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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-N-[2-(4-fluorophenyl)ethyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C20H19FN2OS2
    (2S)-N-[2-(4-fluorophenyl)ethyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]-N-propylacetamide —— C18H22N2O3S3
    N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]-N-propylacetamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C17H20N2O3S3
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-cyclopentyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C17H20N2OS2
    (2S)-N-cyclopentyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-(furan-2-ylmethyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C17H16N2O2S2
    (2S)-N-(furan-2-ylmethyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C17H20N2O3S3
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-benzyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C19H18N2OS2
    (2S)-N-benzyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— N-(4-methylcyclohexyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C18H22N2OS2
    N-(4-methylcyclohexyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-benzyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C19H18N2OS2
    (2R)-N-benzyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C19H16F2N2OS2
    N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C16H18N2O3S3
    N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-benzyl-N-methyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C20H20N2OS2
    (2S)-N-benzyl-N-methyl-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— N-[(2R)-butan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C15H18N2OS2
    N-[(2R)-butan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-[(1R,2R)-2-methylcyclohexyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C18H22N2OS2
    N-[(1R,2R)-2-methylcyclohexyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-[(1S,2S)-2-methylcyclohexyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C18H22N2OS2
    N-[(1S,2S)-2-methylcyclohexyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— 2-(Furan-2-yl)-5-[(4-phenyl-1,3-thiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C16H11N3O2S2
    2-(Furan-2-yl)-5-[(4-phenyl-1,3-thiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— N-[(1R)-1-(2,4-difluorophenyl)ethyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C19H16F2N2OS2
    N-[(1R)-1-(2,4-difluorophenyl)ethyl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— 2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C17H16N2OS3
    2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— N-[(2S)-butan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C15H18N2OS2
    N-[(2S)-butan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C17H19N3OS2
    N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-[(2R)-3-methylbutan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C16H20N2OS2
    N-[(2R)-3-methylbutan-2-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C16H18N2O3S3
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— N-(3-methoxypropyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C15H18N2O2S2
    N-(3-methoxypropyl)-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylacetamide —— C15H20BrNO3S2
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylacetamide —— C15H20BrNO3S2
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-propylacetamide —— C16H22BrNO3S2
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-propylacetamide
    —— N-[(S)-cyclopropyl-(4-methylphenyl)methyl]-2-(2-methylphenyl)sulfanylacetamide —— C20H23NOS
    N-[(S)-cyclopropyl-(4-methylphenyl)methyl]-2-(2-methylphenyl)sulfanylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-propylacetamide —— C16H22BrNO3S2
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-propylacetamide
    —— N-[(R)-cyclopropyl-(4-methylphenyl)methyl]-2-(2-methylphenyl)sulfanylacetamide —— C20H23NOS
    N-[(R)-cyclopropyl-(4-methylphenyl)methyl]-2-(2-methylphenyl)sulfanylacetamide
    —— (2R)-N-benzyl-N-ethyl-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide —— C18H19F3N2OS
    (2R)-N-benzyl-N-ethyl-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide
    —— (2R)-N-benzyl-N-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide —— C17H17F3N2OS
    (2R)-N-benzyl-N-methyl-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide
    —— (2R)-N-benzyl-N-methyl-2-[[5-(methylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C15H19N3O2S2
    (2R)-N-benzyl-N-methyl-2-[[5-(methylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-N-benzyl-N-ethyl-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide —— C18H19F3N2OS
    (2S)-N-benzyl-N-ethyl-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropanamide
    —— (2S)-N-benzyl-N-methyl-2-[[5-(methylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C15H19N3O2S2
    (2S)-N-benzyl-N-methyl-2-[[5-(methylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— 4-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-N-(4-methylphenyl)-1,3-thiazol-2-amine —— C18H16N4O2S2
    4-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-N-(4-methylphenyl)-1,3-thiazol-2-amine
    —— 2-(2-bromophenyl)sulfanyl-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methylacetamide —— C17H17BrFNOS
    2-(2-bromophenyl)sulfanyl-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C16H20BrNO3S2
    2-(4-bromo-2-methylphenyl)sulfanyl-N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C18H22ClNO2S
    2-(2-chlorophenyl)sulfanyl-1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— 2-(2-chlorophenyl)sulfanyl-1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C18H22ClNO2S
    2-(2-chlorophenyl)sulfanyl-1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— 1-methyl-2-[(1R)-1-phenylethyl]sulfanylimidazole —— C12H14N2S
    1-methyl-2-[(1R)-1-phenylethyl]sulfanylimidazole
    —— (2S)-2-(1-methylimidazol-2-yl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide —— C9H12F3N3OS
    (2S)-2-(1-methylimidazol-2-yl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide
    —— (2R)-N-benzyl-2-(2-chlorophenyl)sulfanyl-N-ethylpropanamide —— C18H20ClNOS
    (2R)-N-benzyl-2-(2-chlorophenyl)sulfanyl-N-ethylpropanamide
    —— (2R)-2-(1-methylimidazol-2-yl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide —— C9H12F3N3OS
    (2R)-2-(1-methylimidazol-2-yl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide
    —— 2-(2-methoxyphenoxy)-N-(2-phenylsulfanylphenyl)acetamide —— C21H19NO3S
    2-(2-methoxyphenoxy)-N-(2-phenylsulfanylphenyl)acetamide
    —— [2-[2-(4-Chlorophenyl)sulfanylanilino]-2-oxoethyl] 1-oxidopyridin-1-ium-4-carboxylate —— C20H15ClN2O4S
    [2-[2-(4-Chlorophenyl)sulfanylanilino]-2-oxoethyl] 1-oxidopyridin-1-ium-4-carboxylate
    —— (2S)-2-[4-[4-[(2R)-1-amino-1-oxopropan-2-yl]oxyphenyl]sulfanylphenoxy]propanamide —— C18H20N2O4S
    (2S)-2-[4-[4-[(2R)-1-amino-1-oxopropan-2-yl]oxyphenyl]sulfanylphenoxy]propanamide
    —— N-cyclopropyl-2-[4-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]sulfanylphenoxy]acetamide —— C22H24N2O4S
    N-cyclopropyl-2-[4-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]sulfanylphenoxy]acetamide
    —— (2S)-2-[4-[4-[(2S)-1-amino-1-oxopropan-2-yl]oxyphenyl]sulfanylphenoxy]propanamide —— C18H20N2O4S
    (2S)-2-[4-[4-[(2S)-1-amino-1-oxopropan-2-yl]oxyphenyl]sulfanylphenoxy]propanamide
    —— (4-Methylsulfanylphenyl)methyl 2-(2-cyanophenyl)sulfanylbenzoate —— C22H17NO2S2
    (4-Methylsulfanylphenyl)methyl 2-(2-cyanophenyl)sulfanylbenzoate
    —— 2-(2-Fluorophenyl)sulfanylethyl 2-(2-cyanophenyl)sulfanylbenzoate —— C22H16FNO2S2
    2-(2-Fluorophenyl)sulfanylethyl 2-(2-cyanophenyl)sulfanylbenzoate