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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylcarbamoyl)propanamide —— C19H24N4O3S
    (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylcarbamoyl)propanamide
    —— (3S)-3-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]oxolan-2-one —— C12H10N2O2S3
    (3S)-3-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]oxolan-2-one
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C15H17N3O4S2
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— (2R)-N-(1-adamantyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C22H27N3O2S
    (2R)-N-(1-adamantyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 2-Benzyl-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole —— C20H17N3OS2
    2-Benzyl-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole
    —— (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide —— C20H20FN3O2S
    (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]propanamide
    —— 1-(1-Adamantyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C21H24N2O2S
    1-(1-Adamantyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide —— C13H12F3N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide
    —— N-[(2-chlorophenyl)methyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H14ClN3OS3
    N-[(2-chlorophenyl)methyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C17H20N4OS3
    (2R)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 4-Phenyl-5-thioxo-2-(2-cyan-aethylmercapto)-1.3.4-thiadiazolin —— C11H9N3S3
    4-Phenyl-5-thioxo-2-(2-cyan-aethylmercapto)-1.3.4-thiadiazolin
    —— 2-[(2-chloro-6-fluorophenyl)methyl]-5-[(1R)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C17H13ClF2N2OS
    2-[(2-chloro-6-fluorophenyl)methyl]-5-[(1R)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— (2S)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]cyclohexan-1-one —— C14H14N2OS3
    (2S)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]cyclohexan-1-one
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H16N4OS3
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(4-Phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]-1-thiophen-2-ylethanone —— C14H10N2OS4
    2-[(4-Phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]-1-thiophen-2-ylethanone
    —— 2-[(2-chloro-6-fluorophenyl)methyl]-5-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C17H13ClF2N2OS
    2-[(2-chloro-6-fluorophenyl)methyl]-5-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-(2,4-dimethylphenyl)-5-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C18H17FN2OS
    2-(2,4-dimethylphenyl)-5-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-(2,4-dimethylphenyl)-5-[(1R)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C18H17FN2OS
    2-(2,4-dimethylphenyl)-5-[(1R)-1-(2-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— N-(3-phenylpropyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C19H19N3OS3
    N-(3-phenylpropyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]cyclohexan-1-one —— C14H14N2OS3
    (2R)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]cyclohexan-1-one
    —— 5-[[2-(4-Methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C19H15N3S4
    5-[[2-(4-Methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— (2R)-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclohexylpropanamide —— C17H20ClN3OS3
    (2R)-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclohexylpropanamide
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C23H29N3O2S
    N-[(1R)-1-(1-adamantyl)ethyl]-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2-cyanoethyl)acetamide —— C14H14N4O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2-cyanoethyl)acetamide
    —— (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one —— C17H23N4OS3+
    (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C18H23N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide
    —— (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H23N3OS3
    (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)ethanone —— C20H23N3O2S
    2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)ethanone
    —— (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H23N3OS3
    (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide —— C18H23N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide
    —— (2R)-N-[(1R,2R)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H23N3OS3
    (2R)-N-[(1R,2R)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 5-[(4-Methylsulfanylphenyl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C16H14N2S4
    5-[(4-Methylsulfanylphenyl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— (2R)-N-cyclohexyl-N-ethyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C19H25N3OS3
    (2R)-N-cyclohexyl-N-ethyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 5-[(2-Methylphenyl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C16H14N2S3
    5-[(2-Methylphenyl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— N-[[(2S)-oxolan-2-yl]methyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C15H17N3O2S3
    N-[[(2S)-oxolan-2-yl]methyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— methyl (2R)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate —— C12H12N2O2S3
    methyl (2R)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanoate
    —— (2S)-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclohexylpropanamide —— C17H20ClN3OS3
    (2S)-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclohexylpropanamide
    —— (2R)-N-cyclopropyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H15N3OS3
    (2R)-N-cyclopropyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— ethyl 4-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate —— C20H21N3O4S
    ethyl 4-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate
    —— (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H23N3OS3
    (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-(1-adamantyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C22H27N3O2S
    (2S)-N-(1-adamantyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propan-2-ylacetamide —— C14H17N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propan-2-ylacetamide
    —— 2-Benzyl-5-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole —— C19H14ClN3OS2
    2-Benzyl-5-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole
    —— (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylcarbamoyl)propanamide —— C19H24N4O3S
    (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexylcarbamoyl)propanamide
    —— N-benzyl-N-methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C18H17N3OS3
    N-benzyl-N-methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-1-(4-ethylpiperazin-1-yl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one —— C17H22N4OS3
    (2R)-1-(4-ethylpiperazin-1-yl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propan-1-one
    —— (2R)-N-benzyl-N-methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C19H19N3OS3
    (2R)-N-benzyl-N-methyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-cyclopropyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H15N3OS3
    (2S)-N-cyclopropyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 5-[(2-Chlorophenyl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C15H11ClN2S3
    5-[(2-Chlorophenyl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[2-(4-fluorophenyl)ethyl]acetamide —— C19H18FN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[2-(4-fluorophenyl)ethyl]acetamide