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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-Methoxy-8-phenylsulfanyl-7-propan-2-ylidenebicyclo[4.2.0]oct-3-ene-2,5-dione —— C18H18O3S
    3-Methoxy-8-phenylsulfanyl-7-propan-2-ylidenebicyclo[4.2.0]oct-3-ene-2,5-dione
    —— (2S)-3-(4-methylphenyl)-2-[1-(2-methylpropyl)tetrazol-5-yl]sulfanylpropanenitrile —— C15H19N5S
    (2S)-3-(4-methylphenyl)-2-[1-(2-methylpropyl)tetrazol-5-yl]sulfanylpropanenitrile
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-methyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]propanamide —— C16H17ClF3N3OS
    (2R)-2-(2-chlorophenyl)sulfanyl-N-methyl-N-[[1-(2,2,2-trifluoroethyl)imidazol-2-yl]methyl]propanamide
    —— (2R)-3-(4-methylphenyl)-2-[1-(2-methylpropyl)tetrazol-5-yl]sulfanylpropanenitrile —— C15H19N5S
    (2R)-3-(4-methylphenyl)-2-[1-(2-methylpropyl)tetrazol-5-yl]sulfanylpropanenitrile
    —— 2-(2-amino-2-ethylbutyl)sulfanyl-4-(furan-2-yl)-6-oxo-1H-pyrimidine-5-carbonitrile —— C15H18N4O2S
    2-(2-amino-2-ethylbutyl)sulfanyl-4-(furan-2-yl)-6-oxo-1H-pyrimidine-5-carbonitrile
    —— (2R)-2-[(5-cyano-4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]-3-methylbutanoic acid —— C13H17N3O3S
    (2R)-2-[(5-cyano-4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]-3-methylbutanoic acid
    —— 4-nitro-7-(4H-1,2,4-triazol-3-ylsulfanyl)-2,1,3-benzoxadiazole —— C8H4N6O3S
    4-nitro-7-(4H-1,2,4-triazol-3-ylsulfanyl)-2,1,3-benzoxadiazole
    —— 6-(furan-2-yl)-4-oxo-2-[[(3R)-piperidin-3-yl]methylsulfanyl]-1H-pyrimidine-5-carbonitrile —— C15H16N4O2S
    6-(furan-2-yl)-4-oxo-2-[[(3R)-piperidin-3-yl]methylsulfanyl]-1H-pyrimidine-5-carbonitrile
    —— 4-(furan-2-yl)-6-oxo-2-(piperidin-4-ylmethylsulfanyl)-1H-pyrimidine-5-carbonitrile —— C15H16N4O2S
    4-(furan-2-yl)-6-oxo-2-(piperidin-4-ylmethylsulfanyl)-1H-pyrimidine-5-carbonitrile
    —— 4-oxo-2-[[(3S)-piperidin-3-yl]methylsulfanyl]-6-propyl-1H-pyrimidine-5-carbonitrile —— C14H20N4OS
    4-oxo-2-[[(3S)-piperidin-3-yl]methylsulfanyl]-6-propyl-1H-pyrimidine-5-carbonitrile
    —— 4-oxo-2-[[(3R)-piperidin-3-yl]methylsulfanyl]-6-propyl-1H-pyrimidine-5-carbonitrile —— C14H20N4OS
    4-oxo-2-[[(3R)-piperidin-3-yl]methylsulfanyl]-6-propyl-1H-pyrimidine-5-carbonitrile
    —— (2S)-1-(4-ethylpiperazin-1-yl)-2-(4-fluorophenyl)sulfanylpropan-1-one —— C15H21FN2OS
    (2S)-1-(4-ethylpiperazin-1-yl)-2-(4-fluorophenyl)sulfanylpropan-1-one
    —— 2-[2-(2-aminoethoxy)ethylsulfanyl]-4-(furan-2-yl)-6-oxo-1H-pyrimidine-5-carbonitrile —— C13H14N4O3S
    2-[2-(2-aminoethoxy)ethylsulfanyl]-4-(furan-2-yl)-6-oxo-1H-pyrimidine-5-carbonitrile
    —— 2-[(2S)-2-aminobutyl]sulfanyl-4-oxo-6-propyl-1H-pyrimidine-5-carbonitrile —— C12H18N4OS
    2-[(2S)-2-aminobutyl]sulfanyl-4-oxo-6-propyl-1H-pyrimidine-5-carbonitrile
    —— 2-[(2S)-1-aminopropan-2-yl]sulfanyl-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile —— C12H12N4O2S
    2-[(2S)-1-aminopropan-2-yl]sulfanyl-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile
    —— 3-(Prop-2-enylthio)-[1,2,4]triazino[5,6-d][3,1]benzoxazepine —— C13H10N4OS
    3-(Prop-2-enylthio)-[1,2,4]triazino[5,6-d][3,1]benzoxazepine
    —— 7-Cyclopropyl-1,3-dimethyl-5-(pyridin-3-ylmethylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4-dione —— C17H17N5O2S
    7-Cyclopropyl-1,3-dimethyl-5-(pyridin-3-ylmethylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4-dione
    —— 2-[(2S)-2-cyanopropyl]sulfanyl-4-oxo-6-propyl-1H-pyrimidine-5-carbonitrile —— C12H14N4OS
    2-[(2S)-2-cyanopropyl]sulfanyl-4-oxo-6-propyl-1H-pyrimidine-5-carbonitrile
    —— 2-[(2R)-2-cyanopropyl]sulfanyl-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile —— C13H10N4O2S
    2-[(2R)-2-cyanopropyl]sulfanyl-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile
    —— 5-((2,4-dioxopentan-3-yl)thio)-7-(4-fluorophenyl)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C19H17FN4O4S
    5-((2,4-dioxopentan-3-yl)thio)-7-(4-fluorophenyl)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 2-{[2-(2,2-Dimethylpropyl)-6,8-dimethyl-5,7-dioxo-5H,6H,7H,8H-[1,3]diazino[4,5-D]pyrimidin-4-YL]sulfanyl}acetamide —— C15H21N5O3S
    2-{[2-(2,2-Dimethylpropyl)-6,8-dimethyl-5,7-dioxo-5H,6H,7H,8H-[1,3]diazino[4,5-D]pyrimidin-4-YL]sulfanyl}acetamide
    —— 1,3-dimethyl-7-propyl-5-((pyridin-3-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C17H19N5O2S
    1,3-dimethyl-7-propyl-5-((pyridin-3-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 1,3-Dimethyl-7-propyl-5-(pyridin-2-ylmethylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4-dione —— C17H19N5O2S
    1,3-Dimethyl-7-propyl-5-(pyridin-2-ylmethylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4-dione
    —— 5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-1,3,7-trimethylpyrimido[4,5-d]pyrimidine-2,4-dione —— C16H14ClFN4O2S
    5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-1,3,7-trimethylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 7-isopropyl-1,3-dimethyl-5-((2-morpholino-2-oxoethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C17H23N5O4S
    7-isopropyl-1,3-dimethyl-5-((2-morpholino-2-oxoethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 2-[7-(2,2-dimethylpropyl)-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-(furan-2-ylmethyl)acetamide —— C20H25N5O4S
    2-[7-(2,2-dimethylpropyl)-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-(furan-2-ylmethyl)acetamide
    —— 7-Ethyl-1,3-dimethyl-5-(pyridin-3-ylmethylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4-dione —— C16H17N5O2S
    7-Ethyl-1,3-dimethyl-5-(pyridin-3-ylmethylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4-dione
    —— 5-(cyclopentylthio)-1,3-dimethyl-7-propylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C16H22N4O2S
    5-(cyclopentylthio)-1,3-dimethyl-7-propylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-Benzylsulfanyl-7-(furan-2-yl)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione —— C19H16N4O3S
    5-Benzylsulfanyl-7-(furan-2-yl)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— Ethyl 2-((6,8-dimethyl-5,7-dioxo-2-(thiophen-2-yl)-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)acetate —— C16H16N4O4S2
    Ethyl 2-((6,8-dimethyl-5,7-dioxo-2-(thiophen-2-yl)-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)acetate
    —— 7-ethyl-1,3-dimethyl-5-((pyridin-2-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C16H17N5O2S
    7-ethyl-1,3-dimethyl-5-((pyridin-2-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-Ethylsulfanyl-1,3-dimethyl-7-thiophen-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione —— C14H14N4O2S2
    5-Ethylsulfanyl-1,3-dimethyl-7-thiophen-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 2-(7-Ethyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide —— C12H15N5O3S
    2-(7-Ethyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide
    —— 5-(cyclopentylthio)-1,3-dimethyl-7-neopentylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C18H26N4O2S
    5-(cyclopentylthio)-1,3-dimethyl-7-neopentylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 1,3-dimethyl-7-neopentyl-5-((pyridin-3-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C19H23N5O2S
    1,3-dimethyl-7-neopentyl-5-((pyridin-3-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 1,3-dimethyl-7-phenyl-5-((pyridin-2-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C20H17N5O2S
    1,3-dimethyl-7-phenyl-5-((pyridin-2-ylmethyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-(isopropylthio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C15H16N4O2S2
    5-(isopropylthio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 1,3-dimethyl-5-((2-morpholino-2-oxoethyl)thio)-7-neopentylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C19H27N5O4S
    1,3-dimethyl-5-((2-morpholino-2-oxoethyl)thio)-7-neopentylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-1,3-dimethyl-7-propan-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione —— C18H18ClFN4O2S
    5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-1,3-dimethyl-7-propan-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 7-Ethyl-1,3-dimethyl-5-{[2-(morpholin-4-YL)-2-oxoethyl]sulfanyl}-1H,2H,3H,4H-[1,3]diazino[4,5-D]pyrimidine-2,4-dione —— C16H21N5O4S
    7-Ethyl-1,3-dimethyl-5-{[2-(morpholin-4-YL)-2-oxoethyl]sulfanyl}-1H,2H,3H,4H-[1,3]diazino[4,5-D]pyrimidine-2,4-dione
    —— 2-({2-Ethyl-6,8-dimethyl-5,7-dioxo-5H,6H,7H,8H-[1,3]diazino[4,5-D]pyrimidin-4-YL}sulfanyl)-N-[(furan-2-YL)methyl]acetamide —— C17H19N5O4S
    2-({2-Ethyl-6,8-dimethyl-5,7-dioxo-5H,6H,7H,8H-[1,3]diazino[4,5-D]pyrimidin-4-YL}sulfanyl)-N-[(furan-2-YL)methyl]acetamide
    —— N-cyclohexyl-2-((5-((1-methyl-1H-pyrrol-2-yl)methyl)-4-phenethyl-4H-1,2,4-triazol-3-yl)thio)acetamide —— C24H31N5OS
    N-cyclohexyl-2-((5-((1-methyl-1H-pyrrol-2-yl)methyl)-4-phenethyl-4H-1,2,4-triazol-3-yl)thio)acetamide
    —— N-Cyclopentyl-2-({5-[(1-methyl-1H-pyrrol-2-YL)methyl]-4-(2-phenylethyl)-4H-1,2,4-triazol-3-YL}sulfanyl)acetamide —— C23H29N5OS
    N-Cyclopentyl-2-({5-[(1-methyl-1H-pyrrol-2-YL)methyl]-4-(2-phenylethyl)-4H-1,2,4-triazol-3-YL}sulfanyl)acetamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]-N-methylacetamide —— C17H17ClFNOS
    2-(4-chlorophenyl)sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]-N-methylacetamide
    —— (2R)-N-tert-butyl-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C11H17F3N4OS2
    (2R)-N-tert-butyl-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-N-(2-phenylethyl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C15H17F3N4OS2
    (2R)-N-(2-phenylethyl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-N-(2-phenylethyl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C15H17F3N4OS2
    (2S)-N-(2-phenylethyl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 3-(4-chlorophenyl)sulfanyl-N-cyclopropyl-N-[(3R)-1,1-dioxothiolan-3-yl]propanamide —— C16H20ClNO3S2
    3-(4-chlorophenyl)sulfanyl-N-cyclopropyl-N-[(3R)-1,1-dioxothiolan-3-yl]propanamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methylacetamide —— C17H17ClFNOS
    2-(4-chlorophenyl)sulfanyl-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N',N'-dimethylacetohydrazide —— C15H21BrN2O3S2
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N',N'-dimethylacetohydrazide