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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 5-methylpyrazine-2-carboxylate —— C22H21N3O3S
    [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 5-methylpyrazine-2-carboxylate
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide —— C24H34N4OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(2S)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide —— C24H34N4OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(2R)-2-(4-methylpiperidin-1-yl)-2-phenylethyl]propanamide
    —— [2-oxo-2-(2-phenylsulfanylanilino)ethyl] (1S)-cyclohex-3-ene-1-carboxylate —— C21H21NO3S
    [2-oxo-2-(2-phenylsulfanylanilino)ethyl] (1S)-cyclohex-3-ene-1-carboxylate
    —— 4-[4-benzyl-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C19H24N6O2S
    4-[4-benzyl-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— (2S)-2-(4-tert-butylphenoxy)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C21H23N3O2S2
    (2S)-2-(4-tert-butylphenoxy)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— 5-[(1S)-1-(2-bromophenyl)sulfanylethyl]-3-ethyl-1,2,4-oxadiazole —— C12H13BrN2OS
    5-[(1S)-1-(2-bromophenyl)sulfanylethyl]-3-ethyl-1,2,4-oxadiazole
    —— (2R)-2-(4-tert-butylphenoxy)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C21H23N3O2S2
    (2R)-2-(4-tert-butylphenoxy)-N-[4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— 5-[(1S)-1-(3-chloropyridin-2-yl)sulfanylethyl]-3-ethyl-1,2,4-oxadiazole —— C11H12ClN3OS
    5-[(1S)-1-(3-chloropyridin-2-yl)sulfanylethyl]-3-ethyl-1,2,4-oxadiazole
    —— 4-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-2,6-dimethylpyrimidine-5-carbonitrile —— C13H15N5OS
    4-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-2,6-dimethylpyrimidine-5-carbonitrile
    —— 4-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-2,6-dimethylpyrimidine-5-carbonitrile —— C13H15N5OS
    4-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-2,6-dimethylpyrimidine-5-carbonitrile
    —— N-[4-(difluoromethylsulfanyl)phenyl]-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C15H15F2N5OS3
    N-[4-(difluoromethylsulfanyl)phenyl]-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 3-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-(3-methoxypropyl)-1H-1,2,4-triazol-5-one —— C12H19N5O3S
    3-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-(3-methoxypropyl)-1H-1,2,4-triazol-5-one
    —— 3-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C13H19N5O3S
    3-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— 3-ethyl-5-[(1R)-1-[[5-(furan-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C15H17N5O2S
    3-ethyl-5-[(1R)-1-[[5-(furan-2-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 3-(3,5-dimethylpyrazol-1-yl)-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-4-amine —— C13H18N8OS
    3-(3,5-dimethylpyrazol-1-yl)-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-4-amine
    —— 3-ethyl-5-[(1R)-1-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C11H17N5O2S
    3-ethyl-5-[(1R)-1-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 3-ethyl-5-[(1R)-1-[[5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H18N6O2S3
    3-ethyl-5-[(1R)-1-[[5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 5-[(1R)-1-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole —— C18H21N5OS
    5-[(1R)-1-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole
    —— 2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-(methylsulfanylmethyl)-1,3,4-oxadiazole —— C10H14N4O2S2
    2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-(methylsulfanylmethyl)-1,3,4-oxadiazole
    —— 5-[(1R)-1-(2-bromophenyl)sulfanylethyl]-3-ethyl-1,2,4-oxadiazole —— C12H13BrN2OS
    5-[(1R)-1-(2-bromophenyl)sulfanylethyl]-3-ethyl-1,2,4-oxadiazole
    —— 2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanylpyrimidine-4,6-diamine —— C10H14N6OS
    2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanylpyrimidine-4,6-diamine
    —— 3-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C13H19N5O3S
    3-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— 5-[(1R)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)ethyl]-3-ethyl-1,2,4-oxadiazole —— C15H18N2O3S
    5-[(1R)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfanyl)ethyl]-3-ethyl-1,2,4-oxadiazole
    —— 5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-N-(2-methoxyethyl)-1,3,4-thiadiazol-2-amine —— C11H17N5O2S2
    5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-N-(2-methoxyethyl)-1,3,4-thiadiazol-2-amine
    —— N-(3-chloro-2-methylphenyl)-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C15H16ClN5OS2
    N-(3-chloro-2-methylphenyl)-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 3-ethyl-5-[(1R)-1-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole —— C10H15N5OS
    3-ethyl-5-[(1R)-1-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanylpyrimidine-4,6-diamine —— C10H14N6OS
    2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanylpyrimidine-4,6-diamine
    —— N-cyclopropyl-N-[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide —— C13H17N5O2S2
    N-cyclopropyl-N-[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide
    —— 2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-(methylsulfanylmethyl)-1,3,4-oxadiazole —— C10H14N4O2S2
    2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-(methylsulfanylmethyl)-1,3,4-oxadiazole
    —— 3-ethyl-5-[(1R)-1-[[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H18N6O2S3
    3-ethyl-5-[(1R)-1-[[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 3-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C13H19N5O3S
    3-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— 5-[(1R)-1-[[4-benzyl-5-(pyrrolidin-1-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole —— C20H26N6OS
    5-[(1R)-1-[[4-benzyl-5-(pyrrolidin-1-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole
    —— N-(3-chloro-2-methylphenyl)-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C15H16ClN5OS2
    N-(3-chloro-2-methylphenyl)-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 5-[(1S)-1-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole —— C18H21N5OS
    5-[(1S)-1-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole
    —— 2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C17H20N4O2S
    2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 4-[4-ethyl-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C14H22N6O2S
    4-[4-ethyl-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 5-[(1R)-1-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole —— C14H19N5OS
    5-[(1R)-1-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole
    —— 2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-6-methylpyrimidin-4-amine —— C11H15N5OS
    2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-6-methylpyrimidin-4-amine
    —— 2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-6-methylpyrimidin-4-amine —— C11H15N5OS
    2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-6-methylpyrimidin-4-amine
    —— N,N-diethyl-4-[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazol-2-yl]aniline —— C18H23N5O2S
    N,N-diethyl-4-[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazol-2-yl]aniline
    —— 3-ethyl-5-[(1S)-1-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C11H17N5O2S
    3-ethyl-5-[(1S)-1-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-N-(2-methoxyethyl)-1,3,4-thiadiazol-2-amine —— C11H17N5O2S2
    5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-N-(2-methoxyethyl)-1,3,4-thiadiazol-2-amine
    —— 2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C17H20N4O2S
    2-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— N-cyclopropyl-N-[5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide —— C13H17N5O2S2
    N-cyclopropyl-N-[5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]acetamide
    —— 3-ethyl-5-[(1S)-1-[[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-1,2,4-oxadiazole —— C14H18N6O2S3
    3-ethyl-5-[(1S)-1-[[5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 3-tert-butyl-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-4-amine —— C12H20N6OS
    3-tert-butyl-5-[(1S)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-4-amine
    —— 2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C17H20N4O2S
    2-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 3-tert-butyl-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-4-amine —— C12H20N6OS
    3-tert-butyl-5-[(1R)-1-(3-ethyl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,2,4-triazol-4-amine
    —— 5-[(1S)-1-[[4-benzyl-5-(pyrrolidin-1-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole —— C20H26N6OS
    5-[(1S)-1-[[4-benzyl-5-(pyrrolidin-1-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-3-ethyl-1,2,4-oxadiazole