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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(2,5-Difluorophenyl)methylsulfanyl]-3-piperidin-1-ylpyrazine —— C16H17F2N3S
    2-[(2,5-Difluorophenyl)methylsulfanyl]-3-piperidin-1-ylpyrazine
    —— 2-(3-Piperidin-1-ylpyrazin-2-yl)sulfanylacetonitrile —— C11H14N4S
    2-(3-Piperidin-1-ylpyrazin-2-yl)sulfanylacetonitrile
    —— 2-[3-(3,5-Dimethylpyrazol-1-yl)pyrazin-2-yl]sulfanylacetonitrile —— C11H11N5S
    2-[3-(3,5-Dimethylpyrazol-1-yl)pyrazin-2-yl]sulfanylacetonitrile
    —— 2-[(4-Methylphenyl)methylsulfanyl]-3-pyrazol-1-ylpyrazine —— C15H14N4S
    2-[(4-Methylphenyl)methylsulfanyl]-3-pyrazol-1-ylpyrazine
    —— 2-[(2,5-Difluorophenyl)methylsulfanyl]-3-(3,5-dimethylpyrazol-1-yl)pyrazine —— C16H14F2N4S
    2-[(2,5-Difluorophenyl)methylsulfanyl]-3-(3,5-dimethylpyrazol-1-yl)pyrazine
    —— N-[(5-chlorothiophen-2-yl)methyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylacetamide —— C16H14ClN3O3S2
    N-[(5-chlorothiophen-2-yl)methyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylacetamide
    —— N-benzyl-N-ethyl-2-(3-pyrazol-1-ylpyrazin-2-yl)sulfanylacetamide —— C18H19N5OS
    N-benzyl-N-ethyl-2-(3-pyrazol-1-ylpyrazin-2-yl)sulfanylacetamide
    —— N-[(4-fluorophenyl)methyl]-2-(3-piperidin-1-ylpyrazin-2-yl)sulfanylacetamide —— C18H21FN4OS
    N-[(4-fluorophenyl)methyl]-2-(3-piperidin-1-ylpyrazin-2-yl)sulfanylacetamide
    —— N-[(4-fluorophenyl)methyl]-2-(3-pyrazol-1-ylpyrazin-2-yl)sulfanylacetamide —— C16H14FN5OS
    N-[(4-fluorophenyl)methyl]-2-(3-pyrazol-1-ylpyrazin-2-yl)sulfanylacetamide
    —— 2-Benzylsulfanyl-3-piperidin-1-ylpyrazine —— C16H19N3S
    2-Benzylsulfanyl-3-piperidin-1-ylpyrazine
    —— 2-(3,5-Dimethylpyrazol-1-yl)-3-[(3-fluorophenyl)methylsulfanyl]pyrazine —— C16H15FN4S
    2-(3,5-Dimethylpyrazol-1-yl)-3-[(3-fluorophenyl)methylsulfanyl]pyrazine
    —— N-[(2-fluorophenyl)methyl]-3-[(3-fluorophenyl)methylsulfanyl]pyrazin-2-amine —— C18H15F2N3S
    N-[(2-fluorophenyl)methyl]-3-[(3-fluorophenyl)methylsulfanyl]pyrazin-2-amine
    —— N-[(4-methylphenyl)methyl]-2-(3-pyrazol-1-ylpyrazin-2-yl)sulfanylacetamide —— C17H17N5OS
    N-[(4-methylphenyl)methyl]-2-(3-pyrazol-1-ylpyrazin-2-yl)sulfanylacetamide
    —— 2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide —— C20H25FN4OS
    2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide
    —— 2-[(3,4-difluorophenyl)methylsulfanyl]-4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H21F2N3S
    2-[(3,4-difluorophenyl)methylsulfanyl]-4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— 3-[(3,4-difluorophenyl)methylsulfanyl]-N-[(2-fluorophenyl)methyl]pyrazin-2-amine —— C18H14F3N3S
    3-[(3,4-difluorophenyl)methylsulfanyl]-N-[(2-fluorophenyl)methyl]pyrazin-2-amine
    —— N-[(4-fluorophenyl)methyl]-2-[3-[(2-fluorophenyl)methylamino]pyrazin-2-yl]sulfanylacetamide —— C20H18F2N4OS
    N-[(4-fluorophenyl)methyl]-2-[3-[(2-fluorophenyl)methylamino]pyrazin-2-yl]sulfanylacetamide
    —— N-cyclohexyl-2-[3-[(2-fluorophenyl)methylamino]pyrazin-2-yl]sulfanylacetamide —— C19H23FN4OS
    N-cyclohexyl-2-[3-[(2-fluorophenyl)methylamino]pyrazin-2-yl]sulfanylacetamide
    —— 2-(3-Pyrazol-1-ylpyrazin-2-yl)sulfanylacetonitrile —— C9H7N5S
    2-(3-Pyrazol-1-ylpyrazin-2-yl)sulfanylacetonitrile
    —— N-butyl-2-[3-[(2-fluorophenyl)methylamino]pyrazin-2-yl]sulfanylacetamide —— C17H21FN4OS
    N-butyl-2-[3-[(2-fluorophenyl)methylamino]pyrazin-2-yl]sulfanylacetamide
    —— 2-(3,5-Dimethylpyrazol-1-yl)-3-[(4-methylphenyl)methylsulfanyl]pyrazine —— C17H18N4S
    2-(3,5-Dimethylpyrazol-1-yl)-3-[(4-methylphenyl)methylsulfanyl]pyrazine
    —— 2-[(3-Fluorophenyl)methylsulfanyl]-3-pyrazol-1-ylpyrazine —— C14H11FN4S
    2-[(3-Fluorophenyl)methylsulfanyl]-3-pyrazol-1-ylpyrazine
    —— 4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-2-[(3-fluorophenyl)methylsulfanyl]pyrimidine —— C18H22FN3S
    4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-2-[(3-fluorophenyl)methylsulfanyl]pyrimidine
    —— N-butyl-2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetamide —— C17H28N4OS
    N-butyl-2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetamide
    —— 4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-2-[(4-methylphenyl)methylsulfanyl]pyrimidine —— C19H25N3S
    4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-2-[(4-methylphenyl)methylsulfanyl]pyrimidine
    —— 4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-2-[(4-methylphenyl)methylsulfanyl]pyrimidine —— C19H25N3S
    4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-2-[(4-methylphenyl)methylsulfanyl]pyrimidine
    —— N-[(2-fluorophenyl)methyl]-3-[(4-methylphenyl)methylsulfanyl]pyrazin-2-amine —— C19H18FN3S
    N-[(2-fluorophenyl)methyl]-3-[(4-methylphenyl)methylsulfanyl]pyrazin-2-amine
    —— 2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetonitrile —— C13H18N4S
    2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetonitrile
    —— 2-benzylsulfanyl-4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H23N3S
    2-benzylsulfanyl-4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— 2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetonitrile —— C13H18N4S
    2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetonitrile
    —— 2-[(2,5-difluorophenyl)methylsulfanyl]-4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H21F2N3S
    2-[(2,5-difluorophenyl)methylsulfanyl]-4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— methyl 2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetate —— C14H21N3O2S
    methyl 2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetate
    —— 2-benzylsulfanyl-4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H23N3S
    2-benzylsulfanyl-4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— 3-benzylsulfanyl-N-[(2-fluorophenyl)methyl]pyrazin-2-amine —— C18H16FN3S
    3-benzylsulfanyl-N-[(2-fluorophenyl)methyl]pyrazin-2-amine
    —— 4-[(3,4-Difluorophenyl)methylsulfanyl]-6-(3,5-dimethylpyrazol-1-yl)pyrimidine —— C16H14F2N4S
    4-[(3,4-Difluorophenyl)methylsulfanyl]-6-(3,5-dimethylpyrazol-1-yl)pyrimidine
    —— N-benzyl-2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-ethylacetamide —— C22H30N4OS
    N-benzyl-2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-ethylacetamide
    —— methyl 2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetate —— C14H21N3O2S
    methyl 2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetate
    —— 4-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-2-[(3-fluorophenyl)methylsulfanyl]pyrimidine —— C18H22FN3S
    4-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-2-[(3-fluorophenyl)methylsulfanyl]pyrimidine
    —— 2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide —— C21H28N4OS
    2-[4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
    —— 2-[(2,5-difluorophenyl)methylsulfanyl]-4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H21F2N3S
    2-[(2,5-difluorophenyl)methylsulfanyl]-4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— 4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-2-[(3-fluorophenyl)methylsulfanyl]pyrimidine —— C18H22FN3S
    4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-2-[(3-fluorophenyl)methylsulfanyl]pyrimidine
    —— 2-[(3,4-difluorophenyl)methylsulfanyl]-4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H21F2N3S
    2-[(3,4-difluorophenyl)methylsulfanyl]-4-[(3S,5S)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— N-benzyl-2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-ethylacetamide —— C22H30N4OS
    N-benzyl-2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-ethylacetamide
    —— N-butyl-2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetamide —— C17H28N4OS
    N-butyl-2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetamide
    —— methyl 2-[4-[(3S,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetate —— C14H21N3O2S
    methyl 2-[4-[(3S,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanylacetate
    —— 2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide —— C21H28N4OS
    2-[4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-methylphenyl)methyl]acetamide
    —— 4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-2-[(4-methylphenyl)methylsulfanyl]pyrimidine —— C19H25N3S
    4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-2-[(4-methylphenyl)methylsulfanyl]pyrimidine
    —— 2-[(2,5-difluorophenyl)methylsulfanyl]-4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidine —— C18H21F2N3S
    2-[(2,5-difluorophenyl)methylsulfanyl]-4-[(3R,5R)-3,5-dimethylpiperidin-1-yl]pyrimidine
    —— N-butyl-2-[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]sulfanylacetamide —— C15H21N5OS
    N-butyl-2-[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]sulfanylacetamide
    —— 2-[4-[(3S,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide —— C20H25FN4OS
    2-[4-[(3S,5R)-3,5-dimethylpiperidin-1-yl]pyrimidin-2-yl]sulfanyl-N-[(4-fluorophenyl)methyl]acetamide