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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]propanamide —— C14H19N5O2S
    (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]propanamide
    —— 2-(2-methylphenyl)sulfanyl-N-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]acetamide —— C15H19N3OS
    2-(2-methylphenyl)sulfanyl-N-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]acetamide
    —— 2-(2-methylphenyl)sulfanyl-N-[(1R)-1-(1-methylpyrazol-4-yl)ethyl]acetamide —— C15H19N3OS
    2-(2-methylphenyl)sulfanyl-N-[(1R)-1-(1-methylpyrazol-4-yl)ethyl]acetamide
    —— (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]propanamide —— C14H19N5O2S
    (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]propanamide
    —— (4R)-4,6-dimethyl-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide —— C13H19N5O2S2
    (4R)-4,6-dimethyl-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
    —— 3-[4-Amino-3-[(3-chlorophenyl)methylsulfanyl]-5-oxo-1,2,4-triazin-6-yl]propanoate —— C13H12ClN4O3S-
    3-[4-Amino-3-[(3-chlorophenyl)methylsulfanyl]-5-oxo-1,2,4-triazin-6-yl]propanoate
    —— (4S)-4-(bromomethyl)-4-methyl-11-propyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C13H20BrN4OS+
    (4S)-4-(bromomethyl)-4-methyl-11-propyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4R)-4-(bromomethyl)-4-methyl-11-propyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C13H20BrN4OS+
    (4R)-4-(bromomethyl)-4-methyl-11-propyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4S)-4,6-dimethyl-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide —— C13H19N5O2S2
    (4S)-4,6-dimethyl-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
    —— (4R)-4-(bromomethyl)-4-methyl-11-propyl-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C13H19BrN4OS
    (4R)-4-(bromomethyl)-4-methyl-11-propyl-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— 3-[(3R)-3-(4-fluorophenyl)oxolan-3-yl]-5-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-1,2,4-oxadiazole —— C15H14FN5O2S
    3-[(3R)-3-(4-fluorophenyl)oxolan-3-yl]-5-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-1,2,4-oxadiazole
    —— 3-[(3S)-3-(4-fluorophenyl)oxolan-3-yl]-5-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-1,2,4-oxadiazole —— C15H14FN5O2S
    3-[(3S)-3-(4-fluorophenyl)oxolan-3-yl]-5-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-1,2,4-oxadiazole
    —— 2-(4-methyl-1,3-thiazol-5-yl)ethyl 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H18N4O3S2
    2-(4-methyl-1,3-thiazol-5-yl)ethyl 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 2-(4-methyl-1,3-thiazol-5-yl)ethyl (2S)-2-phenylsulfanylpropanoate —— C15H17NO2S2
    2-(4-methyl-1,3-thiazol-5-yl)ethyl (2S)-2-phenylsulfanylpropanoate
    —— 2-(4-methyl-1,3-thiazol-5-yl)ethyl (2R)-2-phenylsulfanylpropanoate —— C15H17NO2S2
    2-(4-methyl-1,3-thiazol-5-yl)ethyl (2R)-2-phenylsulfanylpropanoate
    —— (5E)-5-{[5-(phenylsulfanyl)furan-2-yl]methylidene}-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione —— C18H14N2O3S2
    (5E)-5-{[5-(phenylsulfanyl)furan-2-yl]methylidene}-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
    —— 1-[(3R)-3-methyl-4-propan-2-ylpiperazin-1-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C13H22N4OS2
    1-[(3R)-3-methyl-4-propan-2-ylpiperazin-1-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— 1-[(3S)-3-methyl-4-propan-2-ylpiperazin-1-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C13H22N4OS2
    1-[(3S)-3-methyl-4-propan-2-ylpiperazin-1-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— N-(cyanomethyl)-2-[(4-methylphenyl)sulfanyl]acetamide —— C11H12N2OS
    N-(cyanomethyl)-2-[(4-methylphenyl)sulfanyl]acetamide
    —— (2R)-N-[(6-chloropyridin-3-yl)methyl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-methylpropanamide —— C16H19ClN4OS
    (2R)-N-[(6-chloropyridin-3-yl)methyl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-methylpropanamide
    —— (4S)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C17H20N4OS
    (4S)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4R)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C17H20N4OS
    (4R)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4S)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C17H21N4OS+
    (4S)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4R)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C17H21N4OS+
    (4R)-4-methyl-11-[(1S)-1-phenylethyl]-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (5S)-5-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-1,2,5,6-tetrahydropyrazolo[4,3-g]quinolin-7-one —— C17H14N6O2S
    (5S)-5-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-1,2,5,6-tetrahydropyrazolo[4,3-g]quinolin-7-one
    —— (5R)-5-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-1,2,5,6-tetrahydropyrazolo[4,3-g]quinolin-7-one —— C17H14N6O2S
    (5R)-5-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-1,2,5,6-tetrahydropyrazolo[4,3-g]quinolin-7-one
    —— (2R)-5-amino-6-bromo-2-(bromomethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-7-one —— C7H7Br2N3OS
    (2R)-5-amino-6-bromo-2-(bromomethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-7-one
    —— 1-[4-(1-Adamantyl)piperazin-4-ium-1-yl]-2-[(3-methylsulfanyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethanone —— C19H29N4OS3+
    1-[4-(1-Adamantyl)piperazin-4-ium-1-yl]-2-[(3-methylsulfanyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethanone
    —— (2S)-5-amino-6-bromo-2-(bromomethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-7-one —— C7H7Br2N3OS
    (2S)-5-amino-6-bromo-2-(bromomethyl)-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-7-one
    —— 1-[4-(1-Adamantyl)piperazin-4-ium-1-yl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C18H28N5OS2+
    1-[4-(1-Adamantyl)piperazin-4-ium-1-yl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— 2-[[4-[(1S)-1-phenylethyl]-5-(1H-pyrazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C15H15N5O2S
    2-[[4-[(1S)-1-phenylethyl]-5-(1H-pyrazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N'-cyanoethanimidamide —— C10H8N7S+
    2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N'-cyanoethanimidamide
    —— 2-[[4-[(1R)-1-phenylethyl]-5-(1H-pyrazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C15H15N5O2S
    2-[[4-[(1R)-1-phenylethyl]-5-(1H-pyrazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— (4R)-4-(bromomethyl)-11-cyclohexyl-4-methyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C16H24BrN4OS+
    (4R)-4-(bromomethyl)-11-cyclohexyl-4-methyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— 5-nitro-N-(2-phenylsulfanylethyl)pyridin-1-ium-2-amine —— C13H14N3O2S+
    5-nitro-N-(2-phenylsulfanylethyl)pyridin-1-ium-2-amine
    —— (4S)-4-methyl-11-(2-phenylethyl)-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C17H21N4OS+
    (4S)-4-methyl-11-(2-phenylethyl)-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4R)-4-(bromomethyl)-11-cyclohexyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C15H22BrN4OS+
    (4R)-4-(bromomethyl)-11-cyclohexyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— ethyl (6S,7R)-6-(4-chlorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H15ClN4O2S
    ethyl (6S,7R)-6-(4-chlorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— 11-cyclohexyl-4,4-dimethyl-5-thia-7,11,13-triaza-2-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C16H25N4OS+
    11-cyclohexyl-4,4-dimethyl-5-thia-7,11,13-triaza-2-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— methyl (2S)-2-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate —— C18H22N2O3S
    methyl (2S)-2-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate
    —— 2-[(3,5-difluorobenzyl)sulfanyl]-3,6-dimethyl-5-(3-methylbenzyl)-4(3H)-pyrimidinone —— C21H20F2N2OS
    2-[(3,5-difluorobenzyl)sulfanyl]-3,6-dimethyl-5-(3-methylbenzyl)-4(3H)-pyrimidinone
    —— ethyl (6S,7S)-6-(4-fluorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H15FN4O2S
    ethyl (6S,7S)-6-(4-fluorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— ethyl (6R,7R)-6-(4-hydroxyphenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H16N4O3S
    ethyl (6R,7R)-6-(4-hydroxyphenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— ethyl (6R,7R)-6-(4-fluorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H15FN4O2S
    ethyl (6R,7R)-6-(4-fluorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— ethyl (6S,7R)-3-methyl-6-(4-methylphenyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C15H18N4O2S
    ethyl (6S,7R)-3-methyl-6-(4-methylphenyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— ethyl (6R,7S)-6-phenyl-3-(trifluoromethyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H13F3N4O2S
    ethyl (6R,7S)-6-phenyl-3-(trifluoromethyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— [2-[2-(Morpholin-4-ium-4-ylmethyl)phenyl]sulfanylphenyl]methylazanium —— C18H24N2OS+2
    [2-[2-(Morpholin-4-ium-4-ylmethyl)phenyl]sulfanylphenyl]methylazanium
    —— ethyl (6R,7S)-6-(4-chlorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H15ClN4O2S
    ethyl (6R,7S)-6-(4-chlorophenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— ethyl (6S,7S)-6-phenyl-3-(trifluoromethyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H13F3N4O2S
    ethyl (6S,7S)-6-phenyl-3-(trifluoromethyl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate
    —— ethyl (6R,7S)-6-(4-hydroxyphenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate —— C14H16N4O3S
    ethyl (6R,7S)-6-(4-hydroxyphenyl)-3-methyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxylate