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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 7-ethyl-3-(3-hydroxyazetidine-1-carbonyl)-8-methyl-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C14H19N3O3S
    7-ethyl-3-(3-hydroxyazetidine-1-carbonyl)-8-methyl-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— 8-(tert-butyl)-N-(4-chlorophenethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C20H24ClN3O2S
    8-(tert-butyl)-N-(4-chlorophenethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 3-(4-cyclohexylpiperazine-1-carbonyl)-7-ethyl-8-methyl-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C21H32N4O2S
    3-(4-cyclohexylpiperazine-1-carbonyl)-7-ethyl-8-methyl-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— N,N,7-triethyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H23N3O2S
    N,N,7-triethyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-(2-fluorobenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H14FN3O2S
    N-(2-fluorobenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-ethyl-N-(2-hydroxyethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C12H17N3O3S
    N-ethyl-N-(2-hydroxyethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N,N-diisopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C14H21N3O2S
    N,N-diisopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-ethyl-N-(2-hydroxyethyl)-N,8-dimethyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C14H21N3O3S
    7-ethyl-N-(2-hydroxyethyl)-N,8-dimethyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-benzyl-8-(tert-butyl)-6-oxo-N-(pyridin-2-yl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C24H26N4O2S
    N-benzyl-8-(tert-butyl)-6-oxo-N-(pyridin-2-yl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-ethyl-8-methyl-3-(morpholine-4-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C15H21N3O3S
    7-ethyl-8-methyl-3-(morpholine-4-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— 7-ethyl-N-isopropyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C14H21N3O2S
    7-ethyl-N-isopropyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-(2-fluorobenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H22FN3O2S
    8-(tert-butyl)-N-(2-fluorobenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-6-oxo-N-(pyridin-4-ylmethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C18H22N4O2S
    8-(tert-butyl)-6-oxo-N-(pyridin-4-ylmethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-(2-(cyclohex-1-en-1-yl)ethyl)-7-ethyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H27N3O2S
    N-(2-(cyclohex-1-en-1-yl)ethyl)-7-ethyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-(cyclohexylmethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H21N3O2S
    N-(cyclohexylmethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 6-oxo-N-(2-(thiophen-2-yl)ethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C14H15N3O2S2
    6-oxo-N-(2-(thiophen-2-yl)ethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N,N-diallyl-7-ethyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C17H23N3O2S
    N,N-diallyl-7-ethyl-8-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-ethyl-8-methyl-3-(4-methylpiperazine-1-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C16H24N4O2S
    7-ethyl-8-methyl-3-(4-methylpiperazine-1-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— 8-(tert-butyl)-N-ethyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C14H21N3O2S
    8-(tert-butyl)-N-ethyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N,N-diallyl-8-(tert-butyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C18H25N3O2S
    N,N-diallyl-8-(tert-butyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-ethyl-8-methyl-6-oxo-N-(3,3,5-trimethylcyclohexyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C20H31N3O2S
    7-ethyl-8-methyl-6-oxo-N-(3,3,5-trimethylcyclohexyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-6-oxo-N-(1-phenylethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C20H25N3O2S
    8-(tert-butyl)-6-oxo-N-(1-phenylethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-cyclopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H21N3O2S
    8-(tert-butyl)-N-cyclopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 6-oxo-N-((tetrahydrofuran-2-yl)methyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C13H17N3O3S
    6-oxo-N-((tetrahydrofuran-2-yl)methyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-3-(morpholine-4-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C16H23N3O3S
    8-(tert-butyl)-3-(morpholine-4-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— 7-ethyl-8-methyl-6-oxo-N-(pyridin-2-ylmethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C17H20N4O2S
    7-ethyl-8-methyl-6-oxo-N-(pyridin-2-ylmethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-ethyl-3-(4-ethylpiperazine-1-carbonyl)-8-methyl-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C17H26N4O2S
    7-ethyl-3-(4-ethylpiperazine-1-carbonyl)-8-methyl-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— 8-(tert-butyl)-N-(4-fluorobenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H22FN3O2S
    8-(tert-butyl)-N-(4-fluorobenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-(4-fluorophenethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C20H24FN3O2S
    8-(tert-butyl)-N-(4-fluorophenethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-ethyl-8-methyl-N-(4-methylbenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H23N3O2S
    7-ethyl-8-methyl-N-(4-methylbenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-(2,2-dimethoxyethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C16H25N3O4S
    8-(tert-butyl)-N-(2,2-dimethoxyethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-(tert-butyl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C13H19N3O2S
    N-(tert-butyl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-methyl-N-(4-methylbenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C17H19N3O2S
    7-methyl-N-(4-methylbenzyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-ethyl-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C11H15N3O2S
    N-ethyl-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-((1s,3s)-adamantan-1-yl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H25N3O2S
    N-((1s,3s)-adamantan-1-yl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-methyl-N-(1-methylpiperidin-4-yl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H30N4O2S
    8-(tert-butyl)-N-methyl-N-(1-methylpiperidin-4-yl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-cyclohexyl-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H21N3O2S
    N-cyclohexyl-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-(3-(dimethylamino)propyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C17H28N4O2S
    8-(tert-butyl)-N-(3-(dimethylamino)propyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N,7-dimethyl-N-(1-methylpiperidin-4-yl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C16H24N4O2S
    N,7-dimethyl-N-(1-methylpiperidin-4-yl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-cyclohexyl-N-isopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C21H33N3O2S
    8-(tert-butyl)-N-cyclohexyl-N-isopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-(2,2-diethoxyethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C18H29N3O4S
    8-(tert-butyl)-N-(2,2-diethoxyethyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-3-(2,6-dimethylmorpholine-4-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one —— C18H27N3O3S
    8-(tert-butyl)-3-(2,6-dimethylmorpholine-4-carbonyl)-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one
    —— 7-methyl-6-oxo-N-(pyridin-4-ylmethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H16N4O2S
    7-methyl-6-oxo-N-(pyridin-4-ylmethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 7-methyl-6-oxo-N-(2-(thiophen-2-yl)ethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H17N3O2S2
    7-methyl-6-oxo-N-(2-(thiophen-2-yl)ethyl)-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-(2-(2-hydroxyethoxy)ethyl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C13H19N3O4S
    N-(2-(2-hydroxyethoxy)ethyl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N,N-diisopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C18H29N3O2S
    8-(tert-butyl)-N,N-diisopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-isopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C15H23N3O2S
    8-(tert-butyl)-N-isopropyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-(3-morpholinopropyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H30N4O3S
    8-(tert-butyl)-N-(3-morpholinopropyl)-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— N-(2-fluorobenzyl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C16H16FN3O2S
    N-(2-fluorobenzyl)-7-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide
    —— 8-(tert-butyl)-N-cyclohexyl-N-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide —— C19H29N3O2S
    8-(tert-butyl)-N-cyclohexyl-N-methyl-6-oxo-2,3,4,6-tetrahydropyrimido[2,1-b][1,3]thiazine-3-carboxamide