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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-[(1R)-1-(3,4-difluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole —— C11H10F2N2OS
    5-[(1R)-1-(3,4-difluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole
    —— 5-[(1S)-1-(3,4-difluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole —— C11H10F2N2OS
    5-[(1S)-1-(3,4-difluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole
    —— (2S)-2-(2-ethoxyethoxy)-N-(2-pyridin-2-ylsulfanylpyridin-4-yl)propanamide —— C17H21N3O3S
    (2S)-2-(2-ethoxyethoxy)-N-(2-pyridin-2-ylsulfanylpyridin-4-yl)propanamide
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-[(2R)-1-methoxypropan-2-yl]acetamide —— C14H21NO2S
    2-(2,4-dimethylphenyl)sulfanyl-N-[(2R)-1-methoxypropan-2-yl]acetamide
    —— (2R)-2-(2-ethoxyethoxy)-N-(2-pyridin-2-ylsulfanylpyridin-4-yl)propanamide —— C17H21N3O3S
    (2R)-2-(2-ethoxyethoxy)-N-(2-pyridin-2-ylsulfanylpyridin-4-yl)propanamide
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-[(2S)-1-methoxypropan-2-yl]acetamide —— C14H21NO2S
    2-(2,4-dimethylphenyl)sulfanyl-N-[(2S)-1-methoxypropan-2-yl]acetamide
    —— N-[(S)-phenyl(pyridin-4-yl)methyl]-2-phenylsulfanylacetamide —— C20H18N2OS
    N-[(S)-phenyl(pyridin-4-yl)methyl]-2-phenylsulfanylacetamide
    —— 5-[(1R)-1-(4-fluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole —— C11H11FN2OS
    5-[(1R)-1-(4-fluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole
    —— 5-[(1S)-1-(4-fluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole —— C11H11FN2OS
    5-[(1S)-1-(4-fluorophenyl)sulfanylethyl]-3-methyl-1,2,4-oxadiazole
    —— (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]oxolane-2-carboxamide —— C13H12ClN3O2S2
    (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]oxolane-2-carboxamide
    —— [7,7-Dimethyl-4-(methylamino)-6,8-dihydropyrimido[4,5-b][1,4]benzothiazin-9-yl]-hexylazanium —— C19H30N5S+
    [7,7-Dimethyl-4-(methylamino)-6,8-dihydropyrimido[4,5-b][1,4]benzothiazin-9-yl]-hexylazanium
    —— (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]oxolane-2-carboxamide —— C13H12ClN3O2S2
    (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]oxolane-2-carboxamide
    —— (3R)-N-[3-(4-fluorophenyl)sulfanylpropyl]oxolane-3-carboxamide —— C14H18FNO2S
    (3R)-N-[3-(4-fluorophenyl)sulfanylpropyl]oxolane-3-carboxamide
    —— (3S)-N-[3-(4-fluorophenyl)sulfanylpropyl]oxolane-3-carboxamide —— C14H18FNO2S
    (3S)-N-[3-(4-fluorophenyl)sulfanylpropyl]oxolane-3-carboxamide
    —— 2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone —— C17H16N4O2S4
    2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone —— C17H16N4O2S4
    2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-(4-chlorophenyl)sulfanyl-N-[(S)-phenyl(pyridin-2-yl)methyl]acetamide —— C20H17ClN2OS
    2-(4-chlorophenyl)sulfanyl-N-[(S)-phenyl(pyridin-2-yl)methyl]acetamide
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-3-phenylsulfanylpropanamide —— C14H19NO3S2
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-3-phenylsulfanylpropanamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(R)-phenyl(pyridin-2-yl)methyl]acetamide —— C20H17ClN2OS
    2-(4-chlorophenyl)sulfanyl-N-[(R)-phenyl(pyridin-2-yl)methyl]acetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(S)-phenyl(pyridin-2-yl)methyl]acetamide —— C22H17ClN4O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(S)-phenyl(pyridin-2-yl)methyl]acetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(R)-phenyl(pyridin-2-yl)methyl]acetamide —— C22H17ClN4O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(R)-phenyl(pyridin-2-yl)methyl]acetamide
    —— (2R)-N-ethyl-2-(4-hydroxyphenyl)sulfanyl-N-(2-methylprop-2-enyl)propanamide —— C15H21NO2S
    (2R)-N-ethyl-2-(4-hydroxyphenyl)sulfanyl-N-(2-methylprop-2-enyl)propanamide
    —— 2-[(4-Methyl-5-pyrazin-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetate —— C9H8N5O2S-
    2-[(4-Methyl-5-pyrazin-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— 1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H24N4O2S2
    1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(1H-pyrrol-2-yl)ethanone —— C16H16N4OS2
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(1H-pyrrol-2-yl)ethanone
    —— 1-(Azepan-1-yl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H24N4OS2
    1-(Azepan-1-yl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-benzyl-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-butylacetamide —— C20H28N4O2S
    2-[[5-benzyl-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-butylacetamide
    —— 2-[[5-benzyl-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-butylacetamide —— C20H28N4O2S
    2-[[5-benzyl-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-butylacetamide
    —— 2-(4-chloro-6-pyrrolidin-1-ylpyrimidin-2-yl)sulfanyl-1-[(1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone —— C20H29ClN4OS
    2-(4-chloro-6-pyrrolidin-1-ylpyrimidin-2-yl)sulfanyl-1-[(1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone
    —— (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C17H22N4OS2
    (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— 2-(2-cyanophenyl)sulfanyl-N-[(2R)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]benzamide —— C25H25N3O2S
    2-(2-cyanophenyl)sulfanyl-N-[(2R)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]benzamide
    —— 2-(4-chloro-6-pyrrolidin-1-ylpyrimidin-2-yl)sulfanyl-1-[(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone —— C20H29ClN4OS
    2-(4-chloro-6-pyrrolidin-1-ylpyrimidin-2-yl)sulfanyl-1-[(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone
    —— N-[(2S)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]-2-phenylsulfanylpyridine-3-carboxamide —— C23H25N3O2S
    N-[(2S)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]-2-phenylsulfanylpyridine-3-carboxamide
    —— 2-(2-cyanophenyl)sulfanyl-N-[(2S)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]benzamide —— C25H25N3O2S
    2-(2-cyanophenyl)sulfanyl-N-[(2S)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]benzamide
    —— N-[(2R)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]-2-phenylsulfanylpyridine-3-carboxamide —— C23H25N3O2S
    N-[(2R)-2-(dimethylamino)-2-(3-methoxyphenyl)ethyl]-2-phenylsulfanylpyridine-3-carboxamide
    —— N-[(1R)-1-(2,5-dimethylphenyl)ethyl]-3-phenylsulfanylpropanamide —— C19H23NOS
    N-[(1R)-1-(2,5-dimethylphenyl)ethyl]-3-phenylsulfanylpropanamide
    —— 5-[(3,5-Dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione —— C14H13N3OS3
    5-[(3,5-Dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-3-phenyl-1,3,4-thiadiazole-2-thione
    —— N-[(1S)-1-(2,5-dimethylphenyl)ethyl]-3-phenylsulfanylpropanamide —— C19H23NOS
    N-[(1S)-1-(2,5-dimethylphenyl)ethyl]-3-phenylsulfanylpropanamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[(2S)-2-(dimethylamino)-2-(3-fluorophenyl)ethyl]propanamide —— C19H22ClFN2OS
    3-(4-chlorophenyl)sulfanyl-N-[(2S)-2-(dimethylamino)-2-(3-fluorophenyl)ethyl]propanamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C14H15N3O3S4
    N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(4-methylphenyl)methyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C18H17N3OS3
    N-[(4-methylphenyl)methyl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(1H-pyrrol-2-yl)ethanone —— C14H11N3OS3
    2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(1H-pyrrol-2-yl)ethanone
    —— N-(2-adamantyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C20H23N3OS3
    N-(2-adamantyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1,2,4-triazol-4-amine —— C10H11ClN4S
    3-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1,2,4-triazol-4-amine
    —— 1-[2-(4-chlorophenyl)sulfanylethyl]-3-[(1R)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]urea —— C15H18ClN3OS2
    1-[2-(4-chlorophenyl)sulfanylethyl]-3-[(1R)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]urea
    —— N-(2-methoxyethyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H15N3O2S3
    N-(2-methoxyethyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-cyclopentylpropanamide —— C10H17N5OS
    (2R)-2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-cyclopentylpropanamide
    —— 3-(2-chlorophenyl)sulfanyl-N-[(1S)-1-(2,4-difluorophenyl)ethyl]propanamide —— C17H16ClF2NOS
    3-(2-chlorophenyl)sulfanyl-N-[(1S)-1-(2,4-difluorophenyl)ethyl]propanamide
    —— 1-[2-(4-chlorophenyl)sulfanylethyl]-3-[(1S)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]urea —— C15H18ClN3OS2
    1-[2-(4-chlorophenyl)sulfanylethyl]-3-[(1S)-1-(4-methyl-1,3-thiazol-2-yl)ethyl]urea
    —— 3-(4-chlorophenyl)sulfanyl-N-[(2R)-2-(dimethylamino)-2-(3-fluorophenyl)ethyl]propanamide —— C19H22ClFN2OS
    3-(4-chlorophenyl)sulfanyl-N-[(2R)-2-(dimethylamino)-2-(3-fluorophenyl)ethyl]propanamide