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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(2-methylphenyl)sulfanyl-N-(2-morpholin-4-ylethyl)acetamide —— C15H22N2O2S
    2-(2-methylphenyl)sulfanyl-N-(2-morpholin-4-ylethyl)acetamide
    —— 3-(Furan-2-yl)-4-methyl-5-(2-methylsulfanylethylsulfanyl)-1,2,4-triazole —— C10H13N3OS2
    3-(Furan-2-yl)-4-methyl-5-(2-methylsulfanylethylsulfanyl)-1,2,4-triazole
    —— 5-[[4-(2-Methylprop-2-enyl)piperazin-1-yl]methyl]-2-methylsulfanylpyrimidine —— C14H22N4S
    5-[[4-(2-Methylprop-2-enyl)piperazin-1-yl]methyl]-2-methylsulfanylpyrimidine
    —— (1S)-1-(furan-2-yl)-N-methyl-N-[(2-methylsulfanylpyrimidin-5-yl)methyl]ethanamine —— C13H17N3OS
    (1S)-1-(furan-2-yl)-N-methyl-N-[(2-methylsulfanylpyrimidin-5-yl)methyl]ethanamine
    —— (1S)-1-ethyl-2-[(2-methylsulfanylpyrimidin-5-yl)methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine —— C15H20N4S
    (1S)-1-ethyl-2-[(2-methylsulfanylpyrimidin-5-yl)methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine
    —— (3R)-1-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]piperidin-3-ol —— C14H17N3O2S
    (3R)-1-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]piperidin-3-ol
    —— (1R)-1-ethyl-2-[(2-methylsulfanylpyrimidin-5-yl)methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine —— C15H20N4S
    (1R)-1-ethyl-2-[(2-methylsulfanylpyrimidin-5-yl)methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine
    —— (3S)-1-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]piperidin-3-ol —— C14H17N3O2S
    (3S)-1-[(5-pyrimidin-2-ylsulfanylfuran-2-yl)methyl]piperidin-3-ol
    —— N,N-dimethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C12H13N3O2S
    N,N-dimethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(Z)-1-(3-aminophenyl)ethylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide —— C15H18N6O3S
    N-[(Z)-1-(3-aminophenyl)ethylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide
    —— N-[(Z)-1-[4-(dimethylamino)phenyl]ethylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide —— C17H22N6O3S
    N-[(Z)-1-[4-(dimethylamino)phenyl]ethylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide
    —— N-[(Z)-1-(4-aminophenyl)ethylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide —— C15H18N6O3S
    N-[(Z)-1-(4-aminophenyl)ethylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide
    —— N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide —— C18H24N6O3S
    N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-2-[(2,4-dimethyl-3,5-dioxo-1,2,4-triazin-6-yl)sulfanyl]acetamide
    —— [2-Oxo-2-(2-phenylsulfanylethylamino)ethyl] 2-anilino-4-oxofuran-3-carboxylate —— C21H20N2O5S
    [2-Oxo-2-(2-phenylsulfanylethylamino)ethyl] 2-anilino-4-oxofuran-3-carboxylate
    —— 2-(2-Fluorophenyl)sulfanylethyl 2-anilino-4-oxofuran-3-carboxylate —— C19H16FNO4S
    2-(2-Fluorophenyl)sulfanylethyl 2-anilino-4-oxofuran-3-carboxylate
    —— 2-[[4-amino-5-(3,5-dimethylpyrazol-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide —— C18H24N8OS
    2-[[4-amino-5-(3,5-dimethylpyrazol-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide
    —— 5-[[(3S)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-propylsulfanylpyrimidine —— C19H25ClN4O2S2
    5-[[(3S)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-propylsulfanylpyrimidine
    —— 5-[[(3R)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-ethylsulfanylpyrimidine —— C18H23ClN4O2S2
    5-[[(3R)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-ethylsulfanylpyrimidine
    —— 2-(3-cyanopyridin-2-yl)sulfanyl-N-[2-(N-ethyl-3-methylanilino)ethyl]acetamide —— C19H22N4OS
    2-(3-cyanopyridin-2-yl)sulfanyl-N-[2-(N-ethyl-3-methylanilino)ethyl]acetamide
    —— 5-[[(3R)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-propylsulfanylpyrimidine —— C19H25ClN4O2S2
    5-[[(3R)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-propylsulfanylpyrimidine
    —— 5-[[(3S)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-ethylsulfanylpyrimidine —— C18H23ClN4O2S2
    5-[[(3S)-3-(5-chloro-3-methylsulfonylpyridin-2-yl)piperidin-1-yl]methyl]-2-ethylsulfanylpyrimidine
    —— N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H25N5OS2
    N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[1-[[1-(4-methylphenyl)cyclopentyl]methyl]piperidin-4-yl]acetamide —— C23H32N4O2S
    2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[1-[[1-(4-methylphenyl)cyclopentyl]methyl]piperidin-4-yl]acetamide
    —— 4-[[3-(2-fluorophenyl)-1,2-oxazol-5-yl]methyl]-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]oxane-4-carboxamide —— C20H23FN6O3S
    4-[[3-(2-fluorophenyl)-1,2-oxazol-5-yl]methyl]-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]oxane-4-carboxamide
    —— 2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[3-(N-methylanilino)propyl]acetamide —— C16H23N5OS2
    2-[[5-(ethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[3-(N-methylanilino)propyl]acetamide
    —— N-[1-[[1-(3-fluorophenyl)cyclopentyl]methyl]piperidin-4-yl]-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C22H29FN4O2S
    N-[1-[[1-(3-fluorophenyl)cyclopentyl]methyl]piperidin-4-yl]-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-ethyl-5-[[2-(4-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H17N5S3
    N-ethyl-5-[[2-(4-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-[[4-(dimethylamino)phenyl]methyl]-N-methyl-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H27N5OS2
    N-[[4-(dimethylamino)phenyl]methyl]-N-methyl-2-[[5-(2-methylpropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C15H16N4OS4
    2-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— N-[2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]acetamide —— C8H13N3OS3
    N-[2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]acetamide
    —— 2-(2,5-Dimethylfuran-3-yl)-5-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C13H14N4O2S3
    2-(2,5-Dimethylfuran-3-yl)-5-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— [5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methyl 2-(2,4-dimethylphenyl)sulfanylacetate —— C19H20N2O4S
    [5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methyl 2-(2,4-dimethylphenyl)sulfanylacetate
    —— N-[3-(3,5-dimethylpyrazol-1-yl)propyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C14H21N5OS3
    N-[3-(3,5-dimethylpyrazol-1-yl)propyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (3-Thiophen-2-yl-1,2,4-oxadiazol-5-yl)methyl 2-(2-fluorophenyl)sulfanylacetate —— C15H11FN2O3S2
    (3-Thiophen-2-yl-1,2,4-oxadiazol-5-yl)methyl 2-(2-fluorophenyl)sulfanylacetate
    —— (4-oxo-3H-quinazolin-2-yl)methyl 2-(2-cyanophenyl)sulfanylbenzoate —— C23H15N3O3S
    (4-oxo-3H-quinazolin-2-yl)methyl 2-(2-cyanophenyl)sulfanylbenzoate
    —— methyl 2-[2-[2-[[(1S)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C17H18ClN3O4S
    methyl 2-[2-[2-[[(1S)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-(2-benzylsulfanyl-6-oxo-1H-pyrimidin-4-yl)acetate —— C14H14N2O3S
    methyl 2-(2-benzylsulfanyl-6-oxo-1H-pyrimidin-4-yl)acetate
    —— 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-cyclopropylacetamide —— C19H22N4OS2
    2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-cyclopropylacetamide
    —— methyl 2-[2-[(1R)-1-cyanoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H11N3O3S
    methyl 2-[2-[(1R)-1-cyanoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2S)-1-amino-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H13N3O4S
    methyl 2-[2-[(2S)-1-amino-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(methylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H13N3O4S
    methyl 2-[2-[2-(methylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(butylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C13H19N3O4S
    methyl 2-[2-[2-(butylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[methyl-[(2-methylphenyl)methyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C18H21N3O4S
    methyl 2-[2-[2-[methyl-[(2-methylphenyl)methyl]amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 5-[(2R)-2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C18H21N3O6S
    methyl 5-[(2R)-2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— methyl 2-[2-[(2R)-1-(cyclopentylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C15H21N3O4S
    methyl 2-[2-[(2R)-1-(cyclopentylamino)-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2R)-1-[[(1R)-1-(4-fluorophenyl)ethyl]amino]-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C18H20FN3O4S
    methyl 2-[2-[(2R)-1-[[(1R)-1-(4-fluorophenyl)ethyl]amino]-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[2-(4-chlorophenyl)ethylamino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C17H18ClN3O4S
    methyl 2-[2-[2-[2-(4-chlorophenyl)ethylamino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2-methylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidin-4-yl]acetate —— C15H16N2O3S
    methyl 2-[2-[(2-methylphenyl)methylsulfanyl]-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2S)-1-[[(1R)-1-(4-fluorophenyl)ethyl]amino]-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C18H20FN3O4S
    methyl 2-[2-[(2S)-1-[[(1R)-1-(4-fluorophenyl)ethyl]amino]-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(1S)-1-cyanoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H11N3O3S
    methyl 2-[2-[(1S)-1-cyanoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate