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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(4-fluorophenyl)-5-[(1R)-1-(1H-1,2,4-triazol-5-ylsulfanyl)ethyl]-1,3,4-oxadiazole —— C12H10FN5OS
    2-(4-fluorophenyl)-5-[(1R)-1-(1H-1,2,4-triazol-5-ylsulfanyl)ethyl]-1,3,4-oxadiazole
    —— 2-(4-fluorophenyl)-5-[(1S)-1-(1H-1,2,4-triazol-5-ylsulfanyl)ethyl]-1,3,4-oxadiazole —— C12H10FN5OS
    2-(4-fluorophenyl)-5-[(1S)-1-(1H-1,2,4-triazol-5-ylsulfanyl)ethyl]-1,3,4-oxadiazole
    —— N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C14H18N2O4S2
    N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C16H22N2O4S2
    N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C16H22N2O4S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— N-cyclopropyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C14H18N2O4S2
    N-cyclopropyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— 2-(4-methylphenyl)-5-[(1R)-1-(1-oxidopyridin-1-ium-2-yl)sulfanylethyl]-1,3,4-oxadiazole —— C16H15N3O2S
    2-(4-methylphenyl)-5-[(1R)-1-(1-oxidopyridin-1-ium-2-yl)sulfanylethyl]-1,3,4-oxadiazole
    —— 5-[(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylsulfanyl]-1-methyltetrazole —— C12H13ClN4O2S
    5-[(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylsulfanyl]-1-methyltetrazole
    —— N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-pyrimidin-2-ylsulfanylacetamide —— C15H21N3O3S2
    N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-pyrimidin-2-ylsulfanylacetamide
    —— 2-(4-fluorophenyl)-5-[(1S)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole —— C14H11FN4OS
    2-(4-fluorophenyl)-5-[(1S)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole
    —— (2R)-N-ethyl-2-pyrimidin-2-ylsulfanylpropanamide —— C9H13N3OS
    (2R)-N-ethyl-2-pyrimidin-2-ylsulfanylpropanamide
    —— 2-[(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylsulfanyl]pyrimidine —— C14H13ClN2O2S
    2-[(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylsulfanyl]pyrimidine
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-pyrimidin-2-ylsulfanylacetamide —— C15H21N3O3S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-pyrimidin-2-ylsulfanylacetamide
    —— 6-Amino-1-methyl-5-(2-pyrimidin-2-ylsulfanylacetyl)pyrimidine-2,4-dione —— C11H11N5O3S
    6-Amino-1-methyl-5-(2-pyrimidin-2-ylsulfanylacetyl)pyrimidine-2,4-dione
    —— 2-(4-fluorophenyl)-5-[(1R)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole —— C14H11FN4OS
    2-(4-fluorophenyl)-5-[(1R)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole
    —— 2-(4-methylphenyl)-5-[(1R)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole —— C15H14N4OS
    2-(4-methylphenyl)-5-[(1R)-1-pyrimidin-2-ylsulfanylethyl]-1,3,4-oxadiazole
    —— 2-[[4-Methyl-5-[1-[(2-morpholin-4-ylpyrimidin-4-yl)methyl]piperidin-4-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol —— C19H29N7O2S
    2-[[4-Methyl-5-[1-[(2-morpholin-4-ylpyrimidin-4-yl)methyl]piperidin-4-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol
    —— 2-[[4-methyl-5-[(3S)-1-[(2-pyrrolidin-1-ylpyrimidin-4-yl)methyl]piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol —— C19H29N7OS
    2-[[4-methyl-5-[(3S)-1-[(2-pyrrolidin-1-ylpyrimidin-4-yl)methyl]piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol
    —— 2-[[4-methyl-5-[(3R)-1-[(2-pyrrolidin-1-ylpyrimidin-4-yl)methyl]piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol —— C19H29N7OS
    2-[[4-methyl-5-[(3R)-1-[(2-pyrrolidin-1-ylpyrimidin-4-yl)methyl]piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]ethanol
    —— 5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine —— C19H19N5O2S2
    5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-[2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide —— C14H18N4OS2
    N-[2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— N-[2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]acetamide —— C12H14N4OS2
    N-[2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]acetamide
    —— N-phenyl-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H11N5OS3
    N-phenyl-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— Ethyl 4-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate —— C16H21N3O2S2
    Ethyl 4-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate
    —— N-[2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide —— C14H18N4OS2
    N-[2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— N-(3-methylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C16H13N5OS3
    N-(3-methylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine —— C18H17N5O2S2
    5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— 5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(2-methylphenyl)-1,3,4-thiadiazol-2-amine —— C18H17N5O2S2
    5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(2-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-[[1-[(3R)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-(4-methylphenyl)sulfanylacetamide —— C20H27N3O3S2
    N-[[1-[(3R)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-(4-methylphenyl)sulfanylacetamide
    —— N-[3-(3,5-dimethylpyrazol-1-yl)propyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H24N6OS2
    N-[3-(3,5-dimethylpyrazol-1-yl)propyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[[1-[(3S)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-(2-methylphenyl)sulfanylacetamide —— C20H27N3O3S2
    N-[[1-[(3S)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-(2-methylphenyl)sulfanylacetamide
    —— N-[[1-[(3R)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-(2-methylphenyl)sulfanylacetamide —— C20H27N3O3S2
    N-[[1-[(3R)-1,1-dioxothiolan-3-yl]-3,5-dimethylpyrazol-4-yl]methyl]-N-methyl-2-(2-methylphenyl)sulfanylacetamide
    —— Ethyl 4-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate —— C15H19N3O2S2
    Ethyl 4-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate
    —— 5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine —— C18H17N5O2S2
    5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-[2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide —— C13H16N4OS2
    N-[2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— N-(4-methylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C16H13N5OS3
    N-(4-methylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(2-methylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C16H13N5OS3
    N-(2-methylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(2,3-dimethylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H15N5OS3
    N-(2,3-dimethylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-[2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide —— C14H18N4OS2
    N-[2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— N-(3,4-dimethylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H15N5OS3
    N-(3,4-dimethylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-[2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide —— C14H18N4OS2
    N-[2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— Ethyl 4-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate —— C16H21N3O2S2
    Ethyl 4-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanoate
    —— 5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(2,3-dimethylphenyl)-1,3,4-thiadiazol-2-amine —— C19H19N5O2S2
    5-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-(2,3-dimethylphenyl)-1,3,4-thiadiazol-2-amine
    —— 3-benzylsulfanyl-4-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-1H-1,2,4-triazole-5-thione —— C20H23N5S2
    3-benzylsulfanyl-4-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-1H-1,2,4-triazole-5-thione
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-ethoxyacetamide —— C18H21NO2S
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-ethoxyacetamide
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]propanamide —— C17H19NOS
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]propanamide
    —— 1-acetyl-N-[4-(3,4-dimethylphenyl)sulfanylphenyl]piperidine-4-carboxamide —— C22H26N2O2S
    1-acetyl-N-[4-(3,4-dimethylphenyl)sulfanylphenyl]piperidine-4-carboxamide
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-methylsulfanylacetamide —— C17H19NOS2
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-methylsulfanylacetamide
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]acetamide —— C16H17NOS
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]acetamide
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-4-morpholin-4-yl-4-oxobutanamide —— C22H26N2O3S
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-4-morpholin-4-yl-4-oxobutanamide