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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-tert-butyl-5-[(1R)-1-(3-chloro-4-fluorophenyl)ethyl]sulfanyl-1,2,4-triazol-4-amine —— C14H18ClFN4S
    3-tert-butyl-5-[(1R)-1-(3-chloro-4-fluorophenyl)ethyl]sulfanyl-1,2,4-triazol-4-amine
    —— (2R)-3-(4-methylphenyl)-2-(2-methylphenyl)sulfanylpropanenitrile —— C17H17NS
    (2R)-3-(4-methylphenyl)-2-(2-methylphenyl)sulfanylpropanenitrile
    —— 5-(2-bromoprop-2-enylsulfanyl)-1-[[(2R)-oxolan-2-yl]methyl]tetrazole —— C9H13BrN4OS
    5-(2-bromoprop-2-enylsulfanyl)-1-[[(2R)-oxolan-2-yl]methyl]tetrazole
    —— (2R)-N-[(2-chlorophenyl)methyl]-2-(2-methylphenyl)sulfanylpropanamide —— C17H18ClNOS
    (2R)-N-[(2-chlorophenyl)methyl]-2-(2-methylphenyl)sulfanylpropanamide
    —— (2S)-2-(2-methylphenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide —— C12H14F3NOS
    (2S)-2-(2-methylphenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide
    —— 1-[5-(2-bromoprop-2-enylsulfanyl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]-4-methylpiperidine —— C16H25BrN4OS
    1-[5-(2-bromoprop-2-enylsulfanyl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]-4-methylpiperidine
    —— 4-[5-(2-bromoprop-2-enylsulfanyl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]morpholine —— C14H21BrN4O2S
    4-[5-(2-bromoprop-2-enylsulfanyl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]morpholine
    —— (2R)-2-(2-methylphenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide —— C12H14F3NOS
    (2R)-2-(2-methylphenyl)sulfanyl-N-(2,2,2-trifluoroethyl)propanamide
    —— (2S)-N-[(2-chlorophenyl)methyl]-2-(2-methylphenyl)sulfanylpropanamide —— C17H18ClNOS
    (2S)-N-[(2-chlorophenyl)methyl]-2-(2-methylphenyl)sulfanylpropanamide
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(2R)-1-(1,2,4-triazol-1-yl)propan-2-yl]acetamide —— C15H19BrN4OS
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(2R)-1-(1,2,4-triazol-1-yl)propan-2-yl]acetamide
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(2S)-1-(1,2,4-triazol-1-yl)propan-2-yl]acetamide —— C15H19BrN4OS
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(2S)-1-(1,2,4-triazol-1-yl)propan-2-yl]acetamide
    —— 2-(2-cyanophenyl)sulfanyl-N-[(2S)-2-methyl-3-piperidin-1-ylpropyl]benzamide —— C23H27N3OS
    2-(2-cyanophenyl)sulfanyl-N-[(2S)-2-methyl-3-piperidin-1-ylpropyl]benzamide
    —— 2-[(3aR,7aR)-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl]-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide —— C24H24N2O3S
    2-[(3aR,7aR)-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl]-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide
    —— 2-[(3aS,7aR)-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl]-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide —— C24H24N2O3S
    2-[(3aS,7aR)-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl]-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide
    —— tert-butyl N-[(1S,2S)-2-methyl-1-[5-[(2-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate —— C20H29N3O3S
    tert-butyl N-[(1S,2S)-2-methyl-1-[5-[(2-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate
    —— 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide —— C17H24N4O2S
    2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide
    —— [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 2,4-difluorobenzoate —— C21H15F2NO3S
    [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 2,4-difluorobenzoate
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]acetamide —— C24H27ClN4O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]acetamide
    —— N-(6-amino-2,4-dioxo-1-propylpyrimidin-5-yl)-N-butyl-2-(2-chlorophenyl)sulfanylacetamide —— C19H25ClN4O3S
    N-(6-amino-2,4-dioxo-1-propylpyrimidin-5-yl)-N-butyl-2-(2-chlorophenyl)sulfanylacetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide —— C15H20ClNOS
    2-(2-chlorophenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide
    —— (2S)-N-(1-adamantyl)-2-(2-chlorophenyl)sulfanylpropanamide —— C19H24ClNOS
    (2S)-N-(1-adamantyl)-2-(2-chlorophenyl)sulfanylpropanamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(1R)-1-cyano-1-cyclopropylethyl]acetamide —— C14H15ClN2OS
    2-(2-chlorophenyl)sulfanyl-N-[(1R)-1-cyano-1-cyclopropylethyl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-(1-cyanocyclohexyl)-N-methylacetamide —— C16H19ClN2OS
    2-(2-chlorophenyl)sulfanyl-N-(1-cyanocyclohexyl)-N-methylacetamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-(2-chlorophenyl)sulfanylacetamide —— C16H15Cl2NOS
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-(2-chlorophenyl)sulfanylacetamide
    —— 3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide —— C23H32N4O2S
    3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide
    —— (2S)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2OS
    (2S)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2R)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2OS
    (2R)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— 3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide —— C23H32N4O2S
    3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide
    —— 6-Amino-5-[2-(2-chlorophenyl)sulfanylacetyl]-3-methyl-1-propylpyrimidine-2,4-dione —— C16H18ClN3O3S
    6-Amino-5-[2-(2-chlorophenyl)sulfanylacetyl]-3-methyl-1-propylpyrimidine-2,4-dione
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide —— C17H17ClFNOS
    (2S)-2-(2-chlorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— 6-Amino-5-[2-(2-chlorophenyl)sulfanylacetyl]-1-propylpyrimidine-2,4-dione —— C15H16ClN3O3S
    6-Amino-5-[2-(2-chlorophenyl)sulfanylacetyl]-1-propylpyrimidine-2,4-dione
    —— (2S)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2OS
    (2S)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide —— C17H17ClFNOS
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— 2-(2-chlorophenyl)sulfanyl-N-(1-cyanocyclopentyl)acetamide —— C14H15ClN2OS
    2-(2-chlorophenyl)sulfanyl-N-(1-cyanocyclopentyl)acetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]acetamide —— C24H27ClN4O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]acetamide
    —— 2-(2-Chlorophenyl)sulfanyl-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone —— C17H15ClN2OS
    2-(2-Chlorophenyl)sulfanyl-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]acetamide —— C22H30N4OS
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C12H14ClNO3S2
    2-(2-chlorophenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C14H14ClNOS2
    2-(2-chlorophenyl)sulfanyl-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[(1S,2S)-2-methylcyclohexyl]propanamide —— C16H22ClNOS
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[(1S,2S)-2-methylcyclohexyl]propanamide
    —— 2-(4-Chlorophenyl)-5-[(2-chlorophenyl)sulfanylmethyl]-1,3,4-oxadiazole —— C15H10Cl2N2OS
    2-(4-Chlorophenyl)-5-[(2-chlorophenyl)sulfanylmethyl]-1,3,4-oxadiazole
    —— (2R)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2OS
    (2R)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C13H16ClNO2S
    2-(2-chlorophenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-(2-chlorophenyl)sulfanylacetamide —— C16H15Cl2NOS
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-(2-chlorophenyl)sulfanylacetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-(2-cyanoethyl)acetamide —— C11H11ClN2OS
    2-(2-chlorophenyl)sulfanyl-N-(2-cyanoethyl)acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C12H14ClNO3S2
    2-(2-chlorophenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(2S)-2-cyano-3-methylbutan-2-yl]acetamide —— C14H17ClN2OS
    2-(2-chlorophenyl)sulfanyl-N-[(2S)-2-cyano-3-methylbutan-2-yl]acetamide
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-cyclopentylpropanamide —— C14H18ClNOS
    (2S)-2-(2-chlorophenyl)sulfanyl-N-cyclopentylpropanamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C14H14ClNOS2
    2-(2-chlorophenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide —— C17H18ClNOS
    2-(2-chlorophenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide