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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N,3-trimethylbutanamide —— C15H18ClN3O2S
    (2R)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N,3-trimethylbutanamide
    —— 1-(Azepan-1-YL)-2-({5-[(1-methyl-1H-pyrrol-2-YL)methyl]-4-(2-phenylethyl)-4H-1,2,4-triazol-3-YL}sulfanyl)ethan-1-one —— C24H31N5OS
    1-(Azepan-1-YL)-2-({5-[(1-methyl-1H-pyrrol-2-YL)methyl]-4-(2-phenylethyl)-4H-1,2,4-triazol-3-YL}sulfanyl)ethan-1-one
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N',N'-dimethylacetohydrazide —— C16H24N2O3S2
    2-(2,5-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N',N'-dimethylacetohydrazide
    —— 2-({5-[(1-Methyl-1H-pyrrol-2-YL)methyl]-4-(2-phenylethyl)-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(pyrrolidin-1-YL)ethan-1-one —— C22H27N5OS
    2-({5-[(1-Methyl-1H-pyrrol-2-YL)methyl]-4-(2-phenylethyl)-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(pyrrolidin-1-YL)ethan-1-one
    —— 6-hydroxy-7-[(2-hydroxyphenyl)methyl]-3,4-dihydro-2H-pyrimido[2,1-b][1,3]thiazin-8-one —— C14H14N2O3S
    6-hydroxy-7-[(2-hydroxyphenyl)methyl]-3,4-dihydro-2H-pyrimido[2,1-b][1,3]thiazin-8-one
    —— 5-[[(2R)-oxolan-2-yl]methylsulfanyl]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine —— C10H15N3OS2
    5-[[(2R)-oxolan-2-yl]methylsulfanyl]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
    —— 5-[[(2S)-oxolan-2-yl]methylsulfanyl]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine —— C10H15N3OS2
    5-[[(2S)-oxolan-2-yl]methylsulfanyl]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
    —— 2-[[5-[(1-Methylpyrrol-2-yl)methyl]-4-phenethyl-1,2,4-triazol-3-yl]thio]acetamide —— C18H21N5OS
    2-[[5-[(1-Methylpyrrol-2-yl)methyl]-4-phenethyl-1,2,4-triazol-3-yl]thio]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-3-(2-fluorophenyl)sulfanylpropanamide —— C15H20FNO3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-3-(2-fluorophenyl)sulfanylpropanamide
    —— 2-[[5-[(1-Methylpyrrol-2-yl)methyl]-4-phenethyl-1,2,4-triazol-3-yl]thio]-1-morpholino-ethanone —— C22H27N5O2S
    2-[[5-[(1-Methylpyrrol-2-yl)methyl]-4-phenethyl-1,2,4-triazol-3-yl]thio]-1-morpholino-ethanone
    —— 2-methyl-7-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]methyl}-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C12H11N5O2S2
    2-methyl-7-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]methyl}-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 2-(3,4-difluorophenyl)sulfanyl-N-[(2S)-2-phenyl-2-pyrrolidin-1-ylethyl]acetamide —— C20H22F2N2OS
    2-(3,4-difluorophenyl)sulfanyl-N-[(2S)-2-phenyl-2-pyrrolidin-1-ylethyl]acetamide
    —— 4-{5-[(2-chlorobenzyl)sulfanyl]-4-ethyl-4H-1,2,4-triazol-3-yl}-1,2,5-oxadiazol-3-amine —— C13H13ClN6OS
    4-{5-[(2-chlorobenzyl)sulfanyl]-4-ethyl-4H-1,2,4-triazol-3-yl}-1,2,5-oxadiazol-3-amine
    —— N-[(2S)-6-methylheptan-2-yl]-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H23F3N4OS2
    N-[(2S)-6-methylheptan-2-yl]-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-N-(2-methylpropyl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C11H17F3N4OS2
    (2R)-N-(2-methylpropyl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-{[4-benzyl-5-(2-phenylethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-methylbenzyl)acetamide —— C27H28N4OS
    2-{[4-benzyl-5-(2-phenylethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-methylbenzyl)acetamide
    —— 2-{[5-(4-amino-1,2,5-oxadiazol-3-yl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}-N-cycloheptylacetamide —— C15H23N7O2S
    2-{[5-(4-amino-1,2,5-oxadiazol-3-yl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}-N-cycloheptylacetamide
    —— 1,3,4-Oxadiazole, 2-(5-methyl-2-furanyl)-5-[[(1-methyl-1H-imidazol-2-yl)thio]methyl]- —— C12H12N4O2S
    1,3,4-Oxadiazole, 2-(5-methyl-2-furanyl)-5-[[(1-methyl-1H-imidazol-2-yl)thio]methyl]-
    —— Acetonitrile, 2-[[4-ethyl-5-(2-methyl-3-furanyl)-4H-1,2,4-triazol-3-yl]thio]- —— C11H12N4OS
    Acetonitrile, 2-[[4-ethyl-5-(2-methyl-3-furanyl)-4H-1,2,4-triazol-3-yl]thio]-
    —— 4-{4-ethyl-5-[(1H-tetrazol-5-ylmethyl)sulfanyl]-4H-1,2,4-triazol-3-yl}-1,2,5-oxadiazol-3-amine —— C8H10N10OS
    4-{4-ethyl-5-[(1H-tetrazol-5-ylmethyl)sulfanyl]-4H-1,2,4-triazol-3-yl}-1,2,5-oxadiazol-3-amine
    —— (2R)-N,N-di(propan-2-yl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C13H21F3N4OS2
    (2R)-N,N-di(propan-2-yl)-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 5-[[(2R)-oxan-2-yl]methylsulfanyl]-N-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-amine —— C10H14F3N3OS2
    5-[[(2R)-oxan-2-yl]methylsulfanyl]-N-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-amine
    —— {[5-(4-amino-1,2,5-oxadiazol-3-yl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetonitrile —— C8H9N7OS
    {[5-(4-amino-1,2,5-oxadiazol-3-yl)-4-ethyl-4H-1,2,4-triazol-3-yl]sulfanyl}acetonitrile
    —— (2S)-N-prop-2-enyl-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C10H13F3N4OS2
    (2S)-N-prop-2-enyl-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— Acetamide, N-cyclohexyl-2-[[1-(2-propenyl)-1H-1,2,3,4-tetrazol-5-yl]thio]- —— C12H19N5OS
    Acetamide, N-cyclohexyl-2-[[1-(2-propenyl)-1H-1,2,3,4-tetrazol-5-yl]thio]-
    —— 2-(4-Chlorophenyl)-5-({[2-(2-furyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-1,3,4-oxadiazole —— C16H10ClN3O2S2
    2-(4-Chlorophenyl)-5-({[2-(2-furyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-1,3,4-oxadiazole
    —— 4-{[5-(Phenylsulfanyl)thiophen-2-yl]sulfonyl}morpholine —— C14H15NO3S3
    4-{[5-(Phenylsulfanyl)thiophen-2-yl]sulfonyl}morpholine
    —— (2R)-N-[(2S)-butan-2-yl]-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C11H17F3N4OS2
    (2R)-N-[(2S)-butan-2-yl]-2-[[5-(2,2,2-trifluoroethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-(4-methylphenyl)-3-(thiophen-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine —— C15H13N5S2
    N-(4-methylphenyl)-3-(thiophen-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine
    —— 2-[(4-methoxy-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)butanamide —— C17H21N3O3S
    2-[(4-methoxy-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)butanamide
    —— 3-{5-[(2-chloro-4-fluorobenzyl)sulfanyl]-1H-tetrazol-1-yl}pyridine —— C13H9ClFN5S
    3-{5-[(2-chloro-4-fluorobenzyl)sulfanyl]-1H-tetrazol-1-yl}pyridine
    —— 3-(pyrazin-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine —— C8H7N7S
    3-(pyrazin-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine
    —— 2-[(4-methoxy-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)acetamide —— C15H17N3O3S
    2-[(4-methoxy-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(1-phenylethyl)acetamide
    —— 3-{5-[(4-bromobenzyl)sulfanyl]-1H-tetrazol-1-yl}pyridine —— C13H10BrN5S
    3-{5-[(4-bromobenzyl)sulfanyl]-1H-tetrazol-1-yl}pyridine
    —— Methyl 1,2-dimethyl-4-[4-(methylsulfanyl)phenyl]-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate —— C16H19NO3S
    Methyl 1,2-dimethyl-4-[4-(methylsulfanyl)phenyl]-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate
    —— 5,5'-[(5-Nitropyrimidine-4,6-diyl)disulfanediyl]bis(1,3,4-thiadiazol-2-amine) —— C8H5N9O2S4
    5,5'-[(5-Nitropyrimidine-4,6-diyl)disulfanediyl]bis(1,3,4-thiadiazol-2-amine)
    —— [2-[[(3S)-1,1-dioxothiolan-3-yl]-(2-methylpropyl)amino]-2-oxoethyl] 2-(4-chlorophenyl)sulfanylacetate —— C18H24ClNO5S2
    [2-[[(3S)-1,1-dioxothiolan-3-yl]-(2-methylpropyl)amino]-2-oxoethyl] 2-(4-chlorophenyl)sulfanylacetate
    —— N-[3-chloro-4-(pyridin-2-ylsulfanyl)phenyl]cyclopentanecarboxamide —— C17H17ClN2OS
    N-[3-chloro-4-(pyridin-2-ylsulfanyl)phenyl]cyclopentanecarboxamide
    —— 5-[(2-chloro-4,5-difluorobenzyl)sulfanyl]-3-phenyl-1,3,4-thiadiazole-2(3H)-thione —— C15H9ClF2N2S3
    5-[(2-chloro-4,5-difluorobenzyl)sulfanyl]-3-phenyl-1,3,4-thiadiazole-2(3H)-thione
    —— 2-[(2-cyanophenyl)sulfanyl]-N-(4-methylpyridin-2-yl)benzamide —— C20H15N3OS
    2-[(2-cyanophenyl)sulfanyl]-N-(4-methylpyridin-2-yl)benzamide
    —— N-1-adamantyl-2-{[5-(2-chloro-4-methylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}-5-nitrobenzamide —— C32H30ClN5O3S
    N-1-adamantyl-2-{[5-(2-chloro-4-methylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}-5-nitrobenzamide
    —— [2-[[(3R)-1,1-dioxothiolan-3-yl]-(2-methylpropyl)amino]-2-oxoethyl] 2-(4-chlorophenyl)sulfanylacetate —— C18H24ClNO5S2
    [2-[[(3R)-1,1-dioxothiolan-3-yl]-(2-methylpropyl)amino]-2-oxoethyl] 2-(4-chlorophenyl)sulfanylacetate
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-(diethylamino)-2-(furan-2-yl)ethyl]acetamide —— C20H23ClN4O3S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-(diethylamino)-2-(furan-2-yl)ethyl]acetamide
    —— 6-(4-chlorophenyl)-3-(pyrazin-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C14H9ClN6S
    6-(4-chlorophenyl)-3-(pyrazin-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— 6-(4-bromophenyl)-3-(pyrazin-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C14H9BrN6S
    6-(4-bromophenyl)-3-(pyrazin-2-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— 9,10-dimethoxy-2-[(4-methylphenyl)sulfanyl]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one —— C21H20N2O3S
    9,10-dimethoxy-2-[(4-methylphenyl)sulfanyl]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one
    —— 2-({7-Amino-7H-[1,2,4]triazolo[4,3-B][1,2,4]triazol-3-YL}sulfanyl)-N-(2-phenylethyl)acetamide —— C13H15N7OS
    2-({7-Amino-7H-[1,2,4]triazolo[4,3-B][1,2,4]triazol-3-YL}sulfanyl)-N-(2-phenylethyl)acetamide
    —— N-cycloheptyl-2-(4,5-dicyano-2-nitrophenyl)sulfanylbenzamide —— C22H20N4O3S
    N-cycloheptyl-2-(4,5-dicyano-2-nitrophenyl)sulfanylbenzamide
    —— 8-chloro-6-methyl-2-[(4-methylphenyl)sulfanyl]pyrrolo[1,2-b:3,4-d']dipyridazin-5(6H)-one —— C17H13ClN4OS
    8-chloro-6-methyl-2-[(4-methylphenyl)sulfanyl]pyrrolo[1,2-b:3,4-d']dipyridazin-5(6H)-one
    —— 6-methoxy-2-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-1,3-benzothiazole —— C12H11N3OS2
    6-methoxy-2-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-1,3-benzothiazole