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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (5S)-3-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-phenyl-4,5-dihydro-1,2-oxazole —— C15H15NOS2
    (5S)-3-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-phenyl-4,5-dihydro-1,2-oxazole
    —— (1'S,2R,4S,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H16N4O2S
    (1'S,2R,4S,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (5aS,8S,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione —— C13H19NS3
    (5aS,8S,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione
    —— (5aR,8S,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione —— C13H19NS3
    (5aR,8S,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione
    —— (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(2-ethyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl)propan-1-one —— C17H21N5OS
    (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(2-ethyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl)propan-1-one
    —— (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(2-ethyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl)propan-1-one —— C17H21N5OS
    (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(2-ethyl-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl)propan-1-one
    —— 1-cyclopropyl-3-[(2S)-2-methylbutyl]thiourea —— C9H18N2S
    1-cyclopropyl-3-[(2S)-2-methylbutyl]thiourea
    —— 1-{[5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetone —— C11H9BrN2O2S
    1-{[5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetone
    —— N-[2-(4-fluorophenyl)ethyl]-3-(phenylsulfanyl)propanamide —— C17H18FNOS
    N-[2-(4-fluorophenyl)ethyl]-3-(phenylsulfanyl)propanamide
    —— (3R)-3-phenyl-N-(2-phenylsulfanylphenyl)butanamide —— C22H21NOS
    (3R)-3-phenyl-N-(2-phenylsulfanylphenyl)butanamide
    —— (2R)-N-methyl-N-[(5-methylfuran-2-yl)methyl]-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C15H19N3O3S
    (2R)-N-methyl-N-[(5-methylfuran-2-yl)methyl]-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— (2S)-N-methyl-N-[(5-methylfuran-2-yl)methyl]-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C15H19N3O3S
    (2S)-N-methyl-N-[(5-methylfuran-2-yl)methyl]-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— (2R)-2-methyl-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]oxane-2-carboxamide —— C11H19N5O2S
    (2R)-2-methyl-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]oxane-2-carboxamide
    —— 2-(4-methoxyphenyl)sulfanyl-N-[(E)-(5-phenylsulfanylfuran-2-yl)methylideneamino]acetamide —— C20H18N2O3S2
    2-(4-methoxyphenyl)sulfanyl-N-[(E)-(5-phenylsulfanylfuran-2-yl)methylideneamino]acetamide
    —— (2S)-2-methyl-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]oxane-2-carboxamide —— C11H19N5O2S
    (2S)-2-methyl-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]oxane-2-carboxamide
    —— N-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-5-nitropyridin-2-amine —— C16H11ClN4O3S
    N-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-5-nitropyridin-2-amine
    —— N-[(Z)-[5-(4-methylphenyl)sulfanylfuran-2-yl]methylideneamino]aniline —— C18H16N2OS
    N-[(Z)-[5-(4-methylphenyl)sulfanylfuran-2-yl]methylideneamino]aniline
    —— N-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-2-hydroxybenzamide —— C18H13ClN2O3S
    N-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-2-hydroxybenzamide
    —— N-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-3-(dimethylamino)benzamide —— C20H18ClN3O2S
    N-[(Z)-[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylideneamino]-3-(dimethylamino)benzamide
    —— 2-(4,6-Diaminopyrimidin-2-yl)sulfanyl-2-methylpropanoate —— C8H11N4O2S-
    2-(4,6-Diaminopyrimidin-2-yl)sulfanyl-2-methylpropanoate
    —— (5R)-3-[(3-benzylsulfanyl-1H-1,2,4-triazol-5-yl)amino]-5-phenylcyclohex-2-en-1-one —— C21H20N4OS
    (5R)-3-[(3-benzylsulfanyl-1H-1,2,4-triazol-5-yl)amino]-5-phenylcyclohex-2-en-1-one
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[[(3R)-1,3-dimethylpyrrolidin-3-yl]methyl]-N-methylacetamide —— C12H21N5OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[[(3R)-1,3-dimethylpyrrolidin-3-yl]methyl]-N-methylacetamide
    —— (5S)-3-[(3-benzylsulfanyl-1H-1,2,4-triazol-5-yl)amino]-5-phenylcyclohex-2-en-1-one —— C21H20N4OS
    (5S)-3-[(3-benzylsulfanyl-1H-1,2,4-triazol-5-yl)amino]-5-phenylcyclohex-2-en-1-one
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[[(3S)-1,3-dimethylpyrrolidin-3-yl]methyl]-N-methylacetamide —— C12H21N5OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[[(3S)-1,3-dimethylpyrrolidin-3-yl]methyl]-N-methylacetamide
    —— ethyl (3aS,7aR)-2-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-3a,4,5,6,7,7a-hexahydro-1-benzothiophene-3-carboxylate —— C15H21N5O3S2
    ethyl (3aS,7aR)-2-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-3a,4,5,6,7,7a-hexahydro-1-benzothiophene-3-carboxylate
    —— ethyl (3aS,7aS)-2-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-3a,4,5,6,7,7a-hexahydro-1-benzothiophene-3-carboxylate —— C15H21N5O3S2
    ethyl (3aS,7aS)-2-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-3a,4,5,6,7,7a-hexahydro-1-benzothiophene-3-carboxylate
    —— ethyl (3aR,7aS)-2-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-3a,4,5,6,7,7a-hexahydro-1-benzothiophene-3-carboxylate —— C15H21N5O3S2
    ethyl (3aR,7aS)-2-[[2-(1-methyltetrazol-5-yl)sulfanylacetyl]amino]-3a,4,5,6,7,7a-hexahydro-1-benzothiophene-3-carboxylate
    —— 2-[[5-(2-methylpropyl)-4-[(1R)-1-phenylethyl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C16H21N3O2S
    2-[[5-(2-methylpropyl)-4-[(1R)-1-phenylethyl]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
    —— 2-[4-chloro-6-[methyl-(1-methylpiperidin-1-ium-4-yl)amino]pyrimidin-2-yl]sulfanyl-N-(2-methylpropyl)acetamide —— C17H29ClN5OS+
    2-[4-chloro-6-[methyl-(1-methylpiperidin-1-ium-4-yl)amino]pyrimidin-2-yl]sulfanyl-N-(2-methylpropyl)acetamide
    —— 6-Methyl-2-(2-piperidin-1-ium-1-ylethylsulfanyl)pyridine-3-carbonitrile —— C14H20N3S+
    6-Methyl-2-(2-piperidin-1-ium-1-ylethylsulfanyl)pyridine-3-carbonitrile
    —— (2S)-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2S)-pentan-2-yl]propanamide —— C14H24N4O2S2
    (2S)-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2S)-pentan-2-yl]propanamide
    —— (2R)-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2S)-pentan-2-yl]propanamide —— C14H24N4O2S2
    (2R)-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2S)-pentan-2-yl]propanamide
    —— N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C18H24N4O2S2
    N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 6-Methyl-2-(2-piperidin-1-ium-1-ylethylsulfanyl)-4-(trifluoromethyl)pyridine-3-carbonitrile —— C15H19F3N3S+
    6-Methyl-2-(2-piperidin-1-ium-1-ylethylsulfanyl)-4-(trifluoromethyl)pyridine-3-carbonitrile
    —— (2R)-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2R)-pentan-2-yl]propanamide —— C14H24N4O2S2
    (2R)-2-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2R)-pentan-2-yl]propanamide
    —— 3,6-Dimethyl-5-[(3-methylphenyl)methyl]-2-prop-2-enylsulfanylpyrimidin-4-one —— C17H20N2OS
    3,6-Dimethyl-5-[(3-methylphenyl)methyl]-2-prop-2-enylsulfanylpyrimidin-4-one
    —— 4-[5-[[(2S)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-yl]morpholine —— C11H17N3O2S2
    4-[5-[[(2S)-oxolan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-yl]morpholine
    —— 2-[(3-Fluorophenyl)methylsulfanyl]-3,6-dimethyl-5-[(4-methylphenyl)methyl]pyrimidin-4-one —— C21H21FN2OS
    2-[(3-Fluorophenyl)methylsulfanyl]-3,6-dimethyl-5-[(4-methylphenyl)methyl]pyrimidin-4-one
    —— [(3R)-1-[(2-propylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]methanamine —— C13H22N4S
    [(3R)-1-[(2-propylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]methanamine
    —— 2-(1-methyl-6-oxo-4-propylpyrimidin-2-yl)sulfanyl-N,N-di(propan-2-yl)acetamide —— C16H27N3O2S
    2-(1-methyl-6-oxo-4-propylpyrimidin-2-yl)sulfanyl-N,N-di(propan-2-yl)acetamide
    —— [(3S)-1-[(2-propylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]methanamine —— C13H22N4S
    [(3S)-1-[(2-propylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]methanamine
    —— 5-[(2S)-1-[(2-methylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-propan-2-yl-1,2,4-oxadiazole —— C15H21N5OS
    5-[(2S)-1-[(2-methylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-propan-2-yl-1,2,4-oxadiazole
    —— 5-[(2R)-1-[(2-methylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-propan-2-yl-1,2,4-oxadiazole —— C15H21N5OS
    5-[(2R)-1-[(2-methylsulfanylpyrimidin-5-yl)methyl]pyrrolidin-2-yl]-3-propan-2-yl-1,2,4-oxadiazole
    —— N-[5-[(2S)-butan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]-1-phenylmethanesulfonamide —— C13H17N3O2S3
    N-[5-[(2S)-butan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]-1-phenylmethanesulfonamide
    —— (8S,8aS)-6-imino-8-(4-methylsulfanylphenyl)-2-propyl-1,2,3,5,8,8a-hexahydroisoquinolin-2-ium-5,7,7-tricarbonitrile —— C22H24N5S+
    (8S,8aS)-6-imino-8-(4-methylsulfanylphenyl)-2-propyl-1,2,3,5,8,8a-hexahydroisoquinolin-2-ium-5,7,7-tricarbonitrile
    —— (8S,8aS)-6-imino-8-(4-methylsulfanylphenyl)-2-propyl-3,5,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile —— C22H23N5S
    (8S,8aS)-6-imino-8-(4-methylsulfanylphenyl)-2-propyl-3,5,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile
    —— (8R,8aS)-6-imino-8-(4-methylsulfanylphenyl)-2-propan-2-yl-1,2,3,5,8,8a-hexahydroisoquinolin-2-ium-5,7,7-tricarbonitrile —— C22H24N5S+
    (8R,8aS)-6-imino-8-(4-methylsulfanylphenyl)-2-propan-2-yl-1,2,3,5,8,8a-hexahydroisoquinolin-2-ium-5,7,7-tricarbonitrile
    —— (8R,8aR)-6-imino-8-(4-methylsulfanylphenyl)-2-propan-2-yl-3,5,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile —— C22H23N5S
    (8R,8aR)-6-imino-8-(4-methylsulfanylphenyl)-2-propan-2-yl-3,5,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile
    —— (2R)-N-[2-[cyclopropyl(methyl)amino]ethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C15H20N2OS
    (2R)-N-[2-[cyclopropyl(methyl)amino]ethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2S)-N-methyl-2-(4-methylphenyl)sulfanyl-N-[(4-methylthiadiazol-5-yl)methyl]propanamide —— C15H19N3OS2
    (2S)-N-methyl-2-(4-methylphenyl)sulfanyl-N-[(4-methylthiadiazol-5-yl)methyl]propanamide