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有机硫化合物

有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在,在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特,在药物设计、合成化学以及材料制备方面扮演着重要角色。

1. 结构与分类

有机硫化合物可以按硫的连接方式分为饱和和不饱和类,如二硫化物、噻吩衍生物、砜等。常见的结构类型有:

  • 二硫化物:含-S-S-键的化合物。
  • 硫醚(Thiols):含有-R-S-H或-R-S-R 基团的化合物。
  • 磺酸酯(Sulfonates)与磺酸盐(Sulfonates):带有-SO3H基团的化合物,广泛应用于合成和制药领域。
  • 噻吩及其衍生物:具有环状结构的有机硫化物。
2. 生物学活性

许多有机硫化合物在生物学上有重要功能或应用潜力。例如:

  • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
  • 硫代葡萄糖苷(Glycosinolate)是十字花科植物中的一种天然存在物质,具有生物活性。
3. 合成方法

有机硫化合物可通过多种途径合成:

  • 亲核取代反应:使用含硫试剂与卤化物进行反应。
  • 自由基加成法:采用氧化剂引发自由基形成,通过烯烃与H2S、R-S-H等反应制备。
  • 金属催化转化:利用钯、铜等催化剂促进特定硫化过程。
4. 应用领域

有机硫化合物的应用广泛:

  • 医药领域:用于开发抗菌剂、抗病毒药物及抗癌药物等。
  • 农学研究:某些有机硫化合物作为生物农药的有效成分,能够抑制病害的发生。
  • 材料科学与技术:在导电聚合物和塑料添加剂中有重要应用。
5. 环境与安全性

尽管有机硫化合物具有许多潜在益处,但其生产和使用也可能对环境造成影响。因此,在设计和合成这些化合物时需要考虑可持续性和环保性因素。

以上是对有机硫化合物的简单介绍,包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

中文名称 英文名称 CAS号 化学式 结构式图片
—— (3S)-3-(4-aminophenyl)sulfanyloxolan-2-one —— C10H11NO2S
(3S)-3-(4-aminophenyl)sulfanyloxolan-2-one
—— 2-(4-aminophenyl)sulfanyl-N-[(2R)-1-methoxypropan-2-yl]acetamide —— C12H18N2O2S
2-(4-aminophenyl)sulfanyl-N-[(2R)-1-methoxypropan-2-yl]acetamide
—— 2-Oxopropanal oxime,1-methylsulfone 112740-58-6 C4H7NO4S
2-Oxopropanal oxime,1-methylsulfone
—— (1R)-N-methyl-1-(4-methylsulfanylphenyl)-N-[(3R)-thiolan-3-yl]ethane-1,2-diamine —— C14H22N2S2
(1R)-N-methyl-1-(4-methylsulfanylphenyl)-N-[(3R)-thiolan-3-yl]ethane-1,2-diamine
—— (Z)-N-[2-(4-phenylsulfanylphenoxy)ethoxy]propan-1-imine —— C17H19NO2S
(Z)-N-[2-(4-phenylsulfanylphenoxy)ethoxy]propan-1-imine
—— (1R,2S)-2-(2-chlorophenyl)sulfanylcyclopentane-1-carbonitrile —— C12H12ClNS
(1R,2S)-2-(2-chlorophenyl)sulfanylcyclopentane-1-carbonitrile
—— (1R,2R)-2-(3,4-dimethylphenyl)sulfanylcyclopentane-1-carbonitrile —— C14H17NS
(1R,2R)-2-(3,4-dimethylphenyl)sulfanylcyclopentane-1-carbonitrile
—— (1S,2R)-2-(4-bromophenyl)sulfanylcyclopentane-1-carbonitrile —— C12H12BrNS
(1S,2R)-2-(4-bromophenyl)sulfanylcyclopentane-1-carbonitrile
—— (1R,2S)-2-(2,5-dimethylphenyl)sulfanylcyclopentane-1-carbonitrile —— C14H17NS
(1R,2S)-2-(2,5-dimethylphenyl)sulfanylcyclopentane-1-carbonitrile
—— (1S,2S)-2-thiophen-2-ylsulfanylcycloheptane-1-carbonitrile —— C12H15NS2
(1S,2S)-2-thiophen-2-ylsulfanylcycloheptane-1-carbonitrile
—— (1R,2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]cyclohexane-1-carbonitrile —— C10H14N4S
(1R,2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]cyclohexane-1-carbonitrile
—— (2S)-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]-1-pyrazol-1-ylpropan-2-amine —— C15H21N3S
(2S)-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]-1-pyrazol-1-ylpropan-2-amine
—— (1R,2S)-2-(3,4-dimethylphenyl)sulfanylcyclopentane-1-carbonitrile —— C14H17NS
(1R,2S)-2-(3,4-dimethylphenyl)sulfanylcyclopentane-1-carbonitrile
—— (1S,2R)-2-thiophen-2-ylsulfanylcycloheptane-1-carbonitrile —— C12H15NS2
(1S,2R)-2-thiophen-2-ylsulfanylcycloheptane-1-carbonitrile
—— (1S,2S)-2-(1,3,4-thiadiazol-2-ylsulfanyl)cycloheptane-1-carbonitrile —— C10H13N3S2
(1S,2S)-2-(1,3,4-thiadiazol-2-ylsulfanyl)cycloheptane-1-carbonitrile
—— (1R,2R)-2-(2-fluorophenyl)sulfanylcyclohexane-1-carbonitrile —— C13H14FNS
(1R,2R)-2-(2-fluorophenyl)sulfanylcyclohexane-1-carbonitrile
—— (1R,2R)-2-(2-chlorophenyl)sulfanylcyclopentane-1-carbonitrile —— C12H12ClNS
(1R,2R)-2-(2-chlorophenyl)sulfanylcyclopentane-1-carbonitrile
—— (1S,2R)-2-(2-fluorophenyl)sulfanylcyclohexane-1-carbonitrile —— C13H14FNS
(1S,2R)-2-(2-fluorophenyl)sulfanylcyclohexane-1-carbonitrile
—— 2-(2-chlorophenyl)sulfanyl-N-[(2S)-3-methyl-2-morpholin-4-ylbutyl]acetamide —— C17H25ClN2O2S
2-(2-chlorophenyl)sulfanyl-N-[(2S)-3-methyl-2-morpholin-4-ylbutyl]acetamide
—— (1R)-N-[(2S)-butan-2-yl]-N-methyl-1-(4-methylsulfanylphenyl)ethane-1,2-diamine —— C14H24N2S
(1R)-N-[(2S)-butan-2-yl]-N-methyl-1-(4-methylsulfanylphenyl)ethane-1,2-diamine
—— N-[(2R)-2-methylpentyl]-4-(1H-1,2,4-triazol-5-ylsulfanyl)aniline —— C14H20N4S
N-[(2R)-2-methylpentyl]-4-(1H-1,2,4-triazol-5-ylsulfanyl)aniline
—— (1R)-N-cyclopropyl-1-(4-methylsulfanylphenyl)-N-propylethane-1,2-diamine —— C15H24N2S
(1R)-N-cyclopropyl-1-(4-methylsulfanylphenyl)-N-propylethane-1,2-diamine
—— N-[(2S)-2-methylpentyl]-4-(1H-1,2,4-triazol-5-ylsulfanyl)aniline —— C14H20N4S
N-[(2S)-2-methylpentyl]-4-(1H-1,2,4-triazol-5-ylsulfanyl)aniline
—— 6-[(2S)-butan-2-yl]sulfanyl-2-methoxypyridin-3-amine —— C10H16N2OS
6-[(2S)-butan-2-yl]sulfanyl-2-methoxypyridin-3-amine
—— (1S)-N-cyclopropyl-N-methyl-1-[4-(trifluoromethylsulfanyl)phenyl]ethane-1,2-diamine —— C13H17F3N2S
(1S)-N-cyclopropyl-N-methyl-1-[4-(trifluoromethylsulfanyl)phenyl]ethane-1,2-diamine
—— 6-[(2R)-butan-2-yl]sulfanyl-2-methoxypyridin-3-amine —— C10H16N2OS
6-[(2R)-butan-2-yl]sulfanyl-2-methoxypyridin-3-amine
—— N-[(1S,3R)-3-methylcyclohexyl]-4-(trifluoromethylsulfanyl)aniline —— C14H18F3NS
N-[(1S,3R)-3-methylcyclohexyl]-4-(trifluoromethylsulfanyl)aniline
—— N-[(1R,3S)-3-methylcyclohexyl]-4-(trifluoromethylsulfanyl)aniline —— C14H18F3NS
N-[(1R,3S)-3-methylcyclohexyl]-4-(trifluoromethylsulfanyl)aniline
—— N-[[(1S)-cyclohex-3-en-1-yl]methyl]-4-(trifluoromethylsulfanyl)aniline —— C14H16F3NS
N-[[(1S)-cyclohex-3-en-1-yl]methyl]-4-(trifluoromethylsulfanyl)aniline
—— 2-(2-amino-4-chlorophenyl)sulfanyl-N-[(2R)-3-methylbutan-2-yl]acetamide —— C13H19ClN2OS
2-(2-amino-4-chlorophenyl)sulfanyl-N-[(2R)-3-methylbutan-2-yl]acetamide
—— 2-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]aniline —— C11H15NO2S
2-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]aniline
—— 5-chloro-2-[[(3R)-1,4-dioxaspiro[4.4]nonan-3-yl]methylsulfanyl]aniline —— C14H18ClNO2S
5-chloro-2-[[(3R)-1,4-dioxaspiro[4.4]nonan-3-yl]methylsulfanyl]aniline
—— 2-(2-aminophenyl)sulfanyl-1-[(2R)-2-methylmorpholin-4-yl]ethanone —— C13H18N2O2S
2-(2-aminophenyl)sulfanyl-1-[(2R)-2-methylmorpholin-4-yl]ethanone
—— 2-(2-amino-4-chlorophenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C13H17ClN2O2S
2-(2-amino-4-chlorophenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
—— (1S,2R)-2-ethyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]cyclohexan-1-amine —— C17H27NS
(1S,2R)-2-ethyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]cyclohexan-1-amine
—— 2-(2-aminophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]acetamide —— C14H16N2O2S
2-(2-aminophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]acetamide
—— (2R)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C5H9N5OS
(2R)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
—— (5S)-5-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-oxazolidin-2-one —— C6H9N5O2S
(5S)-5-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-oxazolidin-2-one
—— 6-amino-2-[[(2S)-oxan-2-yl]methylsulfanyl]-1H-pyrimidin-4-one —— C10H15N3O2S
6-amino-2-[[(2S)-oxan-2-yl]methylsulfanyl]-1H-pyrimidin-4-one
—— (1R)-N-[(1S)-1-(5-chlorothiophen-2-yl)ethyl]-1-(4-methylsulfanylphenyl)ethanamine —— C15H18ClNS2
(1R)-N-[(1S)-1-(5-chlorothiophen-2-yl)ethyl]-1-(4-methylsulfanylphenyl)ethanamine
—— (1R)-N-[(2-methylpyrazol-3-yl)methyl]-1-(4-methylsulfanylphenyl)ethanamine —— C14H19N3S
(1R)-N-[(2-methylpyrazol-3-yl)methyl]-1-(4-methylsulfanylphenyl)ethanamine
—— (3R,5R)-5-methyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]heptan-3-amine —— C17H29NS
(3R,5R)-5-methyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]heptan-3-amine
—— (2S)-2-methyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanenitrile —— C11H16N4S
(2S)-2-methyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanenitrile
—— (1S)-N-[(1S)-1-(5-chlorothiophen-2-yl)ethyl]-1-(4-methylsulfanylphenyl)ethanamine —— C15H18ClNS2
(1S)-N-[(1S)-1-(5-chlorothiophen-2-yl)ethyl]-1-(4-methylsulfanylphenyl)ethanamine
—— N-[(2R)-2-methylpentyl]-2-(2,2,2-trifluoroethylsulfanyl)aniline —— C14H20F3NS
N-[(2R)-2-methylpentyl]-2-(2,2,2-trifluoroethylsulfanyl)aniline
—— (1R)-N-[(1R)-1-(5-chlorothiophen-2-yl)ethyl]-1-(4-methylsulfanylphenyl)ethanamine —— C15H18ClNS2
(1R)-N-[(1R)-1-(5-chlorothiophen-2-yl)ethyl]-1-(4-methylsulfanylphenyl)ethanamine
—— (2R)-2-methyl-3-(3-methylsulfanylanilino)propanenitrile —— C11H14N2S
(2R)-2-methyl-3-(3-methylsulfanylanilino)propanenitrile
—— (2S)-2-methyl-3-(4-methylsulfanylanilino)propanenitrile —— C11H14N2S
(2S)-2-methyl-3-(4-methylsulfanylanilino)propanenitrile
—— (2R)-2,3-dihydro-1-benzothiophene-2-carbohydrazide —— C9H10N2OS
(2R)-2,3-dihydro-1-benzothiophene-2-carbohydrazide
—— 2-(2,4-difluorophenyl)sulfanyl-N'-hydroxypyridine-3-carboximidamide —— C12H9F2N3OS
2-(2,4-difluorophenyl)sulfanyl-N'-hydroxypyridine-3-carboximidamide