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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide —— C21H25N7OS
    2-[[5-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide
    —— 5-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-N-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-amine —— C11H17F3N4S2
    5-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-N-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-amine
    —— (3R)-1-methyl-3-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]piperidine —— C14H20N4S2
    (3R)-1-methyl-3-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]piperidine
    —— N-(furan-2-ylmethyl)-5-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H20N4OS2
    N-(furan-2-ylmethyl)-5-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(furan-2-ylmethyl)-5-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H20N4OS2
    N-(furan-2-ylmethyl)-5-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole —— C14H20N4OS2
    2-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole
    —— (3R)-1-methyl-3-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]piperidine —— C15H22N4S2
    (3R)-1-methyl-3-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]piperidine
    —— [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[(3S)-3-methylmorpholin-4-yl]methanone —— C14H17NO2S
    [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[(3S)-3-methylmorpholin-4-yl]methanone
    —— (3S)-1-methyl-3-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]piperidine —— C14H20N4S2
    (3S)-1-methyl-3-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]piperidine
    —— [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[(3R)-3-methylmorpholin-4-yl]methanone —— C14H17NO2S
    [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[(3R)-3-methylmorpholin-4-yl]methanone
    —— (3S)-1-methyl-3-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]piperidine —— C15H22N4S2
    (3S)-1-methyl-3-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]piperidine
    —— [(2S)-2,3-dihydro-1-benzothiophen-2-yl]-[(3S)-3-methylmorpholin-4-yl]methanone —— C14H17NO2S
    [(2S)-2,3-dihydro-1-benzothiophen-2-yl]-[(3S)-3-methylmorpholin-4-yl]methanone
    —— [(2S)-2,3-dihydro-1-benzothiophen-2-yl]-[(3R)-3-methylmorpholin-4-yl]methanone —— C14H17NO2S
    [(2S)-2,3-dihydro-1-benzothiophen-2-yl]-[(3R)-3-methylmorpholin-4-yl]methanone
    —— 2-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole —— C14H20N4OS2
    2-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole
    —— 5-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-N-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-amine —— C11H17F3N4S2
    5-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-N-(2,2,2-trifluoroethyl)-1,3,4-thiadiazol-2-amine
    —— 3-methyl-5-[(1S)-1-[[4-(2-pyridin-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H16N6OS
    3-methyl-5-[(1S)-1-[[4-(2-pyridin-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 3-methyl-5-[(1R)-1-[[4-(2-pyridin-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H16N6OS
    3-methyl-5-[(1R)-1-[[4-(2-pyridin-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1-methyl-1-(pyridin-4-ylmethyl)urea —— C18H23N3OS
    3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1-methyl-1-(pyridin-4-ylmethyl)urea
    —— 3-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-1-(2-methoxyethyl)-1-methylurea —— C15H24N2O2S
    3-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-1-(2-methoxyethyl)-1-methylurea
    —— 4-acetyl-N-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-1,4-diazepane-1-carboxamide —— C18H27N3O2S
    4-acetyl-N-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-1,4-diazepane-1-carboxamide
    —— N-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]azetidine-1-carboxamide —— C14H20N2OS
    N-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]azetidine-1-carboxamide
    —— 3-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-1-methyl-1-[(1-methylpyrazol-4-yl)methyl]urea —— C17H24N4OS
    3-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-1-methyl-1-[(1-methylpyrazol-4-yl)methyl]urea
    —— 1-methyl-1-[(1-methylpyrazol-4-yl)methyl]-3-[(1R)-1-(4-propan-2-ylsulfanylphenyl)ethyl]urea —— C18H26N4OS
    1-methyl-1-[(1-methylpyrazol-4-yl)methyl]-3-[(1R)-1-(4-propan-2-ylsulfanylphenyl)ethyl]urea
    —— 4-acetyl-N-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1,4-diazepane-1-carboxamide —— C18H27N3O2S
    4-acetyl-N-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1,4-diazepane-1-carboxamide
    —— 1-methyl-1-[(1-methylpyrazol-4-yl)methyl]-3-[(1S)-1-(4-propan-2-ylsulfanylphenyl)ethyl]urea —— C18H26N4OS
    1-methyl-1-[(1-methylpyrazol-4-yl)methyl]-3-[(1S)-1-(4-propan-2-ylsulfanylphenyl)ethyl]urea
    —— 1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]urea —— C17H23N3O2S
    1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]urea
    —— 3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1-(2-methoxyethyl)-1-methylurea —— C15H24N2O2S
    3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1-(2-methoxyethyl)-1-methylurea
    —— 1-methyl-3-[(1R)-1-(4-propan-2-ylsulfanylphenyl)ethyl]-1-(pyridin-4-ylmethyl)urea —— C19H25N3OS
    1-methyl-3-[(1R)-1-(4-propan-2-ylsulfanylphenyl)ethyl]-1-(pyridin-4-ylmethyl)urea
    —— 1-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-3-(2-methoxyethyl)urea —— C14H22N2O2S
    1-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-3-(2-methoxyethyl)urea
    —— 3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1-methyl-1-[(1-methylpyrazol-4-yl)methyl]urea —— C17H24N4OS
    3-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-1-methyl-1-[(1-methylpyrazol-4-yl)methyl]urea
    —— 1-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-3-[(2-methylpyrimidin-4-yl)methyl]urea —— C17H22N4OS
    1-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]-3-[(2-methylpyrimidin-4-yl)methyl]urea
    —— 1-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-3-[(2-methylpyrimidin-4-yl)methyl]urea —— C17H22N4OS
    1-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-3-[(2-methylpyrimidin-4-yl)methyl]urea
    —— 1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]urea —— C17H23N3O2S
    1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-3-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]urea
    —— 1-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-3-[2-(methanesulfonamido)ethyl]urea —— C14H23N3O3S2
    1-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]-3-[2-(methanesulfonamido)ethyl]urea
    —— 2-[(1R)-cyclopent-2-en-1-yl]-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]acetamide —— C18H28N4OS
    2-[(1R)-cyclopent-2-en-1-yl]-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]acetamide
    —— (1S)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclohex-3-ene-1-carboxamide —— C18H28N4OS
    (1S)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclohex-3-ene-1-carboxamide
    —— (1R)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclohex-3-ene-1-carboxamide —— C18H28N4OS
    (1R)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclohex-3-ene-1-carboxamide
    —— (2R)-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one —— C14H22N4O2S
    (2R)-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one
    —— (2R)-N,N-dimethyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C7H13N5OS
    (2R)-N,N-dimethyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(4-methylphenyl)sulfanylacetamide —— C18H25NO3S2
    N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(4-methylphenyl)sulfanylacetamide
    —— N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(4-fluorophenyl)sulfanylacetamide —— C17H22FNO3S2
    N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-(4-fluorophenyl)sulfanylacetamide
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(2-fluorophenyl)sulfanylacetamide —— C17H22FNO3S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(2-fluorophenyl)sulfanylacetamide
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide —— C17H21F3N2O3S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide
    —— (2R)-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]cyclohexan-1-one —— C16H26N4O2S
    (2R)-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]cyclohexan-1-one
    —— 2-(4-chlorophenyl)sulfanyl-N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C17H22ClNO3S2
    2-(4-chlorophenyl)sulfanyl-N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— (2S)-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]cyclohexan-1-one —— C16H26N4O2S
    (2S)-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]cyclohexan-1-one
    —— (2R)-N-benzyl-N-methyl-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C21H31N5O2S
    (2R)-N-benzyl-N-methyl-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— (2S)-N,N-dimethyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C7H13N5OS
    (2S)-N,N-dimethyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(4-methylphenyl)sulfanylacetamide —— C18H25NO3S2
    N-cyclopentyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-(4-methylphenyl)sulfanylacetamide
    —— (2S)-N-benzyl-N-methyl-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C21H31N5O2S
    (2S)-N-benzyl-N-methyl-2-[[4-(2-methylpropyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propanamide