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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (3S)-N-(2-methoxyethyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C19H24N4O2S
    (3S)-N-(2-methoxyethyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-(3-chloro-4-methoxyphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23ClN4O2S
    (3R)-N-(3-chloro-4-methoxyphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(2-piperidin-1-ylethyl)piperidine-3-carboxamide —— C23H31N5OS
    (3R)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(2-piperidin-1-ylethyl)piperidine-3-carboxamide
    —— (3R)-N-(3-fluorophenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H23FN4OS
    (3R)-N-(3-fluorophenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(2,4-dimethoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4O3S
    (3S)-N-(2,4-dimethoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-[2-(cyclohexen-1-yl)ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H30N4OS
    (3S)-N-[2-(cyclohexen-1-yl)ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(4-fluorophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23FN4OS
    (3R)-N-[(4-fluorophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-[(4-methoxyphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4O2S
    (3S)-N-[(4-methoxyphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(3,4-dimethylphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H26N4OS
    (3R)-N-(3,4-dimethylphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(4-methylphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H26N4OS
    (3R)-N-[(4-methylphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(3-methoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H26N4O2S
    (3R)-N-[(3-methoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-(3-chloro-4-methoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H25ClN4O2S
    (3S)-N-(3-chloro-4-methoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(2-chloro-4,6-dimethoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H27ClN4O3S
    (3S)-N-(2-chloro-4,6-dimethoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(1,3-benzodioxol-5-ylmethyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H24N4O3S
    (3R)-N-(1,3-benzodioxol-5-ylmethyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(2-piperidin-1-ylethyl)piperidine-3-carboxamide —— C23H31N5OS
    (3S)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(2-piperidin-1-ylethyl)piperidine-3-carboxamide
    —— (3R)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-3-carboxamide —— C25H28N4O4S
    (3R)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-3-carboxamide
    —— (3R)-N-[(2-ethoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C25H28N4O2S
    (3R)-N-[(2-ethoxyphenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[(3S)-1-(3-phenylsulfanylpyrazin-2-yl)piperidin-3-yl]methanone —— C23H28N4O3S
    1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[(3S)-1-(3-phenylsulfanylpyrazin-2-yl)piperidin-3-yl]methanone
    —— (3R)-N-(4-methoxyphenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H26N4O2S
    (3R)-N-(4-methoxyphenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (5Z)-3-(3,4-dichlorobenzyl)-5-({5-[(4-methylphenyl)sulfanyl]furan-2-yl}methylidene)-1,3-thiazolidine-2,4-dione —— C22H15Cl2NO3S2
    (5Z)-3-(3,4-dichlorobenzyl)-5-({5-[(4-methylphenyl)sulfanyl]furan-2-yl}methylidene)-1,3-thiazolidine-2,4-dione
    —— (3S)-N-(3,4-dimethylphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H26N4OS
    (3S)-N-(3,4-dimethylphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-(furan-2-ylmethyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C22H24N4O2S
    (3S)-N-(furan-2-ylmethyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(3-pyrrolidin-1-ylpropyl)piperidine-3-carboxamide —— C23H31N5OS
    (3S)-1-(3-phenylsulfanylpyrazin-2-yl)-N-(3-pyrrolidin-1-ylpropyl)piperidine-3-carboxamide
    —— (3S)-N-[(2-fluorophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23FN4OS
    (3S)-N-[(2-fluorophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (4-cyclohexylpiperazin-1-yl)-[(3S)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidin-3-yl]methanone —— C27H37N5OS
    (4-cyclohexylpiperazin-1-yl)-[(3S)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidin-3-yl]methanone
    —— (3S)-N-benzyl-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H26N4OS
    (3S)-N-benzyl-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-[(2,5-dimethoxyphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C26H30N4O3S
    (3S)-N-[(2,5-dimethoxyphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(4-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H26N4OS
    (3R)-N-(4-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(4-bromophenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C22H21BrN4OS
    (3R)-N-(4-bromophenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-[(2,4-dimethoxyphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C26H30N4O3S
    (3S)-N-[(2,4-dimethoxyphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(2,5-dimethylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4OS
    (3S)-N-(2,5-dimethylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-[[4-(dimethylamino)phenyl]methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C25H29N5OS
    (3S)-N-[[4-(dimethylamino)phenyl]methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]-N-(3-phenylpropyl)piperidine-3-carboxamide —— C26H30N4OS
    (3S)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]-N-(3-phenylpropyl)piperidine-3-carboxamide
    —— (3R)-N-[3-[(2R)-2-ethylpiperidin-1-yl]propyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C26H37N5OS
    (3R)-N-[3-[(2R)-2-ethylpiperidin-1-yl]propyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-(4-methoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H26N4O2S
    (3S)-N-(4-methoxyphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-[(1S)-1-phenylethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H26N4OS
    (3R)-N-[(1S)-1-phenylethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-benzyl-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H24N4OS
    (3S)-N-benzyl-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-(4-fluorophenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H23FN4OS
    (3R)-N-(4-fluorophenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(3,4-dimethoxyphenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4O3S
    (3R)-N-(3,4-dimethoxyphenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(4-fluorophenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C22H21FN4OS
    (3S)-N-(4-fluorophenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-(3-fluoro-4-methylphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23FN4OS
    (3R)-N-(3-fluoro-4-methylphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]-N-(3-morpholin-4-ylpropyl)piperidine-3-carboxamide —— C24H33N5O2S
    (3R)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]-N-(3-morpholin-4-ylpropyl)piperidine-3-carboxamide
    —— (3S)-N-[(1S)-1-phenylethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H26N4OS
    (3S)-N-[(1S)-1-phenylethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[2-(cyclohexen-1-yl)ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C24H30N4OS
    (3R)-N-[2-(cyclohexen-1-yl)ethyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-(3-morpholin-4-ylpropyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H31N5O2S
    (3R)-N-(3-morpholin-4-ylpropyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(4-methylphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4OS
    (3R)-N-[(4-methylphenyl)methyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— N-[[(2R)-oxolan-2-yl]methyl]-2-(3-phenylsulfanylpyrazin-2-yl)sulfanylacetamide —— C17H19N3O2S2
    N-[[(2R)-oxolan-2-yl]methyl]-2-(3-phenylsulfanylpyrazin-2-yl)sulfanylacetamide
    —— (3S)-N-(1,3-benzodioxol-5-ylmethyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H26N4O3S
    (3S)-N-(1,3-benzodioxol-5-ylmethyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-[(4-fluorophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23FN4OS
    (3S)-N-[(4-fluorophenyl)methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— 1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[(3R)-1-(3-phenylsulfanylpyrazin-2-yl)piperidin-3-yl]methanone —— C23H28N4O3S
    1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[(3R)-1-(3-phenylsulfanylpyrazin-2-yl)piperidin-3-yl]methanone