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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-[(S)-phenyl(pyridin-4-yl)methyl]propanamide —— C21H19ClN2OS
    (2S)-2-(2-chlorophenyl)sulfanyl-N-[(S)-phenyl(pyridin-4-yl)methyl]propanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[(R)-phenyl(pyridin-4-yl)methyl]propanamide —— C21H19ClN2OS
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[(R)-phenyl(pyridin-4-yl)methyl]propanamide
    —— (1R)-1-(2,6-difluorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol —— C17H15F2N3OS2
    (1R)-1-(2,6-difluorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol
    —— (1S)-1-(2,6-difluorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol —— C17H15F2N3OS2
    (1S)-1-(2,6-difluorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[(S)-phenyl(pyridin-4-yl)methyl]propanamide —— C21H19ClN2OS
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[(S)-phenyl(pyridin-4-yl)methyl]propanamide
    —— (1S)-1-(2-chlorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol —— C11H11ClN2OS2
    (1S)-1-(2-chlorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol
    —— (1R)-1-(3-fluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol —— C11H11FN2OS2
    (1R)-1-(3-fluorophenyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol
    —— (1R)-1-(2-chlorophenyl)-2-(1-methyltetrazol-5-yl)sulfanylethanol —— C10H11ClN4OS
    (1R)-1-(2-chlorophenyl)-2-(1-methyltetrazol-5-yl)sulfanylethanol
    —— (1R)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(3-fluorophenyl)ethanol —— C18H18FN3OS2
    (1R)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(3-fluorophenyl)ethanol
    —— (1S)-1-(2,6-difluorophenyl)-2-(1-methyltetrazol-5-yl)sulfanylethanol —— C10H10F2N4OS
    (1S)-1-(2,6-difluorophenyl)-2-(1-methyltetrazol-5-yl)sulfanylethanol
    —— (1R)-1-(2-chlorophenyl)-2-(1-methylimidazol-2-yl)sulfanylethanol —— C12H13ClN2OS
    (1R)-1-(2-chlorophenyl)-2-(1-methylimidazol-2-yl)sulfanylethanol
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-[(R)-phenyl(pyridin-4-yl)methyl]propanamide —— C21H19ClN2OS
    (2S)-2-(2-chlorophenyl)sulfanyl-N-[(R)-phenyl(pyridin-4-yl)methyl]propanamide
    —— (1S)-1-(2-chlorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol —— C17H16ClN3OS2
    (1S)-1-(2-chlorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol
    —— (1R)-1-(2-chlorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol —— C17H16ClN3OS2
    (1R)-1-(2-chlorophenyl)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanol
    —— 2-[[4-benzyl-5-(5-bromofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C23H21BrN4O2S
    2-[[4-benzyl-5-(5-bromofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— 2-[[4-benzyl-5-(5-bromofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C23H21BrN4O2S
    2-[[4-benzyl-5-(5-bromofuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— 4-ethyl-3-[(1S)-1-phenylethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazole —— C16H17N3S2
    4-ethyl-3-[(1S)-1-phenylethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazole
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-[[5-(methylsulfamoyl)thiophen-2-yl]methyl]propanamide —— C15H17ClN2O3S3
    (2R)-2-(2-chlorophenyl)sulfanyl-N-[[5-(methylsulfamoyl)thiophen-2-yl]methyl]propanamide
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-[[5-(methylsulfamoyl)thiophen-2-yl]methyl]propanamide —— C15H17ClN2O3S3
    (2S)-2-(2-chlorophenyl)sulfanyl-N-[[5-(methylsulfamoyl)thiophen-2-yl]methyl]propanamide
    —— 4-ethyl-3-[(1R)-1-phenylethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazole —— C16H17N3S2
    4-ethyl-3-[(1R)-1-phenylethyl]sulfanyl-5-thiophen-2-yl-1,2,4-triazole
    —— 1-(3,5-dimethylpyrazol-1-yl)-2-[[5-[(2Z)-2-(furan-2-ylmethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C14H15N7O2S
    1-(3,5-dimethylpyrazol-1-yl)-2-[[5-[(2Z)-2-(furan-2-ylmethylidene)hydrazinyl]-1H-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 7-[[4-[(2S)-2-(4-bromophenyl)sulfanylpropanoyl]piperazin-1-yl]methyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C20H21BrN4O2S2
    7-[[4-[(2S)-2-(4-bromophenyl)sulfanylpropanoyl]piperazin-1-yl]methyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 7-[[4-[(2R)-2-(4-bromophenyl)sulfanylpropanoyl]piperazin-1-yl]methyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C20H21BrN4O2S2
    7-[[4-[(2R)-2-(4-bromophenyl)sulfanylpropanoyl]piperazin-1-yl]methyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— (3S)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-phenylbutanamide —— C24H25NOS
    (3S)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-phenylbutanamide
    —— (2S)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-phenoxypropanamide —— C23H23NO2S
    (2S)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-phenoxypropanamide
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-(3-phenylpropyl)propanamide —— C18H20ClNOS
    (2S)-2-(2-chlorophenyl)sulfanyl-N-(3-phenylpropyl)propanamide
    —— N-[(1R,2S)-2-methylcyclohexyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C13H19F3N4OS
    N-[(1R,2S)-2-methylcyclohexyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-phenylpropanamide —— C23H23NOS
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-phenylpropanamide
    —— (E)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-(furan-2-yl)prop-2-enamide —— C21H19NO2S
    (E)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-(furan-2-yl)prop-2-enamide
    —— 2-(4-cyanophenoxy)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide —— C23H20N2O2S
    2-(4-cyanophenoxy)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(3-methoxyphenyl)acetamide —— C23H23NO2S
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(3-methoxyphenyl)acetamide
    —— (2R)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-phenoxypropanamide —— C23H23NO2S
    (2R)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-phenoxypropanamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]cyclobutanecarboxamide —— C19H21NOS
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]cyclobutanecarboxamide
    —— 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide —— C17H28N4OS2
    2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(2-methoxyphenyl)acetamide —— C23H23NO2S
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(2-methoxyphenyl)acetamide
    —— 2-(4-chlorophenoxy)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide —— C22H20ClNO2S
    2-(4-chlorophenoxy)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-[3-(trifluoromethyl)phenyl]acetamide —— C23H20F3NOS
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-[3-(trifluoromethyl)phenyl]acetamide
    —— 2-(2-chlorophenyl)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide —— C22H20ClNOS
    2-(2-chlorophenyl)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(2-methylphenoxy)acetamide —— C23H23NO2S
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(2-methylphenoxy)acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-thiophen-3-ylacetamide —— C20H19NOS2
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-thiophen-3-ylacetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(4-fluorophenyl)acetamide —— C22H20FNOS
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(4-fluorophenyl)acetamide
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-phenoxyacetamide —— C22H21NO2S
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-phenoxyacetamide
    —— 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C17H28N4OS2
    2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide
    —— (3R)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-phenylbutanamide —— C24H25NOS
    (3R)-N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-3-phenylbutanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-methoxy-N-methylpropanamide —— C11H14ClNO2S
    (2R)-2-(2-chlorophenyl)sulfanyl-N-methoxy-N-methylpropanamide
    —— (2S)-2-(4-bromophenyl)sulfanyl-N-methoxy-N-methylpropanamide —— C11H14BrNO2S
    (2S)-2-(4-bromophenyl)sulfanyl-N-methoxy-N-methylpropanamide
    —— (2R)-2-(4-bromophenyl)sulfanyl-N-(3-phenylpropyl)propanamide —— C18H20BrNOS
    (2R)-2-(4-bromophenyl)sulfanyl-N-(3-phenylpropyl)propanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-(3-phenylpropyl)propanamide —— C18H20ClNOS
    (2R)-2-(2-chlorophenyl)sulfanyl-N-(3-phenylpropyl)propanamide
    —— (2S)-2-(4-bromophenyl)sulfanyl-N-(3-phenylpropyl)propanamide —— C18H20BrNOS
    (2S)-2-(4-bromophenyl)sulfanyl-N-(3-phenylpropyl)propanamide
    —— (2S)-2-(2-chlorophenyl)sulfanyl-N-methoxy-N-methylpropanamide —— C11H14ClNO2S
    (2S)-2-(2-chlorophenyl)sulfanyl-N-methoxy-N-methylpropanamide