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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(n-butylthio)-4-hydroxy-6-(trifluoromethyl)pyrimidine —— C9H11F3N2OS
    2-(n-butylthio)-4-hydroxy-6-(trifluoromethyl)pyrimidine
    —— 2-((4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-fluorobenzyl)acetamide —— C15H16FN3O2S
    2-((4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-fluorobenzyl)acetamide
    —— N-[[(2R)-oxolan-2-yl]methyl]-2-[[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]sulfanyl]acetamide —— C12H14F3N3O3S
    N-[[(2R)-oxolan-2-yl]methyl]-2-[[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]sulfanyl]acetamide
    —— 3-[(4-fluorophenyl)methylsulfanyl]-6-[(4-methylphenyl)methyl]-4H-1,2,4-triazin-5-one —— C18H16FN3OS
    3-[(4-fluorophenyl)methylsulfanyl]-6-[(4-methylphenyl)methyl]-4H-1,2,4-triazin-5-one
    —— ethyl (2S)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanoate —— C12H18N2O3S
    ethyl (2S)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanoate
    —— N-cyclohexyl-2-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)thio)acetamide —— C13H16F3N3O2S
    N-cyclohexyl-2-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)thio)acetamide
    —— 2-((2-oxo-2-(pyrrolidin-1-yl)ethyl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one —— C11H12F3N3O2S
    2-((2-oxo-2-(pyrrolidin-1-yl)ethyl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one
    —— 2-((2-methylbenzyl)thio)-6-propylpyrimidin-4(3H)-one —— C15H18N2OS
    2-((2-methylbenzyl)thio)-6-propylpyrimidin-4(3H)-one
    —— 4-ethyl-2-prop-2-enylsulfanyl-1H-pyrimidin-6-one —— C9H12N2OS
    4-ethyl-2-prop-2-enylsulfanyl-1H-pyrimidin-6-one
    —— ethyl 2-methyl-2-[[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]sulfanyl]propanoate —— C11H13F3N2O3S
    ethyl 2-methyl-2-[[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]sulfanyl]propanoate
    —— ethyl 2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetate —— C10H14N2O3S
    ethyl 2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetate
    —— 2-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-4,5-dimethyl-1H-pyrimidin-6-one —— C14H21N3O3S
    2-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-4,5-dimethyl-1H-pyrimidin-6-one
    —— 2-[(2R)-butan-2-yl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C11H18N2OS
    2-[(2R)-butan-2-yl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— 2-(butylthio)-6-ethylpyrimidin-4(3H)-one —— C10H16N2OS
    2-(butylthio)-6-ethylpyrimidin-4(3H)-one
    —— 4-ethyl-2-[(1R)-1-phenylethyl]sulfanyl-1H-pyrimidin-6-one —— C14H16N2OS
    4-ethyl-2-[(1R)-1-phenylethyl]sulfanyl-1H-pyrimidin-6-one
    —— (2S)-N,N-dimethyl-3-oxo-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]butanamide —— C13H19N3O3S
    (2S)-N,N-dimethyl-3-oxo-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]butanamide
    —— 2-((2,5-dimethylbenzyl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one —— C14H13F3N2OS
    2-((2,5-dimethylbenzyl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one
    —— ethyl (2R)-2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C12H18N2O3S
    ethyl (2R)-2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— 2-((4-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-methylacetamide —— C9H13N3O2S
    2-((4-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-methylacetamide
    —— 2-[2-(azepan-1-yl)-2-oxoethyl]sulfanyl-4-ethyl-1H-pyrimidin-6-one —— C14H21N3O2S
    2-[2-(azepan-1-yl)-2-oxoethyl]sulfanyl-4-ethyl-1H-pyrimidin-6-one
    —— (2S)-N,N-dimethyl-3-oxo-2-[[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]sulfanyl]butanamide —— C11H12F3N3O3S
    (2S)-N,N-dimethyl-3-oxo-2-[[6-oxo-4-(trifluoromethyl)-1H-pyrimidin-2-yl]sulfanyl]butanamide
    —— 6-n-Propyl-2-(γ-methylbutyl)-thiouracil 62459-10-3 C12H20N2OS
    6-n-Propyl-2-(γ-methylbutyl)-thiouracil
    —— ethyl (2R)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanoate —— C12H18N2O3S
    ethyl (2R)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanoate
    —— 2-((2-(azepan-1-yl)-2-oxoethyl)thio)-5,6-dimethylpyrimidin-4(3H)-one —— C14H21N3O2S
    2-((2-(azepan-1-yl)-2-oxoethyl)thio)-5,6-dimethylpyrimidin-4(3H)-one
    —— 2-[(4,5-dimethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C13H19N3O3S
    2-[(4,5-dimethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 2-(1,3-dioxolan-2-ylmethylsulfanyl)-4-propyl-1H-pyrimidin-6-one —— C11H16N2O3S
    2-(1,3-dioxolan-2-ylmethylsulfanyl)-4-propyl-1H-pyrimidin-6-one
    —— 2-[(2S)-butan-2-yl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C11H18N2OS
    2-[(2S)-butan-2-yl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— ethyl 2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-2-methylpropanoate —— C12H18N2O3S
    ethyl 2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-2-methylpropanoate
    —— 2-((4-Ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide —— C8H11N3O2S
    2-((4-Ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
    —— 2-((3-fluorobenzyl)thio)-6-propylpyrimidin-4(3H)-one —— C14H15FN2OS
    2-((3-fluorobenzyl)thio)-6-propylpyrimidin-4(3H)-one
    —— 2-((4-bromobenzyl)thio)-6-ethylpyrimidin-4(3H)-one —— C13H13BrN2OS
    2-((4-bromobenzyl)thio)-6-ethylpyrimidin-4(3H)-one
    —— 2-[(1S)-1-phenylethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C15H18N2OS
    2-[(1S)-1-phenylethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— 2-[(2R)-butan-2-yl]sulfanyl-4-ethyl-1H-pyrimidin-6-one —— C10H16N2OS
    2-[(2R)-butan-2-yl]sulfanyl-4-ethyl-1H-pyrimidin-6-one
    —— methyl (2R)-2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C11H16N2O3S
    methyl (2R)-2-[(4-ethyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— 6-ethyl-2-((2-morpholino-2-oxoethyl)thio)pyrimidin-4(3H)-one —— C12H17N3O3S
    6-ethyl-2-((2-morpholino-2-oxoethyl)thio)pyrimidin-4(3H)-one
    —— 6-ethyl-2-((2-fluorobenzyl)thio)pyrimidin-4(3H)-one —— C13H13FN2OS
    6-ethyl-2-((2-fluorobenzyl)thio)pyrimidin-4(3H)-one
    —— 6-Benzyl-3-[(4-fluorobenzyl)sulfanyl]-1,2,4-triazin-5-ol —— C17H14FN3OS
    6-Benzyl-3-[(4-fluorobenzyl)sulfanyl]-1,2,4-triazin-5-ol
    —— diethyl 2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanedioate —— C14H20N2O5S
    diethyl 2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanedioate
    —— 6-n-Propyl-2-n-propylthiouracil 62459-08-9 C10H16N2OS
    6-n-Propyl-2-n-propylthiouracil
    —— 6-benzyl-3-[(2-methylphenyl)methylsulfanyl]-4H-1,2,4-triazin-5-one —— C18H17N3OS
    6-benzyl-3-[(2-methylphenyl)methylsulfanyl]-4H-1,2,4-triazin-5-one
    —— 6-ethyl-2-((pyridin-2-ylmethyl)thio)pyrimidin-4(3H)-one —— C12H13N3OS
    6-ethyl-2-((pyridin-2-ylmethyl)thio)pyrimidin-4(3H)-one
    —— N-cyclopentyl-2-[(4-ethyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetamide —— C13H19N3O2S
    N-cyclopentyl-2-[(4-ethyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetamide
    —— 6-benzyl-3-[(4-methylbenzyl)sulfanyl]-1,2,4-triazin-5(4H)-one —— C18H17N3OS
    6-benzyl-3-[(4-methylbenzyl)sulfanyl]-1,2,4-triazin-5(4H)-one
    —— ethyl 3-oxo-4-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C13H18N2O4S
    ethyl 3-oxo-4-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— 3-(3-benzylsulfanyl-5-oxo-4H-1,2,4-triazin-6-yl)propanoic acid —— C13H13N3O3S
    3-(3-benzylsulfanyl-5-oxo-4H-1,2,4-triazin-6-yl)propanoic acid
    —— 3-(3-benzylsulfanyl-5-oxo-4H-1,2,4-triazin-6-yl)propanoate —— C13H12N3O3S-
    3-(3-benzylsulfanyl-5-oxo-4H-1,2,4-triazin-6-yl)propanoate
    —— 4-((2-(azepan-1-yl)-2-oxoethyl)thio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-2(5H)-one —— C15H21N3O2S
    4-((2-(azepan-1-yl)-2-oxoethyl)thio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-2(5H)-one
    —— 4-((2-chlorobenzyl)thio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-2(5H)-one —— C14H13ClN2OS
    4-((2-chlorobenzyl)thio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-2(5H)-one
    —— (2S)-3-(6-ethylsulfanylpyridin-3-yl)-2-(4-methyl-1,3-thiazol-2-yl)-3-oxopropanenitrile —— C14H13N3OS2
    (2S)-3-(6-ethylsulfanylpyridin-3-yl)-2-(4-methyl-1,3-thiazol-2-yl)-3-oxopropanenitrile
    —— (2R)-3-(6-ethylsulfanylpyridin-3-yl)-2-(4-methyl-1,3-thiazol-2-yl)-3-oxopropanenitrile —— C14H13N3OS2
    (2R)-3-(6-ethylsulfanylpyridin-3-yl)-2-(4-methyl-1,3-thiazol-2-yl)-3-oxopropanenitrile