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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [2-[[(2R)-butan-2-yl]-[(3R)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C20H28N4O6S2
    [2-[[(2R)-butan-2-yl]-[(3R)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazole —— C16H16ClN3S2
    3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazole
    —— (2S)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one —— C24H18ClFN4O3S
    (2S)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one
    —— 1-benzyl-4-hydroxy-3-[(R)-[4-(2-hydroxyethyl)piperazin-1-yl]-(4-methylsulfanylphenyl)methyl]-6-methylpyridin-2-one —— C27H33N3O3S
    1-benzyl-4-hydroxy-3-[(R)-[4-(2-hydroxyethyl)piperazin-1-yl]-(4-methylsulfanylphenyl)methyl]-6-methylpyridin-2-one
    —— 1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C16H22N4O2S2
    1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 2-[[4-benzyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide —— C24H30ClN5OS
    2-[[4-benzyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide
    —— [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 2-phenylsulfanylacetate —— C14H14N2O3S
    [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 2-phenylsulfanylacetate
    —— (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one —— C24H18ClFN4O3S
    (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one
    —— N-[(2R)-4-phenylbutan-2-yl]-2-[[4-(2-phenylethyl)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C27H30N4OS2
    N-[(2R)-4-phenylbutan-2-yl]-2-[[4-(2-phenylethyl)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide —— C18H15BrClN3O2S
    2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide
    —— 2-(4-bromophenyl)-5-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12BrClN2OS
    2-(4-bromophenyl)-5-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-[(5-cyclohexyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(2,5-dimethyl-1H-pyrrol-3-yl)ethanone —— C16H21N3O2S
    2-[(5-cyclohexyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(2,5-dimethyl-1H-pyrrol-3-yl)ethanone
    —— 1-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-3-phenylthiourea —— C18H14ClN3OS2
    1-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-3-phenylthiourea
    —— 3-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]triazole-4-carboxamide —— C14H14N8O2S
    3-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]triazole-4-carboxamide
    —— 1-benzyl-4-hydroxy-6-methyl-3-[(S)-(4-methylpiperazin-1-yl)-(4-methylsulfanylphenyl)methyl]pyridin-2-one —— C26H31N3O2S
    1-benzyl-4-hydroxy-6-methyl-3-[(S)-(4-methylpiperazin-1-yl)-(4-methylsulfanylphenyl)methyl]pyridin-2-one
    —— 1-benzyl-4-hydroxy-6-methyl-3-[(R)-(4-methylpiperazin-1-yl)-(4-methylsulfanylphenyl)methyl]pyridin-2-one —— C26H31N3O2S
    1-benzyl-4-hydroxy-6-methyl-3-[(R)-(4-methylpiperazin-1-yl)-(4-methylsulfanylphenyl)methyl]pyridin-2-one
    —— (2S)-N-[3-(4-methylpiperazin-1-yl)propyl]-2-phenylsulfanylpropanamide —— C17H27N3OS
    (2S)-N-[3-(4-methylpiperazin-1-yl)propyl]-2-phenylsulfanylpropanamide
    —— (2R)-2-(6-amino-3,5-dicyano-4-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid —— C18H16N4O2S
    (2R)-2-(6-amino-3,5-dicyano-4-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2S)-2-(6-amino-3,5-dicyano-4-thiophen-2-ylpyridin-2-yl)sulfanylbutanoic acid —— C15H12N4O2S2
    (2S)-2-(6-amino-3,5-dicyano-4-thiophen-2-ylpyridin-2-yl)sulfanylbutanoic acid
    —— (2S)-2-(6-amino-3,5-dicyano-4-thiophen-3-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid —— C19H12N4O2S2
    (2S)-2-(6-amino-3,5-dicyano-4-thiophen-3-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanylpropanoic acid —— C12H14N2O2S
    (2R)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanylpropanoic acid
    —— 1-[(5R)-6-chloro-8,8,9,9-tetrafluoro-1-oxa-4-thiaspiro[4.4]non-6-en-7-yl]-4-methylpiperazine —— C12H15ClF4N2OS
    1-[(5R)-6-chloro-8,8,9,9-tetrafluoro-1-oxa-4-thiaspiro[4.4]non-6-en-7-yl]-4-methylpiperazine
    —— (2S)-2-[3-cyano-4-methyl-6-(trifluoromethyl)pyridin-2-yl]sulfanyl-2-phenylacetic acid —— C16H11F3N2O2S
    (2S)-2-[3-cyano-4-methyl-6-(trifluoromethyl)pyridin-2-yl]sulfanyl-2-phenylacetic acid
    —— (2R)-2-(6-butyl-3-cyanopyridin-2-yl)sulfanyl-2-phenylacetic acid —— C18H18N2O2S
    (2R)-2-(6-butyl-3-cyanopyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-(6-amino-3,5-dicyano-4-thiophen-2-ylpyridin-2-yl)sulfanylbutanoic acid —— C15H12N4O2S2
    (2R)-2-(6-amino-3,5-dicyano-4-thiophen-2-ylpyridin-2-yl)sulfanylbutanoic acid
    —— (2R)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-2-phenylacetic acid —— C16H11F3N2O2S
    (2R)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-2-phenylacetic acid
    —— (2S)-2-(6-butyl-3-cyanopyridin-2-yl)sulfanyl-2-phenylacetic acid —— C18H18N2O2S
    (2S)-2-(6-butyl-3-cyanopyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-[3-cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanylbutanoic acid —— C15H11F3N2O2S2
    (2R)-2-[3-cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanylbutanoic acid
    —— (2S)-2-(6-amino-3,5-dicyano-4-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid —— C18H16N4O2S
    (2S)-2-(6-amino-3,5-dicyano-4-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-(6-amino-3,5-dicyano-4-thiophen-3-ylpyridin-2-yl)sulfanylbutanoic acid —— C15H12N4O2S2
    (2R)-2-(6-amino-3,5-dicyano-4-thiophen-3-ylpyridin-2-yl)sulfanylbutanoic acid
    —— (2S)-2-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)sulfanyl]-2-phenylacetic acid —— C17H14N2O2S
    (2S)-2-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)sulfanyl]-2-phenylacetic acid
    —— (2S)-2-[6-amino-3,5-dicyano-4-(furan-2-yl)pyridin-2-yl]sulfanylpropanoic acid —— C14H10N4O3S
    (2S)-2-[6-amino-3,5-dicyano-4-(furan-2-yl)pyridin-2-yl]sulfanylpropanoic acid
    —— (2S)-2-[3-cyano-6-(2-methylpropyl)pyridin-2-yl]sulfanyl-2-phenylacetic acid —— C18H18N2O2S
    (2S)-2-[3-cyano-6-(2-methylpropyl)pyridin-2-yl]sulfanyl-2-phenylacetic acid
    —— (2S)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid —— C17H16N2O2S
    (2S)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-(3-cyano-6-propylpyridin-2-yl)sulfanylpropanoic acid —— C12H14N2O2S
    (2R)-2-(3-cyano-6-propylpyridin-2-yl)sulfanylpropanoic acid
    —— (2S)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanylbutanoic acid —— C13H16N2O2S
    (2S)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanylbutanoic acid
    —— (2S)-2-[3-cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanylpropanoic acid —— C14H9F3N2O2S2
    (2S)-2-[3-cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanylpropanoic acid
    —— (2R)-2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]butanoic acid —— C15H18N2O2S
    (2R)-2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]butanoic acid
    —— (2R)-2-[(3-cyano-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2-yl)sulfanyl]butanoic acid —— C16H20N2O2S
    (2R)-2-[(3-cyano-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2-yl)sulfanyl]butanoic acid
    —— (2R)-2-(6-amino-3,5-dicyano-4-propan-2-ylpyridin-2-yl)sulfanylbutanoic acid —— C14H16N4O2S
    (2R)-2-(6-amino-3,5-dicyano-4-propan-2-ylpyridin-2-yl)sulfanylbutanoic acid
    —— (2S)-2-(3-cyano-6-propylpyridin-2-yl)sulfanyl-2-phenylacetic acid —— C17H16N2O2S
    (2S)-2-(3-cyano-6-propylpyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid —— C17H16N2O2S
    (2R)-2-(3-cyano-6-propan-2-ylpyridin-2-yl)sulfanyl-2-phenylacetic acid
    —— (2R)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanylpropanoic acid —— C11H9F3N2O2S
    (2R)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanylpropanoic acid
    —— (2S)-2-(3-cyano-6-propylpyridin-2-yl)sulfanylpropanoic acid —— C12H14N2O2S
    (2S)-2-(3-cyano-6-propylpyridin-2-yl)sulfanylpropanoic acid
    —— (2R)-2-(6-butyl-3-cyanopyridin-2-yl)sulfanylbutanoic acid —— C14H18N2O2S
    (2R)-2-(6-butyl-3-cyanopyridin-2-yl)sulfanylbutanoic acid
    —— 1-[(12S)-2-chloro-11,12-dihydro-10H-benzo[b][1]benzothiocin-12-yl]-4-methylpiperazine —— C20H23ClN2S
    1-[(12S)-2-chloro-11,12-dihydro-10H-benzo[b][1]benzothiocin-12-yl]-4-methylpiperazine
    —— [(Z)-1-[4-(methoxymethylsulfanyl)phenyl]ethylideneamino]thiourea —— C11H15N3OS2
    [(Z)-1-[4-(methoxymethylsulfanyl)phenyl]ethylideneamino]thiourea
    —— [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 3-(2-chlorophenyl)sulfanylpropanoate —— C15H15ClN2O3S
    [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 3-(2-chlorophenyl)sulfanylpropanoate
    —— (E)-3-amino-2-[2-[(4-amino-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]but-2-enenitrile —— C12H12N6OS2
    (E)-3-amino-2-[2-[(4-amino-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]but-2-enenitrile
    —— 2-[[1-[(3,4-difluorophenyl)methyl]tetrazol-5-yl]methylsulfanyl]-4-methyl-1,3-thiazole —— C13H11F2N5S2
    2-[[1-[(3,4-difluorophenyl)methyl]tetrazol-5-yl]methylsulfanyl]-4-methyl-1,3-thiazole