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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (E)-2-(1-oxidopyridin-1-ium-2-yl)sulfanyl-3-phenylprop-2-enenitrile —— C14H10N2OS
    (E)-2-(1-oxidopyridin-1-ium-2-yl)sulfanyl-3-phenylprop-2-enenitrile
    —— N-(3-chloro-4-fluorophenyl)-2-[(2Z,5Z)-2-(3,3-dimethyl-2-oxobutylidene)-5-[(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-3-yl]acetamide —— C28H23ClFN5O5S2
    N-(3-chloro-4-fluorophenyl)-2-[(2Z,5Z)-2-(3,3-dimethyl-2-oxobutylidene)-5-[(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-3-yl]acetamide
    —— (E)-3-amino-2-[2-(7-tert-butyl-3-methyl-2,4-dioxo-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetyl]but-2-enenitrile —— C20H26N6O3S
    (E)-3-amino-2-[2-(7-tert-butyl-3-methyl-2,4-dioxo-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetyl]but-2-enenitrile
    —— (2E)-4-(3,5-dimethylphenyl)sulfanyl-3-methyl-2-(nitrosomethylidene)-5-propan-2-yl-1H-imidazole —— C16H21N3OS
    (2E)-4-(3,5-dimethylphenyl)sulfanyl-3-methyl-2-(nitrosomethylidene)-5-propan-2-yl-1H-imidazole
    —— ethyl 2-[[5-amino-4-[(2R)-1-(cyclohexylamino)-1-oxopropan-2-yl]-1,2,4-triazol-3-yl]sulfanyl]acetate —— C15H25N5O3S
    ethyl 2-[[5-amino-4-[(2R)-1-(cyclohexylamino)-1-oxopropan-2-yl]-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— (1R)-1-[5-[(2-chloro-4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethanamine —— C11H11ClFN3OS
    (1R)-1-[5-[(2-chloro-4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethanamine
    —— methyl 2-[[5-amino-4-[(2R)-1-(benzylamino)-1-oxopropan-2-yl]-1,2,4-triazol-3-yl]sulfanyl]acetate —— C15H19N5O3S
    methyl 2-[[5-amino-4-[(2R)-1-(benzylamino)-1-oxopropan-2-yl]-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— (1R)-1-[5-[(3,4-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethanamine —— C13H17N3OS
    (1R)-1-[5-[(3,4-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]ethanamine
    —— (2R)-2-[3-amino-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]-N-(furan-2-ylmethyl)propanamide —— C12H14N6O2S
    (2R)-2-[3-amino-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]-N-(furan-2-ylmethyl)propanamide
    —— (2R)-2-[3-amino-5-[(2-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-N-cyclohexylpropanamide —— C18H24ClN5OS
    (2R)-2-[3-amino-5-[(2-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-N-cyclohexylpropanamide
    —— (2S)-2-[3-amino-5-[(2-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-morpholin-4-ylpropan-1-one —— C16H20ClN5O2S
    (2S)-2-[3-amino-5-[(2-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-morpholin-4-ylpropan-1-one
    —— methyl 2-[[5-amino-4-[(2S)-1-oxo-1-(2-phenylethylamino)propan-2-yl]-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H21N5O3S
    methyl 2-[[5-amino-4-[(2S)-1-oxo-1-(2-phenylethylamino)propan-2-yl]-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— (2R)-2-[3-amino-5-[(2-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-pyrrolidin-1-ylpropan-1-one —— C16H20ClN5OS
    (2R)-2-[3-amino-5-[(2-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]-1-pyrrolidin-1-ylpropan-1-one
    —— (2R)-2-[3-amino-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]-N,N-diethylpropanamide —— C11H18N6OS
    (2R)-2-[3-amino-5-(cyanomethylsulfanyl)-1,2,4-triazol-4-yl]-N,N-diethylpropanamide
    —— (2R)-2-[3-amino-5-(2-phenylethylsulfanyl)-1,2,4-triazol-4-yl]-N-(furan-2-ylmethyl)propanamide —— C18H21N5O2S
    (2R)-2-[3-amino-5-(2-phenylethylsulfanyl)-1,2,4-triazol-4-yl]-N-(furan-2-ylmethyl)propanamide
    —— (2R)-2-(3-amino-5-ethylsulfanyl-1,2,4-triazol-4-yl)-1-pyrrolidin-1-ylpropan-1-one —— C11H19N5OS
    (2R)-2-(3-amino-5-ethylsulfanyl-1,2,4-triazol-4-yl)-1-pyrrolidin-1-ylpropan-1-one
    —— (4E)-4-{4-[(4-chlorophenyl)sulfanyl]-3-nitrobenzylidene}-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one —— C23H16ClN3O3S
    (4E)-4-{4-[(4-chlorophenyl)sulfanyl]-3-nitrobenzylidene}-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
    —— (E)-N,N,N',N'-tetramethyl-2-phenylsulfanylbut-2-ene-1,4-diamine —— C14H22N2S
    (E)-N,N,N',N'-tetramethyl-2-phenylsulfanylbut-2-ene-1,4-diamine
    —— sodium;(Z)-3-ethoxy-1-methylsulfonyl-3-oxoprop-1-en-2-olate —— C6H9NaO5S
    sodium;(Z)-3-ethoxy-1-methylsulfonyl-3-oxoprop-1-en-2-olate
    —— (2S)-2-(3-amino-5-benzylsulfanyl-1,2,4-triazol-4-yl)-N-benzylpropanamide —— C19H21N5OS
    (2S)-2-(3-amino-5-benzylsulfanyl-1,2,4-triazol-4-yl)-N-benzylpropanamide
    —— (2S)-N-benzyl-2-(6-methylpyrimidin-4-yl)sulfanylpropanamide —— C15H17N3OS
    (2S)-N-benzyl-2-(6-methylpyrimidin-4-yl)sulfanylpropanamide
    —— (2S)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N-cyclohexylpropanamide —— C12H21N5OS
    (2S)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N-cyclohexylpropanamide
    —— (2R)-2-(6-methylpyrimidin-4-yl)sulfanyl-1-morpholin-4-ylpropan-1-one —— C12H17N3O2S
    (2R)-2-(6-methylpyrimidin-4-yl)sulfanyl-1-morpholin-4-ylpropan-1-one
    —— (2R)-N-(furan-2-ylmethyl)-2-(6-methylpyrimidin-4-yl)sulfanylpropanamide —— C13H15N3O2S
    (2R)-N-(furan-2-ylmethyl)-2-(6-methylpyrimidin-4-yl)sulfanylpropanamide
    —— (2S)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N-(furan-2-ylmethyl)propanamide —— C11H15N5O2S
    (2S)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N-(furan-2-ylmethyl)propanamide
    —— (2R)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N-benzylpropanamide —— C13H17N5OS
    (2R)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N-benzylpropanamide
    —— (2R)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N,N-diethylpropanamide —— C10H19N5OS
    (2R)-2-(3-amino-5-methylsulfanyl-1,2,4-triazol-4-yl)-N,N-diethylpropanamide
    —— (14Z)-14-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-11-(3,4-dimethoxyphenyl)-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-13-one —— C34H26N4O4S2
    (14Z)-14-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-11-(3,4-dimethoxyphenyl)-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-13-one
    —— S-(2-methylphenyl) N-[(3R)-1,1-dioxothiolan-3-yl]carbamothioate —— C12H15NO3S2
    S-(2-methylphenyl) N-[(3R)-1,1-dioxothiolan-3-yl]carbamothioate
    —— (2-methylphenyl) N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]carbamodithioate —— C13H17NO2S3
    (2-methylphenyl) N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]carbamodithioate
    —— (2-methylphenyl) N-[(3R)-1,1-dioxothiolan-3-yl]carbamodithioate —— C12H15NO2S3
    (2-methylphenyl) N-[(3R)-1,1-dioxothiolan-3-yl]carbamodithioate
    —— (2-methylphenyl) N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]carbamodithioate —— C13H17NO2S3
    (2-methylphenyl) N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]carbamodithioate
    —— (5E)-5-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-1,3-thiazolidine-2,4-dione —— C14H8ClNO3S2
    (5E)-5-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
    —— (2R)-2-(4-bromophenyl)sulfanylpropanenitrile —— C9H8BrNS
    (2R)-2-(4-bromophenyl)sulfanylpropanenitrile
    —— (2R)-2-(2-fluorophenyl)sulfanylpropanenitrile —— C9H8FNS
    (2R)-2-(2-fluorophenyl)sulfanylpropanenitrile
    —— [(Z)-[(4S)-4-(4-chlorophenyl)sulfanyl-4-phenylbutan-2-ylidene]amino]thiourea —— C17H18ClN3S2
    [(Z)-[(4S)-4-(4-chlorophenyl)sulfanyl-4-phenylbutan-2-ylidene]amino]thiourea
    —— 5-{[2-(4-bromophenyl)-2-(hydroxyimino)ethyl]sulfanyl}-2-tert-butyl-4-chloro-3(2H)-pyridazinone —— C16H17BrClN3O2S
    5-{[2-(4-bromophenyl)-2-(hydroxyimino)ethyl]sulfanyl}-2-tert-butyl-4-chloro-3(2H)-pyridazinone
    —— N-[(1R)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)ethyl]-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C18H21N3O4S
    N-[(1R)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)ethyl]-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-[(5-benzyl-4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C22H26N4OS
    2-[(5-benzyl-4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— (2S)-N-(4,5-dihydro-1,3-thiazol-2-yl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C15H24N6O2S2
    (2S)-N-(4,5-dihydro-1,3-thiazol-2-yl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— (2R)-N-(4,5-dihydro-1,3-thiazol-2-yl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C15H24N6O2S2
    (2R)-N-(4,5-dihydro-1,3-thiazol-2-yl)-2-[[4-ethyl-5-(morpholin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— 2-[[5-[(1R)-1-hydroxyethyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide —— C15H20N4O2S
    2-[[5-[(1R)-1-hydroxyethyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide
    —— (2S)-2-(4-ethyl-6-methoxypyrimidin-2-yl)sulfanylbutanoic acid —— C11H16N2O3S
    (2S)-2-(4-ethyl-6-methoxypyrimidin-2-yl)sulfanylbutanoic acid
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(E)-(3,3-dimethyl-5-oxocyclohexylidene)amino]acetamide —— C18H23BrN2O2S
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(E)-(3,3-dimethyl-5-oxocyclohexylidene)amino]acetamide
    —— 7-[[(2Z,5Z)-2-(3,3-dimethyl-2-oxobutylidene)-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-3-yl]methyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C24H23N3O3S3
    7-[[(2Z,5Z)-2-(3,3-dimethyl-2-oxobutylidene)-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-1,3-thiazolidin-3-yl]methyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C13H16N4OS
    2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— (2S)-2,3-dihydro-1,4-benzoxathiine-2-carbonitrile —— C9H7NOS
    (2S)-2,3-dihydro-1,4-benzoxathiine-2-carbonitrile
    —— (2S)-2-methyl-2,3-dihydro-1-benzothiophen-7-amine —— C9H11NS
    (2S)-2-methyl-2,3-dihydro-1-benzothiophen-7-amine
    —— (2R)-N-benzyl-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)propanamide —— C19H21NO3S
    (2R)-N-benzyl-2-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)propanamide
    —— (2R)-2-(4-fluorophenyl)sulfanyl-N-[(1R)-1-phenylethyl]propanamide —— C17H18FNOS
    (2R)-2-(4-fluorophenyl)sulfanyl-N-[(1R)-1-phenylethyl]propanamide