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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (3S)-1-(6-chloro-2-methylsulfanylpyrimidin-4-yl)-N-methylpiperidin-3-amine —— C11H17ClN4S
    (3S)-1-(6-chloro-2-methylsulfanylpyrimidin-4-yl)-N-methylpiperidin-3-amine
    —— 2-[(4-cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]-N-(furan-2-ylmethyl)acetamide —— C21H25N4O2S+
    2-[(4-cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]-N-(furan-2-ylmethyl)acetamide
    —— 2-{[4-Cyano-1-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetamide —— C16H20N4OS
    2-{[4-Cyano-1-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetamide
    —— 3-[(2-Methylprop-2-en-1-yl)sulfanyl]-1-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C18H23N3S
    3-[(2-Methylprop-2-en-1-yl)sulfanyl]-1-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 2-[(4-Cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetamide —— C16H21N4OS+
    2-[(4-Cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetamide
    —— 3-(2-Methylprop-2-enylsulfanyl)-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile —— C18H24N3S+
    3-(2-Methylprop-2-enylsulfanyl)-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile
    —— 2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C21H29N4O3S+
    2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C21H29N4O3S+
    2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C23H33N4O2S+
    2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C23H33N4O2S+
    2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C23H32N4O2S
    2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C21H28N4O3S
    2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 3-[(4-Cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]propyl-dimethylazanium —— C19H30N4S+2
    3-[(4-Cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]propyl-dimethylazanium
    —— 3-(2-Oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile —— C20H27N4OS+
    3-(2-Oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile
    —— 3-[(Phenylsulfanyl)methyl]-6-(2-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C15H11N5S2
    3-[(Phenylsulfanyl)methyl]-6-(2-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C23H32N4O2S
    2-[[4-cyano-1-(4-methylpiperidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 3-(methoxymethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C12H12N4OS
    3-(methoxymethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— Methyl {[4-cyano-1-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetate —— C17H21N3O2S
    Methyl {[4-cyano-1-(pyrrolidin-1-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]sulfanyl}acetate
    —— Methyl 2-[(4-cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetate —— C17H22N3O2S+
    Methyl 2-[(4-cyano-1-pyrrolidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetate
    —— 1-[(4R)-4-[(dimethylamino)methyl]-4-hydroxyazepan-1-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C15H27N5O2S
    1-[(4R)-4-[(dimethylamino)methyl]-4-hydroxyazepan-1-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-(4-chlorophenyl)sulfanyl-1-[(4S)-4-hydroxy-4-(hydroxymethyl)azepan-1-yl]ethanone —— C15H20ClNO3S
    2-(4-chlorophenyl)sulfanyl-1-[(4S)-4-hydroxy-4-(hydroxymethyl)azepan-1-yl]ethanone
    —— 2-(4-chlorophenyl)sulfanyl-1-[(4R)-4-hydroxy-4-(hydroxymethyl)azepan-1-yl]ethanone —— C15H20ClNO3S
    2-(4-chlorophenyl)sulfanyl-1-[(4R)-4-hydroxy-4-(hydroxymethyl)azepan-1-yl]ethanone
    —— 1-[(4S)-4-[(dimethylamino)methyl]-4-hydroxyazepan-1-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C15H27N5O2S
    1-[(4S)-4-[(dimethylamino)methyl]-4-hydroxyazepan-1-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-[(3R)-4-(2-phenylsulfanylacetyl)morpholin-3-yl]acetic acid —— C14H17NO4S
    2-[(3R)-4-(2-phenylsulfanylacetyl)morpholin-3-yl]acetic acid
    —— 2-[(3S)-4-(2-phenylsulfanylacetyl)morpholin-3-yl]acetic acid —— C14H17NO4S
    2-[(3S)-4-(2-phenylsulfanylacetyl)morpholin-3-yl]acetic acid
    —— (3S)-1-[1-(2-phenylsulfanylethyl)piperidin-4-yl]piperidin-3-ol —— C18H28N2OS
    (3S)-1-[1-(2-phenylsulfanylethyl)piperidin-4-yl]piperidin-3-ol
    —— (3R)-1-[1-(2-phenylsulfanylethyl)piperidin-4-yl]piperidin-3-ol —— C18H28N2OS
    (3R)-1-[1-(2-phenylsulfanylethyl)piperidin-4-yl]piperidin-3-ol
    —— methyl 2-[2-(2-methylsulfanylethylsulfanyl)-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H14N2O3S2
    methyl 2-[2-(2-methylsulfanylethylsulfanyl)-6-oxo-1H-pyrimidin-4-yl]acetate
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C14H17N3O5S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-(2-cyanophenyl)sulfanyl-N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide —— C23H18N2O3S
    2-(2-cyanophenyl)sulfanyl-N-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ium-4-ylpropyl)pyridine-3-carboxamide —— C22H30N3O2S+
    2-(2,4-dimethylphenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ium-4-ylpropyl)pyridine-3-carboxamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C14H17N3O5S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-cyclopropylacetamide —— C15H20N4O2S
    2-[(4-amino-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-cyclopropylacetamide
    —— 2-(2-cyanophenyl)sulfanyl-N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide —— C23H18N2O3S
    2-(2-cyanophenyl)sulfanyl-N-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ylpropyl)pyridine-3-carboxamide —— C22H29N3O2S
    2-(2,4-dimethylphenyl)sulfanyl-N-(2-methyl-2-morpholin-4-ylpropyl)pyridine-3-carboxamide
    —— methyl 2-[2-(3-cyanopropylsulfanyl)-6-oxo-1H-pyrimidin-4-yl]acetate —— C11H13N3O3S
    methyl 2-[2-(3-cyanopropylsulfanyl)-6-oxo-1H-pyrimidin-4-yl]acetate
    —— 2-[4-(dimethylsulfamoyl)-3,5-dimethylpyrazol-1-yl]-N-(2-phenylsulfanylethyl)acetamide —— C17H24N4O3S2
    2-[4-(dimethylsulfamoyl)-3,5-dimethylpyrazol-1-yl]-N-(2-phenylsulfanylethyl)acetamide
    —— N-[[5-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]thiophen-2-yl]methyl]acetamide —— C18H17N3O3S2
    N-[[5-[2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]thiophen-2-yl]methyl]acetamide
    —— methyl 2-[2-[[(2S)-oxan-2-yl]methylsulfanyl]-6-oxo-1H-pyrimidin-4-yl]acetate —— C13H18N2O4S
    methyl 2-[2-[[(2S)-oxan-2-yl]methylsulfanyl]-6-oxo-1H-pyrimidin-4-yl]acetate
    —— N-[[5-[2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]thiophen-2-yl]methyl]acetamide —— C17H18N4O3S2
    N-[[5-[2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]thiophen-2-yl]methyl]acetamide
    —— 2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-3-methylbutan-2-yl]acetamide —— C17H23N3O2S
    2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-3-methylbutan-2-yl]acetamide
    —— 3-[[2-(4-Bromophenyl)sulfanylpyridine-3-carbonyl]amino]propyl-dimethylazanium —— C17H21BrN3OS+
    3-[[2-(4-Bromophenyl)sulfanylpyridine-3-carbonyl]amino]propyl-dimethylazanium
    —— 7-[(2-Chlorophenyl)sulfanylmethyl]-2-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C14H12ClN3OS2
    7-[(2-Chlorophenyl)sulfanylmethyl]-2-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 7-[(2,5-Dimethylphenyl)sulfanylmethyl]-2-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C16H17N3OS2
    7-[(2,5-Dimethylphenyl)sulfanylmethyl]-2-ethyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 2-methylsulfanyl-N-[[(6S)-1,4-oxazepan-6-yl]methyl]pyrimidin-4-amine —— C11H18N4OS
    2-methylsulfanyl-N-[[(6S)-1,4-oxazepan-6-yl]methyl]pyrimidin-4-amine
    —— 2-methylsulfanyl-N-[[(6R)-1,4-oxazepan-6-yl]methyl]pyrimidin-4-amine —— C11H18N4OS
    2-methylsulfanyl-N-[[(6R)-1,4-oxazepan-6-yl]methyl]pyrimidin-4-amine
    —— [(2S)-4-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]piperazin-2-yl]-pyrrolidin-1-ylmethanone —— C17H24N6O2S
    [(2S)-4-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]piperazin-2-yl]-pyrrolidin-1-ylmethanone
    —— (2R)-N-[(1R,2R,3S)-2,3-dimethylcyclohexyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H28N4OS2
    (2R)-N-[(1R,2R,3S)-2,3-dimethylcyclohexyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-pyrimidin-2-ylsulfanylacetamide —— C12H14N4OS
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-pyrimidin-2-ylsulfanylacetamide
    —— (2R)-N-[(1S,2R,3S)-2,3-dimethylcyclohexyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H28N4OS2
    (2R)-N-[(1S,2R,3S)-2,3-dimethylcyclohexyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide