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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (4Z)-2,5-dimethyl-4-[(5-methylsulfanylthiophen-2-yl)methylidene]pyrazol-3-one —— C11H12N2OS2
    (4Z)-2,5-dimethyl-4-[(5-methylsulfanylthiophen-2-yl)methylidene]pyrazol-3-one
    —— N-[1-(4-methyl-1,3-thiazol-2-yl)ethyl]-3-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)thio]propanamide —— C16H17N5O2S2
    N-[1-(4-methyl-1,3-thiazol-2-yl)ethyl]-3-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)thio]propanamide
    —— (NZ)-N-(5,6-dihydrothieno[2,3-b]thiopyran-4-ylidene)hydroxylamine —— C7H7NOS2
    (NZ)-N-(5,6-dihydrothieno[2,3-b]thiopyran-4-ylidene)hydroxylamine
    —— N-[(4-ethyl-1,3-thiazol-2-yl)methyl]-2-[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]propanamide —— C14H18N4O2S2
    N-[(4-ethyl-1,3-thiazol-2-yl)methyl]-2-[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]propanamide
    —— 4-{[(3-ethyl-1H-1,2,4-triazol-5-yl)thio]acetyl}-2-(1H-pyrazol-1-ylmethyl)-1,4-oxazepane —— C15H22N6O2S
    4-{[(3-ethyl-1H-1,2,4-triazol-5-yl)thio]acetyl}-2-(1H-pyrazol-1-ylmethyl)-1,4-oxazepane
    —— (Z)-3-(2-methylsulfanylthiophen-3-yl)-2-(thiophene-2-carbonyl)prop-2-enenitrile —— C13H9NOS3
    (Z)-3-(2-methylsulfanylthiophen-3-yl)-2-(thiophene-2-carbonyl)prop-2-enenitrile
    —— 5-(3-chlorobenzylidene)-5,6-dihydro-4H-thieno[2,3-b]thiin-4-one —— C14H9ClOS2
    5-(3-chlorobenzylidene)-5,6-dihydro-4H-thieno[2,3-b]thiin-4-one
    —— 4-{[2-(ethylthio)-1,3-thiazol-4-yl]acetyl}-2-(1H-pyrazol-1-ylmethyl)-1,4-oxazepane —— C16H22N4O2S2
    4-{[2-(ethylthio)-1,3-thiazol-4-yl]acetyl}-2-(1H-pyrazol-1-ylmethyl)-1,4-oxazepane
    —— [(Z)-(5-methylsulfanylthiophen-2-yl)methylideneamino]urea —— C7H9N3OS2
    [(Z)-(5-methylsulfanylthiophen-2-yl)methylideneamino]urea
    —— 1-Cyclohexyl-4-[(pyridin-4-ylthio)acetyl]-1,4-diazepane —— C18H27N3OS
    1-Cyclohexyl-4-[(pyridin-4-ylthio)acetyl]-1,4-diazepane
    —— (Z)-3-(2-methylsulfanylthiophen-3-yl)-2-methylsulfonylprop-2-enenitrile —— C9H9NO2S3
    (Z)-3-(2-methylsulfanylthiophen-3-yl)-2-methylsulfonylprop-2-enenitrile
    —— (5E)-2-heptyl-5-[(4-methylsulfanylphenyl)methylidene]cyclopentan-1-one —— C20H28OS
    (5E)-2-heptyl-5-[(4-methylsulfanylphenyl)methylidene]cyclopentan-1-one
    —— diethyl (2E)-5-amino-7-(4-methylsulfanylphenyl)-2-[(4-methylsulfanylphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate —— C28H28N2O5S3
    diethyl (2E)-5-amino-7-(4-methylsulfanylphenyl)-2-[(4-methylsulfanylphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
    —— dimethyl (2E)-5-amino-7-(4-methylsulfanylphenyl)-2-[(4-methylsulfanylphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate —— C26H24N2O5S3
    dimethyl (2E)-5-amino-7-(4-methylsulfanylphenyl)-2-[(4-methylsulfanylphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
    —— S-[5-(trifluoromethyl)pyridin-2-yl] (Z)-3-thiophen-2-yl-2-thiophen-3-ylprop-2-enethioate —— C17H10F3NOS3
    S-[5-(trifluoromethyl)pyridin-2-yl] (Z)-3-thiophen-2-yl-2-thiophen-3-ylprop-2-enethioate
    —— N-[2-(4-ethyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]propanamide —— C15H20N4O2S2
    N-[2-(4-ethyl-1,3-thiazol-2-yl)ethyl]-2-[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]propanamide
    —— 1-(1-{[(4-Chlorophenyl)thio]acetyl}pyrrolidin-3-yl)-4-methylpiperazine —— C17H24ClN3OS
    1-(1-{[(4-Chlorophenyl)thio]acetyl}pyrrolidin-3-yl)-4-methylpiperazine
    —— 2-[(2-{4-[(2-Methyl-1,3-thiazol-4-yl)methyl]piperazin-1-yl}-2-oxoethyl)thio]pyrimidine —— C15H19N5OS2
    2-[(2-{4-[(2-Methyl-1,3-thiazol-4-yl)methyl]piperazin-1-yl}-2-oxoethyl)thio]pyrimidine
    —— (1R*,5S*)-3-{[2-(ethylthio)-1,3-thiazol-4-yl]acetyl}-6-methyl-3,6-diazabicyclo[3.2.2]nonan-7-one —— C15H21N3O2S2
    (1R*,5S*)-3-{[2-(ethylthio)-1,3-thiazol-4-yl]acetyl}-6-methyl-3,6-diazabicyclo[3.2.2]nonan-7-one
    —— 2-(4-acetyl-3,5-dimethyl-1H-pyrazol-1-yl)-N-[2-(1H-1,2,4-triazol-5-ylthio)ethyl]acetamide —— C13H18N6O2S
    2-(4-acetyl-3,5-dimethyl-1H-pyrazol-1-yl)-N-[2-(1H-1,2,4-triazol-5-ylthio)ethyl]acetamide
    —— N-[2-(3-methylpyridin-2-yl)ethyl]-2-[(4-methyl-1,3-thiazol-2-yl)thio]acetamide —— C14H17N3OS2
    N-[2-(3-methylpyridin-2-yl)ethyl]-2-[(4-methyl-1,3-thiazol-2-yl)thio]acetamide
    —— N-[2-(2-oxoimidazolidin-1-yl)ethyl]-2-(phenylthio)acetamide —— C13H17N3O2S
    N-[2-(2-oxoimidazolidin-1-yl)ethyl]-2-(phenylthio)acetamide
    —— (5E)-5-[(4-methylphenyl)methylidene]-3-(3-methylsulfanylphenyl)-1,3-thiazolidine-2,4-dione —— C18H15NO2S2
    (5E)-5-[(4-methylphenyl)methylidene]-3-(3-methylsulfanylphenyl)-1,3-thiazolidine-2,4-dione
    —— 4-(Diaminomethylideneamino)butanethioamide —— C5H12N4S
    4-(Diaminomethylideneamino)butanethioamide
    —— 4-Amino-2-hydroxybutanethioamide —— C4H10N2OS
    4-Amino-2-hydroxybutanethioamide
    —— 2-Hydroxy-3-methylbutanethioamide —— C5H11NOS
    2-Hydroxy-3-methylbutanethioamide
    —— N-(furan-2-ylmethyl)-2-{[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}acetamide —— C13H12F3N3O2S
    N-(furan-2-ylmethyl)-2-{[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}acetamide
    —— 2-methyl-N-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole-5-carboxamide —— C14H20N6OS
    2-methyl-N-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-4,5,6,7-tetrahydro-1H-benzo[d]imidazole-5-carboxamide
    —— N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-2-[3-(trifluoromethyl)pyrazol-1-yl]acetamide —— C14H13F3N4OS
    N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-2-[3-(trifluoromethyl)pyrazol-1-yl]acetamide
    —— 1-(3-((6-(Dimethylamino)pyridazin-3-yl)oxy)pyrrolidin-1-yl)-2-((4-fluorophenyl)thio)ethanone —— C18H21FN4O2S
    1-(3-((6-(Dimethylamino)pyridazin-3-yl)oxy)pyrrolidin-1-yl)-2-((4-fluorophenyl)thio)ethanone
    —— tert-butyl N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]carbamate —— C13H18N2O2S
    tert-butyl N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]carbamate
    —— 2-((4-Fluorophenyl)thio)-1-(3-(pyridazin-3-yloxy)pyrrolidin-1-yl)ethanone —— C16H16FN3O2S
    2-((4-Fluorophenyl)thio)-1-(3-(pyridazin-3-yloxy)pyrrolidin-1-yl)ethanone
    —— 2-((1-methyl-1H-tetrazol-5-yl)thio)-1-(3-((6-methylpyridazin-3-yl)oxy)pyrrolidin-1-yl)ethanone —— C13H17N7O2S
    2-((1-methyl-1H-tetrazol-5-yl)thio)-1-(3-((6-methylpyridazin-3-yl)oxy)pyrrolidin-1-yl)ethanone
    —— 3-(2-oxo-2-(3-(pyridazin-3-yloxy)pyrrolidin-1-yl)ethyl)-2,3,7,8-tetrahydrocyclopenta[d]thiazolo[3,2-a]pyrimidin-5(6H)-one —— C19H21N5O3S
    3-(2-oxo-2-(3-(pyridazin-3-yloxy)pyrrolidin-1-yl)ethyl)-2,3,7,8-tetrahydrocyclopenta[d]thiazolo[3,2-a]pyrimidin-5(6H)-one
    —— 3-((1-(2-(Pyridin-4-ylthio)acetyl)pyrrolidin-3-yl)oxy)pyrazine-2-carbonitrile —— C16H15N5O2S
    3-((1-(2-(Pyridin-4-ylthio)acetyl)pyrrolidin-3-yl)oxy)pyrazine-2-carbonitrile
    —— 3-((1-(3-(Phenylthio)propanoyl)pyrrolidin-3-yl)oxy)pyrazine-2-carbonitrile —— C18H18N4O2S
    3-((1-(3-(Phenylthio)propanoyl)pyrrolidin-3-yl)oxy)pyrazine-2-carbonitrile
    —— 1-(3-(Pyrazin-2-yloxy)pyrrolidin-1-yl)-2-(pyridin-4-ylthio)ethanone —— C15H16N4O2S
    1-(3-(Pyrazin-2-yloxy)pyrrolidin-1-yl)-2-(pyridin-4-ylthio)ethanone
    —— N-((1r,4r)-4-((5-fluoropyrimidin-2-yl)oxy)cyclohexyl)-3-(phenylthio)propanamide —— C19H22FN3O2S
    N-((1r,4r)-4-((5-fluoropyrimidin-2-yl)oxy)cyclohexyl)-3-(phenylthio)propanamide
    —— N-((1r,4r)-4-((4,6-dimethylpyrimidin-2-yl)oxy)cyclohexyl)-3-(phenylthio)propanamide —— C21H27N3O2S
    N-((1r,4r)-4-((4,6-dimethylpyrimidin-2-yl)oxy)cyclohexyl)-3-(phenylthio)propanamide
    —— 2-(3-cyano-4,6-dimethylpyridin-2-yl)sulfanyl-N-[1-(4-fluorophenyl)ethyl]acetamide —— C18H18FN3OS
    2-(3-cyano-4,6-dimethylpyridin-2-yl)sulfanyl-N-[1-(4-fluorophenyl)ethyl]acetamide
    —— 2-(3-cyano-4,6-dimethylpyridin-2-yl)sulfanyl-N-(3-methylbutan-2-yl)acetamide —— C15H21N3OS
    2-(3-cyano-4,6-dimethylpyridin-2-yl)sulfanyl-N-(3-methylbutan-2-yl)acetamide
    —— N-((1r,4r)-4-((5-chloropyrimidin-2-yl)oxy)cyclohexyl)-2-((1-methyl-1H-tetrazol-5-yl)thio)acetamide —— C14H18ClN7O2S
    N-((1r,4r)-4-((5-chloropyrimidin-2-yl)oxy)cyclohexyl)-2-((1-methyl-1H-tetrazol-5-yl)thio)acetamide
    —— 2-((1-methyl-1H-tetrazol-5-yl)thio)-N-((1r,4r)-4-(pyrimidin-2-yloxy)cyclohexyl)acetamide —— C14H19N7O2S
    2-((1-methyl-1H-tetrazol-5-yl)thio)-N-((1r,4r)-4-(pyrimidin-2-yloxy)cyclohexyl)acetamide
    —— 2-(Pyridin-4-ylthio)-1-(7-(o-tolyl)-1,4-thiazepan-4-yl)ethanone —— C19H22N2OS2
    2-(Pyridin-4-ylthio)-1-(7-(o-tolyl)-1,4-thiazepan-4-yl)ethanone
    —— 1-(7-(2,5-difluorophenyl)-1,4-thiazepan-4-yl)-2-((1-methyl-1H-tetrazol-5-yl)thio)ethanone —— C15H17F2N5OS2
    1-(7-(2,5-difluorophenyl)-1,4-thiazepan-4-yl)-2-((1-methyl-1H-tetrazol-5-yl)thio)ethanone
    —— 2-((4-fluorophenyl)thio)-N-((1r,4r)-4-(pyrimidin-2-yloxy)cyclohexyl)acetamide —— C18H20FN3O2S
    2-((4-fluorophenyl)thio)-N-((1r,4r)-4-(pyrimidin-2-yloxy)cyclohexyl)acetamide
    —— 2-(Pyridin-4-ylthio)-1-(7-(thiophen-2-yl)-1,4-thiazepan-4-yl)ethanone —— C16H18N2OS3
    2-(Pyridin-4-ylthio)-1-(7-(thiophen-2-yl)-1,4-thiazepan-4-yl)ethanone
    —— 3-(2-oxo-2-(7-(thiophen-2-yl)-1,4-thiazepan-4-yl)ethyl)-2,3,7,8-tetrahydrocyclopenta[d]thiazolo[3,2-a]pyrimidin-5(6H)-one —— C20H23N3O2S3
    3-(2-oxo-2-(7-(thiophen-2-yl)-1,4-thiazepan-4-yl)ethyl)-2,3,7,8-tetrahydrocyclopenta[d]thiazolo[3,2-a]pyrimidin-5(6H)-one
    —— 3-(2-(7-(furan-2-yl)-1,4-thiazepan-4-yl)-2-oxoethyl)-2,3,7,8-tetrahydrocyclopenta[d]thiazolo[3,2-a]pyrimidin-5(6H)-one —— C20H23N3O3S2
    3-(2-(7-(furan-2-yl)-1,4-thiazepan-4-yl)-2-oxoethyl)-2,3,7,8-tetrahydrocyclopenta[d]thiazolo[3,2-a]pyrimidin-5(6H)-one
    —— 1-(7-(2,5-Difluorophenyl)-1,4-thiazepan-4-yl)-2-(pyridin-4-ylthio)ethanone —— C18H18F2N2OS2
    1-(7-(2,5-Difluorophenyl)-1,4-thiazepan-4-yl)-2-(pyridin-4-ylthio)ethanone