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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(4-chlorophenyl)-5-[(1R)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12ClFN2OS
    2-(4-chlorophenyl)-5-[(1R)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-(4-chlorophenyl)-5-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12ClFN2OS
    2-(4-chlorophenyl)-5-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— N-[2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]-1-methylpyrrole-2-carboxamide —— C16H13ClN4O3S
    N-[2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]-1-methylpyrrole-2-carboxamide
    —— 2-(4-Chlorophenyl)-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole —— C19H14ClN3OS2
    2-(4-Chlorophenyl)-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,3,4-oxadiazole
    —— ethyl (2R)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-phenylacetate —— C18H15ClN2O3S
    ethyl (2R)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-phenylacetate
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-(3,4-dimethylphenyl)ethyl]acetamide —— C20H20ClN3O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-(3,4-dimethylphenyl)ethyl]acetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N-bis(2-cyanoethyl)acetamide —— C16H14ClN5O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N-bis(2-cyanoethyl)acetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide —— C17H13ClFN3O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide
    —— 3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazole —— C21H24ClN3S2
    3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazole
    —— 3-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazole —— C21H24ClN3S2
    3-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-4-cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazole
    —— 3-[[4-Cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanenitrile —— C16H20N4S2
    3-[[4-Cyclohexyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]propanenitrile
    —— 4-propyl-3-[(1R)-2,2,2-trifluoro-1-[(2S)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C11H16F3N3O2S
    4-propyl-3-[(1R)-2,2,2-trifluoro-1-[(2S)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 4-propyl-3-[(1S)-2,2,2-trifluoro-1-[(2S)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C11H16F3N3O2S
    4-propyl-3-[(1S)-2,2,2-trifluoro-1-[(2S)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— (3S)-3-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one —— C13H13F3N4O2S
    (3S)-3-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
    —— (3R)-1-(2,2,2-trifluoroethyl)-3-[1-(2,2,2-trifluoroethyl)tetrazol-5-yl]sulfanylpyrrolidin-2-one —— C9H9F6N5OS
    (3R)-1-(2,2,2-trifluoroethyl)-3-[1-(2,2,2-trifluoroethyl)tetrazol-5-yl]sulfanylpyrrolidin-2-one
    —— (3S)-3-(5-methylpyridin-2-yl)sulfanyl-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one —— C12H13F3N2OS
    (3S)-3-(5-methylpyridin-2-yl)sulfanyl-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
    —— (3R)-3-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one —— C13H13F3N4O2S
    (3R)-3-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
    —— (3S)-1-(2,2,2-trifluoroethyl)-3-[1-(2,2,2-trifluoroethyl)tetrazol-5-yl]sulfanylpyrrolidin-2-one —— C9H9F6N5OS
    (3S)-1-(2,2,2-trifluoroethyl)-3-[1-(2,2,2-trifluoroethyl)tetrazol-5-yl]sulfanylpyrrolidin-2-one
    —— (3R)-3-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one —— C11H13F3N4OS2
    (3R)-3-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
    —— 4-propyl-3-[(1S)-2,2,2-trifluoro-1-[(2R)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C11H16F3N3O2S
    4-propyl-3-[(1S)-2,2,2-trifluoro-1-[(2R)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— (3S)-3-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one —— C11H13F3N4OS2
    (3S)-3-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
    —— 4-propyl-3-[(1R)-2,2,2-trifluoro-1-[(2R)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C11H16F3N3O2S
    4-propyl-3-[(1R)-2,2,2-trifluoro-1-[(2R)-oxolan-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 2-(3,4-dimethylphenyl)acetate —— C24H23NO3S
    [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 2-(3,4-dimethylphenyl)acetate
    —— 2-[[4-methyl-5-[(3S)-piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]-4-(trifluoromethyl)pyrimidine —— C13H15F3N6S
    2-[[4-methyl-5-[(3S)-piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]-4-(trifluoromethyl)pyrimidine
    —— 1-[2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]ethyl]-4-(2-phenylsulfanylethyl)piperazine —— C20H33N3S
    1-[2-[(2S,5R)-2,5-dimethylpyrrolidin-1-yl]ethyl]-4-(2-phenylsulfanylethyl)piperazine
    —— [(2S)-1-(2-phenylsulfanylethyl)pyrrolidin-2-yl]methanesulfonamide —— C13H20N2O2S2
    [(2S)-1-(2-phenylsulfanylethyl)pyrrolidin-2-yl]methanesulfonamide
    —— 1-[2-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]ethyl]-4-(2-phenylsulfanylethyl)piperazine —— C20H33N3S
    1-[2-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]ethyl]-4-(2-phenylsulfanylethyl)piperazine
    —— (3R)-3-(5-methylpyridin-2-yl)sulfanyl-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one —— C12H13F3N2OS
    (3R)-3-(5-methylpyridin-2-yl)sulfanyl-1-(2,2,2-trifluoroethyl)pyrrolidin-2-one
    —— N-[[(3S)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methyl]methanesulfonamide —— C15H24N2O2S2
    N-[[(3S)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methyl]methanesulfonamide
    —— (2S)-2-methyl-4-[1-(2-phenylsulfanylethyl)piperidin-4-yl]morpholine —— C18H28N2OS
    (2S)-2-methyl-4-[1-(2-phenylsulfanylethyl)piperidin-4-yl]morpholine
    —— [(3S)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methanesulfonamide —— C14H22N2O2S2
    [(3S)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methanesulfonamide
    —— N-[[(2R)-4-[3-(2-chlorophenyl)sulfanylpropyl]morpholin-2-yl]methyl]acetamide —— C16H23ClN2O2S
    N-[[(2R)-4-[3-(2-chlorophenyl)sulfanylpropyl]morpholin-2-yl]methyl]acetamide
    —— [(3R)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methanesulfonamide —— C14H22N2O2S2
    [(3R)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methanesulfonamide
    —— N-[[(3R)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methyl]methanesulfonamide —— C15H24N2O2S2
    N-[[(3R)-1-(2-phenylsulfanylethyl)piperidin-3-yl]methyl]methanesulfonamide
    —— [(2R)-1-(2-phenylsulfanylethyl)pyrrolidin-2-yl]methanesulfonamide —— C13H20N2O2S2
    [(2R)-1-(2-phenylsulfanylethyl)pyrrolidin-2-yl]methanesulfonamide
    —— (2R)-2-methyl-4-[1-(2-phenylsulfanylethyl)piperidin-4-yl]morpholine —— C18H28N2OS
    (2R)-2-methyl-4-[1-(2-phenylsulfanylethyl)piperidin-4-yl]morpholine
    —— N-[[(2S)-4-[3-(2-chlorophenyl)sulfanylpropyl]morpholin-2-yl]methyl]acetamide —— C16H23ClN2O2S
    N-[[(2S)-4-[3-(2-chlorophenyl)sulfanylpropyl]morpholin-2-yl]methyl]acetamide
    —— 2-[[4-methyl-5-[(3R)-piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]-4-(trifluoromethyl)pyrimidine —— C13H15F3N6S
    2-[[4-methyl-5-[(3R)-piperidin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]-4-(trifluoromethyl)pyrimidine
    —— ethyl 2-[2-[(1S)-1-pyridin-4-ylethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C14H16N2O2S2
    ethyl 2-[2-[(1S)-1-pyridin-4-ylethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— ethyl 2-[2-[(1R)-1-pyridin-4-ylethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C14H16N2O2S2
    ethyl 2-[2-[(1R)-1-pyridin-4-ylethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— methyl (2S)-2-[(5-ethyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-fluorophenyl)acetate —— C14H16FN3O2S
    methyl (2S)-2-[(5-ethyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-fluorophenyl)acetate
    —— methyl (2S)-2-(4-fluorophenyl)-2-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H14FN3O3S
    methyl (2S)-2-(4-fluorophenyl)-2-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— methyl (2R)-2-(4-fluorophenyl)-2-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H14FN3O3S
    methyl (2R)-2-(4-fluorophenyl)-2-[[4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— methyl (2R)-2-[(5-ethyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-fluorophenyl)acetate —— C14H16FN3O2S
    methyl (2R)-2-[(5-ethyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-fluorophenyl)acetate
    —— 2-(3-chlorophenyl)-5-[(1R)-1-(1,3-thiazol-2-ylsulfanyl)ethyl]-1,3,4-oxadiazole —— C13H10ClN3OS2
    2-(3-chlorophenyl)-5-[(1R)-1-(1,3-thiazol-2-ylsulfanyl)ethyl]-1,3,4-oxadiazole
    —— 2-(3-chlorophenyl)-5-[(1S)-1-(1,3-thiazol-2-ylsulfanyl)ethyl]-1,3,4-oxadiazole —— C13H10ClN3OS2
    2-(3-chlorophenyl)-5-[(1S)-1-(1,3-thiazol-2-ylsulfanyl)ethyl]-1,3,4-oxadiazole
    —— N-[(2R)-2-cyanopropyl]-1-phenylsulfanylcyclopentane-1-carboxamide —— C16H20N2OS
    N-[(2R)-2-cyanopropyl]-1-phenylsulfanylcyclopentane-1-carboxamide
    —— [2-Oxo-2-(propylamino)ethyl] 2-[(4-benzyl-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]acetate —— C19H24N4O3S
    [2-Oxo-2-(propylamino)ethyl] 2-[(4-benzyl-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— (2R)-3-methyl-N-(pyridin-3-ylmethyl)-2-thiophen-2-ylsulfanylbutanamide —— C15H18N2OS2
    (2R)-3-methyl-N-(pyridin-3-ylmethyl)-2-thiophen-2-ylsulfanylbutanamide
    —— N-[(2S)-2-cyanopropyl]-1-phenylsulfanylcyclopentane-1-carboxamide —— C16H20N2OS
    N-[(2S)-2-cyanopropyl]-1-phenylsulfanylcyclopentane-1-carboxamide