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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-2-phenylpropyl]acetamide —— C21H23N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-2-phenylpropyl]acetamide
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H20ClN3O2S
    N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(2S)-2-(dimethylamino)-2-phenylethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C22H26N4O2S
    N-[(2S)-2-(dimethylamino)-2-phenylethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C18H19N3O3S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C20H21N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— 2-(3,5-dimethylphenyl)-5-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C18H17FN2OS
    2-(3,5-dimethylphenyl)-5-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H20ClN3O2S
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-(3,5-Dimethylphenyl)-5-[(2,5-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C19H20N2OS
    2-(3,5-Dimethylphenyl)-5-[(2,5-dimethylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide —— C19H18FN3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide
    —— N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C22H25N3O2S
    N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]acetamide —— C22H25N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]acetamide
    —— 2-[[5-(3,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)ethanone —— C21H23N3O2S
    2-[[5-(3,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)ethanone
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]acetamide —— C22H25N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]acetamide
    —— (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C18H19N3O3S
    (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-1-methoxypropan-2-yl]acetamide —— C16H21N3O3S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2S)-1-methoxypropan-2-yl]acetamide
    —— N-(2-cyanoethyl)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methylacetamide —— C16H18N4O2S
    N-(2-cyanoethyl)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 6-Amino-5-[2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]-1-propylpyrimidine-2,4-dione —— C19H21N5O4S
    6-Amino-5-[2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]-1-propylpyrimidine-2,4-dione
    —— methyl 5-[(2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C21H23N3O4S
    methyl 5-[(2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-phenylpropyl]acetamide —— C21H23N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-phenylpropyl]acetamide
    —— 2-[[5-(3,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone —— C21H20N4O2S
    2-[[5-(3,5-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C20H21N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H20ClN3O2S
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— methyl 5-[(2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C21H23N3O4S
    methyl 5-[(2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-pentan-3-ylacetamide —— C17H23N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-pentan-3-ylacetamide
    —— 2-[(3-Bromophenyl)methylsulfanyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazole —— C17H15BrN2OS
    2-[(3-Bromophenyl)methylsulfanyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazole
    —— ethyl 4-[2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate —— C21H23N3O4S
    ethyl 4-[2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]-2,5-dimethyl-1H-pyrrole-3-carboxylate
    —— 1-[2-(4-Methylphenyl)sulfanylethyl]-3-propylurea —— C13H20N2OS
    1-[2-(4-Methylphenyl)sulfanylethyl]-3-propylurea
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one —— C16H18N2O2S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one
    —— 1-[2,5-Dimethyl-1-(2-thiophen-2-ylethyl)pyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C17H20N4OS2
    1-[2,5-Dimethyl-1-(2-thiophen-2-ylethyl)pyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-[(4-Cyano-1-methyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]acetate —— C13H13N2O2S-
    2-[(4-Cyano-1-methyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]acetate
    —— 1,3,5-trimethyl-N-(2-phenylsulfanylethyl)pyrazole-4-sulfonamide —— C14H19N3O2S2
    1,3,5-trimethyl-N-(2-phenylsulfanylethyl)pyrazole-4-sulfonamide
    —— 3-[[(2R,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C22H28N5O2S+
    3-[[(2R,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— 3-[[(2R,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C22H27N5O2S
    3-[[(2R,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— 3-[[(2R,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C22H28N5O2S+
    3-[[(2R,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— 3-[[(2R,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C22H27N5O2S
    3-[[(2R,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— 3-[[(2S,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C22H28N5O2S+
    3-[[(2S,5S)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— 3-[[(2S,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C22H28N5O2S+
    3-[[(2S,5R)-2-[4-(dimethylamino)phenyl]-1,3-oxazolidin-3-ium-5-yl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— N-[(1R,3S)-3-methylcyclopentyl]-2-methylsulfanylaniline —— C13H19NS
    N-[(1R,3S)-3-methylcyclopentyl]-2-methylsulfanylaniline
    —— 2-(4-fluorophenyl)sulfanyl-N-[(2S)-3,3,3-trifluoro-2-hydroxy-2-phenylpropyl]acetamide —— C17H15F4NO2S
    2-(4-fluorophenyl)sulfanyl-N-[(2S)-3,3,3-trifluoro-2-hydroxy-2-phenylpropyl]acetamide
    —— N-[(1S,3R)-3-methylcyclopentyl]-3-methylsulfanylaniline —— C13H19NS
    N-[(1S,3R)-3-methylcyclopentyl]-3-methylsulfanylaniline
    —— N-[(1R,3S)-3-methylcyclopentyl]-4-methylsulfanylaniline —— C13H19NS
    N-[(1R,3S)-3-methylcyclopentyl]-4-methylsulfanylaniline
    —— N-[(1S,3R)-3-methylcyclopentyl]-2-methylsulfanylaniline —— C13H19NS
    N-[(1S,3R)-3-methylcyclopentyl]-2-methylsulfanylaniline
    —— N-[(1S,3S)-3-methylcyclopentyl]-4-methylsulfanylaniline —— C13H19NS
    N-[(1S,3S)-3-methylcyclopentyl]-4-methylsulfanylaniline
    —— 1-(2-Phenylsulfanylethyl)-3-propylurea —— C12H18N2OS
    1-(2-Phenylsulfanylethyl)-3-propylurea
    —— 3-phenylsulfanyl-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-phenylpropyl]propanamide —— C18H18F3NO2S
    3-phenylsulfanyl-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-phenylpropyl]propanamide
    —— N-[(1R,3R)-3-methylcyclopentyl]-2-methylsulfanylaniline —— C13H19NS
    N-[(1R,3R)-3-methylcyclopentyl]-2-methylsulfanylaniline
    —— N-[(1R,3R)-3-methylcyclopentyl]-4-methylsulfanylaniline —— C13H19NS
    N-[(1R,3R)-3-methylcyclopentyl]-4-methylsulfanylaniline
    —— N-[(1S,3S)-3-methylcyclopentyl]-3-methylsulfanylaniline —— C13H19NS
    N-[(1S,3S)-3-methylcyclopentyl]-3-methylsulfanylaniline
    —— N-[(1R,3R)-3-methylcyclopentyl]-3-methylsulfanylaniline —— C13H19NS
    N-[(1R,3R)-3-methylcyclopentyl]-3-methylsulfanylaniline
    —— 2-(4-fluorophenyl)sulfanyl-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-phenylpropyl]acetamide —— C17H15F4NO2S
    2-(4-fluorophenyl)sulfanyl-N-[(2R)-3,3,3-trifluoro-2-hydroxy-2-phenylpropyl]acetamide