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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-3-(4-fluorophenyl)-1,3,4-thiadiazole-2-thione —— C13H13FN2O2S3
    5-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-3-(4-fluorophenyl)-1,3,4-thiadiazole-2-thione
    —— 3-[(5-chloro-1,3-dimethylpyrazol-4-yl)methylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C13H18ClN5O2S
    3-[(5-chloro-1,3-dimethylpyrazol-4-yl)methylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— (3R)-1-methyl-3-(3-methylphenyl)sulfanylpyrrolidin-2-one —— C12H15NOS
    (3R)-1-methyl-3-(3-methylphenyl)sulfanylpyrrolidin-2-one
    —— N-cyclopropyl-N-[5-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-yl]acetamide —— C14H22N4OS2
    N-cyclopropyl-N-[5-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-yl]acetamide
    —— N-[[4-(dimethylamino)phenyl]methyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[[(2R)-oxolan-2-yl]methyl]propanamide —— C24H34N4O2S
    N-[[4-(dimethylamino)phenyl]methyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[[(2R)-oxolan-2-yl]methyl]propanamide
    —— N-cyclopropyl-N-[5-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-yl]acetamide —— C14H22N4OS2
    N-cyclopropyl-N-[5-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]-1,3,4-thiadiazol-2-yl]acetamide
    —— (1R)-1-(4-bromophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol —— C11H11BrN2OS2
    (1R)-1-(4-bromophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol
    —— (3S)-3-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1-methylpiperidine —— C14H20N4OS
    (3S)-3-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanylmethyl]-1-methylpiperidine
    —— (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C15H16FN3OS3
    (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— ethyl (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-2-phenylacetate —— C18H15FN2O2S3
    ethyl (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-2-phenylacetate
    —— 2-Ethanimidoyl-4-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxobutanenitrile —— C14H11FN4OS3
    2-Ethanimidoyl-4-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-3-oxobutanenitrile
    —— (2S)-N-cyclopropyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H14FN3OS3
    (2S)-N-cyclopropyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-3-methylbutan-2-yl]acetamide —— C15H18FN3OS3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-3-methylbutan-2-yl]acetamide
    —— 1-(4-Acetylpiperazin-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C16H17FN4O2S3
    1-(4-Acetylpiperazin-1-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— (2S)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C16H14FN3O2S3
    (2S)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
    —— (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C16H14FN3O2S3
    (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
    —— 4-[[4-(4-Fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]butanenitrile —— C12H10FN3S3
    4-[[4-(4-Fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]butanenitrile
    —— N-[(2S)-butan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H16FN3OS3
    N-[(2S)-butan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2S)-N-cyclopentyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H18FN3OS3
    (2S)-N-cyclopentyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)acetamide —— C13H14FN3O2S3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)acetamide
    —— (1S)-1-(4-bromophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol —— C11H11BrN2OS2
    (1S)-1-(4-bromophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propan-2-ylacetamide —— C13H14FN3OS3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propan-2-ylacetamide
    —— N-[(2R)-butan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H16FN3OS3
    N-[(2R)-butan-2-yl]-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-(4-Fluorophenyl)-5-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1,3,4-thiadiazole-2-thione —— C16H10FN3OS4
    3-(4-Fluorophenyl)-5-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1,3,4-thiadiazole-2-thione
    —— 2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-3-methylbutan-2-yl]acetamide —— C15H18FN3OS3
    2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-3-methylbutan-2-yl]acetamide
    —— (2R)-N-cyclopentyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H18FN3OS3
    (2R)-N-cyclopentyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N,N-bis(2-cyanoethyl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H14FN5OS3
    N,N-bis(2-cyanoethyl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-(4-Fluorophenyl)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-thiadiazole-2-thione —— C17H11FN4OS3
    3-(4-Fluorophenyl)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-thiadiazole-2-thione
    —— 3-(4-fluorophenyl)-5-[(1S)-1-phenylethyl]sulfanyl-1,3,4-thiadiazole-2-thione —— C16H13FN2S3
    3-(4-fluorophenyl)-5-[(1S)-1-phenylethyl]sulfanyl-1,3,4-thiadiazole-2-thione
    —— N-(2-cyanoethyl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C13H11FN4OS3
    N-(2-cyanoethyl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N'-acetyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide —— C12H11FN4O2S3
    N'-acetyl-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetohydrazide
    —— 4-[[4-(4-Fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-1-thiophen-2-ylbutan-1-one —— C16H13FN2OS4
    4-[[4-(4-Fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-1-thiophen-2-ylbutan-1-one
    —— 2-[2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-5-ethyl-4-methyl-1H-pyrimidin-6-one —— C15H23N3O3S
    2-[2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-5-ethyl-4-methyl-1H-pyrimidin-6-one
    —— 2-[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-5-ethyl-4-methyl-1H-pyrimidin-6-one —— C15H23N3O3S
    2-[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-5-ethyl-4-methyl-1H-pyrimidin-6-one
    —— 1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H18FN3OS3
    1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-(pyridin-3-ylmethylsulfanyl)-4-(trifluoromethyl)-1H-pyrimidin-6-one —— C11H8F3N3OS
    2-(pyridin-3-ylmethylsulfanyl)-4-(trifluoromethyl)-1H-pyrimidin-6-one
    —— methyl (2S)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate —— C11H16N2O3S
    methyl (2S)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate
    —— diethyl 2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanedioate —— C14H20N2O5S
    diethyl 2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanedioate
    —— 5-ethyl-4-methyl-2-[(3-methylphenyl)methylsulfanyl]-1H-pyrimidin-6-one —— C15H18N2OS
    5-ethyl-4-methyl-2-[(3-methylphenyl)methylsulfanyl]-1H-pyrimidin-6-one
    —— methyl (2R)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate —— C11H16N2O3S
    methyl (2R)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate
    —— 2-[(2,5-dimethylphenyl)methylsulfanyl]-5-ethyl-4-methyl-1H-pyrimidin-6-one —— C16H20N2OS
    2-[(2,5-dimethylphenyl)methylsulfanyl]-5-ethyl-4-methyl-1H-pyrimidin-6-one
    —— (2S)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N,N-dimethyl-3-oxobutanamide —— C13H19N3O3S
    (2S)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N,N-dimethyl-3-oxobutanamide
    —— N-(2-chlorobenzyl)-2-((5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide —— C16H18ClN3O2S
    N-(2-chlorobenzyl)-2-((5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
    —— ethyl (2S)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C13H20N2O3S
    ethyl (2S)-2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— 2-[2-(1,3-dioxan-2-yl)ethylsulfanyl]-5-ethyl-4-methyl-1H-pyrimidin-6-one —— C13H20N2O3S
    2-[2-(1,3-dioxan-2-yl)ethylsulfanyl]-5-ethyl-4-methyl-1H-pyrimidin-6-one
    —— 2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetonitrile —— C9H11N3OS
    2-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetonitrile
    —— 2-(1,3-dioxolan-2-ylmethylsulfanyl)-4,5-dimethyl-1H-pyrimidin-6-one —— C10H14N2O3S
    2-(1,3-dioxolan-2-ylmethylsulfanyl)-4,5-dimethyl-1H-pyrimidin-6-one
    —— ethyl 4-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-3-oxobutanoate —— C13H18N2O4S
    ethyl 4-[(5-ethyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-3-oxobutanoate
    —— 5-ethyl-2-((3-fluorobenzyl)thio)-6-methylpyrimidin-4(3H)-one —— C14H15FN2OS
    5-ethyl-2-((3-fluorobenzyl)thio)-6-methylpyrimidin-4(3H)-one
    —— 2-((4-chlorobenzyl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one —— C12H8ClF3N2OS
    2-((4-chlorobenzyl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one