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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (3R)-N-(4-chlorophenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C22H21ClN4OS
    (3R)-N-(4-chlorophenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3R)-N-[(1R)-1-(4-methoxyphenyl)ethyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C26H30N4O2S
    (3R)-N-[(1R)-1-(4-methoxyphenyl)ethyl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(3-fluoro-4-methoxyphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C23H23FN4O2S
    (3R)-N-(3-fluoro-4-methoxyphenyl)-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (3S)-N-(3,4-dimethylphenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4OS
    (3S)-N-(3,4-dimethylphenyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]-N-(3-phenylpropyl)piperidine-3-carboxamide —— C26H30N4OS
    (3R)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]-N-(3-phenylpropyl)piperidine-3-carboxamide
    —— N-[(1R)-1-(4-methoxyphenyl)ethyl]-2-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide —— C22H23N3O2S2
    N-[(1R)-1-(4-methoxyphenyl)ethyl]-2-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide
    —— (3R)-N-(3-chloro-4-fluorophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H22ClFN4OS
    (3R)-N-(3-chloro-4-fluorophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-1-(3-phenylsulfanylpyrazin-2-yl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-3-carboxamide —— C24H23F3N4OS
    (3R)-1-(3-phenylsulfanylpyrazin-2-yl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-3-carboxamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(2,5-difluorophenyl)methylideneamino]-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]triazole-4-carboxamide —— C16H13F2N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(2,5-difluorophenyl)methylideneamino]-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]triazole-4-carboxamide
    —— (3R)-N-(3-fluorophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H23FN4OS
    (3R)-N-(3-fluorophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— N-[(2R)-butan-2-yl]-2-[3-(2-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide —— C17H21N3OS2
    N-[(2R)-butan-2-yl]-2-[3-(2-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide
    —— (3S)-N-(4-methoxy-2-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4O2S
    (3S)-N-(4-methoxy-2-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]-N-[(1S)-1-phenylethyl]piperidine-3-carboxamide —— C25H28N4OS
    (3S)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]-N-[(1S)-1-phenylethyl]piperidine-3-carboxamide
    —— N-[(2S)-butan-2-yl]-2-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide —— C17H21N3OS2
    N-[(2S)-butan-2-yl]-2-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide
    —— (3R)-N-pentyl-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C21H28N4OS
    (3R)-N-pentyl-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— (E)-1-[2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-5-nitrophenyl]-N-(1,2,4-triazol-4-yl)methanimine —— C15H13N7O2S
    (E)-1-[2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-5-nitrophenyl]-N-(1,2,4-triazol-4-yl)methanimine
    —— (3S)-N-cyclopentyl-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C22H28N4OS
    (3S)-N-cyclopentyl-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(4-fluoro-3-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H25FN4OS
    (3R)-N-(4-fluoro-3-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(3-methylbutyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C22H30N4OS
    (3R)-N-(3-methylbutyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-cyclohexyl-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H30N4OS
    (3R)-N-cyclohexyl-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(2-fluoro-4-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H25FN4OS
    (3R)-N-(2-fluoro-4-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(3-chloro-4-fluorophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H22ClFN4OS
    (3S)-N-(3-chloro-4-fluorophenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-(3,5-dimethylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4OS
    (3S)-N-(3,5-dimethylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3S)-N-[(2S)-butan-2-yl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C21H28N4OS
    (3S)-N-[(2S)-butan-2-yl]-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-[(2,4-dimethoxyphenyl)methyl]-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C26H30N4O3S
    (3R)-N-[(2,4-dimethoxyphenyl)methyl]-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(4-methoxy-2-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C25H28N4O2S
    (3R)-N-(4-methoxy-2-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-[(5-methylfuran-2-yl)methyl]-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C23H26N4O2S
    (3R)-N-[(5-methylfuran-2-yl)methyl]-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(4-fluoro-2-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C24H25FN4OS
    (3R)-N-(4-fluoro-2-methylphenyl)-1-[3-(4-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— (3R)-N-(furan-2-ylmethyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide —— C22H24N4O2S
    (3R)-N-(furan-2-ylmethyl)-1-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]piperidine-3-carboxamide
    —— N-[(2R)-butan-2-yl]-2-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide —— C17H21N3OS2
    N-[(2R)-butan-2-yl]-2-[3-(3-methylphenyl)sulfanylpyrazin-2-yl]sulfanylacetamide
    —— (2Z)-6-chloro-2-[(2-hydroxyphenyl)methylidene]-4-methyl-1-benzothiophen-3-one —— C16H11ClO2S
    (2Z)-6-chloro-2-[(2-hydroxyphenyl)methylidene]-4-methyl-1-benzothiophen-3-one
    —— N-[4-(dimethylamino)phenyl]-1-[3-(2-ethoxy-2-oxo-1-phenylsulfanylethyl)-4-methoxy-6-oxopyran-2-yl]methanimine oxide —— C25H26N2O6S
    N-[4-(dimethylamino)phenyl]-1-[3-(2-ethoxy-2-oxo-1-phenylsulfanylethyl)-4-methoxy-6-oxopyran-2-yl]methanimine oxide
    —— 4-(4-Methyl-6-morpholin-4-ylpyrimidin-1-ium-2-yl)sulfanylbutan-2-one —— C13H20N3O2S+
    4-(4-Methyl-6-morpholin-4-ylpyrimidin-1-ium-2-yl)sulfanylbutan-2-one
    —— 5-[(E)-4-(1H-1,2,4-triazol-5-ylsulfanyl)but-2-enyl]sulfanyl-1H-1,2,4-triazole —— C8H10N6S2
    5-[(E)-4-(1H-1,2,4-triazol-5-ylsulfanyl)but-2-enyl]sulfanyl-1H-1,2,4-triazole
    —— 2-[[5-[(4-chloroanilino)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-3-ylmethylideneamino]acetamide —— C20H20ClN7OS
    2-[[5-[(4-chloroanilino)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-3-ylmethylideneamino]acetamide
    —— prop-2-enyl (2Z)-2-(furan-2-ylmethylidene)-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C23H20N2O4S2
    prop-2-enyl (2Z)-2-(furan-2-ylmethylidene)-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— ethyl (2Z)-7-methyl-5-(4-methylsulfanylphenyl)-2-[(3-methylthiophen-2-yl)methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C23H22N2O3S3
    ethyl (2Z)-7-methyl-5-(4-methylsulfanylphenyl)-2-[(3-methylthiophen-2-yl)methylidene]-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— prop-2-enyl (2Z)-2-[[4-(dimethylamino)phenyl]methylidene]-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C27H27N3O3S2
    prop-2-enyl (2Z)-2-[[4-(dimethylamino)phenyl]methylidene]-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— (E)-1,4-bis(butylsulfanyl)but-2-ene —— C12H24S2
    (E)-1,4-bis(butylsulfanyl)but-2-ene
    —— (6Z)-2-hydroxy-6-[[4-[4-[[(E)-(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]phenyl]sulfanylanilino]methylidene]cyclohexa-2,4-dien-1-one —— C26H20N2O4S
    (6Z)-2-hydroxy-6-[[4-[4-[[(E)-(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]phenyl]sulfanylanilino]methylidene]cyclohexa-2,4-dien-1-one
    —— (3S)-1-[6-(4-bromophenyl)sulfanylpyridazin-3-yl]-N-[(2R)-1-hydroxybutan-2-yl]piperidine-3-carboxamide —— C20H25BrN4O2S
    (3S)-1-[6-(4-bromophenyl)sulfanylpyridazin-3-yl]-N-[(2R)-1-hydroxybutan-2-yl]piperidine-3-carboxamide
    —— 4-bromo-N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]benzamide —— C21H16BrN3O3S
    4-bromo-N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]benzamide
    —— 1-[(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]-3-phenylthiourea —— C20H15ClN4O2S2
    1-[(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]-3-phenylthiourea
    —— 1-(3-methylphenyl)-3-(2-methylsulfanylphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]azepine —— C21H23N3S
    1-(3-methylphenyl)-3-(2-methylsulfanylphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]azepine
    —— 4-amino-N'-[(E)-(4-methylsulfanylphenyl)methylideneamino]-1,2,5-oxadiazole-3-carboximidamide —— C11H12N6OS
    4-amino-N'-[(E)-(4-methylsulfanylphenyl)methylideneamino]-1,2,5-oxadiazole-3-carboximidamide
    —— 2-[6-[(2-chlorophenyl)methylamino]pyrimidin-4-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C18H21ClN4O2S
    2-[6-[(2-chlorophenyl)methylamino]pyrimidin-4-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[[6-methyl-3-(4-methylphenyl)-7-oxo-[1,2]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]acetamide —— C25H26N4O2S2
    2-[[6-methyl-3-(4-methylphenyl)-7-oxo-[1,2]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]acetamide
    —— 4-chloro-2-(methylsulfanyl)-6-[(2E)-2-(phenylmethylidene)hydrazin-1-yl]pyrimidine —— C12H11ClN4S
    4-chloro-2-(methylsulfanyl)-6-[(2E)-2-(phenylmethylidene)hydrazin-1-yl]pyrimidine
    —— (3R)-N-[[(2S)-oxolan-2-yl]methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide —— C21H26N4O2S
    (3R)-N-[[(2S)-oxolan-2-yl]methyl]-1-(3-phenylsulfanylpyrazin-2-yl)piperidine-3-carboxamide
    —— [(3R)-1-(3-phenylsulfanylpyrazin-2-yl)piperidin-3-yl]-piperidin-1-ylmethanone —— C21H26N4OS
    [(3R)-1-(3-phenylsulfanylpyrazin-2-yl)piperidin-3-yl]-piperidin-1-ylmethanone