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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 6-tert-butyl-4-{[(E)-(4-methylphenyl)methylidene]amino}-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one —— C16H20N4OS
    6-tert-butyl-4-{[(E)-(4-methylphenyl)methylidene]amino}-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one
    —— (2E)-2-[1-(3-hydroxyanilino)ethylidene]-1-benzothiophen-3-one —— C16H13NO2S
    (2E)-2-[1-(3-hydroxyanilino)ethylidene]-1-benzothiophen-3-one
    —— (E)-1-(5-methyl-2-methylsulfanylthiophen-3-yl)-N-(1,2,4-triazol-4-yl)methanimine —— C9H10N4S2
    (E)-1-(5-methyl-2-methylsulfanylthiophen-3-yl)-N-(1,2,4-triazol-4-yl)methanimine
    —— N-[[4-(methylsulfonylmethyl)phenyl]methyl]-4-phenylsulfanylbutanamide —— C19H23NO3S2
    N-[[4-(methylsulfonylmethyl)phenyl]methyl]-4-phenylsulfanylbutanamide
    —— 2-[1-(4-Bromo-phenylamino)-eth-(E)-ylidene]-benzo[b]thiophen-3-one 126318-51-2 C16H12BrNOS
    2-[1-(4-Bromo-phenylamino)-eth-(E)-ylidene]-benzo[b]thiophen-3-one
    —— N-[(E)-{4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-3-nitrophenyl}methylidene]-4H-1,2,4-triazol-4-amine —— C13H11N7O2S
    N-[(E)-{4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]-3-nitrophenyl}methylidene]-4H-1,2,4-triazol-4-amine
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[[4-(methylsulfonylmethyl)phenyl]methyl]propanamide —— C18H20ClNO3S2
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[[4-(methylsulfonylmethyl)phenyl]methyl]propanamide
    —— (2E)-2-[1-(3-bromoanilino)ethylidene]-1-benzothiophen-3-one —— C16H12BrNOS
    (2E)-2-[1-(3-bromoanilino)ethylidene]-1-benzothiophen-3-one
    —— (2R)-2-(4-chlorophenyl)sulfanyl-N-[[4-(methylsulfonylmethyl)phenyl]methyl]propanamide —— C18H20ClNO3S2
    (2R)-2-(4-chlorophenyl)sulfanyl-N-[[4-(methylsulfonylmethyl)phenyl]methyl]propanamide
    —— (E)-N-(3-benzylsulfanyl-1,2,4-triazol-4-yl)-1-(4-methylphenyl)methanimine —— C17H16N4S
    (E)-N-(3-benzylsulfanyl-1,2,4-triazol-4-yl)-1-(4-methylphenyl)methanimine
    —— (E)-2-cyano-3-(2-fluorophenyl)sulfanylprop-2-enimidamide —— C10H8FN3S
    (E)-2-cyano-3-(2-fluorophenyl)sulfanylprop-2-enimidamide
    —— [(Z)-1-amino-2-cyano-3-(2-fluorophenyl)sulfanylprop-2-enylidene]azanium —— C10H9FN3S+
    [(Z)-1-amino-2-cyano-3-(2-fluorophenyl)sulfanylprop-2-enylidene]azanium
    —— (E)-1-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]-N-(1,2,4-triazol-4-yl)methanimine —— C14H9N5OS2
    (E)-1-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]-N-(1,2,4-triazol-4-yl)methanimine
    —— 5-(2-Furyl)-4-((4-(methylthio)benzylidene)amino)-4H-1,2,4-triazole-3-thiol —— C14H12N4OS2
    5-(2-Furyl)-4-((4-(methylthio)benzylidene)amino)-4H-1,2,4-triazole-3-thiol
    —— 5-cyclohexyl-4-({(E)-[4-(methylsulfanyl)phenyl]methylidene}amino)-4H-1,2,4-triazole-3-thiol —— C16H20N4S2
    5-cyclohexyl-4-({(E)-[4-(methylsulfanyl)phenyl]methylidene}amino)-4H-1,2,4-triazole-3-thiol
    —— 1-[(E)-(4-methylsulfanylphenyl)methylideneamino]-N-phenyltetrazol-5-amine —— C15H14N6S
    1-[(E)-(4-methylsulfanylphenyl)methylideneamino]-N-phenyltetrazol-5-amine
    —— 3-(2-bromophenyl)sulfanyl-N-[(2R)-1-(2-oxopyrrolidin-1-yl)propan-2-yl]propanamide —— C16H21BrN2O2S
    3-(2-bromophenyl)sulfanyl-N-[(2R)-1-(2-oxopyrrolidin-1-yl)propan-2-yl]propanamide
    —— (2R)-N-[(2S)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylpropanamide —— C22H28N2O2S
    (2R)-N-[(2S)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylpropanamide
    —— N-[(2R)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylacetamide —— C21H26N2O2S
    N-[(2R)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylacetamide
    —— 2-(4-methylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)acetamide —— C20H24N2O2S
    2-(4-methylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)acetamide
    —— (2S)-N-[(2S)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylpropanamide —— C22H28N2O2S
    (2S)-N-[(2S)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylpropanamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)acetamide —— C21H26N2O2S
    2-(2,5-dimethylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)acetamide
    —— 2-(4-methylphenyl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)acetamide —— C20H24N2O2S
    2-(4-methylphenyl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)acetamide
    —— (2S)-N-[(2R)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylpropanamide —— C22H28N2O2S
    (2S)-N-[(2R)-2-(4-methylphenyl)-2-morpholin-4-ylethyl]-2-phenylsulfanylpropanamide
    —— N-[[4-(2-methylphenyl)oxan-4-yl]methyl]-2-(4-methylphenyl)sulfanylacetamide —— C22H27NO2S
    N-[[4-(2-methylphenyl)oxan-4-yl]methyl]-2-(4-methylphenyl)sulfanylacetamide
    —— N-propan-2-yl-N-(pyridin-2-ylmethyl)-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide —— C17H18F3N3OS
    N-propan-2-yl-N-(pyridin-2-ylmethyl)-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide
    —— dimethyl-[[[3-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-1H-1,2,4-triazol-5-yl]amino]methylidene]azanium —— C12H12F3N6O2S+
    dimethyl-[[[3-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-1H-1,2,4-triazol-5-yl]amino]methylidene]azanium
    —— N-(furan-2-ylmethyl)-2-[(2-oxo-1H-pyrimidin-6-yl)sulfanyl]acetamide —— C11H11N3O3S
    N-(furan-2-ylmethyl)-2-[(2-oxo-1H-pyrimidin-6-yl)sulfanyl]acetamide
    —— 1-(3-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propyl)-3-(pyrimidin-2-yl)urea —— C11H15N7OS
    1-(3-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propyl)-3-(pyrimidin-2-yl)urea
    —— 2-((4-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(2-methoxyethyl)acetamide —— C11H17N3O3S
    2-((4-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(2-methoxyethyl)acetamide
    —— 1-(3-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propyl)-3-(5-methylisoxazol-3-yl)urea —— C11H16N6O2S
    1-(3-((4-methyl-4H-1,2,4-triazol-3-yl)thio)propyl)-3-(5-methylisoxazol-3-yl)urea
    —— N-[[4-[(2-oxopyridin-1-yl)methyl]phenyl]methyl]-2-pyridin-4-ylsulfanylacetamide —— C20H19N3O2S
    N-[[4-[(2-oxopyridin-1-yl)methyl]phenyl]methyl]-2-pyridin-4-ylsulfanylacetamide
    —— 6,7-Dihydro-4-methylthio-5H-cyclopentapyrimidinol-(2) 28670-82-8 C8H10N2OS
    6,7-Dihydro-4-methylthio-5H-cyclopentapyrimidinol-(2)
    —— N-benzyl-2-((2-oxo-1,2-dihydropyrimidin-4-yl)thio)acetamide —— C13H13N3O2S
    N-benzyl-2-((2-oxo-1,2-dihydropyrimidin-4-yl)thio)acetamide
    —— N-[1-(5-methyl-1,2,4-oxadiazol-3-yl)cyclopentyl]-4-phenylsulfanylbutanamide —— C18H23N3O2S
    N-[1-(5-methyl-1,2,4-oxadiazol-3-yl)cyclopentyl]-4-phenylsulfanylbutanamide
    —— (2R)-N-[(2R)-2-methyl-3-pyrrolidin-1-ylpropyl]-2-phenylsulfanylpropanamide —— C17H26N2OS
    (2R)-N-[(2R)-2-methyl-3-pyrrolidin-1-ylpropyl]-2-phenylsulfanylpropanamide
    —— (2S)-N-[(2S)-2-methyl-3-pyrrolidin-1-ylpropyl]-2-phenylsulfanylpropanamide —— C17H26N2OS
    (2S)-N-[(2S)-2-methyl-3-pyrrolidin-1-ylpropyl]-2-phenylsulfanylpropanamide
    —— 2-hydroxy-6-[[4-[4-[(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methylamino]phenyl]sulfanylanilino]methylidene]cyclohexa-2,4-dien-1-one —— C26H20N2O4S
    2-hydroxy-6-[[4-[4-[(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methylamino]phenyl]sulfanylanilino]methylidene]cyclohexa-2,4-dien-1-one
    —— 2-[[4-(dimethylamino)anilino]methylidene]-1-benzothiophen-3-one —— C17H16N2OS
    2-[[4-(dimethylamino)anilino]methylidene]-1-benzothiophen-3-one
    —— (2S)-N-[(2R)-2-methyl-3-pyrrolidin-1-ylpropyl]-2-phenylsulfanylpropanamide —— C17H26N2OS
    (2S)-N-[(2R)-2-methyl-3-pyrrolidin-1-ylpropyl]-2-phenylsulfanylpropanamide
    —— 1-[(2S)-2-[(2-chlorophenyl)methyl]pyrrolidin-1-yl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propan-1-one —— C21H26ClN3OS
    1-[(2S)-2-[(2-chlorophenyl)methyl]pyrrolidin-1-yl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propan-1-one
    —— (2R)-2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide —— C18H21FN4O2S2
    (2R)-2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide
    —— 2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-prop-2-enyl-N-(thiophen-2-ylmethyl)acetamide —— C17H20N4O2S3
    2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-prop-2-enyl-N-(thiophen-2-ylmethyl)acetamide
    —— (2S)-2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide —— C18H21FN4O2S2
    (2S)-2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide
    —— (2S)-2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]propanamide —— C18H21FN4O2S2
    (2S)-2-[[5-[acetyl(cyclopropyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]propanamide
    —— N-methyl-N-(2-oxo-2-pyrrolidin-1-ylethyl)-2-phenylsulfanylpyridine-3-carboxamide —— C19H21N3O2S
    N-methyl-N-(2-oxo-2-pyrrolidin-1-ylethyl)-2-phenylsulfanylpyridine-3-carboxamide
    —— 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[(2R)-2-(2-phenylethyl)pyrrolidin-1-yl]ethanone —— C22H26N4O2S
    2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[(2R)-2-(2-phenylethyl)pyrrolidin-1-yl]ethanone
    —— 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[(2S)-2-(2-phenylethyl)pyrrolidin-1-yl]ethanone —— C22H26N4O2S
    2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[(2S)-2-(2-phenylethyl)pyrrolidin-1-yl]ethanone
    —— 6-chloro-N-[(4-methylsulfanylphenyl)methylideneamino]pyridazin-3-amine —— C12H11ClN4S
    6-chloro-N-[(4-methylsulfanylphenyl)methylideneamino]pyridazin-3-amine
    —— N-[[4-(4-fluorophenyl)oxan-4-yl]methyl]-4-phenylsulfanylbutanamide —— C22H26FNO2S
    N-[[4-(4-fluorophenyl)oxan-4-yl]methyl]-4-phenylsulfanylbutanamide