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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (1S,2R,3S)-2,3-dimethyl-N-[2-(4-methylphenyl)sulfanylethyl]-1-oxo-1,4-thiazinane-4-carboxamide —— C16H24N2O2S2
    (1S,2R,3S)-2,3-dimethyl-N-[2-(4-methylphenyl)sulfanylethyl]-1-oxo-1,4-thiazinane-4-carboxamide
    —— (1R,2S,3S)-2,3-dimethyl-N-[2-(4-methylphenyl)sulfanylethyl]-1-oxo-1,4-thiazinane-4-carboxamide —— C16H24N2O2S2
    (1R,2S,3S)-2,3-dimethyl-N-[2-(4-methylphenyl)sulfanylethyl]-1-oxo-1,4-thiazinane-4-carboxamide
    —— ethyl N-[(1S)-2-[(4-chloro-2-phenylsulfanyl-1,3-thiazol-5-yl)methylamino]-1-cyclopropylethyl]carbamate —— C18H22ClN3O2S2
    ethyl N-[(1S)-2-[(4-chloro-2-phenylsulfanyl-1,3-thiazol-5-yl)methylamino]-1-cyclopropylethyl]carbamate
    —— (2S)-N-[(2R)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide —— C19H21NO3S
    (2S)-N-[(2R)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide
    —— 2-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-4,4,4-trifluoro-3-hydroxybutyl]acetamide —— C13H15F3N4O2S2
    2-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-4,4,4-trifluoro-3-hydroxybutyl]acetamide
    —— (2S)-N-[(2S)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide —— C19H21NO3S
    (2S)-N-[(2S)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide
    —— (2R)-N-[(2S)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide —— C19H21NO3S
    (2R)-N-[(2S)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide
    —— 2-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3R)-4,4,4-trifluoro-3-hydroxybutyl]acetamide —— C13H15F3N4O2S2
    2-[(4-methyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3R)-4,4,4-trifluoro-3-hydroxybutyl]acetamide
    —— (2R)-N-[(2R)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide —— C19H21NO3S
    (2R)-N-[(2R)-2-benzyl-3-hydroxypropyl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide
    —— 4-methyl-2-methylsulfanyl-5-[3-oxo-3-[(2R)-2-propyl-1,3-thiazolidin-3-yl]propyl]-1H-pyrimidin-6-one —— C15H23N3O2S2
    4-methyl-2-methylsulfanyl-5-[3-oxo-3-[(2R)-2-propyl-1,3-thiazolidin-3-yl]propyl]-1H-pyrimidin-6-one
    —— (2R)-N-cyclopropyl-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H15FN4OS2
    (2R)-N-cyclopropyl-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-5-(furan-2-yl)-1,3,4-oxadiazole —— C14H11ClN2O2S
    2-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-5-(furan-2-yl)-1,3,4-oxadiazole
    —— 2-(2,3,5,6-tetramethylphenyl)sulfanyl-N-(thiophen-2-ylmethyl)acetamide —— C17H21NOS2
    2-(2,3,5,6-tetramethylphenyl)sulfanyl-N-(thiophen-2-ylmethyl)acetamide
    —— (2S)-N-cyclopropyl-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H15FN4OS2
    (2S)-N-cyclopropyl-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 1-[(2S)-2-(dimethylamino)-2-(1-methylpyrazol-4-yl)ethyl]-3-[(4-methylsulfanylphenyl)methyl]urea —— C17H25N5OS
    1-[(2S)-2-(dimethylamino)-2-(1-methylpyrazol-4-yl)ethyl]-3-[(4-methylsulfanylphenyl)methyl]urea
    —— (2S)-N-(1-cyanocyclohexyl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C19H23N5OS2
    (2S)-N-(1-cyanocyclohexyl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[[5-(4-butylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylacetamide —— C16H22N4OS2
    2-[[5-(4-butylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylacetamide
    —— (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H21FN4OS2
    (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-1-methoxypropan-2-yl]acetamide —— C14H17FN4O2S2
    2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-1-methoxypropan-2-yl]acetamide
    —— (2R)-N-(1-cyanocyclohexyl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C19H23N5OS2
    (2R)-N-(1-cyanocyclohexyl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-1-methoxypropan-2-yl]acetamide —— C14H17FN4O2S2
    2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-1-methoxypropan-2-yl]acetamide
    —— 4-Amino-6-methyl-3-[[2-(4-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazin-5-one —— C15H16N6OS2
    4-Amino-6-methyl-3-[[2-(4-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazin-5-one
    —— (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H21FN4OS2
    (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]propan-1-one —— C18H21FN2O2S2
    (2R)-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]propan-1-one
    —— (2R)-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]propan-1-one —— C18H21FN2O2S2
    (2R)-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]propan-1-one
    —— (2R)-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]propan-1-one —— C18H21FN2O2S2
    (2R)-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]propan-1-one
    —— 2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(4-methylcyclohexyl)acetamide —— C18H24N4OS2
    2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(4-methylcyclohexyl)acetamide
    —— (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H21FN4OS2
    (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-(cyclopropylmethyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide —— C19H26N4OS2
    N-(cyclopropylmethyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— 4-methyl-2-methylsulfanyl-5-[3-oxo-3-[(2S)-2-propyl-1,3-thiazolidin-3-yl]propyl]-1H-pyrimidin-6-one —— C15H23N3O2S2
    4-methyl-2-methylsulfanyl-5-[3-oxo-3-[(2S)-2-propyl-1,3-thiazolidin-3-yl]propyl]-1H-pyrimidin-6-one
    —— (2S)-2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]propanamide —— C21H24N4O3S
    (2S)-2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]propanamide
    —— N-(2,3-dimethylphenyl)-5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-amine —— C13H15N3S2
    N-(2,3-dimethylphenyl)-5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-amine
    —— diethyl 3-methyl-5-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-1H-pyrrole-2,4-dicarboxylate —— C14H17N3O4S2
    diethyl 3-methyl-5-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-1H-pyrrole-2,4-dicarboxylate
    —— (2R)-2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]propanamide —— C21H24N4O3S
    (2R)-2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]propanamide
    —— 1-[(3S)-1-(2-phenylsulfanylethyl)piperidin-3-yl]imidazolidin-2-one —— C16H23N3OS
    1-[(3S)-1-(2-phenylsulfanylethyl)piperidin-3-yl]imidazolidin-2-one
    —— 1-[(2R)-2-(dimethylamino)-2-(1-methylpyrazol-4-yl)ethyl]-3-[(4-methylsulfanylphenyl)methyl]urea —— C17H25N5OS
    1-[(2R)-2-(dimethylamino)-2-(1-methylpyrazol-4-yl)ethyl]-3-[(4-methylsulfanylphenyl)methyl]urea
    —— N-(1-cyanocyclopentyl)-2-({5-[(2,3-dimethylphenyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide —— C18H21N5OS2
    N-(1-cyanocyclopentyl)-2-({5-[(2,3-dimethylphenyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
    —— Tert-butyl 2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C16H21N3O2S2
    Tert-butyl 2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— N-[(1R)-1-cyano-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H19N5OS2
    N-[(1R)-1-cyano-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H21N5OS2
    N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 1-[(3R)-1-(2-phenylsulfanylethyl)piperidin-3-yl]imidazolidin-2-one —— C16H23N3OS
    1-[(3R)-1-(2-phenylsulfanylethyl)piperidin-3-yl]imidazolidin-2-one
    —— N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H21N5OS2
    N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(4-Butylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H18N4OS2
    2-[[5-(4-Butylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[4-amino-5-[(2-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C16H20FN5O2S
    2-[[4-amino-5-[(2-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— N-(3-methylphenyl)-5-[[(2R)-oxan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H19N3OS2
    N-(3-methylphenyl)-5-[[(2R)-oxan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-(4-methylphenyl)sulfanylethanone —— C17H19NO2S
    1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-(4-methylphenyl)sulfanylethanone
    —— diethyl 3-methyl-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1H-pyrrole-2,4-dicarboxylate —— C15H19N3O4S2
    diethyl 3-methyl-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1H-pyrrole-2,4-dicarboxylate
    —— 3-Tert-butyl-7-ethylsulfanyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one —— C10H14N4OS2
    3-Tert-butyl-7-ethylsulfanyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
    —— 1-ethyl-3-(2-phenylsulfanylethyl)-1-[(1S)-1-pyridin-3-ylethyl]urea —— C18H23N3OS
    1-ethyl-3-(2-phenylsulfanylethyl)-1-[(1S)-1-pyridin-3-ylethyl]urea
    —— 1-ethyl-3-(2-phenylsulfanylethyl)-1-[(1R)-1-pyridin-3-ylethyl]urea —— C18H23N3OS
    1-ethyl-3-(2-phenylsulfanylethyl)-1-[(1R)-1-pyridin-3-ylethyl]urea