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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-Methyl-2-[(2-methylphenyl)methylsulfanyl]-6-propylpyrimidin-4-one —— C16H20N2OS
    3-Methyl-2-[(2-methylphenyl)methylsulfanyl]-6-propylpyrimidin-4-one
    —— (3S)-3-[[5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]oxolan-2-one —— C13H11FN2O3S
    (3S)-3-[[5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]oxolan-2-one
    —— 2-[(2-fluorophenyl)methyl]-5-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C14H13FN4O2S
    2-[(2-fluorophenyl)methyl]-5-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— ethyl (2S)-2-[[5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate —— C14H15FN2O3S
    ethyl (2S)-2-[[5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate
    —— (2R)-2-[[5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N,3-trimethylbutanamide —— C16H20FN3O2S
    (2R)-2-[[5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N,3-trimethylbutanamide
    —— 2-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazole —— C17H14F2N2OS
    2-[(1S)-1-(2-fluorophenyl)ethyl]sulfanyl-5-[(2-fluorophenyl)methyl]-1,3,4-oxadiazole
    —— 2-[(2-fluorophenyl)methyl]-5-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C14H13FN4O2S
    2-[(2-fluorophenyl)methyl]-5-[(1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-[(2-fluorophenyl)methyl]-5-[(1S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C14H13FN4O2S
    2-[(2-fluorophenyl)methyl]-5-[(1S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-[(2-fluorophenyl)methyl]-5-[(1R)-1-(5-methyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C14H13FN4O2S
    2-[(2-fluorophenyl)methyl]-5-[(1R)-1-(5-methyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-(4-chloro-6-pyrrolidin-1-ylpyrimidin-2-yl)sulfanyl-N-(2-piperidin-1-ium-1-ylethyl)acetamide —— C17H27ClN5OS+
    2-(4-chloro-6-pyrrolidin-1-ylpyrimidin-2-yl)sulfanyl-N-(2-piperidin-1-ium-1-ylethyl)acetamide
    —— 2-{[(4-Fluorophenyl)methyl]sulfanyl}-3,6-dimethyl-5-[(2-methylphenyl)methyl]-3,4-dihydropyrimidin-4-one —— C21H21FN2OS
    2-{[(4-Fluorophenyl)methyl]sulfanyl}-3,6-dimethyl-5-[(2-methylphenyl)methyl]-3,4-dihydropyrimidin-4-one
    —— (6R)-6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-one —— C5H7N3OS
    (6R)-6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-one
    —— 6-Tert-butyl-2-[(3-chlorophenyl)methylsulfanyl]-3-methylpyrimidin-4-one —— C16H19ClN2OS
    6-Tert-butyl-2-[(3-chlorophenyl)methylsulfanyl]-3-methylpyrimidin-4-one
    —— (6S)-6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-one —— C5H7N3OS
    (6S)-6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-one
    —— 6-[[2-[4-Chloro-6-[methyl(propyl)amino]pyrimidin-2-yl]sulfanylacetyl]amino]hexylazanium —— C16H29ClN5OS+
    6-[[2-[4-Chloro-6-[methyl(propyl)amino]pyrimidin-2-yl]sulfanylacetyl]amino]hexylazanium
    —— methyl (4R)-2,7,7-trimethyl-4-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-oxo-4,4a,6,8-tetrahydroquinoline-3-carboxylate —— C20H25NO3S2
    methyl (4R)-2,7,7-trimethyl-4-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-oxo-4,4a,6,8-tetrahydroquinoline-3-carboxylate
    —— methyl (4S)-2,7,7-trimethyl-4-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-oxo-4,4a,6,8-tetrahydroquinoline-3-carboxylate —— C20H25NO3S2
    methyl (4S)-2,7,7-trimethyl-4-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-oxo-4,4a,6,8-tetrahydroquinoline-3-carboxylate
    —— ethyl (4R)-4-(5-ethyl-2-ethylsulfanylthiophen-3-yl)-2-methyl-5-oxo-4a,6,7,8-tetrahydro-4H-quinoline-3-carboxylate —— C21H27NO3S2
    ethyl (4R)-4-(5-ethyl-2-ethylsulfanylthiophen-3-yl)-2-methyl-5-oxo-4a,6,7,8-tetrahydro-4H-quinoline-3-carboxylate
    —— (2S)-N-(1H-imidazol-2-ylmethyl)-N-methyl-2-(4-methylphenyl)sulfanylpropanamide —— C15H19N3OS
    (2S)-N-(1H-imidazol-2-ylmethyl)-N-methyl-2-(4-methylphenyl)sulfanylpropanamide
    —— (2R)-N-(1H-imidazol-2-ylmethyl)-N-methyl-2-(4-methylphenyl)sulfanylpropanamide —— C15H19N3OS
    (2R)-N-(1H-imidazol-2-ylmethyl)-N-methyl-2-(4-methylphenyl)sulfanylpropanamide
    —— (NE)-N-(4-methoxy-5,7,8,9-tetrahydropyrimido[4,5-b][1,4]benzothiazin-6-ylidene)hydroxylamine —— C11H12N4O2S
    (NE)-N-(4-methoxy-5,7,8,9-tetrahydropyrimido[4,5-b][1,4]benzothiazin-6-ylidene)hydroxylamine
    —— 2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R)-2-pyridin-2-ylpyrrolidin-1-yl]ethanone —— C14H17N5OS
    2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R)-2-pyridin-2-ylpyrrolidin-1-yl]ethanone
    —— Methyl 2-[5-[(4-fluorophenyl)methyl]-1,4-dimethyl-6-oxopyrimidin-2-yl]sulfanylacetate —— C16H17FN2O3S
    Methyl 2-[5-[(4-fluorophenyl)methyl]-1,4-dimethyl-6-oxopyrimidin-2-yl]sulfanylacetate
    —— methyl (2S)-2-[4-ethyl-1-methyl-5-[(3-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate —— C19H24N2O3S
    methyl (2S)-2-[4-ethyl-1-methyl-5-[(3-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate
    —— methyl (2R)-2-[4-ethyl-1-methyl-5-[(3-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate —— C19H24N2O3S
    methyl (2R)-2-[4-ethyl-1-methyl-5-[(3-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate
    —— (4S)-6-methyl-2-oxo-N-(2-pyridin-2-ylsulfanylethyl)-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide —— C17H18N4O2S2
    (4S)-6-methyl-2-oxo-N-(2-pyridin-2-ylsulfanylethyl)-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
    —— (4R)-6-methyl-2-oxo-N-(2-pyridin-2-ylsulfanylethyl)-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide —— C17H18N4O2S2
    (4R)-6-methyl-2-oxo-N-(2-pyridin-2-ylsulfanylethyl)-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
    —— ethyl (4S)-5-cyano-2-methyl-4-(4-methylsulfanylphenyl)-6-pyrrol-1-yl-4H-pyran-3-carboxylate —— C21H20N2O3S
    ethyl (4S)-5-cyano-2-methyl-4-(4-methylsulfanylphenyl)-6-pyrrol-1-yl-4H-pyran-3-carboxylate
    —— ethyl (4R)-5-cyano-2-methyl-4-(4-methylsulfanylphenyl)-6-pyrrol-1-yl-4H-pyran-3-carboxylate —— C21H20N2O3S
    ethyl (4R)-5-cyano-2-methyl-4-(4-methylsulfanylphenyl)-6-pyrrol-1-yl-4H-pyran-3-carboxylate
    —— (2S)-N-[2-(4-chlorophenyl)sulfanylphenyl]oxolane-2-carboxamide —— C17H16ClNO2S
    (2S)-N-[2-(4-chlorophenyl)sulfanylphenyl]oxolane-2-carboxamide
    —— N-(4-methylpiperazin-4-ium-1-yl)-2-phenylsulfanylacetamide —— C13H20N3OS+
    N-(4-methylpiperazin-4-ium-1-yl)-2-phenylsulfanylacetamide
    —— N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-pyridin-4-ylethyl]acetamide —— C13H16N4OS2
    N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-pyridin-4-ylethyl]acetamide
    —— N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R)-1-pyridin-4-ylethyl]acetamide —— C13H16N4OS2
    N-methyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R)-1-pyridin-4-ylethyl]acetamide
    —— 1-[4-[(2R)-oxolane-2-carbonyl]piperazin-1-yl]-2-phenylsulfanylethanone —— C17H22N2O3S
    1-[4-[(2R)-oxolane-2-carbonyl]piperazin-1-yl]-2-phenylsulfanylethanone
    —— 1-[4-[(2S)-oxolane-2-carbonyl]piperazin-1-yl]-2-phenylsulfanylethanone —— C17H22N2O3S
    1-[4-[(2S)-oxolane-2-carbonyl]piperazin-1-yl]-2-phenylsulfanylethanone
    —— 2-(5-Benzyl-6-methyl-2-phenylpyrimidin-4-yl)sulfanylacetate —— C20H17N2O2S-
    2-(5-Benzyl-6-methyl-2-phenylpyrimidin-4-yl)sulfanylacetate
    —— (2R)-2-phenyl-2-phenylsulfanylacetate —— C14H11O2S-
    (2R)-2-phenyl-2-phenylsulfanylacetate
    —— (2S)-2-phenyl-2-phenylsulfanylacetate —— C14H11O2S-
    (2S)-2-phenyl-2-phenylsulfanylacetate
    —— 2-(4-methoxyphenoxy)-N-[(Z)-(5-phenylsulfanylfuran-2-yl)methylideneamino]acetamide —— C20H18N2O4S
    2-(4-methoxyphenoxy)-N-[(Z)-(5-phenylsulfanylfuran-2-yl)methylideneamino]acetamide
    —— (4R)-4-methyl-11-propan-2-yl-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C12H18N4OS
    (4R)-4-methyl-11-propan-2-yl-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (4S)-4-methyl-11-propan-2-yl-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C12H18N4OS
    (4S)-4-methyl-11-propan-2-yl-5-thia-2,7,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— (5R)-3-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-phenyl-4,5-dihydro-1,2-oxazole —— C15H15NOS2
    (5R)-3-(5-methyl-2-methylsulfanylthiophen-3-yl)-5-phenyl-4,5-dihydro-1,2-oxazole
    —— (1'S,2S,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H16N4O2S
    (1'S,2S,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (1'S,2S,4S,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H17N4O2S+
    (1'S,2S,4S,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (1'S,2R,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H17N4O2S+
    (1'S,2R,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (1'S,2S,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H17N4O2S+
    (1'S,2S,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (1'S,2R,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H16N4O2S
    (1'S,2R,4R,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (5aS,8R,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione —— C13H19NS3
    (5aS,8R,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione
    —— (1'S,2R,4S,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C17H17N4O2S+
    (1'S,2R,4S,5'R,6'R)-2'-amino-4-methyl-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azoniabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— (5aR,8R,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione —— C13H19NS3
    (5aR,8R,9aR)-5,5,8-trimethyl-5a,6,7,8,9,9a-hexahydro-3H-isothiochromeno[3,4-d][1,3]thiazole-2-thione