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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propan-2-ol —— C13H24N4O2S2
    (2S)-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propan-2-ol
    —— (2S)-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-3-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propan-2-ol —— C13H24N4O2S2
    (2S)-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-3-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propan-2-ol
    —— 2-[3-cyclopropyl-5-[(1R)-1-(2,4-difluorophenyl)ethyl]sulfanyl-1,2,4-triazol-4-yl]acetamide —— C15H16F2N4OS
    2-[3-cyclopropyl-5-[(1R)-1-(2,4-difluorophenyl)ethyl]sulfanyl-1,2,4-triazol-4-yl]acetamide
    —— N-[(2R)-1-methoxypropan-2-yl]-3-phenylsulfanylpropanamide —— C13H19NO2S
    N-[(2R)-1-methoxypropan-2-yl]-3-phenylsulfanylpropanamide
    —— (1R)-1-[4-butyl-5-[(3-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine —— C19H30N4S
    (1R)-1-[4-butyl-5-[(3-methylphenyl)methylsulfanyl]-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-4-pyridin-2-ylsulfanylbenzamide —— C16H16N2O3S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-4-pyridin-2-ylsulfanylbenzamide
    —— 2-Amino-6-ethylsulfanylpyridin-1-ium-3,5-dicarbonitrile —— C9H9N4S+
    2-Amino-6-ethylsulfanylpyridin-1-ium-3,5-dicarbonitrile
    —— (3S)-3-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C14H22N4O3S
    (3S)-3-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— (3R)-3-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C14H22N4O3S
    (3R)-3-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— 2-[(2R)-3-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-hydroxypropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile —— C17H25N3O2S
    2-[(2R)-3-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-hydroxypropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
    —— (2S)-N-[3-(dimethylamino)-2,2-dimethylpropyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C16H24N2OS
    (2S)-N-[3-(dimethylamino)-2,2-dimethylpropyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— N-[(2R)-2-(dimethylamino)-2-phenylethyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C17H25N5OS
    N-[(2R)-2-(dimethylamino)-2-phenylethyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-1,2-dibromo-3-isothiocyanatopropane —— C4H5Br2NS
    (2R)-1,2-dibromo-3-isothiocyanatopropane
    —— 2-[(2R)-3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-hydroxypropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile —— C17H25N3O2S
    2-[(2R)-3-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-hydroxypropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
    —— (2R)-N-[(6-chloropyridin-3-yl)methylsulfonyl]-2-phenylsulfanylpropanamide —— C15H15ClN2O3S2
    (2R)-N-[(6-chloropyridin-3-yl)methylsulfonyl]-2-phenylsulfanylpropanamide
    —— (2S)-N-cyclohexyl-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-methylpropanamide —— C14H23N3OS3
    (2S)-N-cyclohexyl-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-methylpropanamide
    —— (2S)-N-[(2R)-3-methyl-2-morpholin-4-ylbutyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C18H26N2O2S
    (2S)-N-[(2R)-3-methyl-2-morpholin-4-ylbutyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2R)-N-[(2S)-3-methyl-2-morpholin-4-ylbutyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C18H26N2O2S
    (2R)-N-[(2S)-3-methyl-2-morpholin-4-ylbutyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— [5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl 2-(4-methylphenyl)sulfanylacetate —— C18H15ClN2O3S
    [5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl 2-(4-methylphenyl)sulfanylacetate
    —— 2-(2,4-Dimethylphenyl)sulfanylacetate —— C10H11O2S-
    2-(2,4-Dimethylphenyl)sulfanylacetate
    —— [4-[(2R)-2,3-dihydro-1-benzothiophene-2-carbonyl]piperazin-1-yl]-[(2S)-oxolan-2-yl]methanone —— C18H22N2O3S
    [4-[(2R)-2,3-dihydro-1-benzothiophene-2-carbonyl]piperazin-1-yl]-[(2S)-oxolan-2-yl]methanone
    —— [4-[(2S)-2,3-dihydro-1-benzothiophene-2-carbonyl]piperazin-1-yl]-[(2R)-oxolan-2-yl]methanone —— C18H22N2O3S
    [4-[(2S)-2,3-dihydro-1-benzothiophene-2-carbonyl]piperazin-1-yl]-[(2R)-oxolan-2-yl]methanone
    —— 2-Amino-4-(2-methylpropyl)-6-methylsulfanylpyridin-1-ium-3,5-dicarbonitrile —— C12H15N4S+
    2-Amino-4-(2-methylpropyl)-6-methylsulfanylpyridin-1-ium-3,5-dicarbonitrile
    —— 2-[(1R)-cyclohex-2-en-1-yl]sulfanyl-6-methylpyridine-3-carbonitrile —— C13H14N2S
    2-[(1R)-cyclohex-2-en-1-yl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— (2R)-N-(3-cyclohexylpropyl)-2-propan-2-ylsulfonylpropanamide —— C15H29NO3S
    (2R)-N-(3-cyclohexylpropyl)-2-propan-2-ylsulfonylpropanamide
    —— 2-[(5-methyl-4-nitro-1H-pyrazol-3-yl)sulfanyl]acetate —— C6H6N3O4S-
    2-[(5-methyl-4-nitro-1H-pyrazol-3-yl)sulfanyl]acetate
    —— S-methyl N-[(5S,7R)-3-propan-2-yl-1-adamantyl]carbamothioate —— C15H25NOS
    S-methyl N-[(5S,7R)-3-propan-2-yl-1-adamantyl]carbamothioate
    —— 1-ethyl-3-[[(5S,7R)-3-[2-(methylcarbamothioylamino)ethyl]-1-adamantyl]methyl]thiourea —— C18H32N4S2
    1-ethyl-3-[[(5S,7R)-3-[2-(methylcarbamothioylamino)ethyl]-1-adamantyl]methyl]thiourea
    —— 5-Phenylsulfanyl-1,2,3-triaza-4-azanidacyclopenta-2,5-diene —— C7H5N4S-
    5-Phenylsulfanyl-1,2,3-triaza-4-azanidacyclopenta-2,5-diene
    —— 7,7-dimethyl-9-oxo-8,9a-dihydro-6H-pyrimido[4,5-b][1,4]benzothiazine-4-thiolate —— C12H12N3OS2-
    7,7-dimethyl-9-oxo-8,9a-dihydro-6H-pyrimido[4,5-b][1,4]benzothiazine-4-thiolate
    —— (3R)-3-[(S)-bromo(phenyl)methyl]-5,7-dimethyl-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-4-ium-8-carbonitrile —— C17H16BrN2S+
    (3R)-3-[(S)-bromo(phenyl)methyl]-5,7-dimethyl-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-4-ium-8-carbonitrile
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-pentan-3-ylpropanamide —— C14H20ClNOS
    (2S)-2-(4-chlorophenyl)sulfanyl-N-pentan-3-ylpropanamide
    —— (1S,5S)-6-bromo-6-methyl-7-methylsulfonylbicyclo[3.1.1]heptane —— C9H15BrO2S
    (1S,5S)-6-bromo-6-methyl-7-methylsulfonylbicyclo[3.1.1]heptane
    —— (1'S,5'R,6'S)-2'-amino-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C16H15N4O2S+
    (1'S,5'R,6'S)-2'-amino-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— 1-[[4-(4-Methylphenyl)sulfanyl-3-nitrophenyl]methyl]pyrrolidin-1-ium —— C18H21N2O2S+
    1-[[4-(4-Methylphenyl)sulfanyl-3-nitrophenyl]methyl]pyrrolidin-1-ium
    —— 5-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-1H-1,2,4-triazole —— C10H10FN3S
    5-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-1H-1,2,4-triazole
    —— 4-[[4-(4-Methylphenyl)sulfanyl-3-nitrophenyl]methyl]morpholin-4-ium —— C18H21N2O3S+
    4-[[4-(4-Methylphenyl)sulfanyl-3-nitrophenyl]methyl]morpholin-4-ium
    —— 1-[[4-(4-Chlorophenyl)sulfanyl-3-nitrophenyl]methyl]-4-methylpiperazine-1,4-diium —— C18H22ClN3O2S+2
    1-[[4-(4-Chlorophenyl)sulfanyl-3-nitrophenyl]methyl]-4-methylpiperazine-1,4-diium
    —— 1-[[4-(4-Chlorophenyl)sulfanyl-3-nitrophenyl]methyl]pyrrolidin-1-ium —— C17H18ClN2O2S+
    1-[[4-(4-Chlorophenyl)sulfanyl-3-nitrophenyl]methyl]pyrrolidin-1-ium
    —— 4-[[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methyl]morpholin-4-ium —— C18H18N3O3S2+
    4-[[4-(1,3-Benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methyl]morpholin-4-ium
    —— (3R)-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylbutan-2-one —— C10H9ClF3NOS
    (3R)-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylbutan-2-one
    —— 5-[(1R)-1-(4-fluorophenyl)ethyl]sulfanyl-1H-1,2,4-triazole —— C10H10FN3S
    5-[(1R)-1-(4-fluorophenyl)ethyl]sulfanyl-1H-1,2,4-triazole
    —— (3S)-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylbutan-2-one —— C10H9ClF3NOS
    (3S)-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylbutan-2-one
    —— 2-(6-Acetamidopyridin-3-yl)sulfanylpyridine-3-carboxylate —— C13H10N3O3S-
    2-(6-Acetamidopyridin-3-yl)sulfanylpyridine-3-carboxylate
    —— 2-(4-Methylthiadiazol-5-yl)sulfanylacetate —— C5H5N2O2S2-
    2-(4-Methylthiadiazol-5-yl)sulfanylacetate
    —— (2R)-2-(4-methylthiadiazol-5-yl)sulfanylpropanoate —— C6H7N2O2S2-
    (2R)-2-(4-methylthiadiazol-5-yl)sulfanylpropanoate
    —— 4-(Dimethylamino)-2-(4-methoxyphenyl)sulfanylpyridin-1-ium-3-carbonitrile —— C15H16N3OS+
    4-(Dimethylamino)-2-(4-methoxyphenyl)sulfanylpyridin-1-ium-3-carbonitrile
    —— 2-({1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1H-imidazol-2-yl}sulfanyl)-1-(4-methylphenyl)-1-ethanone oxime —— C18H14ClF3N4OS
    2-({1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1H-imidazol-2-yl}sulfanyl)-1-(4-methylphenyl)-1-ethanone oxime
    —— 2-[4-[(5-Methyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]acetate —— C12H11N2O3S-
    2-[4-[(5-Methyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]acetate
    —— 3-[(5-Pyridin-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C10H8N3O3S-
    3-[(5-Pyridin-2-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate