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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[2-[(3R)-3-methylpiperidin-1-yl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]acetamide —— C23H29N5OS2
    2-[[2-[(3R)-3-methylpiperidin-1-yl]-[1,3]thiazolo[4,5-d]pyrimidin-7-yl]sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]acetamide
    —— N-[2-[(2S)-2-methylpiperidin-1-yl]ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-4-carboxamide —— C24H33N5OS
    N-[2-[(2S)-2-methylpiperidin-1-yl]ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-4-carboxamide
    —— N-[2-[(2R)-2-methylpiperidin-1-yl]ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-4-carboxamide —— C24H33N5OS
    N-[2-[(2R)-2-methylpiperidin-1-yl]ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-4-carboxamide
    —— (1R,5S)-spiro[bicyclo[3.2.1]octane-8,2'-[1,3]dithiolane]-3-carboxylic acid —— C11H16O2S2
    (1R,5S)-spiro[bicyclo[3.2.1]octane-8,2'-[1,3]dithiolane]-3-carboxylic acid
    —— dimethyl-[[[5-(2-nitrophenyl)sulfanyl-1,3-thiazol-2-yl]amino]methylidene]azanium —— C12H13N4O2S2+
    dimethyl-[[[5-(2-nitrophenyl)sulfanyl-1,3-thiazol-2-yl]amino]methylidene]azanium
    —— N-[(2R)-4-(furan-2-yl)butan-2-yl]-4-methylsulfanylaniline —— C15H19NOS
    N-[(2R)-4-(furan-2-yl)butan-2-yl]-4-methylsulfanylaniline
    —— (6Z)-5-imino-2-(3-methylphenyl)-6-[(4-methylsulfanylphenyl)methylidene]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one —— C20H16N4OS2
    (6Z)-5-imino-2-(3-methylphenyl)-6-[(4-methylsulfanylphenyl)methylidene]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
    —— 1-[(Z)-but-2-enyl]sulfanyl-2-methylbenzene —— C11H14S
    1-[(Z)-but-2-enyl]sulfanyl-2-methylbenzene
    —— methyl N-[[(1-methylsulfanylethylideneamino)oxycarbonylamino]sulfanylcarbamoyloxy]ethanimidothioate —— C8H14N4O4S3
    methyl N-[[(1-methylsulfanylethylideneamino)oxycarbonylamino]sulfanylcarbamoyloxy]ethanimidothioate
    —— N-[(1R)-1-[4-(2-methoxyethylsulfanyl)phenyl]ethyl]propan-1-amine —— C14H23NOS
    N-[(1R)-1-[4-(2-methoxyethylsulfanyl)phenyl]ethyl]propan-1-amine
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(4-chlorophenyl)sulfanylmethyl]-N-[(E)-[(Z)-2-methyl-3-phenylprop-2-enylidene]amino]triazole-4-carboxamide —— C22H19ClN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(4-chlorophenyl)sulfanylmethyl]-N-[(E)-[(Z)-2-methyl-3-phenylprop-2-enylidene]amino]triazole-4-carboxamide
    —— (1S)-N-ethyl-1-[3-fluoro-4-(2-methoxyethylsulfanyl)phenyl]ethanamine —— C13H20FNOS
    (1S)-N-ethyl-1-[3-fluoro-4-(2-methoxyethylsulfanyl)phenyl]ethanamine
    —— N-[(1S)-1-(5-chlorothiophen-2-yl)ethyl]-3-methylsulfanylaniline —— C13H14ClNS2
    N-[(1S)-1-(5-chlorothiophen-2-yl)ethyl]-3-methylsulfanylaniline
    —— (1R)-1-(4-methylsulfanylphenyl)-N-(thiophen-3-ylmethyl)ethanamine —— C14H17NS2
    (1R)-1-(4-methylsulfanylphenyl)-N-(thiophen-3-ylmethyl)ethanamine
    —— (1S)-1-(4-methylsulfanylphenyl)-N-(thiophen-3-ylmethyl)ethanamine —— C14H17NS2
    (1S)-1-(4-methylsulfanylphenyl)-N-(thiophen-3-ylmethyl)ethanamine
    —— 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole —— C13H13ClFN3OS
    2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole
    —— 4-ethyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]cyclohexan-1-amine —— C17H27NS
    4-ethyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]cyclohexan-1-amine
    —— N-[(3S)-2-methyl-4-oxopentan-3-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C12H17N3O3S
    N-[(3S)-2-methyl-4-oxopentan-3-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-(butylsulfanyl)-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole —— C10H17N3OS
    2-(butylsulfanyl)-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole
    —— (Z)-2-(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)-3-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]prop-2-enenitrile —— C21H16N6O3S2
    (Z)-2-(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)-3-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]prop-2-enenitrile
    —— (Z)-3-[5-(4-chlorophenyl)sulfanylfuran-2-yl]-2-cyano-N-(3-methylphenyl)prop-2-enamide —— C21H15ClN2O2S
    (Z)-3-[5-(4-chlorophenyl)sulfanylfuran-2-yl]-2-cyano-N-(3-methylphenyl)prop-2-enamide
    —— (5E)-5-[(7-methyl-4-oxo-2-phenylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylidene]-3-[(4-methylphenyl)methyl]-2-sulfanylidene-1,3-thiazolidin-4-one —— C27H21N3O2S3
    (5E)-5-[(7-methyl-4-oxo-2-phenylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylidene]-3-[(4-methylphenyl)methyl]-2-sulfanylidene-1,3-thiazolidin-4-one
    —— N,N-dimethyl-2-({5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide —— C10H16N4O2S
    N,N-dimethyl-2-({5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
    —— (4S,8Z)-2-amino-4-(4-methylsulfanylphenyl)-8-[(4-methylsulfanylphenyl)methylidene]-6-propyl-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile —— C27H29N3OS2
    (4S,8Z)-2-amino-4-(4-methylsulfanylphenyl)-8-[(4-methylsulfanylphenyl)methylidene]-6-propyl-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
    —— (2R)-2-(1-methylimidazol-2-yl)sulfanylcyclohexan-1-one —— C10H14N2OS
    (2R)-2-(1-methylimidazol-2-yl)sulfanylcyclohexan-1-one
    —— [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[4-(2-hydroxyethyl)piperazin-1-yl]methanone —— C15H20N2O2S
    [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[4-(2-hydroxyethyl)piperazin-1-yl]methanone
    —— (2R)-2-(1,3,4-thiadiazol-2-ylsulfanyl)cyclohexan-1-one —— C8H10N2OS2
    (2R)-2-(1,3,4-thiadiazol-2-ylsulfanyl)cyclohexan-1-one
    —— (2S)-2-(3,4-dimethylphenyl)sulfanylcyclohexan-1-one —— C14H18OS
    (2S)-2-(3,4-dimethylphenyl)sulfanylcyclohexan-1-one
    —— (2R)-2-(2,4-dimethylphenyl)sulfanylcyclohexan-1-one —— C14H18OS
    (2R)-2-(2,4-dimethylphenyl)sulfanylcyclohexan-1-one
    —— (2S)-2-(4-fluorophenyl)sulfanylcyclohexan-1-one —— C12H13FOS
    (2S)-2-(4-fluorophenyl)sulfanylcyclohexan-1-one
    —— 2-[(2E,5S)-2-[(Z)-(4-methylsulfanylphenyl)methylidenehydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl]acetic acid —— C13H13N3O3S2
    2-[(2E,5S)-2-[(Z)-(4-methylsulfanylphenyl)methylidenehydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl]acetic acid
    —— (2E)-2-[(pyridin-2-ylamino)methylidene]-1-benzothiophen-3-one —— C14H10N2OS
    (2E)-2-[(pyridin-2-ylamino)methylidene]-1-benzothiophen-3-one
    —— (2S)-2-(2-chlorophenyl)sulfanylcyclohexan-1-one —— C12H13ClOS
    (2S)-2-(2-chlorophenyl)sulfanylcyclohexan-1-one
    —— 2-(propan-2-ylsulfanyl)-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole —— C9H15N3OS
    2-(propan-2-ylsulfanyl)-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole
    —— (5E)-3-[(2S)-2-ethylhexyl]-5-[(7-methyl-4-oxo-2-phenylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one —— C27H29N3O2S3
    (5E)-3-[(2S)-2-ethylhexyl]-5-[(7-methyl-4-oxo-2-phenylsulfanylpyrido[1,2-a]pyrimidin-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
    —— (2R)-2-(6-methyl-2-propan-2-ylpyrimidin-4-yl)sulfanylpropanoic acid —— C11H16N2O2S
    (2R)-2-(6-methyl-2-propan-2-ylpyrimidin-4-yl)sulfanylpropanoic acid
    —— (2S)-2-(6-methyl-2-propan-2-ylpyrimidin-4-yl)sulfanylpropanoic acid —— C11H16N2O2S
    (2S)-2-(6-methyl-2-propan-2-ylpyrimidin-4-yl)sulfanylpropanoic acid
    —— 1-[(3S,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylethanone —— C25H26N4OS3
    1-[(3S,3aS,7Z)-3-thiophen-2-yl-7-(thiophen-2-ylmethylidene)-3a,4,5,6-tetrahydro-3H-indazol-2-yl]-2-(4,5,6-trimethylpyrimidin-2-yl)sulfanylethanone
    —— 1-[(E)-[(Z)-2-methylbut-2-enylidene]amino]-3-[(E)-[(E)-2-methylbut-2-enylidene]amino]thiourea —— C11H18N4S
    1-[(E)-[(Z)-2-methylbut-2-enylidene]amino]-3-[(E)-[(E)-2-methylbut-2-enylidene]amino]thiourea
    —— (2R)-2-(4-chlorophenyl)sulfanyl-N-[(2S)-2-hydroxypropyl]propanamide —— C12H16ClNO2S
    (2R)-2-(4-chlorophenyl)sulfanyl-N-[(2S)-2-hydroxypropyl]propanamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(2S)-1-hydroxybutan-2-yl]acetamide —— C12H16ClNO2S
    2-(4-chlorophenyl)sulfanyl-N-[(2S)-1-hydroxybutan-2-yl]acetamide
    —— 1-[(Z)-[(Z)-2-methylbut-2-enylidene]amino]-3-[(E)-[(Z)-2-methylbut-2-enylidene]amino]thiourea —— C11H18N4S
    1-[(Z)-[(Z)-2-methylbut-2-enylidene]amino]-3-[(E)-[(Z)-2-methylbut-2-enylidene]amino]thiourea
    —— N-[(2R)-1-hydroxybutan-2-yl]-2-(2-methylphenyl)sulfanylacetamide —— C13H19NO2S
    N-[(2R)-1-hydroxybutan-2-yl]-2-(2-methylphenyl)sulfanylacetamide
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2R)-2-hydroxypropyl]propanamide —— C12H16ClNO2S
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2R)-2-hydroxypropyl]propanamide
    —— N-[(2R)-1-hydroxybutan-2-yl]-2-(4-methylphenyl)sulfanylacetamide —— C13H19NO2S
    N-[(2R)-1-hydroxybutan-2-yl]-2-(4-methylphenyl)sulfanylacetamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(2R)-1-hydroxybutan-2-yl]acetamide —— C12H16BrNO2S
    2-(4-bromophenyl)sulfanyl-N-[(2R)-1-hydroxybutan-2-yl]acetamide
    —— N-[(2S)-1-hydroxybutan-2-yl]-2-(2-methylphenyl)sulfanylacetamide —— C13H19NO2S
    N-[(2S)-1-hydroxybutan-2-yl]-2-(2-methylphenyl)sulfanylacetamide
    —— 2-(4-fluorophenyl)sulfanyl-N-[(2S)-1-hydroxybutan-2-yl]acetamide —— C12H16FNO2S
    2-(4-fluorophenyl)sulfanyl-N-[(2S)-1-hydroxybutan-2-yl]acetamide
    —— N-[(2R)-1-hydroxybutan-2-yl]-3-phenylsulfanylpropanamide —— C13H19NO2S
    N-[(2R)-1-hydroxybutan-2-yl]-3-phenylsulfanylpropanamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(2R)-1-hydroxybutan-2-yl]acetamide —— C14H21NO2S
    2-(2,5-dimethylphenyl)sulfanyl-N-[(2R)-1-hydroxybutan-2-yl]acetamide