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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[3-[[(2S)-oxolan-2-yl]methoxy]propyl]propanamide —— C17H24ClNO3S
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[3-[[(2S)-oxolan-2-yl]methoxy]propyl]propanamide
    —— (2S)-2-(4-bromophenyl)sulfanyl-N-[3-[[(2S)-oxolan-2-yl]methoxy]propyl]propanamide —— C17H24BrNO3S
    (2S)-2-(4-bromophenyl)sulfanyl-N-[3-[[(2S)-oxolan-2-yl]methoxy]propyl]propanamide
    —— (1S)-1-(4-methylsulfanylphenyl)-N-(2-pyridin-4-ylethyl)ethanamine —— C16H20N2S
    (1S)-1-(4-methylsulfanylphenyl)-N-(2-pyridin-4-ylethyl)ethanamine
    —— (3S)-3-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]butanimidamide —— C11H18N4OS
    (3S)-3-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]butanimidamide
    —— (1R)-1-(4-methylsulfanylphenyl)-N-(2-pyridin-4-ylethyl)ethanamine —— C16H20N2S
    (1R)-1-(4-methylsulfanylphenyl)-N-(2-pyridin-4-ylethyl)ethanamine
    —— (2R)-2-(2-chlorophenyl)sulfanyl-1-[4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl]propan-1-one —— C18H22ClN3O2S
    (2R)-2-(2-chlorophenyl)sulfanyl-1-[4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl]propan-1-one
    —— (2S)-2-(2-chlorophenyl)sulfanyl-1-[4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl]propan-1-one —— C18H22ClN3O2S
    (2S)-2-(2-chlorophenyl)sulfanyl-1-[4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl]propan-1-one
    —— (2S)-2-(2-chlorophenyl)sulfanyl-1-[4-[(3S)-1,1-dioxothiolan-3-yl]piperazin-1-yl]propan-1-one —— C17H23ClN2O3S2
    (2S)-2-(2-chlorophenyl)sulfanyl-1-[4-[(3S)-1,1-dioxothiolan-3-yl]piperazin-1-yl]propan-1-one
    —— (3R)-N'-hydroxy-3-[5-(trifluoromethyl)pyridin-2-yl]sulfanylbutanimidamide —— C10H12F3N3OS
    (3R)-N'-hydroxy-3-[5-(trifluoromethyl)pyridin-2-yl]sulfanylbutanimidamide
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-methyl-N-(pyridin-3-ylmethyl)propanamide —— C16H17ClN2OS
    (2S)-2-(2-chlorophenyl)sulfanyl-N-methyl-N-(pyridin-3-ylmethyl)propanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ylpropyl)propanamide —— C17H25ClN2O2S
    (2R)-2-(2-chlorophenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ylpropyl)propanamide
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ylpropyl)propanamide —— C17H25ClN2O2S
    (2S)-2-(2-chlorophenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ylpropyl)propanamide
    —— 1-[(1S)-2-(dimethylamino)-1-phenylethyl]-3-(2-phenylsulfanylethyl)urea —— C19H25N3OS
    1-[(1S)-2-(dimethylamino)-1-phenylethyl]-3-(2-phenylsulfanylethyl)urea
    —— (2R)-2-(4-chlorophenyl)sulfanylpropanenitrile —— C9H8ClNS
    (2R)-2-(4-chlorophenyl)sulfanylpropanenitrile
    —— (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-(4-hydroxyphenyl)sulfanylpropanamide —— C17H18FNO2S
    (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-(4-hydroxyphenyl)sulfanylpropanamide
    —— (2S)-N-(1-adamantyl)-2-(4-hydroxyphenyl)sulfanylpropanamide —— C19H25NO2S
    (2S)-N-(1-adamantyl)-2-(4-hydroxyphenyl)sulfanylpropanamide
    —— (2R)-2-(4-hydroxyphenyl)sulfanyl-N-[(1S,2R)-2-methylcyclohexyl]propanamide —— C16H23NO2S
    (2R)-2-(4-hydroxyphenyl)sulfanyl-N-[(1S,2R)-2-methylcyclohexyl]propanamide
    —— (2R)-2-(4-hydroxyphenyl)sulfanyl-N-[(1S)-1-phenylethyl]propanamide —— C17H19NO2S
    (2R)-2-(4-hydroxyphenyl)sulfanyl-N-[(1S)-1-phenylethyl]propanamide
    —— methyl 5-[(2R)-2-(4-hydroxyphenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C17H19NO4S
    methyl 5-[(2R)-2-(4-hydroxyphenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— (2R)-N-(1-adamantyl)-2-(4-hydroxyphenyl)sulfanylpropanamide —— C19H25NO2S
    (2R)-N-(1-adamantyl)-2-(4-hydroxyphenyl)sulfanylpropanamide
    —— methyl (2R)-2-(2-fluorophenyl)sulfanylpropanoate —— C10H11FO2S
    methyl (2R)-2-(2-fluorophenyl)sulfanylpropanoate
    —— N-[(2R)-heptan-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C12H22N4OS
    N-[(2R)-heptan-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— methyl (2S)-2-(4-fluorophenyl)sulfanylpropanoate —— C10H11FO2S
    methyl (2S)-2-(4-fluorophenyl)sulfanylpropanoate
    —— N-[(2S)-6-methylheptan-2-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H23N3OS2
    N-[(2S)-6-methylheptan-2-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(2R)-heptan-2-yl]-2-pyridin-2-ylsulfanylacetamide —— C14H22N2OS
    N-[(2R)-heptan-2-yl]-2-pyridin-2-ylsulfanylacetamide
    —— N-[(2S)-6-methylheptan-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H24N4OS
    N-[(2S)-6-methylheptan-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(2R)-heptan-2-yl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C12H21N3OS3
    N-[(2R)-heptan-2-yl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-1-(4-ethylpiperazin-1-yl)-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one —— C12H20N4OS3
    (2R)-1-(4-ethylpiperazin-1-yl)-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one
    —— (2S)-N-(1-methylpiperidin-4-yl)-2-phenylsulfanylpropanamide —— C15H22N2OS
    (2S)-N-(1-methylpiperidin-4-yl)-2-phenylsulfanylpropanamide
    —— (2R)-2-(4-chlorophenyl)sulfanyl-N,N-bis(2-methoxyethyl)propanamide —— C15H22ClNO3S
    (2R)-2-(4-chlorophenyl)sulfanyl-N,N-bis(2-methoxyethyl)propanamide
    —— N-[(2S)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide —— C18H24N2O2S
    N-[(2S)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide
    —— N-[(2R)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-pyridin-4-ylsulfanylacetamide —— C15H19N3O2S
    N-[(2R)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-pyridin-4-ylsulfanylacetamide
    —— 2-(4-methylphenyl)sulfanyl-1-[4-[(2S)-oxolane-2-carbonyl]piperazin-1-yl]ethanone —— C18H24N2O3S
    2-(4-methylphenyl)sulfanyl-1-[4-[(2S)-oxolane-2-carbonyl]piperazin-1-yl]ethanone
    —— N-[(2R)-2-(dimethylamino)-2-thiophen-2-ylethyl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide —— C16H18F3N3OS2
    N-[(2R)-2-(dimethylamino)-2-thiophen-2-ylethyl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide
    —— N-[(2R)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide —— C16H18F3N3O2S
    N-[(2R)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide
    —— N-[(2S)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H23N5O2S
    N-[(2S)-2-(dimethylamino)-2-(furan-2-yl)ethyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-(3,4-difluorophenyl)sulfanyl-N-[(2S)-2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]propyl]acetamide —— C17H24F2N2O2S
    2-(3,4-difluorophenyl)sulfanyl-N-[(2S)-2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]propyl]acetamide
    —— 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(pyrazin-2-ylamino)ethyl]acetamide —— C16H19N7O2S
    2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(pyrazin-2-ylamino)ethyl]acetamide
    —— 2-(3,4-difluorophenyl)sulfanyl-N-[(2S)-2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]propyl]acetamide —— C17H24F2N2O2S
    2-(3,4-difluorophenyl)sulfanyl-N-[(2S)-2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]propyl]acetamide
    —— (2R)-2-(4-chlorophenyl)sulfanyl-N-(3-imidazol-1-ylpropyl)propanamide —— C15H18ClN3OS
    (2R)-2-(4-chlorophenyl)sulfanyl-N-(3-imidazol-1-ylpropyl)propanamide
    —— 1-(4-acetylpiperazin-1-yl)-4-phenylsulfanylbutan-1-one —— C16H22N2O2S
    1-(4-acetylpiperazin-1-yl)-4-phenylsulfanylbutan-1-one
    —— N-[(2S)-4-methyl-2-morpholin-4-ylpentyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C17H31N5O2S
    N-[(2S)-4-methyl-2-morpholin-4-ylpentyl]-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-N-cyclopropyl-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C18H23ClN4OS
    N-[(1S)-1-(4-chlorophenyl)ethyl]-N-cyclopropyl-2-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-2-(4-methylphenoxy)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C18H17N3O2S2
    (2S)-2-(4-methylphenoxy)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— 2-(2,6-dichlorophenyl)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]acetamide —— C16H11Cl2N3OS2
    2-(2,6-dichlorophenyl)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]acetamide
    —— (2S)-5-(4-methylphenyl)sulfanyl-2-(4-methyl-1,3-thiazol-2-yl)-3-oxopentanenitrile —— C16H16N2OS2
    (2S)-5-(4-methylphenyl)sulfanyl-2-(4-methyl-1,3-thiazol-2-yl)-3-oxopentanenitrile
    —— 5-[(4-cyclopropyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-N,N-dimethylfuran-2-sulfonamide —— C16H23N5O4S2
    5-[(4-cyclopropyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-N,N-dimethylfuran-2-sulfonamide
    —— 1-(2-phenylsulfanylethyl)-4-thiophen-2-ylsulfonylpiperazine —— C16H20N2O2S3
    1-(2-phenylsulfanylethyl)-4-thiophen-2-ylsulfonylpiperazine
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-methyl-N-[(1S)-1-pyridin-4-ylethyl]propanamide —— C18H24N4OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-methyl-N-[(1S)-1-pyridin-4-ylethyl]propanamide
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(2R)-1-imidazol-1-ylpropan-2-yl]acetamide —— C14H19N5OS
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(2R)-1-imidazol-1-ylpropan-2-yl]acetamide