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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-[1-[(3S)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C23H27N3O4S2
    1-[1-[(3S)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-[(4-bromophenyl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C18H17BrN2OS
    2-[(4-bromophenyl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-methyl-5-[2-[(2R)-1-methylpiperidin-2-yl]ethylsulfanyl]-1,3,4-thiadiazole —— C11H19N3S2
    2-methyl-5-[2-[(2R)-1-methylpiperidin-2-yl]ethylsulfanyl]-1,3,4-thiadiazole
    —— N-(cyclopropylcarbamoyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H19N5O2S2
    N-(cyclopropylcarbamoyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(3-chlorophenyl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C18H17ClN2OS
    2-[(3-chlorophenyl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 4-(3-methoxypropyl)-3-[(1R)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H19N3O2S
    4-(3-methoxypropyl)-3-[(1R)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-phenyl-1,3,4-thiadiazol-2-amine —— C15H11N5O2S2
    5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-phenyl-1,3,4-thiadiazol-2-amine
    —— N-butyl-2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C18H27NO3S2
    N-butyl-2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-[(3-fluorophenyl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C18H17FN2OS
    2-[(3-fluorophenyl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— N-(4-ethylphenyl)-5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-amine —— C13H15N3S2
    N-(4-ethylphenyl)-5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-amine
    —— (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C19H25N5OS2
    (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-[(1R)-1-cyano-1-cyclopropylethyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H21N5OS2
    N-[(1R)-1-cyano-1-cyclopropylethyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 4-methyl-2-[(1R)-1-phenylethyl]sulfanyl-1,3-thiazole —— C12H13NS2
    4-methyl-2-[(1R)-1-phenylethyl]sulfanyl-1,3-thiazole
    —— (2S)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate —— C11H8ClN2O3S-
    (2S)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate
    —— 4-benzyl-3-cyclopropyl-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazole —— C20H21N3S
    4-benzyl-3-cyclopropyl-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazole
    —— N-butyl-2-(3,4-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C18H27NO3S2
    N-butyl-2-(3,4-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— 1-[1-[(3R)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C23H27N3O4S2
    1-[1-[(3R)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-(3,4-dimethylphenyl)sulfanyl-1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C20H27NO2S
    2-(3,4-dimethylphenyl)sulfanyl-1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— N-ethyl-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylprop-2-enyl)acetamide —— C18H24N4OS2
    N-ethyl-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylprop-2-enyl)acetamide
    —— (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-1-yl)propan-1-one —— C19H27N5OS2
    (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-1-yl)propan-1-one
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide —— C18H20N4OS3
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C18H20N4OS3
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— N-(4-ethylphenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H15N5O2S2
    N-(4-ethylphenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]-N-methylacetamide —— C20H21FN4OS2
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]-N-methylacetamide
    —— 4-[[(2S)-oxolan-2-yl]methyl]-3-(2-oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1H-1,2,4-triazol-5-one —— C13H20N4O3S
    4-[[(2S)-oxolan-2-yl]methyl]-3-(2-oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1H-1,2,4-triazol-5-one
    —— N-butyl-2-(2,5-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C18H27NO3S2
    N-butyl-2-(2,5-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H21N5OS2
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-(2-methylfuran-3-yl)-5-[(1S)-1-phenylethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazole —— C18H19N3OS
    3-(2-methylfuran-3-yl)-5-[(1S)-1-phenylethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazole
    —— (2R)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate —— C11H8ClN2O3S-
    (2R)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate
    —— (1S,2R,6S,7S,9S,12R)-5-benzyl-12-phenyl-7-phenylsulfanyl-3,8,11,13-tetraoxa-5-azatricyclo[7.4.0.02,6]tridecan-4-one —— C27H25NO5S
    (1S,2R,6S,7S,9S,12R)-5-benzyl-12-phenyl-7-phenylsulfanyl-3,8,11,13-tetraoxa-5-azatricyclo[7.4.0.02,6]tridecan-4-one
    —— 4-[[(2R)-oxolan-2-yl]methyl]-3-(2-oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1H-1,2,4-triazol-5-one —— C13H20N4O3S
    4-[[(2R)-oxolan-2-yl]methyl]-3-(2-oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1H-1,2,4-triazol-5-one
    —— 4-(3-methoxypropyl)-3-[(1S)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H19N3O2S
    4-(3-methoxypropyl)-3-[(1S)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 2-[[4-amino-5-[(1R)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N,N-diethylacetamide —— C16H23N5OS2
    2-[[4-amino-5-[(1R)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N,N-diethylacetamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-propylacetamide —— C17H25NO3S2
    2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-propylacetamide
    —— (2S)-N-benzyl-2-(2,5-dimethylphenyl)sulfanyl-N-methylpropanamide —— C19H23NOS
    (2S)-N-benzyl-2-(2,5-dimethylphenyl)sulfanyl-N-methylpropanamide
    —— N-butyl-2-(3,4-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C18H27NO3S2
    N-butyl-2-(3,4-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— 3-(2-methylfuran-3-yl)-5-[(1R)-1-phenylethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazole —— C18H19N3OS
    3-(2-methylfuran-3-yl)-5-[(1R)-1-phenylethyl]sulfanyl-4-prop-2-enyl-1,2,4-triazole
    —— 2-methyl-5-[2-[(2S)-1-methylpiperidin-2-yl]ethylsulfanyl]-1,3,4-thiadiazole —— C11H19N3S2
    2-methyl-5-[2-[(2S)-1-methylpiperidin-2-yl]ethylsulfanyl]-1,3,4-thiadiazole
    —— 4-benzyl-3-cyclopropyl-5-[(1R)-1-phenylethyl]sulfanyl-1,2,4-triazole —— C20H21N3S
    4-benzyl-3-cyclopropyl-5-[(1R)-1-phenylethyl]sulfanyl-1,2,4-triazole
    —— 2-[[5-[(1S)-1-phenylethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H13N3OS3
    2-[[5-[(1S)-1-phenylethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-[(1R)-1-phenylethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H13N3OS3
    2-[[5-[(1R)-1-phenylethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-butyl-2-(2,4-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C18H27NO3S2
    N-butyl-2-(2,4-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— (1R,2R,6S,7S,9S,12R)-5-benzyl-12-phenyl-7-phenylsulfanyl-3,8,11,13-tetraoxa-5-azatricyclo[7.4.0.02,6]tridecan-4-one —— C27H25NO5S
    (1R,2R,6S,7S,9S,12R)-5-benzyl-12-phenyl-7-phenylsulfanyl-3,8,11,13-tetraoxa-5-azatricyclo[7.4.0.02,6]tridecan-4-one
    —— 2-[[4-amino-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N,N-diethylacetamide —— C16H23N5OS2
    2-[[4-amino-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]sulfanyl]-N,N-diethylacetamide
    —— 2-(2-Fluorophenyl)-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole —— C18H12FN3OS2
    2-(2-Fluorophenyl)-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[2-[2,5-dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C18H20N4O2S2
    2-[2-[2,5-dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— 2-[2-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]sulfanylbenzonitrile —— C23H18N2OS
    2-[2-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]sulfanylbenzonitrile
    —— (3R)-3-[[5-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-1,3,4-oxadiazol-2-yl]methyl]thiolane 1,1-dioxide —— C16H19ClN2O3S3
    (3R)-3-[[5-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-1,3,4-oxadiazol-2-yl]methyl]thiolane 1,1-dioxide
    —— (3S)-3-[5-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C16H20ClN3O2S3
    (3S)-3-[5-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— (3S)-3-[[5-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide —— C17H22ClN3O2S3
    (3S)-3-[[5-[3-(2-chlorophenyl)sulfanylpropylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide