzylsulfanyl-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]propanamide
    —— N-[(E)-[4-bromo-5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-2-naphthalen-1-yloxyacetamide —— C23H16BrClN2O3S
    N-[(E)-[4-bromo-5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-2-naphthalen-1-yloxyacetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[1-(dimethylamino)cyclopentyl]methyl]acetamide —— C18H23ClN4O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[1-(dimethylamino)cyclopentyl]methyl]acetamide
    —— 3-[2-(2-methyl-4-phenylsulfanylanilino)-2-oxoethoxy]benzamide —— C22H20N2O3S
    3-[2-(2-methyl-4-phenylsulfanylanilino)-2-oxoethoxy]benzamide
    —— 1-benzyl-3-[(E)-(5-phenylsulfanylfuran-2-yl)methylideneamino]thiourea —— C19H17N3OS2
    1-benzyl-3-[(E)-(5-phenylsulfanylfuran-2-yl)methylideneamino]thiourea
    —— (2E)-2-{4-[(4-chlorophenyl)sulfanyl]-3-nitrobenzylidene}-N-methylhydrazinecarbothioamide —— C15H13ClN4O2S2
    (2E)-2-{4-[(4-chlorophenyl)sulfanyl]-3-nitrobenzylidene}-N-methylhydrazinecarbothioamide
    —— 2-({5-[(4-bromoanilino)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(3-pyridinylmethylene)acetohydrazide —— C18H18BrN7OS
    2-({5-[(4-bromoanilino)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(3-pyridinylmethylene)acetohydrazide
    —— 2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(3-hydroxybenzylidene)acetohydrazide —— C21H22N6O2S
    2-{[4-allyl-5-(anilinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(3-hydroxybenzylidene)acetohydrazide
    —— 1-[2-(4-methylphenyl)sulfanylethyl]-3-[1-(pyridin-4-ylmethyl)piperidin-4-yl]urea —— C21H28N4OS
    1-[2-(4-methylphenyl)sulfanylethyl]-3-[1-(pyridin-4-ylmethyl)piperidin-4-yl]urea
    —— N-[(2R)-2-cyanopropyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-ethylpropanamide —— C16H24N4OS
    N-[(2R)-2-cyanopropyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-ethylpropanamide
    —— N-[(2S)-2-cyanopropyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-ethylpropanamide —— C16H24N4OS
    N-[(2S)-2-cyanopropyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-ethylpropanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-(1-methylsulfonylpiperidin-4-yl)propanamide —— C15H21ClN2O3S2
    (2R)-2-(2-chlorophenyl)sulfanyl-N-(1-methylsulfonylpiperidin-4-yl)propanamide
    —— 2-({4-allyl-5-[(4-chloroanilino)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(4-fluorobenzylidene)acetohydrazide —— C21H20ClFN6OS
    2-({4-allyl-5-[(4-chloroanilino)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(4-fluorobenzylidene)acetohydrazide
    —— 2-({4-allyl-5-[(4-chloroanilino)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(2-methylbenzylidene)acetohydrazide —— C22H23ClN6OS
    2-({4-allyl-5-[(4-chloroanilino)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(2-methylbenzylidene)acetohydrazide
    —— 2-{[4-allyl-5-(4-toluidinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(3-pyridinylmethylene)acetohydrazide —— C21H23N7OS
    2-{[4-allyl-5-(4-toluidinomethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-(3-pyridinylmethylene)acetohydrazide
    —— N'-[(E)-(1,3-dimethyl-1H-pyrazol-4-yl)methylidene]-2-[(4-methyl-5-{[(2-methylphenyl)amino]methyl}-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide —— C19H24N8OS
    N'-[(E)-(1,3-dimethyl-1H-pyrazol-4-yl)methylidene]-2-[(4-methyl-5-{[(2-methylphenyl)amino]methyl}-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide
    —— 2-[[5-[(3-chloroanilino)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-[4-(diethylamino)phenyl]methylideneamino]acetamide —— C23H28ClN7OS
    2-[[5-[(3-chloroanilino)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-[4-(diethylamino)phenyl]methylideneamino]acetamide
    —— (2R)-N-[[4-(2-methylphenyl)oxan-4-yl]methyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C19H26N4O2S
    (2R)-N-[[4-(2-methylphenyl)oxan-4-yl]methyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(1S)-1-(5-methylthiophen-2-yl)ethyl]acetamide —— C15H16BrNOS2
    2-(4-bromophenyl)sulfanyl-N-[(1S)-1-(5-methylthiophen-2-yl)ethyl]acetamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(1R)-1-(5-methylthiophen-2-yl)ethyl]acetamide —— C15H16BrNOS2
    2-(4-bromophenyl)sulfanyl-N-[(1R)-1-(5-methylthiophen-2-yl)ethyl]acetamide
    —— 3-(1-methyltetrazol-5-yl)sulfanyl-N-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methyl]propanamide —— C13H14N6O2S2
    3-(1-methyltetrazol-5-yl)sulfanyl-N-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methyl]propanamide
    —— N'-[3-(1-methyltetrazol-5-yl)sulfanylpropanoyl]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide —— C13H18N8O2S
    N'-[3-(1-methyltetrazol-5-yl)sulfanylpropanoyl]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide
    —— 3-[(1R)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole —— C19H24F2N4OS
    3-[(1R)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole
    —— 3-[3-[(1R)-1-(3-fluorophenyl)ethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C17H17FN4OS2
    3-[3-[(1R)-1-(3-fluorophenyl)ethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— 3-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole —— C19H24F2N4OS
    3-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole
    —— 3-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole —— C19H24F2N4OS
    3-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole
    —— 3-[3-[(1S)-1-(3-fluorophenyl)ethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide —— C17H17FN4OS2
    3-[3-[(1S)-1-(3-fluorophenyl)ethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazol-4-yl]propanamide
    —— 4-[4-cyclopropyl-5-[(1R)-1-(3-fluorophenyl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C17H21FN4OS
    4-[4-cyclopropyl-5-[(1R)-1-(3-fluorophenyl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 4-[4-cyclopropyl-5-[(1S)-1-(3-fluorophenyl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C17H21FN4OS
    4-[4-cyclopropyl-5-[(1S)-1-(3-fluorophenyl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 3-[(1R)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole —— C19H24F2N4OS
    3-[(1R)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-5-pyrrolidin-1-yl-1,2,4-triazole
    —— 1-[5-[(1R)-1-(3-fluorophenyl)ethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]piperidine —— C20H23FN4OS
    1-[5-[(1R)-1-(3-fluorophenyl)ethyl]sulfanyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]piperidine
    —— 2-[[5-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H11F2N3OS3
    2-[[5-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 4-benzyl-3-[(1R)-1-(2,5-difluorophenyl)ethyl]sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,2,4-triazole —— C22H24F2N4S
    4-benzyl-3-[(1R)-1-(2,5-difluorophenyl)ethyl]sulfanyl-5-(pyrrolidin-1-ylmethyl)-1,2,4-triazole
    —— (3R)-3-[[5-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide —— C16H19F2N3O2S2
    (3R)-3-[[5-[(1S)-1-(2,5-difluorophenyl)ethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide